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14. Orexins mitigate obesity‐associated dysfunctions in mice.

Author

Blais, Anne, Denis, Isabelle, Andriamihaja, Mireille, Gratio, Valérie, Champeil‐Potokar, Gaelle, Laouirem, Samira, Chassac, Anais, Couvelard, Anne, Paradis, Valérie, Voisin, Thierry, Davila, Anne‐Marie, and Couvineau, Alain

Subjects
WEIGHT loss, WEIGHT gain, OREXINS, GUT microbiome, INSULIN resistance
Abstract

Objective: Obesity is a chronic disease that affects more than 400 million adults with severe comorbidities. The search for new treatments to reduce its negative consequences is necessary. Orexins are hypothalamic neuropeptides involved in various physiological processes related to obesity. The aim of this study was to investigate the consequences of chronic orexin‐A treatment in mouse models. Methods: Female wild‐type C57BL/6 mice that were obesity‐prone or obesity‐resistant and mice that were deficient for orexin receptors were fed with a high‐fat diet. Glucose tolerance, indirect calorimetry, expression of brain neuropeptides and receptors, microglial activation, and microbiota were determined to evaluate the role of orexins on metabolic flexibility. Results: Orexin‐A reduces weight gain in obesity‐prone mice. This reduction is associated with a decrease in body fat, food intake, steatosis, and insulin resistance, as well as alterations of intestinal microbiota composition. A decreased expression of orexin receptors and neuropeptides involved in food intake was also observed in the hypothalamus. Conclusions: Our data support the notion that orexin receptor signaling is involved in different aspects of energy metabolism and can mitigate several dysfunctions associated with obesity, suggesting that orexin receptors can represent new targets for obesity treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Effectiveness of intradiscal ozone injections for treating pain following herniated lumbar disc: A systematic review and meta-analysis.

Author

Chang, Min Cheol, Choo, Yoo Jin, Denis, Isabelle, Mares, Christopher, Majdalani, Carl, and Yang, Seoyon

Subjects
OZONE therapy, PAIN measurement, MEDICAL information storage & retrieval systems, SPINAL injections, RESEARCH funding, VISUAL analog scale, TREATMENT effectiveness, META-analysis, DESCRIPTIVE statistics, SYSTEMATIC reviews, MEDLINE, LUMBAR vertebrae, OZONE, PAIN management, MEDICAL databases, INTERVERTEBRAL disk displacement, ONLINE information services, CONFIDENCE intervals, LUMBAR pain, DISEASE complications
Abstract

BACKGROUND: Low back pain and sciatica caused by herniated lumbar discs (HLDs) are common complaints among patients visiting pain clinics. Among the various therapeutic methods, intradiscal ozone injections have emerged as an effective alternative or additional treatment option for HLDs. OBJECTIVE: This meta-analysis aimed to investigate the effectiveness of intradiscal ozone injections in the treatment of HLDs. METHODS: We searched the PubMed, Embase, Cochrane Library, and Scopus databases for relevant studies published until January 25, 2024. We included studies that investigated the efficacy of intradiscal ozone injections in patients with HLDs. We evaluated the methodological quality of individual studies using the Cochrane Collaboration tool. RESULTS: At ⩾ 6 months after treatment, the therapeutic effect of intradiscal ozone injections in patients with HLDs was greater than that of steroid injections (treatment success rate, 6 months: odds ratio = 3.95, 95% confidence interval [CI] [2.44, 6.39], P < 0.01) or conventional medications (changes in the Visual Analog Scale [VAS], 6 months: standardized mean difference [SMD] = 1.65, 95% CI [1.08, 2.22], P < 0.01; 12 months: SMD = 1.52, 95% CI [0.96, 2.08], P < 0.01) but similar to that of microdiscectomy (changes in VAS, 18 months: SMD = - 0.05, 95% CI [ - 0.67, 0.57], P = 0.87). At < 6 months after treatment, the reduction in the VAS score after intradiscal ozone injections was higher than that after steroid injections (changes in VAS, 1 month: SMD = 2.53, 95% CI [1.84, 3.21], P < 0.01). CONCLUSION: Intradiscal ozone injections may be a useful therapeutic tool in patients with HLDs. Compared with other conventional treatment methods such as steroid injections and oral medications, intradiscal ozone injection has great long-term (⩾ 6 months) effectiveness. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Influence of resident involvement on fluoroscopy time and ionizing radiation exposure in fluoroscopy‐guided spinal procedures.

