Search

Your search keyword '"Deng, Hongxia"' showing total 388 results
Start Over Author "Deng, Hongxia"
388 results on '"Deng, Hongxia"'

14. Image Derain Method for Generative Adversarial Network Based on Wavelet High Frequency Feature Fusion

Author

Li, Jiao, Feng, Hao, Deng, Zhennan, Cui, Xintong, Deng, Hongxia, Li, Haifang, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Yu, Shiqi, editor, Zhang, Zhaoxiang, editor, Yuen, Pong C., editor, Han, Junwei, editor, Tan, Tieniu, editor, Guo, Yike, editor, Lai, Jianhuang, editor, and Zhang, Jianguo, editor

Published
2022
Full Text
View/download PDF

27. Single-cell sequencing reveals the cell map and transcriptional network of sporadic vestibular schwannoma

Author

Chu Yidian, Lin Chen, Deng Hongxia, Li Yanguo, and Shen Zhisen

Subjects
sporadic vestibular schwannoma, single-cell transcriptomics, differentially expressed genes, immune cell infiltration, Schwann cells, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

In this study, based on three tumor samples obtained from patients with sporadic vestibular schwannoma, 32,011 cells were obtained by single-cell transcriptome sequencing, and 22,309 high-quality cells were obtained after quality control and double cells removal. Then, 18 cell clusters were obtained after cluster analysis, and each cluster was annotated as six types of cells. Afterward, an in-depth analysis was conducted based on the defined six cell clusters, including characterizing the functional characteristics of each cell subtype, describing the cell development and differentiation pathway, exploring the interaction between cells, and analyzing the transcriptional regulatory network within the clusters. Based on these four dimensions, various types of cells in sporadic vestibular schwannoma tumor tissues were described in detail. For the first time, we expanded on the functional state of cell clusters that have been reported and described Schwann cells in the peripheral nervous system, which have not been reported in previous studies. Combined with the data of sporadic vestibular schwannoma and normal tissues in the gene expression omnibus (GEO) database, the candidate biomarkers of sporadic vestibular schwannoma were explored. Overall, this study described the single-cell map of sporadic vestibular schwannoma for the first time, revealing the functional state and development trajectory of different cell types. Combined with the analysis of data in the GEO database and immunohistochemical verification, it was concluded that HLA-DPB1 and VSIG4 may be candidate biomarkers and potential therapeutic targets for patients with sporadic vestibular schwannoma.

Published
2022
Full Text
View/download PDF

31. Multiscale Entropy Analysis of EEG Based on Non-uniform Time

Author

Deng, Hongxia, Guo, Jinxiu, Yang, Xiaofeng, Hou, Jinxiu, Liu, Haoqi, Li, Haifang, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Lin, Zhouchen, editor, Wang, Liang, editor, Yang, Jian, editor, Shi, Guangming, editor, Tan, Tieniu, editor, Zheng, Nanning, editor, Chen, Xilin, editor, and Zhang, Yanning, editor

Published
2019
Full Text
View/download PDF

47. mTORC2-driven chromatin cGAS mediates chemoresistance through epigenetic reprogramming in colorectal cancer

Author

Lv, Guoqing, Wang, Qian, Lin, Lin, Ye, Qiao, Li, Xi, Zhou, Qian, Kong, Xiangzhen, Deng, Hongxia, You, Fuping, Chen, Hebing, Wu, Song, and Yuan, Lin

Abstract

Cyclic GMP–AMP synthase (cGAS), a cytosolic DNA sensor that initiates a STING-dependent innate immune response, binds tightly to chromatin, where its catalytic activity is inhibited; however, mechanisms underlying cGAS recruitment to chromatin and functions of chromatin-bound cGAS (ccGAS) remain unclear. Here we show that mTORC2-mediated phosphorylation of human cGAS serine 37 promotes its chromatin localization in colorectal cancer cells, regulating cell growth and drug resistance independently of STING. We discovered that ccGAS recruits the SWI/SNF complex at specific chromatin regions, modifying expression of genes linked to glutaminolysis and DNA replication. Although ccGAS depletion inhibited cell growth, it induced chemoresistance to fluorouracil treatment in vitro and in vivo. Moreover, blocking kidney-type glutaminase, a downstream ccGAS target, overcame chemoresistance caused by ccGAS loss. Thus, ccGAS coordinates colorectal cancer plasticity and acquired chemoresistance through epigenetic patterning. Targeting both mTORC2–ccGAS and glutaminase provides a promising strategy to eliminate quiescent resistant cancer cells.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results