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3 results on '"Denis, Klukovsky"'

1. Multigram Synthesis of trans-2-(Trifluoromethyl)cyclopropanamine

Author

Andrii V. Bezdudny, Yurii M. Pustovit, Denis Klukovsky, Natalia Simurova, Pavel K. Mykhailiuk, and Oleg V. Shishkin

Subjects
chemistry.chemical_classification, Trifluoromethyl, Trifluoromethylation, Carboxylic acid, Organic Chemistry, chemistry.chemical_element, Sulfur tetrafluoride, Chemical synthesis, Catalysis, chemistry.chemical_compound, chemistry, Fluorine, Organic chemistry, Amine gas treating
Abstract

Trifluoromethyl)cyclopropanamine was synthesized. The key step of the synthesis is a transformation of the carboxy group into the trifluoromethyl group by using sulfur tetrafluoride. Twenty gram of the target product was conveniently prepared in a single batch.

Published
2010
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3. An Improved Synthesis of 2-, 3-, and 4-(Trifluoromethyl)cyclohexylamines.

Author

Alekseenko, Anatoliy N., Denis, Klukovsky, Lukin, Oleg, Mykhailiuk, Pavel K., Shishkin, Oleg V., and Pustovit, Yurii M.

Subjects
*CYCLOHEXYLAMINE, *ORGANIC synthesis, *HYDROGENATION, *TRIFLUOROACETIC acid, *ISOMERS, *ATMOSPHERIC pressure
Abstract

An improved synthesis of 2-, 3-, and 4-trifluoromethylcyclohexylamines on a multigram scale via PtO2-mediated hydrogenation of the corresponding trifluoromethylanilines in trifluoroacetic acid at room temperature under atmospheric pressure is reported. The hydrogenation occurred with a remarkable stereoselectivity favoring the formation of cis-isomers. [ABSTRACT FROM AUTHOR]

Published
2012
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