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Today, the demand for environmentally responsible tourism is growing noticeably. Travelers demonstrate an interest in exploring undisturbed nature that can be found in special protection areas. As part of a network of such areas, botanical gardens can become important elements in the development of sustainable tourism in regions and cities. However, this is no easy task, as it requires preserving natural ecosystems while providing comfortable conditions for tourists. One of the foundations for environmental activities is the opinion of local communities about nature conservation. As the first step towards promoting sustainable tourism on the territory of the Polar-Alpine Botanical Garden-Institute of N. A. Avrorin (PABGI; Kola Science Centre of the Russian Academy of Sciences), the only botanical garden in Russia operating in the Arctic, a survey was conducted to investigate the opinions of local residents about this institution as a special protection area and the possibilities for tourism development. The Botanical Garden is an essential element of the historical and cultural landscape not only of the city of Kirovsk but also of the neighboring city of Apatity. The respondents generally demonstrated a high level of environmental awareness. However, questions about the PABGI’s territorial boundaries and the species of plants listed in the Red Book of the Murmansk region posed challenges. The survey revealed that residents of the Kirovsko-Apatitsky district have a positive attitude towards tourism development on the PABGI’s territory. They recognize that it is a protected area and that maintaining special visitation rules is crucial. The results indicate that PABGI needs to intensify its efforts in organizing educational events and interacting with the population, as respondents repeatedly noted the need to expand such activities. According to the citizens, the territory of the botanical garden is a platform where researchers, residents, nature, and culture can interact. Currently, PABGI faces difficulties in performing functions other than its primary ones of natural ecosystem conservation and research. This is largely because special regulations are required on the territory of protected areas, and there are not enough opportunities for sustainable tourism development. A consistent strategy for improving and developing tourism infrastructure needs to be developed in the future.

This study aimed to test the hypothesis of the year-round presence of toxigenic Microcystis and cyanotoxins in the water and ice of the shallow eutrophic Lake Ytyk-Kyuyol located in the continuous permafrost zone. Three independent approaches—mass-spectrometry, molecular methods and light microscopy—were applied in the study. The cyanobacterial biomass ranged from 1.0 × 10−4 to 4.8 mg L−1. Microcystis flos-aquae and M. aeruginosa were the dominant morphospecies in plankton throughout the observation. In environmental DNA, the presence of M. aeruginosa was supported and mcy gene regions responsible for microcystin biosynthesis were detected through a BLAST (Basic Local Alignment Search Tool) search and phylogenetic estimation based on newly obtained 16S rRNA, 16S–23S ITS rRNA, mcyA and mcyE nucleotide sequences. The intracellular microcystin concentration ranged from −1, and the microcystin quota in the Microcystis biomass was extremely low. For the first time, it was shown that Microcystis cells containing mcy genes and microcystins presented permanently in the water column, both during the ice-free period and under ice, as well as inside thick ice covers within 7 months of severe winter. We hypothesized that minor pelagic and ice populations of Microcystis could participate in increasing cell density in the spring. However, further studies are needed to confirm the viability of the overwintering Microcystis colonies in the water and inside the ice of Lake Ytyk-Kyuyol.

Edema, i.e., fluid accumulation in the interstitial space, accompanies numerous pathological states of the human organism, including heart failure (HF), inflammatory response, and lymphedema. Nevertheless, techniques for quantitative assessment of the edema’s severity and dynamics are absent in clinical practice, and the analysis is mainly limited to physical examination. This fact stimulates the development of novel methods for fast and reliable diagnostics of fluid retention in tissues. In this work, we focused on the possibilities of two microscopic techniques, nailfold video capillaroscopy (NVC) and confocal laser scanning microscopy (CLSM), in the assessment of the short-term and long-term cutaneous edema. We showed that for the patients with HF, morphological parameters obtained by NVC—namely, the apical diameter of capillaries and the size of the perivascular zone—indicate long-term edema. On the other hand, for healthy volunteers, the application of two models of short-term edema, venous occlusion, and histamine treatment of the skin, did not reveal notable changes in the capillary parameters. However, a significant reduction of the NVC image sharpness was observed in this case, which was suggested to be due to water accumulation in the epidermis. To verify these findings, we made use of CLSM, which provides the skin structure with cellular resolution. It was observed that for the histamine-treated skin, the areas of the dermal papillae become hyporefractive, leading to the loss of contrast and the lower visibility of capillaries. Similar effect was observed for patients undergoing infusion therapy. Collectively, our results reveal the parameters can be used for pericapillary edema assessment using the NVC and CLSM, and paves the way for their application in a clinical set-up.

