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126 results on '"Deng, Wenying"'

2. Towards a Unified Framework for Uncertainty-aware Nonlinear Variable Selection with Theoretical Guarantees

Author

Deng, Wenying, Coker, Beau, Mukherjee, Rajarshi, Liu, Jeremiah Zhe, and Coull, Brent A.

Subjects
Statistics - Machine Learning, Computer Science - Machine Learning
Abstract

We develop a simple and unified framework for nonlinear variable selection that incorporates uncertainty in the prediction function and is compatible with a wide range of machine learning models (e.g., tree ensembles, kernel methods, neural networks, etc). In particular, for a learned nonlinear model $f(\mathbf{x})$, we consider quantifying the importance of an input variable $\mathbf{x}^j$ using the integrated partial derivative $\Psi_j = \Vert \frac{\partial}{\partial \mathbf{x}^j} f(\mathbf{x})\Vert^2_{P_\mathcal{X}}$. We then (1) provide a principled approach for quantifying variable selection uncertainty by deriving its posterior distribution, and (2) show that the approach is generalizable even to non-differentiable models such as tree ensembles. Rigorous Bayesian nonparametric theorems are derived to guarantee the posterior consistency and asymptotic uncertainty of the proposed approach. Extensive simulations and experiments on healthcare benchmark datasets confirm that the proposed algorithm outperforms existing classic and recent variable selection methods., Comment: 50 pages, 16 figures, 11 tables

Published
2022

4. Safety and efficacy of apatinib in patients with advanced gastric or gastroesophageal junction adenocarcinoma after the failure of two or more lines of chemotherapy (AHEAD): a prospective, single-arm, multicenter, phase IV study

Author

Li, Jin, Qin, Shukui, Wen, Lu, Wang, Junsheng, Deng, Wenying, Guo, Weijian, Jia, Tongfu, Jiang, Da, Zhang, Guifang, He, Yifu, Ba, Yi, Zhong, Haijun, Wang, Lin, Lin, Xiaoyan, Yang, Jianwei, Zhao, Jun, Bai, Yuxian, Wu, Xiangyuan, Gao, Feng, Sun, Guogui, Wu, Yongjuan, Ye, Feng, Wang, Qiong, Xie, Zhong, Yi, Tienan, Huang, Yong, Yu, Guohua, Lu, Lin, Yuan, Ying, Li, Wei, Liu, Likun, Sun, Yuping, Sun, Ying, Yin, Lifeng, and Hou, Zhiguo

Published
2023
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6. CVEK: Robust Estimation and Testing for Nonlinear Effects using Kernel Machine Ensemble

Author

Deng, Wenying, Liu, Jeremiah Zhe, Lake, Erin, and Coull, Brent A.

Subjects
Statistics - Computation, Statistics - Applications, Statistics - Methodology
Abstract

The R package CVEK introduces a suite of flexible machine learning models and robust hypothesis tests for learning the joint nonlinear effects of multiple covariates in limited samples. It implements the Cross-validated Ensemble of Kernels (CVEK)(Liu and Coull 2017), an ensemble-based kernel machine learning method that adaptively learns the joint nonlinear effect of multiple covariates from data, and provides powerful hypothesis tests for both main effects of features and interactions among features. The R Package CVEK provides a flexible, easy-to-use implementation of CVEK, and offers a wide range of choices for the kernel family (for instance, polynomial, radial basis functions, Mat\'ern, neural network, and others), model selection criteria, ensembling method (averaging, exponential weighting, cross-validated stacking), and the type of hypothesis test (asymptotic or parametric bootstrap). Through extensive simulations we demonstrate the validity and robustness of this approach, and provide practical guidelines on how to design an estimation strategy for optimal performance in different data scenarios., Comment: 5 figures. arXiv admin note: text overlap with arXiv:1710.01406

Published
2018

10. Research Advances in Fusion Protein-Based Drugs for Diabetes Treatment

Author

Deng,Wenying, Zhao,Zeyi, Zou,Tao, Kuang,Tongdong, Wang,Jing, Deng,Wenying, Zhao,Zeyi, Zou,Tao, Kuang,Tongdong, and Wang,Jing

