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368 results on '"Demougeot, Céline"'

1. The new quinazoline derivative (N2-methyl-N4-[(thiophen-2-yl)methyl]quinazoline-2,4-diamine) vasodilates isolated mesenteric arteries through endothelium-independent mechanisms and has acute hypotensive effects in Wistar rats

Author

Chatturong, Usana, Chootip, Krongkarn, Martin, Hélène, Tournier-Nappey, Maude, Ingkaninan, Kornkanok, Temkitthawon, Prapapan, Sermsenaphorn, Saharat, Somarin, Thanachon, Konsue, Adchatawut, Gleeson, M. Paul, Totoson, Perle, and Demougeot, Céline

Published
2023
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13. Lipid profiling following intake of the omega 3 fatty acid DHA identifies the peroxidized metabolites F4-neuroprostanes as the best predictors of atherosclerosis prevention.

Author

Gladine, Cécile, Newman, John W, Durand, Thierry, Pedersen, Theresa L, Galano, Jean-Marie, Demougeot, Céline, Berdeaux, Olivier, Pujos-Guillot, Estelle, Mazur, Andrzej, and Comte, Blandine

Subjects
Liver, Animals, Mice, Knockout, Mice, Docosahexaenoic Acids, Fatty Acids, Unsaturated, Receptors, LDL, Chromatography, Liquid, Analysis of Variance, Cluster Analysis, Blood Pressure, Heart Rate, Dose-Response Relationship, Drug, Atherosclerosis, Lipid Metabolism, Gas Chromatography-Mass Spectrometry, Tandem Mass Spectrometry, Neuroprostanes, Biomarkers, Chromatography, Liquid, Dose-Response Relationship, Drug, Fatty Acids, Unsaturated, Knockout, Receptors, LDL, General Science & Technology
Abstract

The anti-atherogenic effects of omega 3 fatty acids, namely eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) are well recognized but the impact of dietary intake on bioactive lipid mediator profiles remains unclear. Such a profiling effort may offer novel targets for future studies into the mechanism of action of omega 3 fatty acids. The present study aimed to determine the impact of DHA supplementation on the profiles of polyunsaturated fatty acids (PUFA) oxygenated metabolites and to investigate their contribution to atherosclerosis prevention. A special emphasis was given to the non-enzymatic metabolites knowing the high susceptibility of DHA to free radical-mediated peroxidation and the increased oxidative stress associated with plaque formation. Atherosclerosis prone mice (LDLR(-/-)) received increasing doses of DHA (0, 0.1, 1 or 2% of energy) during 20 weeks leading to a dose-dependent reduction of atherosclerosis (R(2) = 0.97, p = 0.02), triglyceridemia (R(2) = 0.97, p = 0.01) and cholesterolemia (R(2) = 0.96, p

Published
2014

14. Vasorelaxant and hypotensive effects of an ethanolic extract of Nymphaea pubescens and its main compound quercetin 3-methyl ether 3'-O-β-xylopyranoside.

Author

Teerapap Panklai, Kornkanok Ingkaninan, Krongkarn Chootip, Prapapan Temkitthawon, Nungruthai Suphrom, Tournier-Nappey, Maude, Girard, Corine, Demougeot, Céline, and Totoson, Perle

Subjects
DIASTOLIC blood pressure, QUERCETIN, SYSTOLIC blood pressure, LABORATORY rats, MESENTERIC artery, ASYMMETRIC dimethylarginine, BLOOD pressure
Abstract

