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An effective way to reduce A/C energy use is to switch off air conditioning during unoccupied periods. The main concern is, however, whether occupants' thermal comfort is sacrificed. This paper reports a study of the impacts of switching off A/C during unoccupied hours in an office on thermal comfort of occupant after returning to office and resuming the operation of A/C system. Site measurements for both indoor thermal environmental parameters and energy consumption of A/C were carried out and the thermal comfort of occupants was assessed. Measurement and assessment results indicated that up to 11% of annual energy consumption of A/C for the office could be saved, but the level of thermal comfort of occupants was not greatly degraded. Practical applications: Intermittent operation of A/C is often ignored when people talk about energy saving. It requires no additional cost and equipment, but the saving is significant. Moreover, no advanced technology or knowledge is required. The most important result is that thermal comfort level is not scarified during occupied hours. [ABSTRACT FROM AUTHOR]

The use of direct expansion (DX) air conditioning (A/C) systems is widely seen in residential buildings in tropics and sub-tropics. However, most DX A/C systems are equipped with single-speed compressor and supply fan, relying on On-Off cycling as a low-cost approach to maintain only indoor dry-bulb temperature, whereas the indoor air humidity is not controlled directly. This also leads to potential inefficient energy use due to space overcooling. This paper suggests a novel control strategy (termed Hi-Lo strategy) of using twospeed compressors in DX A/C systems for better indoor thermal environment control and higher energy efficiency. Experimental work has been carried out to test the Hi-Lo control strategy. Experimental results suggested that the novel control strategy can help improve the indoor humidity control without sacrificing energy efficiency. Practical application: The use of ON/OFF control at part load conditions in conventional DX A/C systems will lead to undesirable relative humidity levels. The problem is more prominent when the latent load is dominant. In order to have a better dehumidification effect, a lower indoor dry bulb temperature has been often set. On the other hand, the use of variable speed compressors in DX A/C systems can be a solution to the problem of humidity control, but its cost is comparatively high. The suggested novel control strategy is a low cost approach, which can save energy and provide a better indoor humidity control using DX A/C systems. [ABSTRACT FROM AUTHOR]

A quad-band inverted-F antenna for PDA-phone applications is presented. The proposed antenna measures only 46×12×0.8 mm. It has an inverted-L element combined with a meander-line branch to excite two resonant modes. By using a matching element, the bandwidth can be broadened to cover GSM850/GSM900/DCS/PCS bands. Simulation was performed by HFSS to optimally design the antenna, and a practical structure was fabricated to verify the simulation results. The antenna parameters were measured and are presented to validate the proposed antenna. [ABSTRACT FROM AUTHOR]

To analyze the epidemiological characteristics of pulmonary tuberculosis (PTB) in Motuo County from 2012 to 2021 and provide evidence for the prevention and control of PTB. A total of 223 cases of PTB were reported from 2012 to 2021 in Motuo County, with an average annual reported incidence rate of 171.39/100 000. Joinpoint regression model analysis showed that the average decline rate was 9.2% ( P <0.001) from 2012 to 2021. Among the various types of PTB patients reported from 2012 to 2021, there were 69 cases of etiologic-positive cases which increased from 28.57% to 52.63%. Results from the circular distribution methods showed that there was no obvious peak time of PTB in Motuo County. There was no statistical difference in the average annual incidence of PTB between different genders ( χ 2 =0.108, P =0.743). Among all age groups, the 20-29 years group had the highest proportion (26.91%, 60/223). The Monpa ethnic group (153 cases, 68.61%) had the largest number of cases, followed by the Lhoba people (44 cases, 19.73%) and the Tibetan (22 cases, 9.87%). Farmers (168 cases, 75.34%) had the highest occupational composition ratio, followed by students (40 cases, 17.94%). The main detection methods of PTB were clinical consultation and transferring consultation. Overall, the incidence rate of PTB decreased from 2012 to 2021. The majority of PTB patients were young adults with high transmission risk. It is necessary to pay more attention to the key populations and strengthen the comprehensive prevention and control for reducing the risk of PTB.

