Search

Your search keyword '"Deng, Saul"' showing total 8 results
Start Over Author "Deng, Saul"
8 results on '"Deng, Saul"'

3. Culture-Confirmed Invasive Meningococcal Disease in Canada, 2010 to 2014: Characterization of Serogroup B Neisseria meningitidis Strains and Their Predicted Coverage by the 4CMenB Vaccine

Author

Tsang, Raymond S. W., primary, Law, Dennis K. S., additional, De Paola, Rosita, additional, Giuliani, Maria, additional, Stella, Maria, additional, Zhou, Jianwei, additional, Deng, Saul, additional, Boccadifuoco, Giuseppe, additional, Giuliani, Marzia Monica, additional, and Serino, Laura, additional

Published
2020
Full Text
View/download PDF

4. The evolving nature of Bordetella pertussis in Ontario, Canada, 2009–2017: strains with shifting genotypes and pertactin deficiency

Author

Tsang, Raymond S.W., primary, Shuel, Michelle, additional, Cronin, Kirby, additional, Deng, Saul, additional, Whyte, Kathleen, additional, Marchand-Austin, Alex, additional, Ma, Jennifer, additional, Bolotin, Shelly, additional, Crowcroft, Natasha, additional, Schwartz, Kevin, additional, Van Domselaar, Gary, additional, Graham, Morag, additional, and Jamieson, Frances B., additional

Published
2019
Full Text
View/download PDF

8. Invasive Serogroup B Neisseria meningitidisin Québec, Canada, 2003 to 2010: Persistence of the ST-269 Clone Since It First Emerged in 2003

Author

Zhou, Jianwei, Lefebvre, Brigitte, Deng, Saul, Gilca, Rodica, Deceuninck, Genevieve, Law, Dennis K. S., De Wals, Philippe, and Tsang, Raymond S. W.

Abstract

ABSTRACTIn the era after the introduction of the meningococcal serogroup C conjugate vaccine, from 1 January 2003 to 31 December 2010, serogroup B meningococci were the major cause of invasive meningococcal disease in the province of Québec, Canada, being responsible for 72% of all meningococcal disease cases. Of the 334 invasive serogroup B Neisseria meningitidisstrains analyzed, 53.9% belonged to the ST-269 clonal complex (CC). Since it first emerged in 2003, the percentage of invasive serogroup B isolates that belonged to the ST-269 CC had increased from 35% in 2003 to 76% in 2010. Among the 180 meningococci in the ST-269 CC, 91.7% belonged to a single ST (ST-269). The most common PorA genotypes identified in the ST-269 CC were (i) VR1 19-1, VR2 15-11, VR3 36 (84%) and (ii) VR1 18-7, VR2 9, VR3 35-1 (9%). Cases of invasive disease due to the ST-269 CC were commonly found in those aged 11 to 19 years (30.5%) and 20 to 40 years (25.5%). Meningococci of the ST-269 CC were uncommon in other Canadian provinces. In contrast to the ST-269 CC, invasive serogroup B meningococci that belonged to the ST-41/44 CC were much more diverse genetically. However, one ST (ST-571), which is uncommon in the United States, accounted for 35% of all cases due to this CC. The current finding suggests that the ST-269 clone may indeed represent an emerging hypervirulent clone of meningococci.

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results