1. Increases in serum concentration of human heart-type fatty acid-binding protein following elective coronary intervention
- Author
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Demosthenes B. Panagiotakos, Demitrios Degiannis, Vassilis Voudris, Eftihia Sbarouni, Antigoni Chaidaroglou, Ioannis Sklavainas, and Panagiota Georgiadou
- Subjects
Male ,medicine.medical_specialty ,Myocardial ischemia ,Health, Toxicology and Mutagenesis ,medicine.medical_treatment ,Clinical Biochemistry ,Coronary Disease ,Fatty Acid-Binding Proteins ,Biochemistry ,Fatty acid-binding protein ,Internal medicine ,Angioplasty ,Humans ,Medicine ,business.industry ,Human heart ,Middle Aged ,Serum concentration ,Peripheral ,Endocrinology ,Coronary vessel ,Circulatory system ,Cardiology ,Female ,business ,Fatty Acid Binding Protein 3 ,Angioplasty, Balloon ,Biomarkers - Abstract
Heart-type fatty acid-binding protein (H-FABP) is considered a marker of myocardial necrosis but whether or not it is modified by myocardial ischemia is not clear. We sought to investigate if H-FABP serum levels increase following non-urgent coronary angioplasty.We studied 31 patients undergoing coronary angioplasty. Peripheral venous samples were drawn immediately before angioplasty, 1 h after the first balloon inflation and 24 h after the procedure and assayed for H-FABP.Serum levels of H-FABP increased significantly at 1 h vs baseline from 2554 +/- 1268 to 3322 +/- 245 pg ml(-1) (p = 0.024). However, no differences were observed between 1 h and 24 h after angioplasty (3268 +/- 1861 vs 3322 +/- 2459 pg ml(-1), p = 0.87). Moreover, no significant difference was observed when we compared 24 h after angioplasty with the baseline (3268 +/- 1861 vs 2554 +/- 1268 pg ml(-1), p = 0.112).We conclude that H-FABP significantly increases after elective coronary angioplasty at 1 h compared with baseline values; whether or not this has any prognostic significance for future events, as it occurs with troponins, needs to be studied further.
- Published
- 2009
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