Abstract

Wenying Deng,1,* Zeyi Zhao,1,* Tao Zou,2 Tongdong Kuang,3,* Jing Wang1,* 1School of Basic Medical Sciences, University of South China, Hengyang, Hunan Province, 421001, People’s Republic of China; 2Department of Cardiovascular Medicine, First Affiliated Hospital of University of South China, Hengyang, Hunan Province, 421001, People’s Republic of China; 3Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi Province, 541199, People’s Republic of China*These authors contributed equally to this workThese authors contributed equally to this studyCorrespondence: Tongdong Kuang, Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, 541199, People’s Republic of China, Email 594536067@qq.com Jing Wang, School of Basic Medical Sciences, University of South China, Hengyang, Hunan Province, 421001, People’s Republic of China, Tel +86 15200735915, Email 738212405@qq.comAbstract: Diabetes mellitus (DM) is a chronic metabolic disease characterized by elevated blood glucose levels, resulting in multi-organ dysfunction and various complications. Fusion proteins can form multifunctional complexes by combining the target proteins with partner proteins. It has significant advantages in improving the performance of the target proteins, extending their biological half-life, and enhancing patient drug compliance. Fusion protein-based drugs have emerged as promising new drugs in diabetes therapeutics. However, there has not been a systematic review of fusion protein-based drugs for diabetes therapeutics. Hence, we conducted a comprehensive review of published literature on diabetic fusion protein-based drugs for diabetes, with a primary focus on immunoglobulin G (IgG) fragment crystallizable (Fc) region, albumin, and transferrin (TF). This review aims to provide a reference for the subsequent development and clinical application of fusion protein-based drugs in dia

Published
2024

16. Apatinib in the treatment of gastric cancer in Henan Province: a multicenter prospective real-world observational study (Ahead-HAP01)

Author

Ma, Yijie, primary, Zhao, Weijie, additional, Sun, Peichun, additional, Deng, Wenying, additional, Deng, Junli, additional, Zong, Hong, additional, Wang, Junsheng, additional, Guo, Yanzhen, additional, Liu, Huaimin, additional, Cang, Shundong, additional, Shang, Ke, additional, Chen, Xiaobing, additional, Wang, Jin, additional, He, Dezhi, additional, Wu, Gang, additional, Zhang, Zhen, additional, Zhang, Liguo, additional, Xu, Feng, additional, Tian, Chuntao, additional, Qiao, Chaofeng, additional, Chen, Gongbin, additional, Zhang, Guifang, additional, Ma, Tianjiang, additional, Gao, Liwei, additional, Zhang, Guozheng, additional, Liu, Jing, additional, Eslick, Guy D., additional, Almhanna, Khaldoun, additional, Lino-Silva, Leonardo S., additional, Aprile, Giuseppe, additional, Li, Ning, additional, and Luo, Suxia, additional

Published
2022
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20. Phase II study of SHR1210 and trastuzumab in combination with CAPOX for neoadjuvant treatment of HER2-positive gastric or gastroesophageal junction (GEJ) adenocarcinoma.

Author

Li, Ning, primary, Li, Zhi, additional, Fu, Qiang, additional, Zhang, Bin, additional, Zhang, Jian, additional, Wan, XiangBin, additional, Lu, Chaomin, additional, Wang, Jinbang, additional, Deng, Wenying, additional, Wei, Chen, additional, Ma, Yijie, additional, Bie, Liangyu, additional, Wang, Mengyu, additional, and Luo, Suxia, additional

Published
2022
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24. A Cross-Validated Ensemble Approach to Robust Hypothesis Testing of Continuous Nonlinear Interactions: Application to Nutrition-Environment Studies

Author

Liu, Jeremiah Zhe, primary, Deng, Wenying, additional, Lee, Jane, additional, Lin, Pi-i Debby, additional, Valeri, Linda, additional, Christiani, David C., additional, Bellinger, David C., additional, Wright, Robert O., additional, Mazumdar, Maitreyi M., additional, and Coull, Brent A., additional

Published
2021
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28. Clinical effectiveness of apatinib at different doses in patients with advanced gastric cancer as the third-line or further treatment: Results from a post-marketing phase IV study.

Author

Li, Jin, primary, Qin, Shukui, additional, Wen, Lu, additional, Wang, Junsheng, additional, Deng, Wenying, additional, Guo, Weijian, additional, Jia, Tongfu, additional, Zhao, Qun, additional, Zhang, Guifang, additional, He, Yifu, additional, Zhong, Haijun, additional, Ba, Yi, additional, Lin, Xiaoyan, additional, Yang, Jianwei, additional, Zhao, Jun, additional, Bai, Yuxian, additional, Sun, Guogui, additional, Wu, Yongjuan, additional, Wang, Meng, additional, and Sun, Ying, additional

Published
2021
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29. Safety and efficacy of apatinib as third or later line treatment for advanced gastric cancer or gastroesophageal junction adenocarcinoma: A post-marketing phase IV study.

