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146 results on '"Deng, Guofang"'

6. Evaluation of Sulfasalazine as an Adjunctive Therapy in Treating Pulmonary Pre-XDR-TB: Efficacy, Safety, and Treatment Implication

Author

Fu, Liang, additional, Wang, Wenfei, additional, Xiong, Juan, additional, Zhang, Peize, additional, Li, Hui, additional, Zhang, Xilin, additional, Liang, Hancheng, additional, Yang, Qianting, additional, Wang, Zhaoqin, additional, Chen, Xinchun, additional, Deng, Guofang, additional, Cai, Yi, additional, and Tang, Shenjie, additional

Published
2024
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8. Adjunctive interleukin-2 for the treatment of drug-susceptible tuberculosis: a randomized control trial in China

Author

Nie, Wenjuan, Wang, Jun, Zeng, Jianfeng, Wang, Qingfeng, Du, Yadong, Tan, Qi, Xie, Weiping, Deng, Qunyi, Deng, Guofang, Li, Xiujie, Li, Zhihui, Zhao, Jie, Pang, Jianjian, Luan, Kun, Chu, Lixiang, Duan, Huiping, Zhang, Chunyan, Ji, Qing, Chen, Xiaohong, Chen, Jing, Wang, Nian, Chen, Yu, Qiu, Chao, Deng, Aihua, Ren, Pengfei, Liu, Yufeng, Li, Chunxiang, Cao, Shipeng, Liu, Haiqing, Yan, Hao, and Chu, Naihui

Published
2022
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14. Detecting latent tuberculosis infection with a breath test using mass spectrometer: A pilot cross-sectional study

Author

Fu, Liang, primary, Feng, Yong, additional, Ren, Tantan, additional, Yang, Min, additional, Yang, Qianting, additional, Lin, Yi, additional, Zeng, Hui, additional, Zhang, Jiaohong, additional, Liu, Lei, additional, Li, Qingyun, additional, He, Mengqi, additional, Zhang, Peize, additional, Chen, Haibin, additional, and Deng, Guofang, additional

Published
2023
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16. Additional file 1 of Sleep quality and influencing factors and correlation with T-lymphocyte subpopulation counts in patients with pulmonary tuberculosis: a cross-sectional study

Author

Zhang, Hailin, Li, Ao, Jiang, Youli, Chen, Wenqiu, Wang, Jin, Zhang, Peize, Deng, Guofang, Wang, Weiyu, Chen, Jingfang, and Lin, Yi

Abstract

Additional file 1. Patient Admission Survey Assessment Form: A pre-tested admission questionnaire for TB patients, including a survey of patients’ psychological concerns, a SDS scale, a PSQI scale and a NRS 2002 scale.

Published
2023
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17. Additional file 2 of Sleep quality and influencing factors and correlation with T-lymphocyte subpopulation counts in patients with pulmonary tuberculosis: a cross-sectional study

Author

Zhang, Hailin, Li, Ao, Jiang, Youli, Chen, Wenqiu, Wang, Jin, Zhang, Peize, Deng, Guofang, Wang, Weiyu, Chen, Jingfang, and Lin, Yi

Abstract

Additional file 2. A subgroup analysis of immunological indicators was performed for the two groups of patients, and all variables with statistically significant differences were included in the figure.

Published
2023
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18. Mycobacterium tuberculosis Utilizes Host Histamine Receptor H1 to Modulate Reactive Oxygen Species Production and Phagosome Maturation via the p38MAPK-NOX2 Axis

Author

Mo, Siwei, primary, Guo, Jiubiao, additional, Ye, Taosheng, additional, Zhang, Ximeng, additional, Zeng, Jiang, additional, Xu, Yuzhong, additional, Peng, Bin, additional, Dai, Youchao, additional, Xiao, Wei, additional, Zhang, Peize, additional, Deng, Guofang, additional, Xu, Dechang, additional, Long, Xiaoru, additional, Cai, Yi, additional, and Chen, Xinchun, additional

Published
2022
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19. Population Pharmacokinetic Modeling of Bedaquiline among Multidrug-Resistant Pulmonary Tuberculosis Patients from China