Author

Soucy, Béatrice, Lee, Dillon, Moreau‐Bourbonnais, Amélie, Filiatrault, Marc, Denis, Isabelle, Chang, Min Cheol, and Boudier‐Revéret, Mathieu

Subjects
RADIATION exposure, IONIZING radiation, FLUOROSCOPY, EPIDURAL injections, RADIATION doses, TEACHING hospitals
Abstract

Background: Fluoroscopic guidance has become the standard for a variety of medical procedures. Mastering these techniques requires practice, which may entail additional radiation for patients and providers. Despite their widespread use, the literature examining factors influencing radiation exposure in fluoroscopically guided pain procedures is scarce. Objective: To evaluate the influence of resident involvement on radiation exposure during fluoroscopy‐guided spinal interventions. Design: Single‐center, observational study. Setting: Outpatient physiatry clinic in a teaching hospital. Patients: All patients who received cervical or lumbar facet block(s) (FBs), transforaminal epidural steroid injection(s) (TFESIs) without digital subtraction, or a caudal epidural (CE) during the study period were included. Interventions: Resident involvement in the procedures: absent, observing, or participating. Main Outcome Measures: Machine‐indicated fluoroscopy time (seconds) and radiation dose (milligrays [mGy]). Results: Two hundred ninety six procedures were included: 188 FBs (58 cervical, 130 lumbar), 48 CEs, and 60 TFESIs. For lumbar FBs, fluoroscopy time and radiation dose increased significantly when residents performed them (meantime = 24.5 s, confidence interval [CI] = 20.4–28.7; meandose = 3.53 mGy, CI = 2.57–4.49) compared to when they observed (meantime = 9.9 s, CI = 8.1–11.7; meandose = 1.28 mGy, CI = 0.98–1.59) (mean difference: time = 14.63 s, CI = 9.31–19.94; dose = 2.25 mGy, CI = 1.17–3.33) and were absent during the procedure (meantime = 12.9 s, CI = 11.1–14.6; meandose = 1.65 mGy, CI = 1.40–1.89) (mean difference: time = 11.67 s, CI = 7.35–15.98; dose = 1.88 mGy, CI = 1.01–2.76). In the case of TFESIs, time, but not dose, increased significantly when residents observed (meantime = 39.1 s, CI = 30.7–47.6; meandose = 6.73 mGy, CI = 3.39–10.07) compared to when they were absent (meantime = 27.1 s, CI = 22.4–31.8; meandose = 4.41 mGy, CI = 3.06–5.76 (mean difference: time = 11.99 s, CI = 1.37–22.61; dose = 2.32 mGy, CI = −1.20–5.84). Finally, resident involvement did not significantly affect the outcomes for CEs (ptime =.032, pdose =.74) and cervical FBs (ptime =.64, pdose =.68). Conclusion: Resident participation affected lumbar FBs the most, with an increase in both fluoroscopy time and radiation dose. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Incidence and Risk Factors of Systemic Adverse Effects and Complications of Ultrasound- and Fluoroscopy-Guided Glucocorticoid Injections

Author

Lavigne, Alexandre, primary, Nguyen, Don, additional, Chartrand-Oberoi, Olivier, additional, Noyon, Brandon, additional, Spiliotopoulos, Stevie, additional, Kfoury, Céline, additional, Vanasse, Lorence, additional, Chamieh, Ralph, additional, Bouhadana, Haïm, additional, Boudier-Revéret, Mathieu, additional, Denis, Isabelle, additional, and Mares, Christopher, additional

Published
2023
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30. Oser une évaluation partagée : étude de cas dans une école québécoise

Author

Nizet, Isabelle, Lépine, Martin, Denis, Isabelle, and Hétu, Suzane

Subjects
compétences, évaluation, appétence, accompagnement interprofessionnel, littératie
Abstract

L’évaluation des compétences en lecture génère chez beaucoup d’élèves en difficulté, une diminution de leur appétence pour la lecture (effet Matthieu) ; on sait aussi que les perceptions normatives de l’activité évaluative freinent chez les personnes enseignantes, les innovations didactiques susceptibles d’aider ces élèves à rester des lectrices et lecteurs motivés. Nous présentons quelques résultats d’une recherche-action ayant pour objectif principal le développement interprofessionnel d’enseignantes dans une perspective de formation à la littératie, au développement de la compétence en lecture de textes littéraires, afin de conserver l’appétence des élèves en lecture. L’entrée par les problématiques d’évaluation a été choisie pour permettre aux enseignantes participant au projet de se réapproprier leur autonomie professionnelle et favoriser l’intervention des élèves aux différentes étapes du processus d’évaluation. Dans ce contexte plusieurs enjeux de démocratisation du point de vue didactique et du point de vue de l’évaluation sont décrits dans une étude de cas avec la collaboration d’une enseignante qui l’a exploré avec sa classe de 6e année pendant trois ans et d’une conseillère pédagogique qui l’a accompagnée.

