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Introduction. One of the main objectives of prosthodontics is the rehabilitation and maintenance of oral function and health of edentulous patients, including people with disabilities such as patients with Down's syndrome. These patients usually present both systemic compromises and dental anomalies, resulting in difficult oral care and a commitment to your oral health, so in the most severe cases, the placement of a total prosthesis is essential and of utmost importance to reestablish the functions of the stomatognathic apparatus, optimize chewing capacity, comfort, preservation of the alveolar bone and improve the psychosocial condition of the patient. Objective. Restoring function and aesthetics in a Down's syndrome patient by placing an analogically produced total denture in combination with digital workflow. Clinical case. The clinical case of a female patient with Down's syndrome is presented, 46 years old, with bimaxillary loss of dental organs. A total prosthesis is made by using the analogical method for taking physiological impressions, making the registration bases, threading and characterizing the prosthesis, in combination with the digital workflow for scanning the impressions, making the working models and milling the characterized prosthesis. Conclusion. Due to the complexity that a prosthetic treatment represents in a patient with some type of disability, the combination of CAD-CAM technology and the analogous method in the elaboration of a total denture improves the prognosis and increases the success, there is a better adjustment and retention of these, they are more durable and tend to a lower accumulation of dentobacterial plaque. [ABSTRACT FROM AUTHOR]