Author

Zou, Jin, primary, Chen, Shuyan, additional, Rao, Weiqiao, additional, Fu, Liang, additional, Zhang, Jiancong, additional, Liao, Yunli, additional, Zhang, Ying, additional, Lv, Ning, additional, Deng, Guofang, additional, Yang, Shijin, additional, Lin, Liang, additional, Li, Lujin, additional, Liu, Siqi, additional, and Qu, Jiuxin, additional

Published
2022
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23. Mycobacterium tuberculosis-Induced Upregulation of the COX-2/mPGES-1 Pathway in Human Macrophages Is Abrogated by Sulfasalazine

Author

Wang, Wenfei, primary, Ning, Yuping, additional, Wang, Yejun, additional, Deng, Guofang, additional, Pace, Simona, additional, Barth, Stefanie A., additional, Menge, Christian, additional, Zhang, Kehong, additional, Dai, Youchao, additional, Cai, Yi, additional, Chen, Xinchun, additional, and Werz, Oliver, additional

Published
2022
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27. Diagnostic Performance of a Novel CXCL10 mRNA Release Assay for Mycobacterium tuberculosis Infection

Author

Pan, Liping, primary, Huang, Mailing, additional, Jia, Hongyan, additional, Deng, Guofang, additional, Chen, Yu, additional, Wei, Rongrong, additional, Zhang, Mingxia, additional, Li, Xin, additional, Sun, Qi, additional, Fang, Mutong, additional, Ren, Pengfei, additional, Xing, Aiying, additional, Chen, Qi, additional, Li, Xinxin, additional, Du, Boping, additional, Chen, Tao, additional, Gao, Mengqiu, additional, and Zhang, Zongde, additional

Published
2022
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28. Challenges Faced by Multidrug-Resistant Tuberculosis Patients in Three Financially Affluent Chinese Cities

Author

Zhang, Peize, Xu, Guanghui, Song, Yanhua, Tan, Jie, Chen, Tao, and Deng, Guofang

Subjects
Risk Management and Healthcare Policy, financial support, patient care, catastrophic cost, socioeconomic burden, MDR-TB, treatment adherence, Original Research
Abstract

Peize Zhang,1,* Guanghui Xu,2,* Yanhua Song,3,* Jie Tan,1 Tao Chen,1 Guofang Deng1 1Department of Pulmonary Medicine & Tuberculosis, The Third People’s Hospital of Shenzhen, Shenzhen, People’s Republic of China; 2Jiangmen Institute of Tuberculosis Prevention and Control, Guangdong, People’s Republic of China; 3Department of Tuberculosis, Chest Hospital of Peking, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guofang Deng Email jxxk1035@yeah.netPurpose: The aim of this study was to analyze socioeconomic burdens and other difficulties that multidrug-resistant tuberculosis (MDR-TB) patients in cities are facing, to identify major obstacles and which groups of patients are most affected.Methods: Face-to-face and phone-call interviews were conducted in early 2018 to follow-up with patients newly diagnosed with MDR-TB in 2017 in three tuberculosis hospitals in three financially affluent Chinese cities. Demographic data and information on their medical care, insurance coverage, and medical expenses were collected and analyzed.Results: A total of 144 newly diagnosed MDR-TB cases were reviewed during the study period, excluding 38 who were lost to follow-up and 29 patients who refused to participate, 77 patients were enrolled in this study. A total of 61 (79%) of these patients were hospitalized after MDR-TB diagnosis with an average hospital stay of 14 days, of them 57 (74%) were sputum positive on diagnosis. The proportion of patients who failed community care were 48% married, 56% in white collar employment and 43% in temp jobs/unemployed. In terms of insurance coverage, the proportion of patients who failed community care were 23% with no insurance and/or New Rural Co-operative Medical Care Scheme (NRCMS) and 45% with Urban Employee Basic Medical Insurance (UEBMI)/Urban Residents Basic Medical Insurance (URBMI) and commercial insurance. Difficulties patients encountered were, financial pressure (33%), psychological stress (26%), adverse drug reactions (23%), repulsive reaction to injections (17%). Fourty-eight percent of the patients spent over ¥ 2000 (USD300) per month on TB treatment.Conclusion: Despite insurance coverage, financial hardship remains the number one difficulty MDR-TB patients encountered in relatively financially affluent cities. Among them, the married working class were found to be the most financially sensitive group and have the highest tendency to fail community care. It is of utmost urgency to enhance the current medical policy to improve treatment adherence.Keywords: socioeconomic burden, MDR-TB, patient care, financial support, catastrophic cost, treatment adherence