Author

Li, Jin, primary, Qin, Shukui, additional, Wen, Lu, additional, Wang, Junsheng, additional, Deng, Wenying, additional, Guo, Weijian, additional, Jia, Tongfu, additional, Jiang, Da, additional, Zhang, Guifang, additional, He, Yifu, additional, Zhong, Haijun, additional, Ba, Yi, additional, Lin, Xiaoyan, additional, Yang, Jianwei, additional, Zhao, Jun, additional, Bai, Yuxian, additional, Wu, Xiangyuan, additional, Gao, Feng, additional, Sun, Ying, additional, and Hou, Zhiguo, additional

Published
2021
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31. Mechanism of Deformation and Failure of In₄Se₃ based Thermoelectric Materials

Author

Deng, Wenying, Li, Guodong, Zhang, Xiaoliang, Morozov, Sergey I., Goddard, William A., III, and Zhai, Pengcheng

Abstract

The layered In₄Se₃ based material is recognized as a state-of-the-art n-type thermoelectric material for the middle temperature range of 500 K to 900 K. Despite excellent thermoelectric properties, its inferior mechanical properties restrict its commercial possibilities. In this work, we use Quantum Mechanics (density functional theory) to investigate the ideal strength and failure mechanisms of ideal and Se deficient In₄Se₃ under pure shear and biaxial shear loads. We found that the lowest ideal shear strength of ideal In₄Se₃ is 1.25 GPa along the (100)/ slip system. Slippage between the In/Se layer dominates its deformation and failure. With Se vacancies, the ideal strength of In₄Se_(2.75) drops to 1.00 GPa while the failure mechanism remains almost the same as that of ideal In₄Se₃. Moreover, under biaxial shear loads (as in nano-indentation experiments) the ideal strength of In4₄Se₃ increases to 1.50 GPa, with compression now accounting for the failure. Even so, In₄Se₃ shows poorer mechanical properties under biaxial shear loads. These insights into the deformation and failure mechanism of In₄Se₃ compounds should help suggest designing modifications to improve mechanical properties.

Published
2020

32. Serum miR-191 and miR-425 as Diagnostic and Prognostic Markers of Advanced Gastric Cancer Can Predict the Sensitivity of FOLFOX Chemotherapy Regimen

Author

Bie,Liangyu, Li,Ning, Deng,Wenying, Lu,Xiaoyu, Guo,Ping, Luo,Suxia, Bie,Liangyu, Li,Ning, Deng,Wenying, Lu,Xiaoyu, Guo,Ping, and Luo,Suxia

Abstract

Liang-Yu Bie,1 Ning Li,1 Wen-Ying Deng,1 Xiao-Yu Lu,2 Ping Guo,3 Su-Xia Luo1 1Department of Oncology, Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Zhengzhou 450008, Henan Province, People’s Republic of China; 2Department of Pathology, Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Zhengzhou 450008, Henan Province, People’s Republic of China; 3Department of Oncology, The First Affiliated Hospital of Nanyang Medical College, Nanyang 473061, People’s Republic of ChinaCorrespondence: Su-Xia LuoDepartment of Oncology, Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, No. 127 Dongming Road Jinshui District, Zhengzhou 450008, Henan Province, People’s Republic of ChinaEmail luosuxia000@qq.comPurpose: miR-191 and miR-425 have been proved to be highly expressed in gastric carcinoma (GC). However, little research has been done on their clinical value in serum of patients with advanced GC. In addition, it is not clear whether they can be used as markers for the response and prognosis of GC patients treated with oxaliplatin combined with 5-fluorouracil and FOLFOX chemotherapy.Patients and Methods: A total of 230 patients with advanced GC admitted to our hospital were selected as the study objects, all of whom received FOLFOX chemotherapy regimen. Another 100 cases of healthy subjects were included. QRT-PCR was employed to detect the serum expression of miR-191 and miR-425 in patients.Results: Compared with the healthy subjects, the serum expressions of miR-191 and miR-425 in GC patients were significantly upregulated, which were correlated with differentiation degree and TNM staging, respectively. According to the ROC curve, the AUC of miR-191 and miR-425 for GC diagnosis was 0.937 and 0.901, respectively, while the AUC for differentiation degree diagnosis was 0.854 and 0.822, and that for TNM staging diagnosis was 0.860 and 0.829, respectively. The predictive

Published
2020

33. Efficacy and safety of apatinib in treatment of gastric cancer: A real-world study.

Author

Ma, Yijie, primary, Zong, Hong, additional, Wang, Junsheng, additional, Guo, Yanzhen, additional, LIU, Huaimin, additional, Li, Ning, additional, Cang, Shundong, additional, Shang, Ke, additional, Chen, Xiaobing, additional, Wang, Jin, additional, He, Dezhi, additional, Deng, Wenying, additional, Sun, Peichun, additional, Zhang, Zhen, additional, Zhang, Liguo, additional, Xu, Feng, additional, Tian, Chuntao, additional, Qiao, Chaofeng, additional, Chen, Gongbin, additional, and Luo, Suxia, additional

Published
2021
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34. Phase II study of sintilimab combined with FLOT regimen for neoadjuvant treatment of gastric or gastroesophageal junction (GEJ) adenocarcinoma.