Objective: To explore correlative factors and construct predictive model of intestinal flora imbalance in patients with acute exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Methods: The patients in acute exacerbation stage of COPD (AECOPD) hospitalized in Yixing People's Hospital from January 1 to December 31, 2019 were included. According to the clinical symptoms and results of fecal examination, the subjects were divided into case group ( n= 45) and control group ( n= 83). Multivariate logistic regression was used to analyze the correlative factors of intestinal flora imbalance in AECOPD patients. The prediction model of intestinal flora imbalance in patients with AECOPD was constructed according to the results of factor logistic regression analysis, and the effectiveness of the prediction model was evaluated by receiver operating characteristic (ROC) curve analysis. Results: The ages of subjects in case group and control group were (76±9) and (74±8) years old, respectively, among which males accounted for 80.0% (36/45) and 69.9% (58/83), respectively. The multivariate logistic regression model analysis showed that serum albumin concentration, frequency of acute exacerbation ≥2 times/year, complicated with chronic cor pulmonale and diabetes mellitus were correlative factors of intestinal flora imbalance in patients with AECOPD. The OR (95 %CI ) were 0.98 (0.80-0.97), 3.70 (1.79-11.72), 2.62 (1.46-10.80) and 3.85 (1.17-8.58), respectively. The prediction model of intestinal flora imbalance was logit P= 3.858-0.13×serum albumin consentration+1.52×acute exacerbation ≥2 times/year+1.379×chronic cor pulmonale+1.155×diabetes mellitus. The area under the ROC curve of this model was 0.847 and the sensitivity and specificity of the prediction model were 88.9% and 71.1%, respectively. Conclusions: Serum albumin, frequency of acute exacerbation ≥2 times/year, complicated with chronic cor pulmonale and diabetes mellitus are correlative factors of intestinal flora imbalance in patients with AECOPD. The predictive model shows high clinical value in predicting intestinal flora imbalance in patients with AECOPD.

Objective: To evaluate the clinical value of changes of maximum standardized uptake value (SUVmax) in series 18 F-FDG PET/CT imaging before and after chemotherapy for non-small cell lung cancer. Methods: From July 2008 to July 2014, a total of 18 patients with pathological confirmed advanced NSCLC who received systemic chemotherapy were enrolled. 18 F-FDG PET/CT scans were performed before, 3-4 weeks after 2-4 cycles chemotherapy, 3-4 weeks after the end of chemotherapy for all patients, and added fourth scan for 3 patients 1 year later.The SUVmax of region of interesting was calculated.The histological diagnosis or clinical findings in a 36 months follow-up period served as the standard of control. Results: New metastases foci were found by 18 F-FDG PET/CT scans before chemotherapy in 7 of 18 patients.The plans of chemotherapy for 5 patients were changed as therapeutic responses were evaluated according to changes of SUVmax.Targeted therapy was added for 2 patients after the end of chemotherapy.There was a statistically significant difference in outcome of survival analysis between patients performed PET/CT scans and non-performed ( P <0.05). Conclusion: Changes of SUVmax in series 18 F-FDG PET/CT imaging before and after chemotherapy could be used to evaluate therapeutic response and effectively predict survival in patients with advanced NSCLC.

A colored phenotype is an important feature of ornamental fish. In mammals, microphthalmia-associated transcription factor (MITF) was found to regulate the development of melanocytes. In this study, the mitfa cDNA was first cloned from the Japanese ornamental (Koi) carp (Cyprinus carpio L.), an important ornamental freshwater fish. The full-length cDNA of the mitfa gene contains 1634 bp, coding for 412 amino acids in Koi. The identity degree of mitfa amino acid sequences between the Koi carp and zebrafish is 92.9%. We tested the expression of the mitfa gene in several varieties of Koi using reverse transcription-polymerase chain reaction and found that the mitfa gene is highly expressed in the skin tissues of the Taisho sanke and the Procypris merus. Interestingly, the mitfa gene was also expressed in the Kohaku and Yamabaki ogon, although melanocytes were not observed in the skin. Koi carp embryos were transparent and colorless, while after hatching, different types of pigment cells successively emerged in a fixed order. In Taisho sanke, melanocytes first appeared in the trunk at approximately 12 days of age. Subsequently, there was a large area of melanocytes by 30 days of age. The expression level of the mitfa mRNA was low in early embryos and newly hatched larvae, and increased to high levels in 30-day-old fry. The results show that the mitfa gene is involved in regulating fish body color in the development of both melanocytes and pigment cells.

The purpose of this study was to develop a specific targeting magnetic nanoparticle probe for magnetic resonance imaging and therapy in the form of local hyperthermia. Carboxymethyl dextran-coated ultrasmall superparamagnetic iron oxide nanoparticles with carboxyl groups were coupled to cyclic arginine-glycine-aspartic peptides for integrin α(v)β₃ targeting. The particle size, magnetic properties, heating effect, and stability of the arginine-glycine-aspartic-ultrasmall superparamagnetic iron oxide were measured. The arginine-glycine-aspartic-ultrasmall superparamagnetic iron oxide demonstrates excellent stability and fast magneto-temperature response. Magnetic resonance imaging signal intensity of Bcap37 cells incubated with arginine-glycine-aspartic-ultrasmall superparamagnetic iron oxide was significantly decreased compared with that incubated with plain ultrasmall superparamagnetic iron oxide. The preferential uptake of arginine-glycine-aspartic-ultrasmall superparamagnetic iron oxide by target cells was further confirmed by Prussian blue staining and confocal laser scanning microscopy.