191 results on '"Denis Mariano-Goulart"'
Search Results
2. Relationship between Lean Tissue Mass and Muscle Function in Women with Obesity
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Laurent Maïmoun, Elise Bourgeois, Chris Serrand, Thibault Mura, Jean-Paul Cristol, Justine Myzia, Antoine Avignon, Denis Mariano-Goulart, and Ariane Sultan
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sarcopenic obesity ,lean tissue mass ,physical performance ,muscle strength ,muscle function ,women with obesity ,Nutrition. Foods and food supply ,TX341-641 - Abstract
It is well documented that lean tissue mass (LTM) decreases with aging in patients with obesity, but there is no information available regarding muscle strength changes, a parameter that may be better associated with sarcopenic obesity (SO). The objectives of this study were to analyze the changes in LTM and fat mass (FM), muscle strength and muscle function with aging in women with obesity and to determine the prevalence of SO. LTM and FM were determined by DXA, muscle strength with the hand-grip test and muscle function with the 6 min walk test (6MWT) in 383 women with obesity. A redistribution of the LTM and FM occurred with age, characterized by a gain at the trunk to the detriment of the lower limbs, thus reducting in appendicular LTM indices. The physical performances evaluated by the muscle strength and muscle function decreased concomitantly, and the prevalence of low values for both these parameters was 22.8% and 13.4%, respectively, in the older patients. In summary, although a reduction in appendicular LTM and muscle performances occurred with age and resulted in an increase in the prevalence of SO, the number of women with obesity affected by SO remained low (n ≤ 15), even in those older than 60 years.
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- 2023
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3. Effect of Nutritional Deprivation after Sleeve Gastrectomy on Bone Mass, Periostin, Sclerostin and Semaphorin 4D: A Two-Year Longitudinal Study
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Laurent Maïmoun, Safa Aouinti, Marion Puech, Patrick Lefebvre, Mélanie Deloze, Pascal de Santa Barbara, Jean-Paul Cristol, Séverine Brabant, Thomas Gautier, Marius Nedelcu, Eric Renard, Marie-Christine Picot, Denis Mariano-Goulart, and David Nocca
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areal bone mineral density ,markers of bone turnover ,sleeve gastrectomy ,periostin ,sclerostin ,semaphorin 4D ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Bariatric surgery induces bone loss, but the exact mechanisms by which this process occurs are not fully known. The aims of this 2-year longitudinal study were to (i) investigate the changes in areal bone mineral density (aBMD) and bone turnover markers following sleeve gastrectomy (SG) and (ii) determine the parameters associated with the aBMD variations. Bone turnover markers, sclerostin, periostin and semaphorin 4D were assessed before and 1, 12 and 24 months after SG, and aBMD was determined by DXA at baseline and after 12 and 24 months in 83 patients with obesity. Bone turnover increased from 1 month, peaked at 12 months and remained elevated at 24 months. Periostin and sclerostin presented only modest increases at 1 month, whereas semaphorin 4D showed increases only at 12 and 24 months. A significant aBMD decrease was observed only at total hip regions at 12 and 24 months. This demineralisation was mainly related to body weight loss. In summary, reduced aBMD was observed after SG in the hip region (mechanical-loading bone sites) due to an increase in bone turnover in favour of bone resorption. Periostin, sclerostin and semaphorin 4D levels varied after SG, showing different time lags, but contrary to weight loss, these biological parameters did not seem to be directly implicated in the skeletal deterioration.
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- 2023
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4. In patients with anorexia nervosa, myokine levels are altered but are not associated with bone mineral density loss and bone turnover alteration
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Laurent Maïmoun, Denis Mariano-Goulart, Helena Huguet, Eric Renard, Patrick Lefebvre, Marie-Christine Picot, Anne-Marie Dupuy, Jean-Paul Cristol, Philippe Courtet, Vincent Boudousq, Antoine Avignon, Sébastien Guillaume, and Ariane Sultan
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anorexia nervosa ,myokines ,bone loss ,irisin ,myostatin ,follistatin ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Objectives: The two-fold aim of this study was: (i) to determine the effect s of undernutrition on the myokines in patients with restrictive anorexia nervosa (AN) and (ii) to examine the potential link between myokines and bone parameters. Methods: In this study, 42 young women with restrictive AN and 42 age-matched controls (CON) (mean age, 18.5 ± 4.2 years and 18.6 ± 4.2 years, respectively) were enrolled. aBMD and body composition were determined with DXA. Resting energy expenditure (REEm), a marker of energy status, was indirectly assessed by calorimetry. Bone turnover markers and myokines (follistatin, myostatin and irisin) were concomitantly evaluated. Results: AN patients presented low aBMD at all bone sites. REEm, bone formation markers, myostatin and IGF-1 were significantly lower, whereas t he bone resorption marker and follistatin were higher in AN compared with controls . No difference was observed between groups for irisin levels. When the whole population was studied, among myokines, only myostatin was positively correlated with aBMD at all bone sites. However, multiple regression analyses showed that in the AN group, the independent variables for aBMD were principally amenorrhoea duration, lean tissue mass (LTM) and procollagen type I N-terminal propeptide (PINP). For CON, the independent variables for aBMD were principally LTM, age and PINP. Whatever the group analysed, none of the myokines appeared as explicative independent variables of aBMD. Conclusion: This study demonstrated that despite the altered myokine levels in patients with AN, their direct effect on aBMD loss and bone turnover alte ration seems limited in comparison with other well-known disease-related factors such as oestrogen deprivation.
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- 2022
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5. Functional PET Neuroimaging in Consciousness Evaluation: Study Protocol
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Tom Paunet, Denis Mariano-Goulart, Jeremy Deverdun, Emmanuelle Le Bars, Marjolaine Fourcade, and Florentin Kucharczak
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18F-FDG ,PET ,constant infusion ,glucose metabolism ,stimuli ,functional PET ,Medicine (General) ,R5-920 - Abstract
Ensuring a robust and reliable evaluation of coma deepness and prognostication of neurological outcome is challenging. We propose to develop PET neuroimaging as a new diagnostic and prognosis tool for comatose patients using a recently published methodology to perform functional PET (fPET). This exam permits the quantification of task-specific changes in neuronal metabolism in a single session. The aim of this protocol is to determine whether task-specific changes in glucose metabolism during the acute phase of coma are able to predict recovery at 18 months. Participation will be proposed for all patients coming for a standard PET-CT in our center in order to evaluate global cerebral metabolism during the comatose state. Legally appointed representative consent will be obtained to slightly modify the exam protocol: (1) 18F-fluorodeoxyglucose (18F-FDG) bolus plus continuous infusion instead of a simple bolus and (2) more time under camera to perform dynamic acquisition. Participants will undergo a 55-min fPET session with a 20% bolus + 80% infusion protocol. Two occurrences of three block (5-min rest, 10-min auditory stimulation and 10-min emotional auditory stimulation) will be performed after reaching equilibrium of FDG arterial concentration. We will compare the regional brain metabolism at rest and during the sessions of auditory and emotional auditory stimulation to search for a determinant of coma recovery (18 months of follow-up after the exam). Emotional auditory stimulation should induce an activation of: the auditory cortex, the consciousness areas and the neural circuitry for emotion (function to coma deepness). An activation analysis will be carried out to highlight regional brain activation using dedicated custom-made software based on Python statistical and image processing toolboxes. The association between activation levels and the Coma Recovery Scale-Revisited (CRS-R) will be assessed using multivariate analysis. If successful, the results from this study will help improve coma prognosis evaluation based on the pattern of neuronal metabolism at the onset of the pathology. The study protocol, rationale and methods are described in this paper.
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- 2023
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6. Changes in Lean Tissue Mass, Fat Mass, Biological Parameters and Resting Energy Expenditure over 24 Months Following Sleeve Gastrectomy
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Laurent Maïmoun, Safa Aouinti, Marion Puech, Patrick Lefebvre, Melanie Deloze, Pascal de Santa Barbara, Eric Renard, Jean-Paul Christol, Justine Myzia, Marie-Christine Picot, Denis Mariano-Goulart, and David Nocca
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sleeve gastrectomy ,fat mass ,lean tissue mass ,visceral adipose tissue ,IGF-1 ,IGFBP-3 ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Sleeve gastrectomy (SG) induces weight loss but its effects on body composition (BC) are less well known. The aims of this longitudinal study were to analyse the BC changes from the acute phase up to weight stabilization following SG. Variations in the biological parameters related to glucose, lipids, inflammation, and resting energy expenditure (REE) were concomitantly analysed. Fat mass (FM), lean tissue mass (LTM), and visceral adipose tissue (VAT) were determined by dual-energy X-ray absorptiometry in 83 obese patients (75.9% women) before SG and 1, 12 and 24 months later. After 1 month, LTM and FM losses were comparable, whereas at 12 months the loss of FM exceeded that of LTM. Over this period, VAT also decreased significantly, biological parameters became normalized, and REE was reduced. For most of the BC, biological and metabolic parameters, no substantial variation was demonstrated beyond 12 months. In summary, SG induced a modification in BC changes during the first 12 months following SG. Although the significant LTM loss was not associated with an increase in sarcopenia prevalence, the preservation of LTM might have limited the reduction in REE, which is a longer-term weight-regain criterion.
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- 2023
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7. Analysis of differences between 99mTc-MAA SPECT- and 90Y-microsphere PET-based dosimetry for hepatocellular carcinoma selective internal radiation therapy
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Marilyne Kafrouni, Carole Allimant, Marjolaine Fourcade, Sébastien Vauclin, Boris Guiu, Denis Mariano-Goulart, and Fayçal Ben Bouallègue
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MAA ,Y-90 microspheres ,SIRT ,Dosimetry ,Hepatocellular carcinoma ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background The aim of this study was to compare predictive and post-treatment dosimetry and analyze the differences, investigating factors related to activity preparation and delivery, imaging modality used, and interventional radiology. Methods Twenty-three HCC patients treated by selective internal radiation therapy with 90Y glass microspheres were included in this study. Predictive and post-treatment dosimetry were calculated at the voxel level based on 99mTc-MAA SPECT/CT and 90Y-microsphere PET/CT respectively. Dose distribution was analyzed through mean dose, metrics extracted from dose-volume histograms, and Dice similarity coefficients applied on isodoses. Reproducibility of the radiological gesture and its influence on dose deviation was evaluated. Results 90Y delivered activity was lower than expected in 67% (16/24) of the cases mainly due to the residual activity. A mean deviation of − 6 ± 11% was observed between the delivered activity and the 90Y PET’s FOV activity. In addition, a substantial difference of − 20 ± 8% was measured on 90Y PET images between the activity in the liver and in the whole FOV. After normalization, 99mTc-MAA SPECT dosimetry was highly correlated and concordant with 90Y-microsphere PET dosimetry for all dose metrics evaluated (ρ = 0.87, ρ c = 0.86, P = 3.10−8 and ρ = 0.91, ρ c = 0.90, P = 7.10−10 for tumor and normal liver mean dose respectively for example). Besides, mean tumor dose deviation was lower when the catheter position was identical than when it differed (16 Gy vs. 37 Gy, P = 0.007). Concordance between predictive and post-treatment dosimetry, evaluated with Dice similarity coefficients applied on isodoses, significantly correlated with the distance of the catheter position from artery bifurcation (P = 0.04, 0.0004, and 0.05, for 50 Gy, 100 Gy, and 150 Gy isodoses respectively). Conclusions Discrepancies between planned activity and activity measured on 90Y PET images were observed and seemed to be mainly related to clinical hazards and equipment issues. Predictive vs. post-treatment comparison of relative dose distributions between tumor and normal liver showed a good correlation and no significant difference highlighting the predictive value of 99mTc MAA SPECT/CT-based dosimetry. Besides, the reproducibility of catheter tip position appears critical in the agreement between predictive and actual dose distribution.