Aim: Nymphaea plants were traditionally used to treat diseases associated with endothelial dysfunction. The present study investigated the effects of an ethanolic extract of Nymphaea pubescens Willd. (commonly named water lily, WL) and its main compound 1 (quercetin 3-methyl ether 3'-O-β-xylopyranoside) on vascular function in rats. Materials and methods: The vasorelaxant effects of the WL extract and its main compound 1 and their underlying mechanisms of action were evaluated on isolated mesenteric arteries from Wistar rats. Blood pressure and heart ratewere measured in anesthetized rats after infusion (i.v) of vehicle, WL extract, and compound 1 (at 0.01, 0.025, 0.05, 0.1, 0.5, and 1mg/kg). Nifedipine was used as a positive control. Results: Both WL extract and compound 1 induced vasorelaxant effects (with EC50 of 0.08 ± 0.01mg/mL and 42.8 ± 6.3 µM, respectively) that were reduced by endothelium removal. A significant decrease in these relaxations was observed with L-NAME but not with apamin--charybdotoxin or indomethacin. In the endotheliumdenuded condition, WL extract-induced relaxation was enhanced by 4-aminopyridine and glibenclamide, while iberiotoxin and ODQ (1H-[1,2,4] oxadiazolo[4,3-a]quinoxaline-1-one) had no effect. In contrast, compound 1-induced relaxation was not changed by any of these inhibitors. Both WL extract and compound 1 enhanced sodium nitroprusside-induced relaxation and inhibited receptor-operated Ca2+ channels.Only the WL extract was able to reduce PE-induced contraction (p < 0.001). As compared to the vehicle, the infusion of WL extract and compound 1 lowered systolic and diastolic blood pressure. Interestingly, the hypotensive effect of the compound was similar to that of nifedipine. The rebound tachycardia found at the highest dose of nifedipine was not observed with the WL extract or compound 1 (p < 0.05). Conclusion and discussion: Our study demonstrated a vasorelaxant effect of the WLextract and itsmain compound quercetin 3-methyl ether 3'-O-β-xylopyranoside, relying on the potentiation of the NO-cGMP pathway and calcium inhibitory effects. These vasorelaxant effects were associated with a potent hypotensive effect, providing pharmacological evidence for the traditional use of this plant. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Increased gut permeability and intestinal inflammation precede arthritis onset in the adjuvant-induced model of arthritis

Author

Hecquet, Sophie, primary, Totoson, Perle, additional, Martin, Hélène, additional, Algros, Marie-Paule, additional, Saas, Philippe, additional, Pais-de-Barros, Jean-Paul, additional, Atchon, Alban, additional, Valot, Benoît, additional, Hocquet, Didier, additional, Tournier, Maude, additional, Prati, Clément, additional, Wendling, Daniel, additional, Demougeot, Céline, additional, and Verhoeven, Frank, additional

Published
2023
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32. Quinazoline-Based Human Phosphodiesterase 5 Inhibitors Exhibited a Selective Vasorelaxant Effect on Rat Isolated Pulmonary Arteries Involving NO-sGC-cGMP Pathway and Calcium Inhibitory Effects

Author

Chatturong, Usana, primary, Martin, Hélène, additional, Totoson, Perle, additional, Ingkaninan, Kornkanok, additional, Temkitthawon, Prapapan, additional, Sermsenaphorn, Saharat, additional, Somarin, Thanachon, additional, Konsue, Adchatawut, additional, Gleeson, M. Paul, additional, Demougeot, Céline, additional, and Chootip, Krongkarn, additional

Published
2022
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37. Tofacitinib improved peripheral endothelial dysfunction and brain‐derived neurotrophic factor levels in the rat adjuvant‐induced arthritis model

Author

Totoson, Perle, primary, Peyronnel, Célian, additional, Quirié, Aurore, additional, Pédard, Martin, additional, Cefis, Marina, additional, Bermont, Laurent, additional, Prigent‐Tessier, Anne, additional, Prati, Clément, additional, Tournier, Maude, additional, Wendling, Daniel, additional, Marie, Christine, additional, and Demougeot, Céline, additional

Published
2021
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41. Mammalian Arginase Inhibitory Activity of Methanolic Extracts and Isolated Compounds from Cyperus Species

Author

Arraki, Kamel, Totoson, Perle, Decendit, Alain, Zedet, Andy, Maroilley, Justine, Badoc, Alain, Demougeot, Céline, Girard, Corine, Pathologies et épithéliums : prévention, innovation, traitements, évaluation (EA 4267) (PEPITE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Unité de Recherche Oenologie [Villenave d'Ornon], and Université de Bordeaux (UB)-Institut des Sciences de la Vigne et du Vin (ISVV)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Cyperus thunbergii, Male, vasorelaxante activity, Magnetic Resonance Spectroscopy, [SDV]Life Sciences [q-bio], Vasodilator Agents, Aorta, Thoracic, stilbenes, In Vitro Techniques, Article, lcsh:QD241-441, lcsh:Organic chemistry, Animals, [CHIM]Chemical Sciences, Cyperus, Enzyme Inhibitors, arginase inhibitors, Benzofurans, Flavonoids, Arginase, Molecular Structure, Cyperus glomeratus, Plant Extracts, Methanol, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, Arthritis, Experimental, Rats, Resveratrol, Calamus, Cattle, Endothelium, Vascular
Abstract