Published
2023
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40. Investigating the relationship between the five-factor model of distress tolerance, anxiety and anxiety sensitivity.

Author

de Lafontaine, Marie-France, Turcotte, Stéphane, Denis, Isabelle, and Foldes-Busque, Guillaume

Subjects
FIVE-factor model of personality, ANXIETY sensitivity
Abstract

Distress tolerance (DT) has been conceptualized as a vulnerability factor for several psychopathologies. A five factor model of DT has been suggested, but its associations with anxiety and anxiety sensitivity have yet to be explored. This study aimed to further validate the five-factor model of DT, identify the associations between its factors and elevated anxiety, and assess if anxiety sensitivity mediates the association between DT and anxiety. This observational study included 330 students and university workers (women = 82.7%; mean age = 27.7 years, SD = 9.4). They completed online questionnaires assessing DT, anxiety sensitivity and anxiety levels. The five-factor model was a good fit to the data (RMSEA =.04). Two factors, and the sex of the participants, contributed to the variance in anxiety (r2 =.418, p <.001). Tolerance of negative emotion was directly (β = −1.98, 95% CI = [−2.53, −1.42]) and indirectly (β = −1.10, 95% CI = [−1.55, -.78]) associated with lower anxiety through anxiety sensitivity. Tolerance of uncertainty was also directly (β = -.08, 95% CI = [-.10, -.06]) and indirectly (β = -.04, 95% CI = [-.05, -.02]) associated with lower anxiety through anxiety sensitivity. Tolerance of negative emotion and uncertainty were associated with anxiety independently of the other factors of DT. These associations seem partially explained by the effect of anxiety sensitivity. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Randomized Ablation-Based Rhythm-Control Versus Rate-Control Trial in Patients With Heart Failure and Atrial Fibrillation: Results from the RAFT-AF trial