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- 2019
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8. Feasibility of biventricular volume and function assessment using first-pass gated 15O-water PET
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Fayçal Ben Bouallègue, Denis Mariano-Goulart, Denis Agostini, and Alain Manrique
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15O-water PET ,First-pass ,Ventricular volume ,Ventricular function ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background We investigated the feasibility of left ventricular (LV) and right ventricular (RV) volume and function estimation using a first-pass gated 15O-water PET. This prospective study included 19 patients addressed for myocardial perfusion reserve assessment using 15O-water PET. PET data were acquired at rest and after regadenoson stress, and gated first-pass images were reconstructed over the time range corresponding to tracer first-pass through the cardiac cavities and post-processed using TomPool software; LV and RV were segmented using a semi-automated 4D immersion algorithm. LV volumes were computed using a count-based model and a fixed threshold at 30% of the maximal activity. RV volumes were computed using a geometrical model and an adjustable threshold that was set so as to fit LV and RV stroke volumes. Ejection curves were fitted using a deformable reference curve model. LV results were compared to those obtained using 99mTc-sestamibi gated myocardial SPECT in terms of end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and ejection fraction (EF). Results There was an excellent concordance between rest and stress PET in terms of EDV and ESV (Lin’s coefficient ~ 0.85–0.90), SV (~ 0.80), and EF (~ 0.75) for both ventricles. Correlation with myocardial SPECT was high for LV EDV (Pearson’s R = 0.89, p
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- 2018
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9. Cardiac Sympathetic Activity differentiates Idiopathic and Symptomatic Rapid Eye Movement Sleep Behaviour Disorder
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Lucie Barateau, Isabelle Jaussent, Régis Lopez, Elisa Evangelista, Sofiene Chenini, Meriem Benkiran, Denis Mariano-Goulart, and Yves Dauvilliers
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Medicine ,Science - Abstract
Abstract The pathophysiology of rapid eye movement sleep behavior disorder (RBD) associated with narcolepsy type 1 (NT1) is still poorly understood, potentially distinct from idiopathic RBD (iRBD), but may share affected common pathways. We investigated whether MIBG cardiac uptake differs between iRBD and NT1 comorbid with RBD. Thirty-four patients with NT1-RBD and 15 patients with iRBD underwent MIBG cardiac scintigraphy. MIBG uptake was measured by calculating the early and delayed heart to mediastinum (H/M) ratios. A delayed H/M ratio lower than 1.46 was considered abnormal based on a population of 78 subjects without neurological or cardiac diseases. Patients with iRBD were older, had an older RBD onset age and higher REM sleep phasic and tonic muscular activities than NT1-RBD. Lower delayed and early H/M ratios were associated with iRBD, but not with NT1-RBD, in crude and adjusted associations. The delayed H/M ratio differed between iRBD and controls, after adjustment, but not between patients with NT1-RBD and controls. In conclusion, the MIBG cardiac uptake difference between NT1-RBD and iRBD supports the hypothesis of different processes involved in RBD pathogenesis, providing for the first time a cardiac biomarker to differentiate those disorders.
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- 2018
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10. Colchicine to Prevent Sympathetic Denervation after an Acute Myocardial Infarction: The COLD-MI Trial Protocol
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Fabien Huet, Quentin Delbaere, Sylvain Aguilhon, Valentin Dupasquier, Delphine Delseny, Richard Gervasoni, Jean-Christophe Macia, Florence Leclercq, Nidal Jammoul, Sandra Kahlouche, Sonia Soltani, Fanny Cardon, Anne-Marie Dupuy, Jean-Paul Cristol, Denis Mariano-Goulart, Myriam Akodad, Nicolas Nagot, and François Roubille
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colchicine ,sympathetic innervation ,myocardial infarction ,heart rate variability ,nuclear imaging ,Medicine (General) ,R5-920 - Abstract
Inflammatory processes are deeply involved in ischemia-reperfusion injuries (IRI) and ventricular remodelling (VR) after a ST-segment elevation myocardial infarction (STEMI). They are associated with clinical adverse events (heart failure and cardiovascular death) adding damage to the myocardium after reperfusion. Moreover, acute myocardial infarction (AMI) induces a local sympathetic denervation leading to electrical instability and arrythmia. Colchicine, a well-known alkaloid with direct anti-inflammatory effects, was shown to reduce the myocardial necrosis size and limit the VR. In a recent proof of concept study, colchicine appears to prevent sympathetic denervation in a mice model of ischemia/reperfusion, but not in the necrosis or in the border zone areas. The Colchicine to Prevent Sympathetic Denervation after an AMI study (COLD-MI) is an ongoing, confirmative, prospective, monocentre, randomized, open-label trial. The COLD-MI trial aims to evaluate the intensity of sympathetic denervation after AMI and its potential modulation due to low dose colchicine. Sympathetic denervation will be noninvasively evaluated using single-photon emission computed tomography (SPECT). After a first episode of STEMI (Initial TIMI flow ≤ 1) and primary percutaneous coronary intervention (PPCI), patients will be randomized (n = 56) in a 1:1 ratio to either receive colchicine or not for 30 days. The primary end point will be the percentage of myocardial denervation measured by 123I-metaiodobenzylguanidine (123I-MIBG) SPECT at a 6-month follow-up. The main secondary end points will be basic ECG parameters (QRS duration, corrected QT) and HRV parameters from a 24 hour-recording Holter at 1- and 6-months follow-up. Results from this study will contribute to a better understanding of the cardioprotective effect of colchicine after AMI. The present study describes the rationale, design, and methods of the trial.
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- 2021
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11. Place of the 18F-FDG-PET/CT in the Diagnostic Workup in Patients with Classical Fever of Unknown Origin (FUO)
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Simon Letertre, Pierre Fesler, Laetitia Zerkowski, Marie-Christine Picot, Jean Ribstein, Philippe Guilpain, Vincent Le Moing, Denis Mariano-Goulart, and Camille Roubille
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fever of unknown origin ,18F-FDG-PET/CT ,Medicine - Abstract
Objective: To explore the diagnostic contribution of the 18F-FDG-PET/CT in a population of patients with classical fever of unknown origin (FUO), to pinpoint its place in the diagnostic decision tree in a real-life setting, and to identify the factors associated with a diagnostic 18F-FDG-PET/CT. Method: All adult patients (aged ≥ 18 years) with a diagnosis of classical FUO who underwent an 18F-FDG-PET/CT in the University Hospital of Montpellier (France) between April 2012 and December 2017 were included. True positive 18F-FDG-PET/CT, which evidenced a specific disease causing FUO, were considered to be contributive. Results: Forty-four patients with FUO have been included (20 males, 24 females; mean age 57.5 ± 17.1 years). Diagnoses were obtained in 31 patients (70.5%), of whom 17 (38.6%) had non-infectious inflammatory diseases, 9 had infections (20.5%), and 3 had malignancies (6.8%). 18F-FDG-PET/CT was helpful for making a final diagnosis (true positive) in 43.6% of all patients. Sensitivity and specificity levels were 85% and 37%, respectively. A total of 135 investigations were performed before 18F-FDG-PET/CT, mostly CT scans (93.2%) and echocardiography (59.1%), and 108 after 18F-FDG-PET/CT, mostly biopsies (including the biopsy of a temporal artery) (25%) and MRIs (34%). In multivariate analysis, the hemoglobin level was significantly associated with a helpful 18F-FDG-PET/CT (p = 0.019, OR 0.41; 95% CI (0.20–0.87)), while the CRP level was not associated with a contributive 18F-FDG-PET/CT. Conclusion: 18F-FDG-PET/CT may be proposed as a routine initial non-invasive procedure in the diagnostic workup of FUO, especially in anemic patients who could be more likely to benefit from 18F-FDG-PET/CT.
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- 2021
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12. Hepatobiliary Scintigraphy and Glass 90Y Radioembolization with Personalized Dosimetry: Dynamic Changes in Treated and Nontreated Liver
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Carole Allimant, Emmanuel Deshayes, Marilyne Kafrouni, Lore Santoro, Delphine de Verbizier, Marjolaine Fourcade, Christophe Cassinotto, Margaux Hermida, Chloé Guillot, Denis Mariano-Goulart, and Boris Guiu
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selective internal radiation therapy ,mebrofenin ,hepatobiliary scintigraphy ,liver ,Medicine (General) ,R5-920 - Abstract
Background: The functional changes that occur over time in the liver following 90Y-radioembolization (RE) using personalized dosimetry (PD) remain to be investigated. Methods: November 2016–October 2019: we retrospectively included hepatocellular carcinoma (HCC) patients treated by 90Y-glass RE using PD, who underwent hepatobiliary scintigraphy (HBS) at baseline and at 15 days, 1, 2, 3, and 6 months after RE. Results: There were 16 patients with unilobar disease (100%) included, and 64 HBS were performed. Whole liver function significantly decreased over time. The loss was maximal at 2 weeks: −32% (p = 0.002) and remained below baseline at 1 (−15%; p = 0.002), 2 (−25%; p < 0.001), and 3 months (−16%; p = 0.027). No radioembolization-induced liver disease was observed. Treated liver function strongly decreased to reach −64% (p < 0.001) at 2 months. Nontreated liver function decreased at 2 weeks (−21%; p = 0.027) and remained below baseline before reaching +20% (p = 0.002) and +59% (p < 0.001) at 3 and 6 months, respectively. Volumetric and functional changes exhibited parallel evolutions in the treated livers (p = 0.01) but independent evolutions in the nontreated livers (p = 0.08). Conclusion: RE using PD induces significant regional changes in liver function over time. As early as 15 days following RE, both the treated and nontreated livers showed a decreased function. Nontreated liver function recovered after 3 months and greatly increased afterwards.