Published
2020

29. Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion

Author

Cai, Yi, primary, Wang, Yejun, additional, Shi, Chenyan, additional, Dai, Youchao, additional, Li, Fuxiang, additional, Xu, Yuzhong, additional, Zhang, Peize, additional, Kong, Fanhui, additional, Deng, Guofang, additional, Wen, Zhihua, additional, Zhou, Qi, additional, Kang, Boxi Chris, additional, Singhal, Amit, additional, Yang, Qianting, additional, Feng, Carl G., additional, and Chen, Xinchun, additional

Published
2022
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32. Allogeneic Vγ9Vδ2 T-Cell Therapy Promotes Pulmonary Lesion Repair: An Open-Label, Single-Arm Pilot Study in Patients With Multidrug-Resistant Tuberculosis

Author

Liang, Juan, primary, Fu, Liang, additional, Li, Man, additional, Chen, Yuyuan, additional, Wang, Yi, additional, Lin, Yi, additional, Zhang, Hailin, additional, Xu, Yan, additional, Qin, Linxiu, additional, Liu, Juncai, additional, Wang, Weiyu, additional, Hao, Jianlei, additional, Liu, Shuyan, additional, Zhang, Peize, additional, Lin, Li, additional, Alnaggar, Mohammed, additional, Zhou, Jie, additional, Zhou, Lin, additional, Guo, Huixin, additional, Wang, Zhaoqin, additional, Liu, Lei, additional, Deng, Guofang, additional, Zhang, Guoliang, additional, Wu, Yangzhe, additional, and Yin, Zhinan, additional

Published
2021
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33. Adjunctive interleukin-2 for the treatment of drug-susceptible tuberculosis: a randomized control trial in China

Author

Nie, Wenjuan, primary, Wang, Jun, additional, Zeng, Jianfeng, additional, Wang, Qingfeng, additional, Du, Yadong, additional, Tan, Qi, additional, Xie, Weiping, additional, Deng, Qunyi, additional, Deng, Guofang, additional, Li, Xiujie, additional, Li, Zhihui, additional, Zhao, Jie, additional, Pang, Jianjian, additional, Luan, Kun, additional, Chu, Lixiang, additional, Duan, Huiping, additional, Zhang, Chunyan, additional, Ji, Qing, additional, Chen, Xiaohong, additional, Chen, Jing, additional, Wang, Nian, additional, Chen, Yu, additional, Qiu, Chao, additional, Deng, Aihua, additional, Ren, Pengfei, additional, Liu, Yufeng, additional, Li, Chunxiang, additional, Cao, Shipeng, additional, Liu, Haiqing, additional, Yan, Hao, additional, and Chu, Naihui, additional

Published
2021
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34. Performance of Xpert MTB/RIF Ultra for the Diagnosis of Pulmonary Tuberculosis Using Bronchoalveolar Lavage Samples in People Living with HIV/AIDS (PLWHA) in China: A Prospective Study

Author

Zhang, Peize, primary, Liu, HouMing, additional, Wang, Hui, additional, Wu, Yanbo, additional, Sun, Liqin, additional, Rao, Man, additional, Jia, Xinyun, additional, Song, Ying, additional, Deng, Guofang, additional, Li, Tianpin, additional, Ye, Feidi, additional, Zhou, Yang, additional, and Liao, Yi, additional

Published
2021
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36. Predictive value of a Five-Biomarker Signature to Diagnose Active Pulmonary Tuberculosis Patients

Author

Zeng, Jiang, primary, Yang, Qianting, additional, Xu, Dechang, additional, Chen, Qi, additional, Huang, Kaisong, additional, Cai, Yi, additional, Dai, Youchao, additional, Hai, Xie, additional, Zeng, Zhong, additional, Gong, Xiangwen, additional, Peng, Haiying, additional, Deng, Guofang, additional, Chen, Xinchun, additional, Zhang, Huihua, additional, and Liu, Hui, additional