Introduction Fractures of the distal metaepipheseal fractures of the radius (DMER) have a leading place in the overall structure of upper limb injuries. DMER fractures are frequently associated with soft- tissue injuries of the wrist joint, and namely, the triangular fibrocartilage complex (TFCC). The additional use of arthroscopy of the wrist joint in the treatment of patients with a DMER fractiures reduces the duration of recovery of patients and improves the result of their treatment. The aim of the study was to determine the effect of arthroscopic surgical treatment of TFCC injuries during bone osteosynthesis for DMER fractures on the functions of the upper extremities (extension/flexion of the hand, hand grip strength, pronation/supination of the forearm, DASH index). Materials and methods The study included 68 patients with DMER fractures, who were divided into 2 groups, depending on the treatment of the fracture. After reduction and osteosynthesis, all patients underwent arthroscopy of the wrist joint. If TFCC injury was detected, either a debridement or a TFCC suture was performed. Results TFCC injury was detected in 61.7 % (n = 42). Debridement was performed in 42.9 % (n = 18); suture using the inside-out technique was performed in 47.6 % (n = 20); one patient underwent reinsertion. After 6 months, the function of flexion and extension of the hand was significantly worse in patients with combined TFCC and DMER injuries, but after 12 months, the indicators were similar. The strength of the hand grip and the rotational function of the forearm did not differ between the subgroups. The subjective assessment of DASH after 6 months was worse in the group with TFCC injury, but after 12 months the results were similar. Conclusion Surgical treatment of TFCС injury in intraarticular fractures of the distal radius contributes to the restoration of the upper limb function to a premorbid level 12 months after surgical treatment.

Background. Lung function tests should be performed to patients with penetrating wounds of the lungs to identify lung function disorders, and the data obtained should be taken into account when correcting medical treatment and prescribing individual medical rehabilitation programs. The aim was to study the impact of penetrating lung wounds on the lung function in the early recovery period. Materials and methods. 13 patients were enrolled in the study, 100% male, median age 26 [21; 31] years. Spirometry, body plethysmography, and a diffusion test were performed on an average of 14 days from the injury. Results. A prospective cross-sectional study was performed. A moderate decrease in the vital capacity (VC), the forced vital capacity (FVC), the volume of forced exhalation in the first second (FEV1) was revealed while the total lung capacity (TLCpl) and the FEV1/FVC ratio were within normal values. However, in 2 (15.4%) and 3 (23%) patients, a restrictive ventilation disorders (TLC lower limit of normal) was detected when using Global Lung Function Initiative (GLI) and European Community for Steel and Coal (ECSC) 1993 predicted value system, respectively. The residual lung (RV) and RV/TLCpl were increased. Functional residual capacity (FRC), FRCpl/TLCpl, airway resistance remained within normal values. The diffusion lung capacity impairment was detected in 92.3% and 61.5% cases according to the ECSC 1993 and the GLI system, respectively. Conclusion. In the early period of recovery after penetrating lung wounds, a nonspecific pattern of ventilation disorders was the most often abnormality namely a decrease in VC while TLC and FEV1/FVC were within normal values. Less frequently, the classic restrictive pattern of ventilation disorders was diagnosed. Besides, the diffusion lung capacity impairment was detected. The system of predicted values has a significant impact on the frequency of detection of the lung function disorders. The revealed functional disorders should be taken into account for adjusting medical and rehabilitation interventions.

Objective. To analyze clinical outcomes and complication rates of transforaminal and interlaminar endoscopic decompression and open microsurgical operations performed for lumbosacral spinal canal stenosis. Material and Methods. The data of 60 literature sources selected in accordance with the inclusion and exclusion criteria in the PubMed, Science Direct, Google Scholar and Cochrane Library databases were systematized by evaluating diagnostic methods, clinical pictures and surgical treatment of the lumbar spinal canal stenosis. Original studies, case series and reviews containing information on surgical methods for the treatment of spinal stenosis at the lumbar level were analyzed. Results. The complication rate after transforaminal endoscopic decompression (relapses, infectious complications, damage to the dural membrane and spinal roots) does not exceed 2.7 %, which is significantly lower than that in open microsurgical operation (4.8–8.8 %). Endoscopic decompression and reconstruction of the spinal canal demonstrate good clinical outcomes, lower number of bed-days, readmissions, and good economic benefits. When stenosis is combined with instability of the spinal motion segment, performing only a decompressive operation in any volume does not give a significant clinical result, and stabilization surgery is required. Conclusion. The introduction of endoscopic reconstructive surgery for spinal canal stenosis in the lumbosacral spine is associated not only with technical progress and improvement of endoscopic optics, but also with the search for the causes of unsatisfactory results of open operations. Endoscopic interventions showed good clinical outcomes and a decrease in the complication rate. However, the evidence base needs to be expanded due to the lack of randomized trials to compare open decompression and stabilization, and endoscopic reconstructive surgeries in patients with various manifestations of spinal stenosis.