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- 2021
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13. Comparison of CSF markers and semi-quantitative amyloid PET in Alzheimer’s disease diagnosis and in cognitive impairment prognosis using the ADNI-2 database
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Fayçal Ben Bouallègue, Denis Mariano-Goulart, Pierre Payoux, and the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
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Alzheimer’s disease ,MCI ,Amyloid PET ,CSF markers ,ADNI ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background The relative performance of semi-quantitative amyloid positron emission tomography (PET) and cerebrospinal fluid (CSF) markers in diagnosing Alzheimer’s disease (AD) and predicting the cognitive evolution of patients with mild cognitive impairment (MCI) is still debated. Methods Subjects from the Alzheimer’s Disease Neuroimaging Initiative 2 with complete baseline cognitive assessment (Mini Mental State Examination, Clinical Dementia Rating [CDR] and Alzheimer’s Disease Assessment Scale–Cognitive Subscale [ADAS-cog] scores), CSF collection (amyloid-β1–42 [Aβ], tau and phosphorylated tau) and 18F-florbetapir scans were included in our cross-sectional cohort. Among these, patients with MCI or substantial memory complaints constituted our longitudinal cohort and were followed for 30 ± 16 months. PET amyloid deposition was quantified using relative retention indices (standardised uptake value ratio [SUVr]) with respect to pontine, cerebellar and composite reference regions. Diagnostic and prognostic performance based on PET and CSF was evaluated using ROC analysis, multivariate linear regression and survival analysis with the Cox proportional hazards model. Results The cross-sectional study included 677 participants and revealed that pontine and composite SUVr values were better classifiers (AUC 0.88, diagnostic accuracy 85%) than CSF markers (AUC 0.83 and 0.85, accuracy 80% and 75%, for Aβ and tau, respectively). SUVr was a strong independent determinant of cognition in multivariate regression, whereas Aβ was not; tau was also a determinant, but to a lesser degree. Among the 396 patients from the longitudinal study, 82 (21%) converted to AD within 22 ± 13 months. Optimal SUVr thresholds to differentiate AD converters were quite similar to those of the cross-sectional study. Composite SUVr was the best AD classifier (AUC 0.86, sensitivity 88%, specificity 81%). In multivariate regression, baseline cognition (CDR and ADAS-cog) was the main predictor of subsequent cognitive decline. Pontine and composite SUVr were moderate but independent predictors of final status and CDR/ADAS-cog progression rate, whereas baseline CSF markers had a marginal influence. The adjusted HRs for AD conversion were 3.8 (p = 0.01) for PET profile, 1.2 (p = ns) for Aβ profile and 1.8 (p = 0.03) for tau profile. Conclusions Semi-quantitative amyloid PET appears more powerful than CSF markers for AD grading and MCI prognosis in terms of cognitive decline and AD conversion.
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- 2017
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14. Absence of Relationship Between Self-Reported Sleep Measures and Amyloid Load in Elderly Subjects
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Audrey Gabelle, Laure-Anne Gutierrez, Isabelle Jaussent, Fayçal Ben Bouallegue, Delphine De Verbizier, Sophie Navucet, Caroline Grasselli, Karim Bennys, Cécilia Marelli, Renaud David, Denis Mariano-Goulart, Sandrine Andrieu, Bruno Vellas, Pierre Payoux, Claudine Berr, and Yves Dauvilliers
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amyloid ,amyloidosis ,sleep ,elderly ,PET—positron emission tomography ,NAPS ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Objective: To determine the relationships between self-reported sleep profile and cortical amyloid load in elderly subjects without dementia.Methods: This cross-sectional study included 143 community-dwelling participants aged ≥70 years (median: 73 years [70–85]; 87 females) with spontaneous memory complaints but dementia-free. Sociodemographic characteristics, health status, neuropsychological tests, sleep, and 18F-florbetapir (amyloid) PET data were collected. The clinical sleep interview evaluated nighttime sleep duration, but also daytime sleep duration, presence of naps, and restless leg syndrome (RLS) at time of study. Validated questionnaires assessed daytime sleepiness, insomnia, and risk of sleep apnea. The cortical standardized uptake value ratio (SUVr) was computed across six cortical regions. The relationship between sleep parameters and SUVr (cut-off ratio>1.17 and tertiles) was analyzed using logistic regression models.Results: Amyloid-PET was positive in 40.6% of participants. Almost 40% were at risk for apnea, 13.5% had RLS, 35.5% insomnia symptoms, 22.1% daytime sleepiness, and 18.8% took sleep drugs. No significant relationship was found between positive amyloid PET and nighttime sleep duration (as a continuous variable, or categorized into
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- 2019
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15. Modification of Muscle-Related Hormones in Women with Obesity: Potential Impact on Bone Metabolism
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Laurent Maïmoun, Thibault Mura, Vincent Attalin, Anne Marie Dupuy, Jean-Paul Cristol, Antoine Avignon, Denis Mariano-Goulart, and Ariane Sultan
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myokines ,obesity ,areal bone mineral density ,bone remodelling markers ,Medicine - Abstract
Lean body mass (LBM) is a determinant of areal bone mineral density (aBMD) through its mechanical actions and quite possibly through its endocrine functions. The threefold aims of this study are: to determine the effects of obesity (OB) on aBMD and myokines; to examine the potential link between myokines and bone parameters; and to determine whether the effects of LBM on aBMD are mediated by myokines. aBMD and myokine levels were evaluated in relation to the body mass index (BMI) in 179 women. Compared with normal-weight controls (CON; n = 40), women with OB (n = 139) presented higher aBMD, myostatin and follistatin levels and lower irisin levels. Except for irisin levels, all differences between the OB and CON groups were accentuated with increasing BMI. For the whole population (n = 179), weight, BMI, fat mass (FM) and LBM were positively correlated with aBMD at all bone sites, while log irisin were negatively correlated. The proportion of the LBM effect on aBMD was partially mediated (from 14.8% to 29.8%), by log irisin, but not by follistatin or myosin. This study showed that myokine levels were greatly influenced by obesity. However, irisin excepted, myokines do not seem to mediate the effect of LBM on bone tissue.
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- 2020
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16. Body Composition in Individuals with Obesity According to Age and Sex: A Cross-Sectional Study
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Laurent Maïmoun, Thibault Mura, Antoine Avignon, Denis Mariano-Goulart, and Ariane Sultan
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obesity ,body composition ,sarcopenia ,skeletal muscle index ,lean tissue mass and fat mass ,Medicine - Abstract
Obesity is characterized by an alteration in body composition (BC); however, it is not known whether this alteration is modified by aging or sex. The aims of this study were to analyze BC in individuals with obesity based on age and sex and to determine the prevalence of sarcopenia. Seven hundred and fifty-five obese individuals were subdivided into four age groups. The hole (WB) and segmental BC were determined using dual-energy X-ray absorptiometry (DXA). In men, the WB lean tissue mass (LTM) and fat mass (FM) adjusted by weight and height were relatively constant with age. In women, the WBLTM was higher and WBFM was lower in the >65 group compared to the 18–34 group. A decrease in the LTM and FM at lower limbs and an increase in the trunk were observed, particularly in women, inducing a lower appendicular lean mass index (ALMI; appendicular LTM/height2) in the >65 group compared to the 18–34 group in both sexes. This study demonstrated that even though the WBLTM and FM are relatively constant with age, individuals with obesity present a localized redistribution of these two components. This body composition change leads to a decrease of the ALMI with age, one of the criteria included in the sarcopenia definition.
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- 2020
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17. Assessment of Translocator Protein Density, as Marker of Neuroinflammation, in Major Depressive Disorder: A Pilot, Multicenter, Comparative, Controlled, Brain PET Study (INFLADEP Study)
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Antoine Yrondi, Bruno Aouizerate, Wissam El-Hage, Fanny Moliere, Claire Thalamas, Nicolas Delcourt, Marie Sporer, Simon Taib, Laurent Schmitt, Nicolas Arlicot, Deborah Meligne, Agnes Sommet, Anne S. Salabert, Sebastien Guillaume, Philippe Courtet, Florence Galtier, Denis Mariano-Goulart, Nicolas Menjot De Champfleur, Emmanuelle Le Bars, Thomas Desmidt, Mathieu Lemaire, Vincent Camus, Maria J. Santiago-Ribeiro, Jean P. Cottier, Philippe Fernandez, Marie Meyer, Vincent Dousset, Olivier Doumy, Didier Delhaye, Lucile Capuron, Marion Leboyer, Emmanuel Haffen, Patrice Péran, Pierre Payoux, and Christophe Arbus
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depressive disorder ,depression ,neuroinflammation ,inflammation ,TSPO ,DPA-714 ,Psychiatry ,RC435-571 - Abstract
Background: Major depressive disorder (MDD) is a serious public health problem with high lifetime prevalence (4.4–20%) in the general population. The monoamine hypothesis is the most widespread etiological theory of MDD. Also, recent scientific data has emphasized the importance of immuno-inflammatory pathways in the pathophysiology of MDD. The lack of data on the magnitude of brain neuroinflammation in MDD is the main limitation of this inflammatory hypothesis. Our team has previously demonstrated the relevance of [18F] DPA-714 as a neuroinflammation biomarker in humans. We formulated the following hypotheses for the current study: (i) Neuroinflammation in MDD can be measured by [18F] DPA-714; (ii) its levels are associated with clinical severity; (iii) it is accompanied by anatomical and functional alterations within the frontal-subcortical circuits; (iv) it is a marker of treatment resistance.Methods: Depressed patients will be recruited throughout 4 centers (Bordeaux, Montpellier, Tours, and Toulouse) of the French network from 13 expert centers for resistant depression. The patient population will be divided into 3 groups: (i) experimental group—patients with current MDD (n = 20), (ii) remitted depressed group—patients in remission but still being treated (n = 20); and, (iii) control group without any history of MDD (n = 20). The primary objective will be to compare PET data (i.e., distribution pattern of neuroinflammation) between the currently depressed group and the control group. Secondary objectives will be to: (i) compare neuroinflammation across groups (currently depressed group vs. remitted depressed group vs. control group); (ii) correlate neuroinflammation with clinical severity across groups; (iii) correlate neuroinflammation with MRI parameters for structural and functional integrity across groups; (iv) correlate neuroinflammation and peripheral markers of inflammation across groups.Discussion: This study will assess the effects of antidepressants on neuroinflammation as well as its role in the treatment response. It will contribute to clarify the putative relationships between neuroinflammation quantified by brain neuroimaging techniques and peripheral markers of inflammation. Lastly, it is expected to open innovative and promising therapeutic perspectives based on anti-inflammatory strategies for the management of treatment-resistant forms of MDD commonly seen in clinical practice.Clinical trial registration (reference: NCT03314155): https://www.clinicaltrials.gov/ct2/show/NCT03314155?term=neuroinflammation&cond=depression&cntry=FR&rank=1
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- 2018
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18. Skeletal Muscle Insulin Resistance and Absence of Inflammation Characterize Insulin-Resistant Grade I Obese Women.
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Cacylde Amouzou, Cyril Breuker, Odile Fabre, Annick Bourret, Karen Lambert, Olivier Birot, Christine Fédou, Anne-Marie Dupuy, Jean-Paul Cristol, Thibault Sutra, Nicolas Molinari, Laurent Maimoun, Denis Mariano-Goulart, Florence Galtier, Antoine Avignon, Françoise Stanke-Labesque, Jacques Mercier, Ariane Sultan, and Catherine Bisbal
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Medicine ,Science - Abstract
CONTEXT:Obesity is associated with insulin-resistance (IR), the key feature of type 2 diabetes. Although chronic low-grade inflammation has been identified as a central effector of IR development, it has never been investigated simultaneously at systemic level and locally in skeletal muscle and adipose tissue in obese humans characterized for their insulin sensitivity. OBJECTIVES:We compared metabolic parameters and inflammation at systemic and tissue levels in normal-weight and obese subjects with different insulin sensitivity to better understand the mechanisms involved in IR development. METHODS:30 post-menopausal women were classified as normal-weight insulin-sensitive (controls, CT) and obese (grade I) insulin-sensitive (OIS) or insulin-resistant (OIR) according to their body mass index and homeostasis model assessment of IR index. They underwent a hyperinsulinemic-euglycemic clamp, blood sampling, skeletal muscle and subcutaneous adipose tissue biopsies, an activity questionnaire and a self-administrated dietary recall. We analyzed insulin sensitivity, inflammation and IR-related parameters at the systemic level. In tissues, insulin response was assessed by P-Akt/Akt expression and inflammation by macrophage infiltration as well as cytokines and IκBα expression. RESULTS:Systemic levels of lipids, adipokines, inflammatory cytokines, and lipopolysaccharides were equivalent between OIS and OIR subjects. In subcutaneous adipose tissue, the number of anti-inflammatory macrophages was higher in OIR than in CT and OIS and was associated with higher IL-6 level. Insulin induced Akt phosphorylation to the same extent in CT, OIS and OIR. In skeletal muscle, we could not detect any inflammation even though IκBα expression was lower in OIR compared to CT. However, while P-Akt/Akt level increased following insulin stimulation in CT and OIS, it remained unchanged in OIR. CONCLUSION:Our results show that systemic IR occurs without any change in systemic and tissues inflammation. We identified a muscle defect in insulin response as an early mechanism of IR development in grade I obese post-menopausal women.