Author

Li, Ning, primary, Li, Zhi, additional, Fu, Qiang, additional, Zhang, Bin, additional, Zhang, Jian, additional, Wan, XiangBin, additional, Lu, Chaomin, additional, Wang, Jinbang, additional, Deng, Wenying, additional, Wei, Chen, additional, Ma, Yijie, additional, Bie, Liangyu, additional, Wang, Mengyu, additional, and Luo, Suxia, additional

Published
2021
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36. A Cross-Validated Ensemble Approach to Robust Hypothesis Testing of Continuous Nonlinear Interactions: Application to Nutrition-Environment Studies.

Author

Liu, Jeremiah Zhe, Deng, Wenying, Lee, Jane, Lin, Pi-i Debby, Valeri, Linda, Christiani, David C., Bellinger, David C., Wright, Robert O., Mazumdar, Maitreyi M., and Coull, Brent A.

Subjects
*CHILD nutrition, *MATERNAL nutrition, *FUNCTION spaces, *NUTRITIONAL status, *PREGNANT women, *NUTRITIONAL genomics
Abstract

Gene-environment and nutrition-environment studies often involve testing of high-dimensional interactions between two sets of variables, each having potentially complex nonlinear main effects on an outcome. Construction of a valid and powerful hypothesis test for such an interaction is challenging, due to the difficulty in constructing an efficient and unbiased estimator for the complex, nonlinear main effects. In this work, we address this problem by proposing a cross-validated ensemble of kernels (CVEK) that learns the space of appropriate functions for the main effects using a cross-validated ensemble approach. With a carefully chosen library of base kernels, CVEK flexibly estimates the form of the main-effect functions from the data, and encourages test power by guarding against over-fitting under the alternative. The method is motivated by a study on the interaction between metal exposures in utero and maternal nutrition on children's neurodevelopment in rural Bangladesh. The proposed tests identified evidence of an interaction between minerals and vitamins intake and arsenic and manganese exposures. Results suggest that the detrimental effects of these metals are most pronounced at low intake levels of the nutrients, suggesting nutritional interventions in pregnant women could mitigate the adverse impacts of in utero metal exposures on the children's neurodevelopment. for this article, including a standardized description of the materials available for reproducing the work, are available as an online supplement. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Characterization of gastric cancer stem-like molecular features, immune and pharmacogenomic landscapes.

Author

Wei, Chen, Chen, Mingkai, Deng, Wenying, Bie, Liangyu, Ma, Yijie, Zhang, Chi, Liu, Kangdong, Shen, Wei, Wang, Shuyi, Yang, Chaogang, Luo, Suxia, and Li, Ning

Subjects
STOMACH cancer, CANCER stem cells, PHARMACOGENOMICS, STEM cells, TUMOR microenvironment, CANCER prognosis, CANCER cells
Abstract

Cancer stem cells (CSCs) actively reprogram their tumor microenvironment (TME) to sustain a supportive niche, which may have a dramatic impact on prognosis and immunotherapy. However, our knowledge of the landscape of the gastric cancer stem-like cell (GCSC) microenvironment needs to be further improved. A multi-step process of machine learning approaches was performed to develop and validate the prognostic and predictive potential of the GCSC-related score (GCScore). The high GCScore subgroup was not only associated with stem cell characteristics, but also with a potential immune escape mechanism. Furthermore, we experimentally demonstrated the upregulated infiltration of CD206+ tumor-associated macrophages (TAMs) in the invasive margin region, which in turn maintained the stem cell properties of tumor cells. Finally, we proposed that the GCScore showed a robust capacity for prediction for immunotherapy, and investigated potential therapeutic targets and compounds for patients with a high GCScore. The results indicate that the proposed GCScore can be a promising predictor of prognosis and responses to immunotherapy, which provides new strategies for the precision treatment of GCSCs. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Development of non-hematological adverse events in apatinib-treated gastric cancer and their association with clinical outcome: Results from a phase IV study.