Introduction Meniscus tear is one of the most common injuries of the knee joint. Medial meniscus tear accounts for 23–31 % of knee joint injuries. The main method of treatment is partial resection. As reported, 13.5 % of patients undergo arthroplasty within 15 years after meniscus resection, what is regarded as an unsatisfactory result. Purpose To evaluate and compare the long-term clinical, functional and radiological results of surgical treatment in patients with medial meniscus tear combined with varus deformity of the tibia and without it. Materials and methods From 2013 to 2020, medial meniscus tear was treated in 245 patients. The patients were divided into 4 groups. Group 1 included patients with a mechanical femorotibial angle (MFTА) from 0º to 3º who had arthroscopic meniscus resection (AMR). In the 2nd group, all patients also underwent AMR, but their MFTА was more than 3º. In group 3, patients with MFTА from 3º to 5º underwent simultaneous AMR and proximal fibular osteotomy (PFO) with the formation of a defect. Group 4 included patients with MFTА more than 5º, who underwent high tibial osteotomy (HTO) and AMR. Changes in the main lines and angles were assessed with telemetry radiography of the lower extremities. Functional results were evaluated before and after surgery using the Lysholm Knee Scoring Scale, 2000 IKDC, KOOS. Results Isolated meniscus resection in patients with MFTА more than 3º without axial correction leads to a gradual increase in the deformity by 1,070 ± 0.50º during the first year after surgery, and by 2.20 ± 0.70º to the fifth year. In groups 1, 3 and 4, there was no statistically significant increase in MFTА during the entire observation period. The clinical treatment results of patients of the four groups in the first three years after surgery did not differ statistically. However, within the period from 3 to 5 years, patients with MFTА greater than 3º who underwent only AMR had poorer clinical results than in the other groups (p < 0.001). Conclusions A personalized approach to the method of surgical treatment for medial meniscus tear based on the MFTА enables to correct the mechanical axis of the lower extremities and MFTА, and thus improve the long-term clinical, functional and radiological results of surgical treatment.

Museums today play a pivotal role in creating an environment that follows principles of social inclusion and is accessible for individuals with disabilities including museum visitors with autism spectrum disorders (ASD). Extracurricular activities are an integral part of comprehensive support for children with ASD that require coordinated efforts of museum professionals, psychologists, and educators. However, museum professionals may lack information about autism and appropriate approaches. The Federal Resource Center for Organization of Comprehensive Support to Children with Autism Spectrum Disorders at MSUPE studied this process by conducting a survey about the availability of resources for accommodating individuals with ASD as independent visitors as well as participants in museum programs. The results of the survey attest to a high level of engagement of museum community in creating provisions for visitors with ASD in addition to the demand for consulting centers that would facilitate development of appropriate tools. We present a project that has introduced “social narratives” as an instrument for ASD in a setting that can serve as a model for such a center.

Relevance. The urgent task of the technical and economic development of the Northern and Eastern regions of Russia is to provide reliable and efficient power supply to consumers, geographically located in remote, hard-to-reach areas. The use of wind power plants is a promising way to solve this problem. The primary task of the design and feasibility study of the use of wind power plants is to predict changes in wind speeds at the site of the power plant installation. The stochastic nature of the wind and its spatiotemporal variability explain the high complexity of this problem, for the solution of which the methods of mathematical modeling are used. The known models of wind speed based on Markov chains, autoregressive moving-average and other discrete models do not allow varying the time step, which does not allow their use for simulation of operating modes of wind turbines and wind energy systems. The article proposes a model of wind speed based on the stochastic differential equation which eliminates this drawback. The aim of the study is to construct wind speed model based on fractional Ornstein–Uhlenbeck process with a periodic long-term mean, which provides modeling of static and dynamic modes of operation of a wind power plant at different time intervals. Methods: mathematical and computer modeling using Matlab/Simulink software environment. Results. The proposed model, in contrast to the known SDE-based models, is able to produce autocorrelated wind speed trajectories with long-term dependence, daily and monthly variations to perform more detailed simulation of the operating modes of wind turbines at different time intervals with the required time step. The model was tested using the data of climatic observations of wind speed obtained from electronic archive of the All-Russian Institute of Hydrometeorological Information. The model adequacy was evaluated by comparing characteristics of simulated wind speed trajectories with actual observations collected at 518 weather stations located on territory of Russia.