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- 2016
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19. Large, multifocal or portal vein-invading hepatocellular carcinoma (HCC) downstaged by Y90 using personalized dosimetry: safety, pathological results and outcomes after surgery
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Mohamad Azhar Meerun, Carole Allimant, Benjamin Rivière, Astrid Herrero, Fabrizio Panaro, Eric Assenat, Christophe Cassinotto, Denis Mariano-Goulart, and Boris Guiu
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General Earth and Planetary Sciences ,General Environmental Science - Published
- 2023
20. Confidence Interval Constraint-Based Regularization Framework for PET Quantization.
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Florentin Kucharczak, F. Ben Bouallegue, Olivier Strauss, and Denis Mariano-Goulart
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- 2019
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21. Intraputaminal Gene Delivery in Two Patients with Aromatic L‐Amino Acid Decarboxylase Deficiency
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Marie‐Céline François‐Heude, Gaetan Poulen, Emmanuel Flamand Roze, Marie‐Ange Nguyen Morel, Domitille Gras, Isabelle Roch‐Toreilles, Adeline Quintard, Gaelle Baroux, Pierre Meyer, Philippe Coubes, Christophe Milesi, Gilles Cambonie, Julien Baleine, Chrystelle Sola, Bénédicte Delye, Evgenia Dimopoulou, Stéphanie Sanchez, Mathieu Gasnier, Souad Touati, Alberto Zamora, Daniel Pontal, Nicolas Leboucq, Virginie Kouyoumdjian, Adrien Lebasnier, Sylvia Sanquer, Denis Mariano‐Goulart, Thomas Roujeau, and Agathe Roubertie
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Neurology ,Neurology (clinical) - Published
- 2023
22. Regularized selection: A new paradigm for inverse based regularized image reconstruction techniques.
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Florentin Kucharczak, Cyril Mory, Olivier Strauss, Frédéric Comby, and Denis Mariano-Goulart
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- 2017
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23. Comparison of the Lunar Prodigy and Stratos DR Dual-Energy X-Ray Absorptiometers to Assess Regional Bone Mineral Density
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Laurent Maïmoun, Krishna Kunal Mahadea, Vincent Boudousq, Thibault Mura, and Denis Mariano-Goulart
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Absorptiometry, Photon ,Lumbar Vertebrae ,Bone Density ,Femur Neck ,X-Rays ,Endocrinology, Diabetes and Metabolism ,Humans ,Female ,Radiology, Nuclear Medicine and imaging ,Orthopedics and Sports Medicine ,Middle Aged ,Aged - Abstract
The first objective of the study was to assess the agreement between the Stratos DR (DMS) and the GE Prodigy (GE) DXAs in determining femoral neck, total hip and lumbar spine aBMD. The second objective was to assess the potential impact of leg positioning (hip flexed at 90° or not) on lumbar spine aBMD.Forty-six individuals (n=42 women, 91.3%), with a mean age of 59.7 ± 13 years and mean BMI of 23.8 ± 4.7 kg/m², were scanned consecutively on the same day using the two devices. In a subgroup (n=30), two consecutive Stratos DR scans (with hip flexed at 90° or not) at the lumbar spine were conducted. Predictive equations for hip and lumbar spine aBMD were derived from linear regression of the data.Correlation coefficients for aBMD measured with the two DXAs were characterised by an R² of 0.76 for the femoral neck, 0.89 for the total hip, and 0.86 for the lumbar spine. However, the derived equations for aBMD determination showed an intercept significantly different from 0 for hip aBMD, and a slope significantly different from 1 for lumbar spine aBMD. These results highlight a bias between the two measurements, thus requiring the determination of specific cross-calibration equations for hip and lumbar spine, femoral neck excepted. When compared with values on the Prodigy, mean aBMD on the Stratos DR was higher at the femoral neck (+4.8%, plt;0.001) and total hip (+9.6%, plt;0.001) and lower at L2-L4 (-8.8%, plt;0.001). The coefficient of variation (CV%) for the two consecutive measures at lumbar spine (with different positioning) with the Stratos DR was 2.9%.The difference in aBMD measured with the two DXAs illustrates the need to define cross-calibration equations when comparing data across systems in order to avoid erroneous conclusions.
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- 2022
24. NIBART: A New Interval Based Algebraic Reconstruction Technique for Error Quantification of Emission Tomography Images.
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Olivier Strauss, Abdelkabir Lahrech, Agnès Rico, Denis Mariano-Goulart, and Benoît Telle
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- 2009
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25. Personalised versus standard dosimetry approach of selective internal radiation therapy in patients with locally advanced hepatocellular carcinoma (DOSISPHERE-01): a randomised, multicentre, open-label phase 2 trial
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Etienne Garin, Lambros Tselikas, Boris Guiu, Julia Chalaye, Julien Edeline, Thierry de Baere, Eric Assenat, Vania Tacher, Corentin Robert, Marie Terroir-Cassou-Mounat, Denis Mariano-Goulart, Giuliana Amaddeo, Xavier Palard, Antoine Hollebecque, Marilyne Kafrouni, Hélène Regnault, Karim Boudjema, Serena Grimaldi, Marjolaine Fourcade, Hicham Kobeiter, Eric Vibert, Samuel Le Sourd, Lauranne Piron, Danièle Sommacale, Sophie Laffont, Boris Campillo-Gimenez, Yan Rolland, Corentin Robert Robert, Marc Pracht, Valérie Ardisson, Laurence Lenoir, Thierry De Baere, Frederic Deschamps, Michel Ducreux, Maximiliano Gelli, Christophe Cassinotto, Carole Allimant, Sophie Bonnot-Lours, Margarita Marie, Emmanuel Itti, Lionel Lerman, Mukedaisi Abulizi, Alain Luciani, Charlotte E. Costentin, Milan Milliner, CRLCC Eugène Marquis (CRLCC), Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Institut Gustave Roussy (IGR), Imagerie thérapeutique (radiologie interventionnelle), Département d'imagerie médicale [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), University Hospital of Montpellier, CHU Henri Mondor, Centre Hospitalier Universitaire [Rennes], Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département de médecine oncologique [Gustave Roussy], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Médecine nucléaire, Centre Hépato-Biliaire [Hôpital Paul Brousse] (CHB), Hôpital Paul Brousse-Assistance Publique - Hôpitaux de Paris, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Henri Mondor [Créteil], Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Jonchère, Laurent
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medicine.medical_treatment ,Population ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,[SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Randomized controlled trial ,law ,Clinical endpoint ,Medicine ,Dosimetry ,Progression-free survival ,education ,education.field_of_study ,Hepatology ,business.industry ,Selective internal radiation therapy ,Gastroenterology ,[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,3. Good health ,Radiation therapy ,Clinical trial ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Nuclear medicine ,business - Abstract
International audience; BACKGROUND: All randomised phase 3 studies of selective internal radiation therapy for advanced hepatocellular carcinoma published to date have reported negative results. However, these studies did not use personalised dosimetry. We aimed to compare the efficacy of a personalised versus standard dosimetry approach of selective internal radiation therapy with yttrium-90-loaded glass microspheres in patients with hepatocellular carcinoma.METHODS: DOSISPHERE-01 was a randomised, multicentre, open-label phase 2 trial done at four health-care centres in France. Patients were eligible if they were aged 18 years or older and had unresectable locally advanced hepatocellular carcinoma, at least one measurable lesion 7 cm or more in size, a hepatic reserve of at least 30% after selective internal radiation therapy, no extrahepatic spread (other than to the lymph nodes of the hilum, with a lesion 5% of patients) grade 3 or higher adverse events were ascites (one [3%] patient who received personalised dosimetry vs two [10%] patients who received standard dosimetry), hepatic failure (two [6%] vs none), lymphopenia (12 [34%] vs nine [43%]), increased aspartate aminotransferase concentrations (three [9%] vs two [10%]), increased alanine aminotransferase concentrations (three [9%] vs none), anaemia (two [6%] vs one [5%]), gastrointestinal haemorrhage (none vs two [10%]), and icterus (none vs two [10%]). One treatment-related death occurred in each group.INTERPRETATION: Compared with standard dosimetry, personalised dosimetry significantly improved the objective response rate in patients with locally advanced hepatocellular carcinoma. The results of this study suggest that personalised dosimetry is likely to improve outcomes in clinical practice and should be used in future trials of selective internal radiation therapy. FUNDING: Biocompatibles UK, a Boston Scientific Group company.
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- 2021
26. Towards Automatic Selection of the Regularization Parameters in Emission Tomgraphy by Fourier Synthesis.
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P. Maréchal, Denis Mariano-Goulart, Luc Giraud, and Serge Gratton
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- 2004
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27. Annonce des résultats en médecine nucléaire : enjeux et réflexions. «
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M.-J. Ouvrier, G. Bonardel, J.-M. Israël, G. Fumagalli, Denis Mariano-Goulart, F. Rezungles, Frédéric Comte, D. Huglo, S. Gonzalez, M. Wartski, and J.-P. Vuillez
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03 medical and health sciences ,0302 clinical medicine ,Radiological and Ultrasound Technology ,Biophysics ,Radiology, Nuclear Medicine and imaging ,030218 nuclear medicine & medical imaging - Abstract
Resume L’annonce et la communication des resultats d’un examen de medecine nucleaire au patient, notamment en TEP, relevent de pratiques tres differentes d’un service a l’autre ou d’un praticien a l’autre. Or, la reglementation relative a l’information des patients et a l’acces a leurs donnees de sante ainsi que les recommandations de l’Institut national du cancer concernant l’evolution du dispositif d’annonce d’un cancer plaident pour une plus grande implication des medecins imageurs, radiologues et medecins nucleaires dans le processus d’annonce. Au-dela des considerations legales, il apparait ethiquement et humainement difficile de refuser toute forme de communication medicale au patient qui en fait la demande et le laisser decouvrir seul son resultat sans commentaire ou echange avec le medecin specialiste ayant redige le compte-rendu. Cependant, l’heterogeneite des pratiques au sein de la communaute de medecine nucleaire est reelle et se doit d’etre comprise. Les principaux arguments des medecins ne realisant pas d’annonce sont analyses et des pistes sont evoquees pour tenter de repondre, concretement et de maniere non dogmatique, a l’attente legitime de nombreux patients.