Author

Parkash, Ratika, primary, Wells, George A., additional, Rouleau, Jean, additional, Talajic, Mario, additional, Essebag, Vidal, additional, Skanes, Allan, additional, Wilton, Stephen B., additional, Verma, Atul, additional, Healey, Jeffrey S., additional, Sterns, Laurence, additional, Bennett, Matthew, additional, Roux, Jean-Francois, additional, Rivard, Lena, additional, Leong-Sit, Peter, additional, Jensen-Urstad, Mats, additional, Jolly, Umjeet, additional, Philippon, Francois, additional, Sapp, John L., additional, Tang, Anthony S.L., additional, MacDonald, Paul, additional, Chakrabarti, Santabhanu, additional, Yeung-Lai-Wah, John, additional, Ignaszewski, Andrew, additional, Tung, Stanley, additional, Virani, Shahnawaz, additional, Deyell, Marc, additional, Krahn, Andrew, additional, Andrade, Jason, additional, Straatman, Lynn, additional, Toma, Mustafa, additional, Wong, Graham, additional, Wei, Matthew, additional, Greiss, Isabelle, additional, Raymond, Jean-Marc, additional, Coutu, Benoit, additional, Costi, Paolo, additional, Mansour, Fadi, additional, Saint-Phard, Wouter, additional, Denis, Isabelle, additional, Fleury, Julie, additional, Ayala-Paredes, Felix, additional, Badra-Verdu, Mariano, additional, Dussault, Charles, additional, Vachon, Nadia, additional, Dagenais, Véronique, additional, Lamoureux, Caroline, additional, Healey, Jeff, additional, Connolly, Stuart, additional, Ribas, C. Sebastien, additional, Divakaramenon, Syamkumar, additional, Wong, Jorge, additional, Amit, Guy, additional, Meyer, Wendy, additional, Nault, Isabelle, additional, Champagne, Jean, additional, Sarrazin, Jean-Francois, additional, O’Hara, Gilles, additional, Blier, Louis, additional, Plourde, Benoit, additional, Steinburg, Christian, additional, Roy, Karine, additional, Banville, Paule, additional, Ottinger, Brigitte, additional, Boucher, Marie-Eve, additional, Sanchez, Marina, additional, Dubuc, Marc, additional, Guerra, Peter, additional, Dyrda, Katia, additional, Khairy, Paul, additional, Macle, Laurent, additional, Mondesert, Blandine, additional, Roy, Denis, additional, Thibault, Bernard, additional, Tadros, Rafik, additional, Roy, Véronique, additional, Redfearn, Damian, additional, Abdollah, Hoshiar, additional, Baranchuk, Adrian, additional, Michael, Kevin, additional, Simpson, Christopher, additional, Hammond, Sharlene, additional, Clarke, Brian, additional, Morillo, Carlos, additional, Kuriachan, Vikas, additional, Veenhuyzen, George, additional, Quinn, Russell, additional, Exner, Derek, additional, Howlett, Jonathan, additional, McKeage, Jennifer, additional, Gula, Lorne, additional, Manlucu, Jaimie, additional, Tang, Anthony, additional, Klein, George, additional, Wall, Sabrina, additional, El-Sakka, Yomna, additional, Hadjis, Tom, additional, Bernier, Martin, additional, Joza, Jacqueline, additional, Roux, Jean- Francois, additional, Omelchenko, Alexander, additional, Nascimento, Thais, additional, Rafti, Fiorella, additional, DiStefano, Ida, additional, Parkash, Ratika, additional, Sapp, John, additional, Gray, Chris, additional, Gardner, Martin, additional, Abdel-Wahab, Amir, additional, MacIntyre, Ciorsti J, additional, Rajda, Miroslaw, additional, O’Regan, Patrick, additional, Levins-Lamont, Mary Lee, additional, Lockwood, Evan, additional, Hruczkowski, Tom, additional, Valtuille, Lucas, additional, Chan, Michael, additional, Halenar, Jennifer, additional, McLean, Samantha, additional, Khaykin, Yaariv, additional, Nyman, Lynn, additional, Wulffhart, Zaev, additional, Pantano, Alfredo, additional, Tsang, Bernice, additional, Patterson, Sherri, additional, Nath, Annette, additional, Rinne, Clause, additional, Janzen, Irene, additional, Crystal, Eugene, additional, Lashevsky, Ilan, additional, Singh, Sheldon, additional, Tiong, Irving, additional, Syeda, Ambreen, additional, Tremblay, Anyur, additional, Ha, Andrew C. T., additional, Chauhan, Vijay, additional, Hill, Ann, additional, Nery, Pablo, additional, Birnie, David, additional, Redpath, Calum, additional, Green, Martin, additional, Nair, Girish, additional, Lemery, Robert, additional, Sadek, Mouhannad, additional, MacDonald, Karen, additional, Novak, Paul, additional, Leather, Richard, additional, Swiggum, Elizabeth, additional, Sikkel, Markus, additional, Lane, Chris, additional, Rakochey, Tanner, additional, Patterson, Caitlin, additional, Luz Leiria, Tiago Luiz, additional, Glotz de Lima, Gustavo, additional, Sant’Anna, Roberto, additional, Dutz, Eduardo, additional, Klein Weber, Cristina, additional, Peixoto Deiro, Aline, additional, Hoscheidt, Laís Machado, additional, Linde, Cecile, additional, Saluveer, Ott, additional, Carnlof, Carina, additional, Yu, Chih-Chieh, additional, Chiu, Fu-Chun, additional, Lin, Jiunn-Lee, additional, Huang, Cheng-Yu, additional, Theoret-Patrick, Patricia, additional, Ryan, Janine, additional, Tran, My-Linh, additional, Chen, Li, additional, Singh, Sarah, additional, Wells, George, additional, Newton, Gary, additional, Coyle, Doug, additional, Wyse, George, additional, Cassidy, Dennis, additional, Thabane, Lehana, additional, Mielniczuk, Lisa, additional, Ha, Andrew, additional, Luz Leiria, TIago Luiz, additional, Tzemos, Niko, additional, Mathew, Andrew, additional, Thain, De, additional, MacDonald, Anita, additional, and Shields, Marcia, additional

Published
2022
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45. Dopamine Modulates the Processing of Food Odour in the Ventral Striatum

Author

Rampin, Olivier, primary, saint-albin, Audrey, additional, Ouali, Christian, additional, Burguet, Jasmine, additional, Gry, Elisa, additional, champeil-potokar, Gaelle, additional, jerome, Nathalie, additional, Davidenko, Olga, additional, Darcel, Nicolas, additional, Bombail, Vincent, additional, Andrey, Philippe, additional, and Denis, Isabelle, additional

Published
2022
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49. Targeted Suppression of Lipoprotein Receptor LSR in Astrocytes Leads to Olfactory and Memory Deficits in Mice

Author

El Hajj, Aseel, primary, Herzine, Ameziane, additional, Calcagno, Gaetano, additional, Désor, Frédéric, additional, Djelti, Fathia, additional, Bombail, Vincent, additional, Denis, Isabelle, additional, Oster, Thierry, additional, Malaplate, Catherine, additional, Vigier, Maxime, additional, Kaminski, Sandra, additional, Pauron, Lynn, additional, Corbier, Catherine, additional, Yen, Frances T., additional, Lanhers, Marie-Claire, additional, and Claudepierre, Thomas, additional

Published
2022
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