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9 results on '"Deng, Chaoqiong"'

8. Regulatory Fibroblast‐Like Synoviocytes Cell Membrane Coated Nanoparticles: A Novel Targeted Therapy for Rheumatoid Arthritis.

Author

Liu, Yuan, Rao, Peishi, Qian, Hongyan, Shi, Yesi, Chen, Shiju, Lan, Jingying, Mu, Dan, Chen, Rongjuan, Zhang, Xinwei, Deng, Chaoqiong, Liu, Gang, and Shi, Guixiu

Subjects
RHEUMATOID arthritis, JOINT pain, IMMUNOLOGICAL tolerance, CELL anatomy, CELL membranes, T cells, NANOMEDICINE, BIOMIMETIC materials
Abstract

Fibroblast‐like synoviocytes (FLS) are the main cell component in the inflamed joints of patients with rheumatoid arthritis (RA). FLS intimately interact with infiltrating T cells. Fibroblasts have potent inhibitory effects on T cells, leading to the resolution of inflammation and immune tolerance. However, this "regulatory" phenotype is defect in RA, and FLS in RA instead act as "proinflammatory" phenotype mediating inflammation perpetuation. Signals that orchestrate fibroblast heterogeneity remain unclear. Here, it is demonstrated that different cytokines can induce distinct phenotypes of FLS. Interferon‐gamma (IFN‐γ) is pivotal in inducing the regulatory phenotype of FLS (which is termed FLSreg) characterized by high expressions of several inhibitory molecules. Rapamycin enhances the effect of IFN‐γ on FLS. Based on the characteristics of FLSreg, a novel biomimetic therapeutic strategy for RA is designed by coating cell membrane derived from FLSreg induced by IFN‐γ and rapamycin on nanoparticles, which is called FIRN. FIRN show good efficacy, stability, and inflammatory joint targeting ability in an RA mouse model. The findings clarify how fibroblast phenotypes are modulated in the inflammatory microenvironment and provide insights into novel therapeutic designs for autoimmune diseases based on regulatory fibroblasts. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Influencing factors and correlation of anxiety, psychological stress sources, and psychological capital among women pregnant with a second child in Guangdong and Shandong Province

Author

Zhang Xueqin, Liao Minglu, Fang Fang, Deng Chaoqiong, Liu Guanxi, and Zhang Yuxiang

Subjects
China, Protective factor, Anxiety, medicine.disease_cause, Correlation, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, medicine, Humans, Psychological stress, Child, medicine.disease, Anxiety Disorders, 030227 psychiatry, Psychiatry and Mental health, Clinical Psychology, Capital (economics), Female, Residence, Pregnant Women, medicine.symptom, Psychology, Stress, Psychological, 030217 neurology & neurosurgery, Anxiety scale, Clinical psychology
Abstract

Background After the one-child policy has been effective for over 30 years, China implemented the universal two-child policy in 2015. The number of high-risk pregnant women had increased dramatically ever since, increasing negative health outcomes for both mothers and children. Our study aims to investigate the status of anxiety, psychological stress sources, and psychological capital among women pregnant with a second child, and to assess influencing factors and correlations, providing scientific basis for promoting women's health during pregnancy. Methods We recruited 513 participants from maternity hospitals in Guangdong and Shandong Province. All participants completed the Zung Self-Rating Anxiety Scale (SAS), Pregnant women psychological stress sources questionnaire and the psychological capital questionnaire (PCQ-24). Results The prevalence of anxiety of women pregnant with a second child was 27.5%. The score of psychological stress sources was 74.93 ± 16.07. The risk factors for the anxiety of the women pregnant with a second child included low education level of the husband, gender expectation and the sources of psychological stress of the pregnant woman. The risk factors for psychological stress were dissatisfaction of residence and unplanned pregnancy. The main factors influencing psychological capital were the participants’ education level, whether they have learned antenatal care knowledge and satisfaction with the residence. Limitations All participants were recruited only from tertiary hospitals in Guangdong and Shandong province. Conclusions Anxiety and psychological stress is prevalent during pregnancy among women pregnant with a second child in Guangdong and Shandong. Psychological capital was a protective factor for anxiety.

Published
2020

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