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- 2020
28. Ultrasonic transmission through small tubes such as rat tibias for axial Young’s modulus estimation: Discussion and recommendations
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Didier Laux, Eric Rondet, Joel Grabulos, Rémi Dore, Léa Ollier, Anne Virsolvy, Denis Mariano-Goulart, Laurent Maimoun, Institut d’Electronique et des Systèmes (IES), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Acoustique (ACO), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Photonique et Ondes (PO), Démarche intégrée pour l'obtention d'aliments de qualité (UMR QualiSud), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Avignon Université (AU)-Université de La Réunion (UR)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Département Performances des systèmes de production et de transformation tropicaux (Cirad-PERSYST), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)
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[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph] ,Acoustics and Ultrasonics ,0206 medical engineering ,Ultrasound Young’s modulus ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,02 engineering and technology ,Osteoporosis mCT ,020601 biomedical engineering ,01 natural sciences ,Guided modes ,Rat tibias ,0103 physical sciences ,010301 acoustics ,Porosity ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience; In the framework of in vitro osteoporosis investigation with ultrasound on rat model, we propose a study of axisymmetric modes guided in small cylindrical structures such as rat tibias. The main objective is to analyze how an ultrasonic pulse (with a frequency close to the MHz) transmitted through the cortical bone diaphysis can be used to obtain a rapid estimation of the axial Young's modulus. Thanks to a numerical approach and experimentations on bone phantoms we show that the velocity of the first arrival signal (VFAS) measured with a simple time of flight method corresponds to the maximum of the group velocity of the axisymmetric L(0,2) mode. Considering the geometry of the cylinders analyzed, we show that it is possible to use this velocity to estimate the axial Young's modulus. The ratio (internal radius / thickness) is an important parameter for small tubes such as rat tibias and has to be considered for results analysis. In this framework, µCT measurements are of first interest. At the end of this communication, preliminary experiments on rat tibias are presented and discussed.
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- 2022
29. Choquet integrals as projection operators for quantified tomographic reconstruction.
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Agnès Rico, Olivier Strauss, and Denis Mariano-Goulart
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- 2009
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30. Evaluation of a new gridding method for fully 3D direct Fourier PET reconstruction based on a two-plane geometry.
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F. Ben Bouallegue, Jean-François Crouzet, and Denis Mariano-Goulart
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- 2008
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31. The quantitative ultrasound method for assessing low bone mass in women with anorexia nervosa
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Laura Gaspari, Denis Mariano-Goulart, Rémi Doré, Patrick Lefebvre, Maude Seneque, Eric Renard, Philippe Courtet, Didier Laux, Sébastien Guillaume, Pascal Philibert, Laurent Maïmoun, Krishna Kunal Mahadea, Charles Sultan, Ariane Sultan, Marie Picot, Helena Huguet, Vincent Boudousq, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), MORNET, Dominique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Lapeyronie [Montpellier] (CHU), CIC Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Saint Eloi (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génomique Fonctionnelle (IGF), Hôpital de la Colombière, Service de Médecine Nucléaire [Nîmes], Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Université de Montpellier (UM), Institut d’Electronique et des Systèmes (IES), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biochimie [CHRU Nîmes], Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Hôpital Arnaud de Villeneuve [CHRU Montpellier], Acoustique (ACO), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Photonique et Ondes (PO), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)
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musculoskeletal diseases ,0301 basic medicine ,medicine.medical_specialty ,Heel ,Areal bone mineral density (aBMD) ,[SDV]Life Sciences [q-bio] ,030209 endocrinology & metabolism ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,Standard score ,[SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Orthopedics and Sports Medicine ,[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM] ,[SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM] ,ComputingMilieux_MISCELLANEOUS ,[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism ,2. Zero hunger ,Bone mineral ,business.industry ,Dual-X-ray absorptiometry (DXA) ,[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism ,3. Good health ,Quantitative ultrasound ,[SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,medicine.anatomical_structure ,Anorexia nervosa (differential diagnoses) ,Orthopedic surgery ,Broadband ultrasound attenuation (BUA) bone demineralization ,Amenorrhea ,Quantitative ultrasound (QUS) ,030101 anatomy & morphology ,medicine.symptom ,business ,Nuclear medicine ,Body mass index - Abstract
International audience; This study investigated the potential role of quantitative ultrasound (QUS) to assess low bone mass in anorexia nervosa patients (AN). Bone parameters from QUS and DXA were positively correlated and significantly reduced in AN compared with controls, suggesting that QUS is a pertinent technique to assess low bone mass in these patients.Purpose: The aim of this study was to investigate the potential role of an alternative technique, quantitative ultrasound (QUS), to assess low bone mass in patients with anorexia nervosa (AN).Methods: Two hundred seven young women (134 patients with AN and 73 healthy controls) with ages ranging from 14.4 to 38.4 years participated in this observational cross-sectional study. Bone mass was concomitantly evaluated by DXA to determine areal bone mineral density (aBMD; g/cm2) at hip, lumbar spine, and radius and by QUS to determine broadband ultrasound attenuation (BUA; dB/MHz) at the heel.Results: BUA (66.5 ± 4.6 dB/MHz vs 61.0 ± 5.0 dB/MHz) and aBMD at the hip (0.916 ± 0.013 g/cm2 vs 0.806 ± 0.010 g/cm2), lumbar spine (0.966 ± 0.012 g/cm2 vs 0.886 ± 0.010 g/cm2), and radius (0.545 ± 0.005 g/cm2 vs 0.526 ± 0.04 g/cm2) were significantly decreased (p < 0.01) in patients with AN compared with controls. When patient and control data were pooled, BUA was significantly correlated with aBMD at the hip (r = 0.60, p < 0.001), lumbar spine (r = 0.48, p < 0.001), and radius (r = 0.40, p
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- 2021
32. Exact and Approximate Fourier Rebinning Algorithms for the Solution of the Data Truncation Problem in 3-D PET.
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F. Ben Bouallegue, Jean-François Crouzet, Claude Comtat, M. Fourcade, B. Mohammadi, and Denis Mariano-Goulart
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- 2007
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33. A priori selection of the regularization parameters in emission tomography by Fourier synthesis.
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Denis Mariano-Goulart, P. Maréchal, Serge Gratton, Luc Giraud, and M. Fourcade
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- 2007
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34. Place of the 18F-FDG-PET/CT in the Diagnostic Workup in Patients with Classical Fever of Unknown Origin (FUO)
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Denis Mariano-Goulart, Philippe Guilpain, Marie-Christine Picot, Camille Roubille, S. Letertre, Vincent Le Moing, Jean Ribstein, Laetitia Zerkowski, Pierre Fesler, Hôpital Lapeyronie [Montpellier] (CHU), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), CIC Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Saint Eloi (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Saint Eloi (CHRU Montpellier), MORNET, Dominique, Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-CHU Saint-Eloi-Institut National de la Santé et de la Recherche Médicale (INSERM), and CHU Saint-Eloi
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medicine.medical_specialty ,Multivariate analysis ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Population ,18F-FDG-PET/CT ,Article ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Biopsy ,medicine ,In patient ,030212 general & internal medicine ,Fever of unknown origin ,Medical diagnosis ,education ,education.field_of_study ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,medicine.diagnostic_test ,Adult patients ,business.industry ,General Medicine ,medicine.disease ,3. Good health ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,fever of unknown origin ,Medicine ,Fdg pet ct ,Radiology ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Objective: To explore the diagnostic contribution of the 18F-FDG-PET/CT in a population of patients with classical fever of unknown origin (FUO), to pinpoint its place in the diagnostic decision tree in a real-life setting, and to identify the factors associated with a diagnostic 18F-FDG-PET/CT. Method: All adult patients (aged ≥ 18 years) with a diagnosis of classical FUO who underwent an 18F-FDG-PET/CT in the University Hospital of Montpellier (France) between April 2012 and December 2017 were included. True positive 18F-FDG-PET/CT, which evidenced a specific disease causing FUO, were considered to be contributive. Results: Forty-four patients with FUO have been included (20 males, 24 females, mean age 57.5 ± 17.1 years). Diagnoses were obtained in 31 patients (70.5%), of whom 17 (38.6%) had non-infectious inflammatory diseases, 9 had infections (20.5%), and 3 had malignancies (6.8%). 18F-FDG-PET/CT was helpful for making a final diagnosis (true positive) in 43.6% of all patients. Sensitivity and specificity levels were 85% and 37%, respectively. A total of 135 investigations were performed before 18F-FDG-PET/CT, mostly CT scans (93.2%) and echocardiography (59.1%), and 108 after 18F-FDG-PET/CT, mostly biopsies (including the biopsy of a temporal artery) (25%) and MRIs (34%). In multivariate analysis, the hemoglobin level was significantly associated with a helpful 18F-FDG-PET/CT (p = 0.019, OR 0.41, 95% CI (0.20–0.87)), while the CRP level was not associated with a contributive 18F-FDG-PET/CT. Conclusion: 18F-FDG-PET/CT may be proposed as a routine initial non-invasive procedure in the diagnostic workup of FUO, especially in anemic patients who could be more likely to benefit from 18F-FDG-PET/CT.
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- 2021
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35. Automatic generation of noise-free time-activity curve with gated blood-pool emission tomography using deformation of a reference curve.
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Charles Caderas de Kerleau, Jean-François Crouzet, Ehoud Ahronovitz, Michel Rossi, and Denis Mariano-Goulart
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- 2004
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36. A Fast 3-D Multimodality Registration Algorithm for Human Brain.
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Jean-Luc Bernon, Denis Mariano-Goulart, Michel Zanca, and Michel Rossi
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- 1999
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37. Hepatobiliary Scintigraphy and Glass 90Y Radioembolization with Personalized Dosimetry: Dynamic Changes in Treated and Nontreated Liver
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Christophe Cassinotto, Denis Mariano-Goulart, Carole Allimant, Chloé Guillot, Delphine de Verbizier, Marilyne Kafrouni, Boris Guiu, M. Fourcade, Lore Santoro, Emmanuel Deshayes, Margaux Hermida, CHU Saint-Eloi, Institut du Cancer de Montpellier (ICM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Saint Eloi (CHRU Montpellier), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and MORNET, Dominique
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Medicine (General) ,medicine.medical_specialty ,Clinical Biochemistry ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,liver ,Scintigraphy ,selective internal radiation therapy ,Gastroenterology ,Article ,[SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,mebrofenin ,hepatobiliary scintigraphy ,03 medical and health sciences ,Liver disease ,R5-920 ,0302 clinical medicine ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Internal medicine ,medicine ,Dosimetry ,medicine.diagnostic_test ,business.industry ,Selective internal radiation therapy ,Whole liver ,[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,medicine.disease ,[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,3. Good health ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,030211 gastroenterology & hepatology ,Liver function ,business - Abstract
Background: The functional changes that occur over time in the liver following 90Y-radioembolization (RE) using personalized dosimetry (PD) remain to be investigated. Methods: November 2016–October 2019: we retrospectively included hepatocellular carcinoma (HCC) patients treated by 90Y-glass RE using PD, who underwent hepatobiliary scintigraphy (HBS) at baseline and at 15 days, 1, 2, 3, and 6 months after RE. Results: There were 16 patients with unilobar disease (100%) included, and 64 HBS were performed. Whole liver function significantly decreased over time. The loss was maximal at 2 weeks: −32% (p = 0.002) and remained below baseline at 1 (−15%; p = 0.002), 2 (−25%; p < 0.001), and 3 months (−16%; p = 0.027). No radioembolization-induced liver disease was observed. Treated liver function strongly decreased to reach −64% (p < 0.001) at 2 months. Nontreated liver function decreased at 2 weeks (−21%; p = 0.027) and remained below baseline before reaching +20% (p = 0.002) and +59% (p < 0.001) at 3 and 6 months, respectively. Volumetric and functional changes exhibited parallel evolutions in the treated livers (p = 0.01) but independent evolutions in the nontreated livers (p = 0.08). Conclusion: RE using PD induces significant regional changes in liver function over time. As early as 15 days following RE, both the treated and nontreated livers showed a decreased function. Nontreated liver function recovered after 3 months and greatly increased afterwards.