Polyphenolic enriched extracts from two species of Cyperus, Cyperus glomeratus and Cyperus thunbergii, possess mammalian arginase inhibitory capacities, with the percentage inhibition ranging from 80% to 95% at 100 µg/mL and 40% to 64% at 10 µg/mL. Phytochemical investigation of these species led to the isolation and identification of two new natural stilbene oligomers named thunbergin A-B (1–2), together with three other stilbenes, trans-resveratrol (3), trans-scirpusin A (4), trans-cyperusphenol A (6), and two flavonoids, aureusidin (5) and luteolin (7), which were isolated for the first time from C.thunbergii and C. glomeratus. Structures were established on the basis of the spectroscopic data from MS and NMR experiments. The arginase inhibitory activity of compounds 1–7 was evaluated through an in vitro arginase inhibitory assay using purified liver bovine arginase. As a result, five compounds (1, 4–7) showed significant inhibition of arginase, with IC50 values between 17.6 and 60.6 µM, in the range of those of the natural arginase inhibitor piceatannol (12.6 µM). In addition, methanolic extract from Cyperus thunbergii exhibited an endothelium and NO-dependent vasorelaxant effect on thoracic aortic rings from rats and improved endothelial dysfunction in an adjuvant-induced arthritis rat model.

Published
2021

47. Polyphenolic compounds of Euphorbia umbellata (Pax) Bruyns (Euphorbiaceae) improved endothelial dysfunction through arginase inhibition

Author

Minozzo, Bruno Rodrigo, primary, de Andrade, Evelyn Assis, additional, Vellosa, José Carlos Rebuglio, additional, Lipinski, Leandro Cavalcante, additional, Fernandes, Daniel, additional, Nardi, Geisson Marcos, additional, Rodrigues, Ricardo Pereira, additional, Kitagawa, Rodrigo Rezende, additional, Girard, Corine, additional, Demougeot, Céline, additional, and Beltrame, Flávio Luís, additional

Published
2020
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50. Tofacitinib improved peripheral endothelial dysfunction and brain‐derived neurotrophic factor levels in the rat adjuvant‐induced arthritis model.

Author

Totoson, Perle, Peyronnel, Célian, Quirié, Aurore, Pédard, Martin, Cefis, Marina, Bermont, Laurent, Prigent‐Tessier, Anne, Prati, Clément, Tournier, Maude, Wendling, Daniel, Marie, Christine, and Demougeot, Céline

Subjects
BRAIN-derived neurotrophic factor, ADJUVANT arthritis, ENDOTHELIUM diseases, LDL cholesterol, BLOOD pressure, CHOLESTEROL content of food, CEREBRAL circulation
Abstract

This study aimed to explore the effect of Tofacitinib on endothelial dysfunction and cerebral levels of brain‐derived neurotrophic factor (BDNF) in the adjuvant‐induced arthritis (AIA) rat model. Tofacitinib (10 mg/kg twice a day) or vehicle was administered from the first signs of inflammation. Arthritis scores were daily monitored while other parameters including endothelial function assessed from aortic rings, radiographic scores, blood pressure, heart rate, circulating levels of triglycerides, cholesterol, and interleukin (IL)‐1β, tumor necrosis factor‐α (TNF‐α), IL‐17A, and cerebral BDNF levels were determined after 3 weeks of treatment. A group of non‐AIA rats served as controls. In AIA rats, as compared with vehicle, Tofacitinib significantly reduced arthritis and radiographic scores, decreased total cholesterol and low‐density lipoprotein cholesterol (LDL‐C), but changed neither blood pressure nor heart rate and proinflammatory cytokines levels. It also fully restored acetylcholine (Ach)‐induced relaxation (p < 0.05) through increased nitric oxide (NO) synthase activity, reduced BH4 deficiency and O2−° production, decreased cyclo‐oxygenase‐2 (COX‐2)/arginase activities, and enhanced endothelium‐derived hyperpolarizing factor (EDHF) production. These effects translated into a decrease in atherogenic index and an elevation of BDNF levels in the prefrontal cortex (p < 0.05) and hippocampus (p < 0.001). The present study identified Tofacitinib as an efficient therapeutic option to reduce cardiovascular risk and improve BDNF‐dependent cognition in arthritis. [ABSTRACT FROM AUTHOR]

Published
2022
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