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2. Plasma extracellular vesicles in meningioma patients following radiotherapy as liquid biopsy- a prospective explorative biomarker study (ARO 2023-05/AG-NRO-07)

Author

Deng, Maximilian Y., da Silva, Amanda Salviano, Göller, Pauline Carlotta, König, Laila, Schäfer, Henning, Maire, Cecile, Lentz-Hommertgen, Adriane, Held, Thomas, Regnery, Sebastian, Eichkorn, Tanja, Stritzke, Florian, Bauer, Lukas, Schnell, Daniel, Herfarth, Klaus, von Deimling, Andreas, Krieg, Sandro, Wick, Antje, Wick, Wolfgang, Grosu, Anca, Debus, Jürgen, Sahm, Felix, and Ricklefs, Franz

Published
2024
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4. Efficacy and toxicity of bimodal radiotherapy in WHO grade 2 meningiomas following subtotal resection with carbon ion boost:Prospective phase 2 MARCIE trial

Author

Deng, Maximilian Y., Maas, Sybren L.N., Hinz, Felix, Karger, Christian P., Sievers, Philipp, Eichkorn, Tanja, Meixner, Eva, Hoegen-Sassmannshausen, Philipp, Hörner-Rieber, Juliane, Lischalk, Jonathan W., Seidensaal, Katharina, Bernhardt, Denise, Jungk, Christine, Unterberg, Andreas, Wick, Antje, Wick, Wolfgang, Deimling, Andreas von, Sahm, Felix, Combs, Stephanie, Herfarth, Klaus, Debus, Jürgen, König, Laila, Deng, Maximilian Y., Maas, Sybren L.N., Hinz, Felix, Karger, Christian P., Sievers, Philipp, Eichkorn, Tanja, Meixner, Eva, Hoegen-Sassmannshausen, Philipp, Hörner-Rieber, Juliane, Lischalk, Jonathan W., Seidensaal, Katharina, Bernhardt, Denise, Jungk, Christine, Unterberg, Andreas, Wick, Antje, Wick, Wolfgang, Deimling, Andreas von, Sahm, Felix, Combs, Stephanie, Herfarth, Klaus, Debus, Jürgen, and König, Laila

Abstract

Background: Novel radiotherapeutic modalities using carbon ions provide an increased relative biological effectiveness (RBE) compared to photons, delivering a higher biological dose while reducing radiation exposure for adjacent organs. This prospective phase 2 trial investigated bimodal radiotherapy using photons with carbon-ion (C12)-boost in patients with WHO grade 2 meningiomas following subtotal resection (Simpson grade 4 or 5).Methods:A total of 33 patients were enrolled from July 2012 until July 2020. The study treatment comprised a C12-boost (18 Gy [RBE] in 6 fractions) applied to the macroscopic tumor in combination with photon radiotherapy (50 Gy in 25 fractions). The primary endpoint was the 3-year progression-free survival (PFS), and the secondary endpoints included overall survival, safety and treatment toxicities. Results:With a median follow-up of 42 months, the 3-year estimates of PFS, local PFS and overall survival were 80.3%, 86.7%, and 89.8%, respectively. Radiation-induced contrast enhancement (RICE) was encountered in 45%, particularly in patients with periventricularly located meningiomas. Patients exhibiting RICE were mostly either asymptomatic (40%) or presented immediate neurological and radiological improvement (47%) after the administration of corticosteroids or bevacizumab in case of radiation necrosis (3/33). Treatment-associated complications occurred in 1 patient with radiation necrosis who died due to postoperative complications after resection of radiation necrosis. The study was prematurely terminated after recruiting 33 of the planned 40 patients. Conclusions:Our study demonstrates a bimodal approach utilizing photons with C12-boost may achieve a superior local PFS to conventional photon RT, but must be balanced against the potential risks of toxicities.

Published
2024

5. Efficacy and toxicity of bimodal radiotherapy in WHO grade 2 meningiomas following subtotal resection with carbon ion boost: prospective phase 2 MARCIE trial

Author

Deng, Maximilian Y, primary, Maas, Sybren L N, additional, Hinz, Felix, additional, Karger, Christian P, additional, Sievers, Philipp, additional, Eichkorn, Tanja, additional, Meixner, Eva, additional, Hoegen-Sassmannshausen, Philipp, additional, Hörner-Rieber, Juliane, additional, Lischalk, Jonathan W, additional, Seidensaal, Katharina, additional, Bernhardt, Denise, additional, Jungk, Christine, additional, Unterberg, Andreas, additional, Wick, Antje, additional, Wick, Wolfgang, additional, von Deimling, Andreas, additional, Sahm, Felix, additional, Combs, Stephanie, additional, Herfarth, Klaus, additional, Debus, Jürgen, additional, and König, Laila, additional

Published
2023
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6. Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

Author

Deng, Maximilian Y., Sturm, Dominik, Pfaff, Elke, Sill, Martin, Stichel, Damian, Balasubramanian, Gnana Prakash, Tippelt, Stephan, Kramm, Christof, Donson, Andrew M., Green, Adam L., Jones, Chris, Schittenhelm, Jens, Ebinger, Martin, Schuhmann, Martin U., Jones, Barbara C., van Tilburg, Cornelis M., Wittmann, Andrea, Golanov, Andrey, Ryzhova, Marina, Ecker, Jonas, Milde, Till, Witt, Olaf, Sahm, Felix, Reuss, David, Sumerauer, David, Zamecnik, Josef, Korshunov, Andrey, von Deimling, Andreas, Pfister, Stefan M., and Jones, David T. W.