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- 2021
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38. The effect of excessive fat tissue on the measure of bone mineral density by dual X‐ray absorptiometry: the impact of substantial weight loss following sleeve gastrectomy
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Denis Mariano-Goulart, Laurent Maïmoun, David Nocca, Audrey Jaussent, Krishna Kunal Mahadea, Fayçal Ben Bouallègue, Clémence Fouillade, Vincent Boudousq, Marie-Christine Picot, Patrick Lefebvre, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes), MORNET, Dominique, Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), and CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
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Male ,Time Factors ,[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Physiology ,[SDV]Life Sciences [q-bio] ,medicine.medical_treatment ,Adipose tissue ,030204 cardiovascular system & hematology ,Overweight ,Obese ,Absorptiometry, Photon ,0302 clinical medicine ,Bone Density ,Weight loss ,Medicine ,ComputingMilieux_MISCELLANEOUS ,Adiposity ,Bone mineral ,Fat mass ,medicine.diagnostic_test ,Dual-energy X-ray absorptiometry ,General Medicine ,Middle Aged ,Treatment Outcome ,Adipose Tissue ,Female ,medicine.symptom ,Adult ,musculoskeletal diseases ,Sleeve gastrectomy ,Adolescent ,Bone and Bones ,Young Adult ,03 medical and health sciences ,Gastrectomy ,Predictive Value of Tests ,Physiology (medical) ,Weight Loss ,Bone mineral density ,[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ,Humans ,Obesity ,Aged ,business.industry ,Reproducibility of Results ,030229 sport sciences ,Trunk ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,Underestimation ,business ,Nuclear medicine - Abstract
International audience; Purpose: Dual‐energy X‐ray absorptiometry (DXA ) is used in clinical routine to determine areal bone mineral density (aBMD ). However, it is not clear whether excessive fat mass or substantial weight loss modify the aBMD measurements. The aim of this study was to evaluate the effect of soft tissue composition on aBMD measured by DXA using a clinical model (i.e. sleeve gastrectomy: SG ) that induces substantial body weight loss.Methods: Areal bone mineral density and body composition (fat mass: FM and lean tissue mass: LTM ) were determined by DXA in 41 obese patients (33 women, 80.5%) just before SG and 1 month later.Results: One month after SG , mean weight loss was −9.8 ± 2.6 kg, with a significant decrease in LTM and FM (kg) ranging from −7.3% to −9.5%. The relative variation in aBMD was increased at the lumbar spine (2.45 ± 3.44%) and decreased at the hip (−1.47 ± 2.28%), whereas no variation was observed for the whole body and radius. The variation in aBMD at the lumbar spine was inversely correlated with variations in weight, whole‐body FM and trunk FM , but not LTM.Conclusion: This study shows evidence of a potential effect of body composition, particularly FM , on aBMD . However, given the modest change in aBMD , which was close to the precision error of aBMD measurements, it appears that significant weight loss does not have a clinically significant impact on the evaluation of aBMD using DXA.
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- 2019
39. Reduced brain amyloid burden in elderly patients with narcolepsy type 1
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Denis Mariano-Goulart, Isabelle Jaussent, Caroline Grasselli, Régis Lopez, Delphine de Verbizier, Alzheimer’s Disease Neuroimaging Initiative, Lucie Barateau, Multi-Domain Intervention Alzheimer's Prevention Trial study groups, Bertrand Carlander, Yves Dauvilliers, Audrey Gabelle, Fayçal Ben Bouallègue, Sylvain Lehmann, Séverine Béziat, and Carole Pesenti
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0301 basic medicine ,Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,Amyloid ,business.industry ,Neuropsychology ,medicine.disease ,Pons ,3. Good health ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Neurology ,Neuroimaging ,Positron emission tomography ,mental disorders ,medicine ,Dementia ,Neurology (clinical) ,Alzheimer's disease ,business ,030217 neurology & neurosurgery ,Narcolepsy - Abstract
OBJECTIVE To determine whether brain amyloid burden in elderly patients with narcolepsy type 1 (NT1) is lower than in controls, and to assess in patients with NT1 the relationships between amyloid burden, cerebral spinal fluid (CSF) markers of Alzheimer disease (AD), CSF orexin-A, and cognitive profile. METHODS Cognitive and 18 F-florbetapir positron emission tomography (PET) data were compared in patients with NT1 aged ≥ 65 years (n = 23) and in age- and sex-matched controls free of clinical dementia selected from the Alzheimer's Disease Neuroimaging Initiative (ADNI; n = 69) and the Multi-Domain Intervention Alzheimer's Prevention Trial (MAPT-18F AV45-PET; n = 23) cohorts. The standardized uptake values (SUVs) of the cortical retention index for 6 regions of interest were computed and averaged to create a mean SUV ratio normalized to 3 subcortical reference regions (cerebellum, pons, and a composite region). A cortical/cerebellum SUV ratio ≥ 1.17 defined positive PET amyloid. RESULTS Lower cortical amyloid burden was observed in the NT1 than in the ADNI and MAPT-AV45 groups (mean cortical/cerebellum SUV ratios = 0.95 ± 0.15, 1.11 ± 0.18 [p
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- 2018
40. Complication and lung function impairment prediction using perfusion and computed tomography air trapping (CLIPPCAIR): protocol for the development and validation of a novel multivariable model for the prediction of post-resection lung function
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Nicolas Molinari, Laurence Solovei, Jérémy Charriot, Lucie Gamon, Denis Mariano Goulart, Isabelle Vachier, Isabelle Serre, Carey M. Suehs, Sébastien Bommart, Arnaud Bourdin, Kheira Hireche, Université de Montpellier (UM), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Montpelliérain Alexander Grothendieck (IMAG), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and MORNET, Dominique
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medicine.medical_specialty ,lobectomy ,[SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Population ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,[SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery ,Air trapping ,Scintigraphy ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Study Protocol ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Non-small cell lung cancer ,DLCO ,respiratory function ,medicine ,Respiratory function ,education ,Lung cancer ,pneumectomy ,education.field_of_study ,COPD ,Lung ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,3. Good health ,medicine.anatomical_structure ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Radiology ,medicine.symptom ,business ,mean lung density - Abstract
BACKGROUND: Recent advancements in computed tomography (CT) scanning and post processing have provided new means of assessing factors affecting respiratory function. For lung cancer patients requiring resection, and especially those with respiratory comorbidities such as chronic obstructive pulmonary disease (COPD), the ability to predict post-operative lung function is a crucial step in the lung cancer operability assessment. The primary objective of the CLIPPCAIR study is to use novel CT data to develop and validate an algorithm for the prediction of lung function remaining after pneumectomy/lobectomy. METHODS: Two sequential cohorts of non-small cell lung cancer patients requiring a pre-resection CT scan will be recruited at the Montpellier University Hospital, France: a test population (N=60) on which predictive models will be developed, and a further model validation population (N=100). Enrolment will occur during routine pre-surgical consults and follow-up visits will occur 1 and 6 months after pneumectomy/lobectomy. The primary outcome to be predicted is forced expiratory volume in 1 second (FEV1) six months after lung resection. The baseline CT variables that will be used to develop the primary multivariable regression model are: expiratory to inspiratory ratios of mean lung density (MLD(e/i) for the total lung and resected volume), the percentage of voxels attenuating at less than ‒950 HU (PVOX(‒950) for the total lung and resected volume) and the ratio of iodine concentrations for the resected volume over that of the total lung. The correlation between predicted and real values will be compared to (and is expected to improve upon) that of previously published methods. Secondary analyses will include the prediction of transfer factor for carbon monoxide (TLCO) and complications in a similar fashion. The option to explore further variables as predictors of post-resection lung function or complications is kept open. DISCUSSION: Current methods for estimating post-resection lung function are imperfect and can add assessments (such as scintigraphy) to the pre-surgical workup. By using CT imaging data in a novel fashion, the results of the CLIPPCAIR study may not only improve such estimates, it may also simplify patient pathways. TRIAL REGISTRATION: Clinicaltrials.gov (NCT03885765).
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- 2021
41. Colchicine to Prevent Sympathetic Denervation after an Acute Myocardial Infarction: The COLD-MI Trial Protocol
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Anne-Marie Dupuy, Florence Leclercq, Nicolas Nagot, Delphine Delseny, Valentin Dupasquier, Jean-Paul Cristol, François Roubille, M. Akodad, Jean-Christophe Macia, Sandra Kahlouche, Sonia Soltani, Quentin Delbaere, Fabien Huet, Fanny Cardon, Nidal Jammoul, Sylvain Aguilhon, Denis Mariano-Goulart, Richard Gervasoni, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and MORNET, Dominique
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medicine.medical_specialty ,Medicine (General) ,medicine.medical_treatment ,Ischemia ,030204 cardiovascular system & hematology ,colchicine ,03 medical and health sciences ,QRS complex ,Study Protocol ,Mice ,0302 clinical medicine ,R5-920 ,Percutaneous Coronary Intervention ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Internal medicine ,medicine ,sympathetic innervation ,Animals ,Humans ,030212 general & internal medicine ,Myocardial infarction ,Prospective Studies ,cardiovascular diseases ,Sympathectomy ,Randomized Controlled Trials as Topic ,First episode ,Denervation ,nuclear imaging ,business.industry ,heart rate variability ,Percutaneous coronary intervention ,General Medicine ,medicine.disease ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,3. Good health ,myocardial infarction ,[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology ,Heart failure ,Cardiology ,[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology ,ST Elevation Myocardial Infarction ,business ,TIMI - Abstract
International audience; Inflammatory processes are deeply involved in ischemia-reperfusion injuries (IRI) and ventricular remodelling (VR) after a ST-segment elevation myocardial infarction (STEMI). They are associated with clinical adverse events (heart failure and cardiovascular death) adding damage to the myocardium after reperfusion. Moreover, acute myocardial infarction (AMI) induces a local sympathetic denervation leading to electrical instability and arrythmia. Colchicine, a well-known alkaloid with direct anti-inflammatory effects, was shown to reduce the myocardial necrosis size and limit the VR. In a recent proof of concept study, colchicine appears to prevent sympathetic denervation in a mice model of ischemia/reperfusion, but not in the necrosis or in the border zone areas. The Colchicine to Prevent Sympathetic Denervation after an AMI study (COLD-MI) is an ongoing, confirmative, prospective, monocentre, randomized, open-label trial. The COLD-MI trial aims to evaluate the intensity of sympathetic denervation after AMI and its potential modulation due to low dose colchicine. Sympathetic denervation will be noninvasively evaluated using single-photon emission computed tomography (SPECT). After a first episode of STEMI (Initial TIMI flow ≤ 1) and primary percutaneous coronary intervention (PPCI), patients will be randomized (n = 56) in a 1:1 ratio to either receive colchicine or not for 30 days. The primary end point will be the percentage of myocardial denervation measured by 123I-metaiodobenzylguanidine (123I-MIBG) SPECT at a 6-month follow-up. The main secondary end points will be basic ECG parameters (QRS duration, corrected QT) and HRV parameters from a 24 hour-recording Holter at 1- and 6-months follow-up. Results from this study will contribute to a better understanding of the cardioprotective effect of colchicine after AMI. The present study describes the rationale, design, and methods of the trial.