Introduction Correction of the shape of the lower extremities for aesthetic purposes has specific features that are associated with the role of the patient in the treatment process and assessment of results. An important element is the relationship between the appearance of the limb and changes in the axes of the skeleton. Aim of study Assessment of many-years of experience in orthopedic correction of the shape of the lower extremities for aesthetic purposes, discussion of possibilities, analysis of problems and search for possible ways to prevent them. Methods The material of the study was 123 patients who underwent aesthetic surgical correction in the period from 2005 to 2020. Their results were followed in the period from 6 months to 11 years. In all cases, operations were performed simultaneously on both limbs. The total number of operations, thus, amounted to 246. The main indication for surgery was the so-called true O-shaped curvature (varus deformity) of the lower extremities. In all cases, the main elements of the operation were osteosynthesis with the Ilizarov apparatus and osteotomy of the tibia. Wires and half-pins were used as transosseous elements. To assess the main reference lines and angles (RLA), X-ray examination of the lower extremities was performed with the capture of the hip and ankle joints. Results and discussion Corrective manipulations in the group of patients led to a change in the position of the main RLA. Before treatment, MAD value was 15 ± 7 mm, after correction MAD = -2 ± 4 mm, before surgery MPTA = 85 ± 40, after correction MPTA = 91 ± 20. Subjective satisfaction was reported in 114 (92.7 %) cases. Subjectively unsatisfactory results were recorded in 4 (3.3 %) cases; objectively unsatisfactory results were detected in 5 (4.1 %) cases. Conclusions Aesthetic surgery of the lower extremities is a part of orthopedic practice and has its specific features due to the goal of realizing the patient's wishes about changing the appearance of the lower extremities indirectly by performing operations on the skeleton. Corrective interventions should be considered as a preventive measure aimed at preventing the development of gonarthrosis in old age. The key to a good result is careful selection of candidates for surgery and their compliance, along with a thorough explanation of the principles and features of correction.

Introduction Practical application of regenerative medicine to restore structural and functional properties of damaged tissues and organs using bioactive implants could solve complex problems in contemporary traumatology and orthopedics. Objective To improve treatment results in posttraumatic diaphyseal defects of lower extremities. Material and Methods Treatment outcomes of 19 patients with posttraumatic bone defects of the femur and tibia that averaged of 8.8 ± 3.5 cm were studied. In the main group (9 patients), osteosynthesis of fragments was performed sequentially, first with external fixation and then with intramedullary nailing. Bone defect was bridged by a combination of a biomimetic tissue with a spongy autograft from the iliac wing. In the control group (10 patients), the Ilizarov method of non-free bone plasty was used. Results The results were studied after follow-up of two years. Bone defects were covered in all patients of both groups. However, in the main group, the physiological load on the limb was possible, on average, 7.6 months after surgery, which required 61 % less operations as compared to the control group. Also, the rate of complications was 29.2 % lower in the main group. When assessing the functional results using the LEFS questionnaire, the patients of the main group experienced some minor difficulties in performing physical activities, and patients in the control group experienced moderate difficulties (average score 70.3 and 50.4, respectively). Conclusion The combination of biomimetic tissue with a spongy autograft from the iliac wing under the conditions of stable functional osteosynthesis enables to manage extensive defects of the femur and tibia and improve the functional outcomes.

This paper formulates and solves a practical problem of data recovery regarding the distribution of languages on regional level in context of China. The necessity of this recovery is related to the problem of the determination of the linguistic diversity indices, which, in turn, are used to analyze empirically and to predict sources of social and economic development as well as to indicate potential conflicts at regional level. We use Ethnologue database and China census as the initial data sources. For every language spoken in China, the data contains (a) an estimate of China residents who claim this language to be their mother tongue, and (b) indicators of the presence of such residents in China provinces. For each pair language/province, we aim to estimate the number of the province inhabitants that claim the language to be their mother tongue. This base problem is reduced to solving an undetermined system of algebraic equations. Given additional restriction that Ethnologue database introduces data collected at different time moments because of gaps in Ethnologue language surveys and accompanying data collection expenses, we relate those data to a single time moment, that turns the initial task to an ill-posed system of algebraic equations with imprecisely determined right hand side. Therefore, we are looking for an approximate solution characterized by a minimal discrepancy of the system. Since some languages are much less distributed than the others, we minimize the weighted discrepancy, introducing weights that are inverse to the right hand side elements of the equations. This definition of discrepancy allows to recover the required variables. More than 92% of the recovered variables are robust to probabilistic modelling procedure for potential errors in initial data.

The paper considers an interval model of interregional trade interaction potential, based on the combination of the input-output balance approach, the entropy equilibrium principle and the conception of universal solutions of interval optimization problems. The modeling results for the Russian Far East are cited

В статье представлено понимание проблемы экспансивно развивающегося информационного пространства как фактора влияющего на социализацию школьников. Дается характеристика современного информационного пространства, анализируются подходы к его изучению. Уделено внимание рассмотрению проблемы нормы и отклонения в поведении школьников, феномену влияния информационного пространства на выбор детьми и подростками моделей поведения, а также выдвинуто предположение о трансформации понятий социальная норма и поведенческое отклонение в силу усиливающегося влияния масс-медиа на формирование личности школьника.