Published
2021
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7. Efficacy and toxicity of bimodal radiotherapy in WHO grade 2 meningiomas following subtotal resection with carbon ion boost: Prospective phase 2 MARCIE trial.

Author

Deng, Maximilian Y, Maas, Sybren L N, Hinz, Felix, Karger, Christian P, Sievers, Philipp, Eichkorn, Tanja, Meixner, Eva, Hoegen-Sassmannshausen, Philipp, Hörner-Rieber, Juliane, Lischalk, Jonathan W, Seidensaal, Katharina, Bernhardt, Denise, Jungk, Christine, Unterberg, Andreas, Wick, Antje, Wick, Wolfgang, Deimling, Andreas von, Sahm, Felix, Combs, Stephanie, and Herfarth, Klaus

Published
2024
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9. Mapping pediatric brain tumors to their origins in the developing cerebellum

Author

Okonechnikov, Konstantin, primary, Joshi, Piyush, additional, Sepp, Mari, additional, Leiss, Kevin, additional, Sarropoulos, Ioannis, additional, Murat, Florent, additional, Sill, Martin, additional, Beck, Pengbo, additional, Chan, Kenneth Chun-Ho, additional, Korshunov, Andrey, additional, Sah, Felix, additional, Deng, Maximilian Y, additional, Sturm, Dominik, additional, DeSisto, John, additional, Donson, Andrew M, additional, Foreman, Nicholas K, additional, Green, Adam L, additional, Robinson, Giles, additional, Orr, Brent A, additional, Gao, Qingsong, additional, Darrow, Emily, additional, Hadley, Jennifer L, additional, Northcott, Paul A, additional, Gojo, Johannes, additional, Kawauchi, Daisuke, additional, Hovestadt, Volker, additional, Filbin, Mariella G, additional, von Deimling, Andreas, additional, Zuckermann, Marc, additional, Pajtler, Kristian W, additional, Kool, Marcel, additional, Jones, David T W, additional, Jäger, Natalie, additional, Kutscher, Lena M, additional, Kaessmann, Henrik, additional, and Pfister, Stefan M, additional

Published
2023
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10. Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features

Author

Deng, Maximilian Y., Sill, Martin, Chiang, Jason, Schittenhelm, Jens, Ebinger, Martin, Schuhmann, Martin U., Monoranu, Camelia-Maria, Milde, Till, Wittmann, Andrea, Hartmann, Christian, Sommer, Clemens, Paulus, Werner, Gärtner, Jutta, Brück, Wolfgang, Rüdiger, Thomas, Leipold, Alfred, Jaunmuktane, Zane, Brandner, Sebastian, Giangaspero, Felice, Nozza, Paolo, Mora, Jaume, Morales la Madrid, Andres, Cruz Martinez, Ofelia, Hansford, Jordan R., Pietsch, Torsten, Tietze, Anna, Hernáiz-Driever, Pablo, Stoler, Iris, Capper, David, Korshunov, Andrey, Ellison, David W., von Deimling, Andreas, Pfister, Stefan M., Sahm, Felix, and Jones, David T. W.

Published
2018
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11. Analysis of recurrence probability following radiotherapy in patients with CNS WHO grade 2 meningioma using integrated molecular-morphologic classification

Author

Deng, Maximilian Y, primary, Hinz, Felix, additional, Maas, Sybren L N, additional, Anil, Günes, additional, Sievers, Philipp, additional, Conde-Lopez, Cristina, additional, Lischalk, Jonathan, additional, Rauh, Sophie, additional, Eichkorn, Tanja, additional, Regnery, Sebastian, additional, Bauer, Lukas, additional, Held, Thomas, additional, Meixner, Eva, additional, Lang, Kristin, additional, Hörner-Rieber, Juliane, additional, Herfarth, Klaus, additional, Jones, David, additional, Pfister, Stefan M, additional, Jungk, Christine, additional, Unterberg, Andreas, additional, Wick, Wolfgang, additional, von Deimling, Andreas, additional, Debus, Jürgen, additional, Sahm, Felix, additional, and König, Laila, additional

Published
2023
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12. Mapping pediatric brain tumors to their origins in the developing cerebellum