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- 2021
42. Evaluating the Effectiveness of Yttrium-90 Glass Microspheres in the Treatment of Hepatocellular Carcinoma, Intrahepatic Cholangiocarcinoma, and Metastatic Colorectal Cancer in Practice: Protocol for the Prospective PROACTIF Phase IV Registry Study in France
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Hélène Regnault, Boris Guiu, Charles Mastier, Denis Mariano-Goulart, Sylvain Manfredi, Etienne Garin, Julien Edeline, Antoine Bouvier, Stéphanie Becker, David Sefrioui, Eric Vibert, Eric Vicaut, Binal Patel, Christian Sengel, Jean-Baptiste Pinaquy, Patrick Chevallier, Jeremie Tordo, Thierry de Baere, Agnès Rode, Clement Bailly, Claude Somma, Jean-Frédéric Blanc, Jean Goupil, Eveline Boucher, CRLCC Eugène Marquis (CRLCC), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), The PROACTIF Registry study is funded by Biocompatibles/Boston Scientific Corporation. The funding body provided support in the analysis of data and in providing medical writing support for the manuscript., Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
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Target lesion ,medicine.medical_specialty ,Yttrium-90 ,Carcinoma, Hepatocellular ,Liver tumor ,Colorectal cancer ,Hepatocellular carcinoma ,[SDV]Life Sciences [q-bio] ,Selective internal radiation therapy ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Clinical Trials, Phase IV as Topic ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,Cholangiocarcinoma ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Internal medicine ,medicine ,Humans ,Liver metastatic colorectal cancer ,Yttrium Radioisotopes ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Registries ,Intrahepatic Cholangiocarcinoma ,Reimbursement ,Intrahepatic cholangiocarcinoma ,business.industry ,Liver Neoplasms ,[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,medicine.disease ,Embolization, Therapeutic ,Microspheres ,3. Good health ,Bile Ducts, Intrahepatic ,Treatment Outcome ,Bile Duct Neoplasms ,030220 oncology & carcinogenesis ,Quality of Life ,030211 gastroenterology & hepatology ,Colorectal Neoplasms ,Cardiology and Cardiovascular Medicine ,business - Abstract
International audience; Primary objective: Recently, selective internal radiation therapy using yttrium-90 (Y90) glass microspheres (TheraSphere™) was approved for reimbursement by health authorities in France. The PROACTIF study aims to gather data on effectiveness, patient quality of life, and safety with use of Y90 glass microspheres in real-world clinical settings in France.Inclusion criteria: Patient with a diagnosis of hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCC), and/or metastatic colorectal cancer (mCRC) who was treated with a dose of Y90 glass microspheres that has been reimbursed in France and who do not oppose use of their personal medical data.Exclusion criteria: If data collection is opposed, treatment is reimbursed but not administered, or treatment is administered but not reimbursed.Outcome measures: Primary outcome measures include overall survival from time of Y90 glass microsphere treatment and quality of life, as assessed using the Functional Assessment of Cancer Therapy- Hepatobiliary questionnaire.Estimated number of patients to be included: This is an open study and there is no set number of patients; 115 have already been enrolled.Planned subgroup analyses: Analyses will be stratified by disease state (HCC, iCC, or mCRC). Subgroups to be analyzed include age group, unilobar/bilobar disease at baseline, Eastern Cooperative Oncology Group (ECOG) status at baseline, liver tumor burden at baseline, target lesion size, and standard versus multi-compartment personalized dosimetry treatment.Planned recruitment and observation period: Recruitment includes patients who are prescribed and treated with a commercial vial of Y90 glass microspheres between 01 January 2019 and 31 December 2024.Trial registration: ClinicalTrials.gov Identifier: NCT04069468.
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- 2021
43. Left ventricle function assessment using gated first-pass 18F-FDG PET: Validation against equilibrium radionuclide angiography
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Fayçal Ben Bouallègue, Eric Rondet, Boramy Hay, Denis Mariano-Goulart, Laurent Maïmoun, Florentin Kucharczak, Pierre Le Fur, Fabien Vauchot, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Image & Interaction (ICAR), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Démarche intégrée pour l'obtention d'aliments de qualité (UMR Qualisud), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de La Réunion (UR)-Université de Montpellier (UM)-Avignon Université (AU)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Montpellier 1 (UM1), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Démarche intégrée pour l'obtention d'aliments de qualité (UMR QualiSud), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM)-Institut Agro - Montpellier SupAgro, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)
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First-pass ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Coefficient of variation ,Concordance ,030204 cardiovascular system & hematology ,030218 nuclear medicine & medical imaging ,18f fdg pet ,03 medical and health sciences ,0302 clinical medicine ,Radionuclide angiography ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,medicine ,Radiology, Nuclear Medicine and imaging ,Reproducibility ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Left ventricular function ,Left ventricular volume ,medicine.anatomical_structure ,Cardiac PET ,Ventricle ,Cardiology and Cardiovascular Medicine ,Nuclear medicine ,business ,18F-FDG PET - Abstract
We appraised the feasibility of left ventricle (LV) function assessment using gated first-pass 18F-FDG PET, and assessed the concordance of the produced measurements with equilibrium radionuclide angiography (ERNA). Twenty-four oncologic patients benefited from 99mTc-labeled red-blood-cell ERNA, in planar mode (all patients) and using SPECT (22 patients). All patients underwent gated first-pass 18F-FDG cardiac PET. Gated dynamic PET images were reconstructed over 1 minute during tracer first-pass inside the LV and post-processed using in-house software (TomPool). After re-orientation into cardiac canonical axes and adjustment of the valves plane using a phase image, pseudo-planar PET images obtained by re-projection were automatically segmented using thresholded region growing and gradient-based delineation to produce an LV ejection fraction (EF) estimate. PET images were also post-processed in fully-tomographic mode to produce LV end diastole volume (EDV), end systole volume (ESV), and EF estimates. Concordance was assessed using Lin’s concordance (ccc) and Bland-Altman analysis. Reproducibility was assessed using the coefficient of variation (CoV) and intra-class correlation (ICC). Pseudo-planar PET EF estimates were concordant with planar ERNA (ccc = 0.81, P
- Published
- 2021
44. The quantitative ultrasound method for assessing low bone mass in women with anorexia nervosa
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Laurent, Maïmoun, Eric, Renard, Héléna, Huguet, Patrick, Lefebvre, Vincent, Boudousq, Krishna, Mahadea, Marie Christine, Picot, Rémi, Doré, Pascal, Philibert, Maude, Seneque, Laura, Gaspari, Philippe, Courtet, Charles, Sultan, Ariane, Sultan, Didier, Laux, Sébastien, Guillaume, and Denis, Mariano-Goulart
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Adult ,Calcaneus ,Young Adult ,Absorptiometry, Photon ,Anorexia Nervosa ,Adolescent ,Bone Density ,Humans ,Female ,Bone and Bones ,Ultrasonography - Abstract
This study investigated the potential role of quantitative ultrasound (QUS) to assess low bone mass in anorexia nervosa patients (AN). Bone parameters from QUS and DXA were positively correlated and significantly reduced in AN compared with controls, suggesting that QUS is a pertinent technique to assess low bone mass in these patients.The aim of this study was to investigate the potential role of an alternative technique, quantitative ultrasound (QUS), to assess low bone mass in patients with anorexia nervosa (AN).Two hundred seven young women (134 patients with AN and 73 healthy controls) with ages ranging from 14.4 to 38.4 years participated in this observational cross-sectional study. Bone mass was concomitantly evaluated by DXA to determine areal bone mineral density (aBMD; g/cmBUA (66.5 ± 4.6 dB/MHz vs 61.0 ± 5.0 dB/MHz) and aBMD at the hip (0.916 ± 0.013 g/cmBUA measurement at the heel by QUS appears to be a pertinent nonionizing technique to assess low bone mass in patients with AN.
- Published
- 2020
45. Brain
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Florentin, Kucharczak, Marie, Suau, Olivier, Strauss, Fayçal, Ben Bouallègue, and Denis, Mariano-Goulart
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Adult ,Aged, 80 and over ,Male ,Brain ,Middle Aged ,Alzheimer Disease ,Fluorodeoxyglucose F18 ,Case-Control Studies ,Positron-Emission Tomography ,Image Processing, Computer-Assisted ,Humans ,Female ,Software ,Aged - Abstract
We propose an innovative approach forBrainBoth methods provided cortical ROI indices that were significantly different between controls and AD patients. The area under the ROC curve for control/AD classification was statistically identical (0.96 for NIBEM IR and 0.95 for Scenium SUVr SD). At the optimal threshold, the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were, respectively, 100%, 88%, 92%, 83%, and 100% for both Scenium SUVr SD and NIBEM IR methods.This preliminary study shows that interval-valued reconstruction allows self-consistent analysis of brain
- Published
- 2020
46. Should patients with an incidental finding of focal myocardial 18FDG uptake be screened by myocardial perfusion scintigraphy?
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D. De Verbizier, Aurélie Bourdon, Meriem Benkiran, Nicolas Molinari, Vincent Boudousq, Denis Mariano-Goulart, T. Fidani, Fabien Vauchot, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
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medicine.medical_specialty ,Myocardial ischemia ,Radiological and Ultrasound Technology ,business.industry ,Biophysics ,Ischemia ,medicine.disease ,3. Good health ,030218 nuclear medicine & medical imaging ,Coronary artery disease ,03 medical and health sciences ,Basal (phylogenetics) ,0302 clinical medicine ,Internal medicine ,Right coronary artery ,medicine.artery ,Myocardial perfusion scintigraphy ,Cardiology ,[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ,Medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,Abnormality ,business - Abstract
International audience; Purpose. – Focal F-18-fluoro-deoxy-glucose uptake in the myocardium can be a sign of resting myocardial ischemia. The purpose of our study was to assess the relevance of performing myocardial perfusion scintigraphy to screen for myocardial ischemia in patients with an incidental finding of focal myocardial F-18-fluoro-deoxy-glucose uptake on a routine F-18-fluoro-deoxy-glucose positron- emission-tomography-computed-tomography.Methods. – In our retrospective multicentric study, patients were included if they had had an incidental finding of myocardial focal F-18-fluoro-deoxy-glucose uptake on a routine F-18-fluoro-deoxy-glucose positron-emission-tomography-computed-tomography and had also undergone myocardial perfusion scintigraphy within 3 months before or after the F-18-fluoro-deoxy-glucose positron-emission- tomography-computed-tomography. Patients with a pattern of ischemia or scar on the myocardial perfusion scintigraphy in the same territory as the focal F-18-fluoro-deoxy-glucose uptake were considered positive.Results. – Seven of the 34 included patients were positive, with an abnormality on the MPS data in the same territory as the focal myocardial F-18-fluoro-deoxy-glucose uptake. 2 of the 6 patients with focal F- 18-fluoro-deoxy-glucose uptake in the left anterior descending vascular supply territory and 2 of the 4 patients with focal F-18-fluoro-deoxy-glucose uptake in the standard right coronary artery territory had an abnormal myocardial perfusion scintigraphy. All 12 patients with focal F-18-fluoro-deoxy- glucose uptake restricted to the basal anterolateral and basal inferolateral segments were negative. Conclusion. – PatientswithanincidentalfindingoffocalF-18-fluoro-deoxy-glucoseuptakeonaroutine F-18-fluoro-deoxy-glucose positron-emission-tomography-computed-tomography may be considered as being at risk for coronary artery disease, when this uptake is multisegmentary in the same typical coronary territory and not restricted to the basal anterolateral and basal inferolateral segments.