Published
2021
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41. Identification and Treatment of Tuberculosis in Pediatric Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: Case Series and Review of the Literature

Author

Wang, Xiaodong, primary, Yu, Uet, additional, Li, Xiaonan, additional, Wang, Chunjing, additional, Zhang, Qian, additional, Yang, Chunlan, additional, Zhang, Xiaoling, additional, Zhang, Yu, additional, Wang, Ying, additional, Zheng, Yuejie, additional, Deng, Jikui, additional, Yang, Weiguo, additional, Liu, Guosheng, additional, Deng, Guofang, additional, Liu, Sixi, additional, and Wen, Feiqiu, additional

Published
2020
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43. Cutting Edge: Characterization of Human Tissue-Resident Memory T Cells at Different Infection Sites in Patients with Tuberculosis

Author

Yang, Qianting, primary, Zhang, Mingxia, additional, Chen, Qi, additional, Chen, Weixin, additional, Wei, Cailin, additional, Qiao, Kun, additional, Ye, Taosheng, additional, Deng, Guofang, additional, Li, Jin, additional, Zhu, Jialou, additional, Cai, Yi, additional, Chen, Xinchun, additional, and Ma, Li, additional

Published
2020
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45. Identification of eight-protein biosignature for diagnosis of tuberculosis

Author

Yang, Qianting, primary, Chen, Qi, additional, Zhang, Mingxia, additional, Cai, Yi, additional, Yang, Fan, additional, Zhang, Jieyun, additional, Deng, Guofang, additional, Ye, Taosheng, additional, Deng, Qunyi, additional, Li, Guobao, additional, Zhang, Huihua, additional, Yi, Yuhua, additional, Huang, Ruo-Pan, additional, and Chen, Xinchun, additional

Published
2020
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49. Activated pulmonary tuberculosis in a patient with melanoma during PD-1 inhibition: a case report

Author

He,Wan, Zhang,Xiangmei, Li,Wenwen, Kong,Cheng, Wang,Yuanyang, Zhu,Lianyu, Xu,Ruilian, Deng,Guofang, and Zhang,Peize

Subjects
OncoTargets and Therapy
Abstract

Wan He,1,* Xiangmei Zhang,2,* Wenwen Li,1 Cheng Kong,1 Yuanyang Wang,3 Lianyu Zhu,1 Ruilian Xu,1 Guofang Deng,4 Peize Zhang4 1Department of Oncology, The Second Clinical Medical College, Shenzhen People’s Hospital, Jinan University, Shenzhen, Guangdong 518020, China; 2Department of Pathology, The Third People’s Hospital of Shenzhen, Shenzhen, Guangdong 518112, China; 3Department of Surgery, The Second Clinical Medical College, Shenzhen People’s Hospital, Jinan University, Shenzhen, Guangdong 518020, China; 4Department of Pulmonary Medicine, The Third People’s Hospital of Shenzhen, Shenzhen, Guangdong 518112, China *These authors contributed equally tothis work Background: PD-1 checkpoint inhibitors have shown a robust tumor response in the treatment of various cancers. Pembrolizumab is an anti-PD-1 checkpoint antibody approved for the treatment of unresectable or metastatic melanoma in more than 40 countries. Although autoimmune pneumonitis is considered a common immune-related adverse event of PD-1 inhibitors, only limited studies have assessed the development of opportunistic infections such as pulmonary tuberculosis (TB). Case presentation: A patient with metastatic melanoma whose pulmonary TB was activated after administration of pembrolizumab for melanoma is reported. Anti-TB drugs were administered, followed by pembrolizumab (2 mg/kg, repeated every 28 days), which successfully cured the TB and achieved complete response for melanoma.Conclusion: Activated pulmonary TB was observed during the administration of pembrolizumab. It was safe and effective in the current patient to combine anti-TB drugs and PD-1 inhibitors. More importantly, screening pulmonary TB before administration of PD-1 inhibitors is recommended. Keywords: checkpoint inhibitor, PD-1, pembrolizumab, metastatic melanoma, pulmonary tuberculosis, anti-tuberculosis treatment

Published
2018

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