Author

Ba, Yi, primary, Li, Jin, additional, Qin, Shukui, additional, Wen, Lu, additional, Deng, Wenying, additional, Zhang, Guifang, additional, Jia, Tongfu, additional, Zhong, Haijun, additional, Yang, Jianwei, additional, Lin, Xiaoyan, additional, Bai, Yu-Xian, additional, He, Yifu, additional, Xie, Zhong, additional, Yi, Tienan, additional, Wu, Xiangyuan, additional, Ye, Feng, additional, Liu, Likun, additional, Huang, Yong, additional, Wang, Mei, additional, and Wang, Junsheng, additional

Published
2018
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46. Does hypertension history in patients with advanced gastric cancer has an impact on clinical outcomes following apatinib treatment? A subgroup analysis based on data from Ahead-G201 study.

Author

Yi, Tienan, primary, Li, Jin, additional, Qin, Shukui, additional, Wen, Lu, additional, Wang, Junsheng, additional, Deng, Wenying, additional, Zhang, Guifang, additional, Jia, Tongfu, additional, Ba, Yi, additional, Zhong, Haijun, additional, Yang, Jianwei, additional, Lin, Xiaoyan, additional, Bai, Yu-Xian, additional, He, Yifu, additional, Xie, Zhong, additional, Wu, Xiangyuan, additional, Ye, Feng, additional, Liu, Likun, additional, Huang, Yong, additional, and Wang, Mei, additional

Published
2018
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47. Safety of apatinib as third-line or beyond treatment in advanced or metastatic gastric cancer: Results from a multicenter phase IV study (Ahead-G201).

Author

Li, Jin, primary, Wen, Lu, additional, Wang, Junsheng, additional, Deng, Wenying, additional, Zhang, Guifang, additional, Jia, Tongfu, additional, Ba, Yi, additional, Zhong, Haijun, additional, Yang, Jianwei, additional, Lin, Xiaoyan, additional, Bai, Yu-Xian, additional, He, Yifu, additional, Xie, Zhong, additional, Yi, Tienan, additional, Wu, Xiangyuan, additional, Ye, Feng, additional, Liu, Likun, additional, Huang, Yong, additional, Wang, Mei, additional, and Qin, Shukui, additional

Published
2018
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48. Response to apatinib by the number of metastatic organs in patients with advanced or metastatic gastric cancer: Subgroup analysis from a phase IV study (Ahead-G201).

Author

He, Yifu, primary, Li, Jin, additional, Qin, Shukui, additional, Wen, Lu, additional, Wang, Junsheng, additional, Deng, Wenying, additional, Zhang, Guifang, additional, Jia, Tongfu, additional, Ba, Yi, additional, Zhong, Haijun, additional, Yang, Jianwei, additional, Lin, Xiaoyan, additional, Bai, Yu-Xian, additional, Xie, Zhong, additional, Yi, Tienan, additional, Wu, Xiangyuan, additional, Ye, Feng, additional, Huang, Yong, additional, Wang, Mei, additional, and Liu, Likun, additional

Published
2018
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49. Impact of time to progression on first-line therapy on clinical outcomes in advanced gastric cancer treated with apatinib: data from a phase IV study (Ahead-G201).

Author

Xie, Zhong, primary, Qin, Shukui, additional, Li, Jin, additional, Wen, Lu, additional, Wang, Junsheng, additional, Deng, Wenying, additional, Zhang, Guifang, additional, Jia, Tongfu, additional, Ba, Yi, additional, Zhong, Haijun, additional, Yang, Jianwei, additional, Lin, Xiaoyan, additional, Bai, Yu-Xian, additional, He, Yifu, additional, Yi, Tienan, additional, Wu, Xiangyuan, additional, Ye, Feng, additional, Liu, Likun, additional, Wang, Mei, additional, and Huang, Yong, additional

Published
2018
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50. Effect of ECOG PS on outcome of advanced or metastatic gastric patients treated with apatinib: Analysis from a post-marketing phase IV study.

Author

Lin, Xiaoyan, primary, Li, Jin, additional, Qin, Shukui, additional, Wen, Lu, additional, Wang, Junsheng, additional, Deng, Wenying, additional, Jia, Tongfu, additional, Ba, Yi, additional, Zhong, Haijun, additional, Yang, Jianwei, additional, Bai, Yu-Xian, additional, He, Yifu, additional, Xie, Zhong, additional, Yi, Tienan, additional, Wu, Xiangyuan, additional, Ye, Feng, additional, Liu, Likun, additional, Huang, Yong, additional, Wang, Mei, additional, and Zhang, Guifang, additional

Published
2018
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