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- 2020
47. Brain 18F-FDG PET analysis via interval-valued reconstruction: proof of concept for Alzheimer’s disease diagnosis
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Denis Mariano-Goulart, Olivier Strauss, Florentin Kucharczak, Marie Suau, Fayçal Ben Bouallègue, Image & Interaction (ICAR), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and MORNET, Dominique
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Brain 18F-FDG PET ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,[SDV]Life Sciences [q-bio] ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,Interval valued ,Standard deviation ,030218 nuclear medicine & medical imaging ,18f fdg pet ,[SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,03 medical and health sciences ,0302 clinical medicine ,Expectation–maximization algorithm ,Healthy control ,Medicine ,Radiology, Nuclear Medicine and imaging ,business.industry ,General Medicine ,Alzheimer's disease ,Clinical routine ,Assisted diagnostic ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,030220 oncology & carcinogenesis ,Clinical diagnosis ,Interval-valued reconstructrion ,Nuclear medicine ,business ,Area under the roc curve - Abstract
International audience; ObjectiveWe propose an innovative approach for 18F-FDG PET analysis based on an interval-valued reconstruction of 18F-FDG brain distribution. Its diagnostic performance for Alzheimer’s disease (AD) diagnosis with comparison to a validated post-processing software was assessed.Methods Brain 18F-FDG PET data from 26 subjects were acquired in a clinical routine setting. Raw data were reconstructed using an interval-valued version of the ML–EM algorithm called NIBEM that stands for Non-Additive interval-based expectation maximization. Subject classification was obtained via interval-based statistical comparison (intersection ratio, IR) between cortical regions of interest (ROI) including parietal, temporal, and temporo-mesial cortices and a reference region, the sub-cortical grey nuclei, known not to be affected by AD. In parallel, PET images were post-processed using a validated automated software based on the computation of ROI normalized uptake ratios standard deviation (SUVr SD) with reference to a healthy control database (Siemens Scenium). Clinical diagnosis made during follow-up was considered as the gold-standard for patient classification (16 healthy controls and 10 AD patients).Results Both methods provided cortical ROI indices that were significantly different between controls and AD patients. The area under the ROC curve for control/AD classification was statistically identical (0.96 for NIBEM IR and 0.95 for Scenium SUVr SD). At the optimal threshold, the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were, respectively, 100%, 88%, 92%, 83%, and 100% for both Scenium SUVr SD and NIBEM IR methods.Conclusion This preliminary study shows that interval-valued reconstruction allows self-consistent analysis of brain 18F-FDG PET data, yielding diagnostic performances that seem promising with respect to those of a commercial post-processing software based on SUVr SD analysis.
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- 2020
48. Retrospective Voxel-Based Dosimetry for Assessing the Ability of the Body-Surface-Area Model to Predict Delivered Dose and Radioembolization Outcome
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Fayçal Ben Bouallègue, Alina-Diana Ilonca, Sébastien Vauclin, Nicolas Molinari, Federico Manna, Boris Guiu, Marilyne Kafrouni, M. Fourcade, Carole Allimant, Julien Delicque, and Denis Mariano-Goulart
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Male ,Carcinoma, Hepatocellular ,Population ,computer.software_genre ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Voxel ,medicine ,Humans ,Dosimetry ,Yttrium Radioisotopes ,Radiology, Nuclear Medicine and imaging ,Radiometry ,education ,Radiation treatment planning ,Technetium Tc 99m Aggregated Albumin ,Retrospective Studies ,Tomography, Emission-Computed, Single-Photon ,Body surface area ,education.field_of_study ,business.industry ,Liver Neoplasms ,Middle Aged ,medicine.disease ,Embolization, Therapeutic ,3. Good health ,Treatment Outcome ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Absorbed dose ,Radionuclide therapy ,Female ,business ,Nuclear medicine ,computer - Abstract
The aim of this study was to quantitatively evaluate the ability of the body-surface-area (BSA) model to predict tumor-absorbed dose and treatment outcome through retrospective voxel-based dosimetry. Methods: Data from 35 hepatocellular carcinoma patients with a total of 42 90Y-resin microsphere radioembolization treatments were included. Injected activity was planned with the BSA model. Voxel dosimetry based on 99mTc-labeled macroaggregated albumin SPECT and 90Y-microsphere PET was retrospectively performed using a dedicated treatment planning system. Average dose and dose–volume histograms (DVHs) of the anatomically defined tumors were analyzed. The selected dose metrics extracted from DVHs were minimum dose to 50% and 70% of the tumor volume and percentage of the volume receiving at least 120 Gy. Treatment response was evaluated 6 mo after therapy according to the criteria of the European Association for the Study of the Liver. Results: Six-month response was evaluated in 26 treatments: 14 were considered to produce an objective response and 12 a nonresponse. Retrospective evaluation of 90Y-microsphere PET–based dosimetry showed a large interpatient variability with a median average absorbed dose of 60 Gy to the tumor. In 62% (26/42) of the cases, tumor, nontumoral liver, and lung doses would have complied with the recommended thresholds if the injected activity calculated by the BSA method had been increased. Average doses, minimum dose to 50% and 70% of the tumor volume, and percentage of the volume receiving at least 120 Gy were significantly higher in cases of objective response than in nonresponse. Conclusion: In our population, average tumor-absorbed dose and DVH metrics were associated with tumor response. However, the activity calculated by the BSA method could have been increased to reach the recommended tumor dose threshold. Tumor uptake, target and nontarget volumes, and dose distribution heterogeneity should be considered for activity planning.
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- 2018
49. Modification of bone mineral density, bone geometry and volumetric BMD in young women with obesity
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Pascal Philibert, Patrick Lefebvre, Ludovic Humbert, Pascal de Santa-Barbara, Ariane Sultan, Krishna Kunal Mahadea, Denis Mariano-Goulart, Sébastien Guillaume, Eric Renard, Antoine Avignon, Safa Aouinti, David Nocca, Vincent Boudousq, Thibault Mura, Laurent Maïmoun, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
- Subjects
Adult ,musculoskeletal diseases ,0301 basic medicine ,Histology ,Adolescent ,Physiology ,[SDV]Life Sciences [q-bio] ,Endocrinology, Diabetes and Metabolism ,Population ,030209 endocrinology & metabolism ,Young Adult ,03 medical and health sciences ,Absorptiometry, Photon ,0302 clinical medicine ,Bone Density ,medicine ,Humans ,Obesity ,education ,ComputingMilieux_MISCELLANEOUS ,Femoral neck ,Bone geometry ,Orthodontics ,Bone mineral ,education.field_of_study ,Proximal femur ,Femur Neck ,business.industry ,Infant ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,Hip bone ,Lean body mass ,Female ,business ,Osteoporotic Fractures - Abstract
Background Most obese women with low-trauma fractures present normal areal bone mineral density (aBMD), suggesting that other bone parameters are more determinant for fracture risk in these patients. Objectives (i) Determine the effects of obesity in young women on areal bone mineral density (aBMD), bone geometry, strength, and volumetric BMD determined by advanced DXA-based methods; (ii) model the profiles of bone parameters for each population with age; and (iii) determine the factors related to body composition (i.e. lean tissue mass and fat mass) potentially implicated in the “bone adaptation” in the femoral region. Subjects and methods Two hundred and twenty adolescent and young women from 18 to 35 years old were enrolled in this study: 128 patients with obesity and 92 age-matched (±6 months) normal-weight controls. aBMD was determined with DXA, whereas hip geometry and strength parameters were assessed by hip structural analysis (HSA) and volumetric BMD by 3D-SHAPER® software. Results Compared with controls, subjects with obesity presented significantly higher aBMD at all bone sites, but the difference was greater at hip compared with lumbar spine or radius. Bone size estimates (i.e. cortical thickness), as well as strength estimates (i.e. cross-sectional area) were higher at all femoral subregions including femoral neck, intertrochanteric region and femoral shaft in young women with obesity. In whole proximal femur and all femoral compartments, vBMD was also higher in subjects with obesity, but the difference between groups was greater for cortical vBMD compared with trabecular vBMD. When hip bone parameters were modelled for each group from individual values, maximal values were reached between 20 and 26 years in both groups but, whatever the age, subjects with obesity presented higher values than controls. In both groups, lean body mass (LBM) was the parameter most positively associated with the greatest number of bone parameters studied. Conclusion Our study confirmed that young women with obesity presented higher aBMD, better hip geometry and greater strength compared with normal-weight controls. Additionally, cortical and trabecular compartments measured by 3D-SHAPER® were favourably and concomitantly modified. However, it remains to be demonstrated whether the evaluation of these new parameters would provide better prediction of fracture risk in this population than aBMD.
- Published
- 2021
50. Body composition changes in the first month after sleeve gastrectomy based on gender and anatomic site
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Audrey Jaussent, Clémence Fouillade, Denis Mariano-Goulart, Patrick Lefebvre, Laurent Maïmoun, David Nocca, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Adult ,Male ,Sleeve gastrectomy ,Longitudinal study ,medicine.medical_specialty ,Adolescent ,[SDV]Life Sciences [q-bio] ,medicine.medical_treatment ,030209 endocrinology & metabolism ,Anatomic Site ,[SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery ,Body composition ,Fat mass ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Lean tissue mass ,Gastrectomy ,Weight loss ,Weight Loss ,medicine ,Humans ,Longitudinal Studies ,Prospective Studies ,030212 general & internal medicine ,ComputingMilieux_MISCELLANEOUS ,Aged ,Postoperative Care ,Bariatric surgery ,Sex Characteristics ,business.industry ,fungi ,Middle Aged ,University hospital ,Trunk ,Obesity, Morbid ,Surgery ,Adipose Tissue ,Female ,medicine.symptom ,Whole body ,business ,psychological phenomena and processes - Abstract
Background Sleeve gastrectomy (SG) induces acute weight loss, but its impact on the very early postoperative changes in body composition (BC) is less clear. Objectives This longitudinal study examined the BC changes in the first month after SG according to gender and anatomic site. Methods BC (lean tissue mass [LTM] and fat mass [FM]) were determined by dual-energy x-ray absorptiometry in 41 obese patients (33 women, 80.5%) just before SG and 1 month later. Setting University hospital of Montpellier, France. Results One month after SG, mean weight loss was –9.8±2.6 kg, with a significant decrease in LTM and FM (kg) ranging from –7.3% to 9.5%, depending on site. FM (kg) loss in men exceeded that in women at whole body, upper limbs, and trunk. FM (%) and the LTM/FM ratio decreased only in the trunk in men and the lower limbs in women, but the gender difference was only observed for the trunk. In women, age was positively correlated with relative FM variation (% and kg) in the lower limbs and negatively correlated with LTM and LTM/FM. In men, weight was negatively correlated with the relative LTM and FM (kg) variations in the upper limbs. Conclusion SG induces acute weight loss, but this loss comprises losses in both FM and LTM. Because excessive LTM loss can have deleterious consequences, preventive strategies should be implemented soon after bariatric surgery. The specific changes in BC are highlighted according to gender and anatomic site.
- Published
- 2017
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