Author

Okonechnikov, Konstantin, primary, Joshi, Piyush, additional, Sepp, Mari, additional, Leiss, Kevin, additional, Sarropoulos, Ioannis, additional, Murat, Florent, additional, Sill, Martin, additional, Beck, Pengbo, additional, Chan, Kenneth Chun-Ho, additional, Korshunov, Andrey, additional, Sahm, Felix, additional, Deng, Maximilian Y., additional, Sturm, Dominik, additional, DeSisto, John, additional, Donson, Andrew M., additional, Foreman, Nicholas K., additional, Green, Adam L., additional, Robinson, Giles, additional, Orr, Brent A., additional, Gao, Qingsong, additional, Darrow, Emily, additional, Hadley, Jennifer L., additional, Northcott, Paul A., additional, Gojo, Johannes, additional, Ryzhova, Marina, additional, Kawauchi, Daisuke, additional, Hovestadt, Volker, additional, Filbin, Mariella G., additional, Deimling, Andreas von, additional, Zuckermann, Marc, additional, Pajtler, Kristian W., additional, Kool, Marcel, additional, Jones, David T.W., additional, Jäger, Natalie, additional, Kutscher, Lena M., additional, Kaessmann, Henrik, additional, and Pfister, Stefan M., additional

Published
2021
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13. Abstract 3646: (Epi-)genomic homogeneity in radiation-induced glioblastoma with recurrentPDGFRAamplification and loss ofCDKN2A/Bfollowing primary acute lymphatic leukemia and medulloblastoma

Author

Deng, Maximilian Y., primary, Sturm, Dominik, additional, Pfaff, Elke, additional, Balasubramanian, Gnana P., additional, Schittenhelm, Jens, additional, Ebinger, Martin, additional, Schuhmann, Martin U., additional, Korshunov, Andrey, additional, Deimling, Andreas von, additional, Witt, Olaf, additional, Pfister, Stefan M., additional, and Jones, David T., additional

Published
2019
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14. LGG-20. MOLECULARLY-DEFINED DIFFUSE LEPTOMENINGEAL GLIONEURONAL TUMOR (DLGNT) COMPRISES TWO SUBGROUPS WITH DISTINCT CLINICAL AND GENETIC FEATURES

Author

Deng, Maximilian Y, primary, Sahm, Felix, additional, Sill, Martin, additional, Chiang, Jason, additional, Capper, David, additional, Milde, Till, additional, Ebinger, Martin, additional, Schuhmann, Martin, additional, Schittenhelm, Jens, additional, Monoranu, Camelia-Maria, additional, Korshunov, Andrey, additional, Ellison, David, additional, von Deimling, Andreas, additional, Pfister, Stefan M, additional, and Jones, David, additional

Published
2018
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17. Analysis of safety and efficacy of proton radiotherapy for optic nerve sheath meningioma.

Author

Deng MY, Rauh S, Anil G, Lischalk JW, Hahnemann L, Eichkorn T, Hörner-Rieber J, Paul A, Sandrini E, Hoegen-Sassmannshausen P, Held T, Regnery S, Bauer L, Sahm F, von Deimling A, Wick A, Wick W, Jungk C, Krieg SM, Herfarth K, Debus J, and König L

Abstract

Background: Primary optic nerve sheath meningiomas (ONSMs) represent a group of benign tumors originating from the optic nerve sheath, typically causing painless, gradual onset monocular visual loss, which can result in blindness if left untreated. Radiation therapy represents an important treatment option for patients with ONSM, allowing for preservation and potential improvement in visual function. In particular, proton radiotherapy may enable a reduction of the side effects due to its physical advantage of an inverted dose profile with a steep dose gradient. The study investigates the visual acuity, local tumor control, and treatment-related toxicities following proton beam radiotherapy with a single institutional cohort comprising 32 patients treated for ONSM., Methods: Patients with primary ONSM, either histologically (16/32) or radiologically confirmed (16/32), which were treated at the Department of Radiation Oncology at the University Hospital Heidelberg (Germany) were assessed in regard to their visual outcomes, treatment toxicity, and local tumor control following radiotherapy according to response assessment in neuro-oncology criteria., Results: After a median follow-up time of 39.5 months, the 5-year local progression-free survival was estimated at 100%, with 84.4% of patients reporting improvement or stability in visual acuity during their last follow-up. Radiation-induced optic neuropathy (RION) was encountered in 9.4%., Conclusions: Our study demonstrates proton beam therapy as a safe and effective treatment alternative in the therapeutic management of ONSMs. RION represents a rare but dreaded complication after treatment. Future head-to-head comparisons with photon radiotherapy in a prospective setting are required to demonstrate a potential, additional clinical benefit., Competing Interests: P.H.S. received honoraria from Novocure for participation in the Advisory Board. A.v.D. has licenses and patents for the VE1 (Roche Ventana) and H09 (Dianova) antibodies, and patent pending for the methylation-based tumor classification. F.S. and A.v.D. are the founders and shareholders of Heidelberg Epignostix GmbH. J.D. received honorary from RaySearch Laboratories, Vision RT Limited, Merck Serono, Siemens Healthcare, PTW-Freiburg Dr. Pychlau, and Accuray Incorporated. S.M.K. is a consultant for Brainlab (Munich), Ulrich Medical (Ulm) and Need Inc. (Santa Monica), and shareholder of Need Inc. (Santa Monica), and received travel funding from Nextim Pic (Helsinki). J.D. is the CEO of the Heidelberg Ion Beam Therapy Center (HIT), and a member of the Board of Directors at the Heidelberg University Hospital., (© The Author(s) 2024. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.)

Published
2024
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