84,383 results on '"Deshpande A"'
Search Results
2. Zanubrutinib in Treating Waldenström Macroglobulinemia, the Last Shall Be the First
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Deshpande A and Munoz J
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zanubrutinib ,waldenstrom macroglobulinemia ,bruton tyrosine kinase inhibitor ,ibrutinib ,rituximab ,efficacy ,safety ,atrial fibrillation ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Anagha Deshpande,1 Javier Munoz2 1Mayo Clinic Alix School of Medicine, Scottsdale, AZ, USA; 2Division of Hematology and Oncology, Mayo Clinic, Phoenix, AZ, USACorrespondence: Anagha Deshpande, Mayo Clinic Alix School of Medicine, 13400 E Shea Blvd, Scottsdale, AZ, 85259, USA, Tel +1 480 251-0289, Email deshpande.anagha@mayo.eduAbstract: In Waldenström macroglobulinemia (WM), a lymphoplasmacytic lymphoma characterized by monoclonal immunoglobulin M (IgM) gammopathy, aberrant Bruton tyrosine kinase (BTK) signaling has been identified as one mechanism of pathogenesis. For this reason, selective BTK inhibiting therapies have emerged as an attractive option for treatment within the therapeutic landscape also comprising chemotherapy, monoclonal antibodies, proteasome inhibitors, and B-cell lymphoma 2 (BCL2) inhibitors. The first BTK inhibiting therapy, ibrutinib, showed great efficacy in treating WM. However, response rates were dependent on whether patients had the CXCR4 mutation, a molecular aberration that may confer resistance to BTK inhibitors. Furthermore, ibrutinib’s toxicities, most notably hypertension and atrial arrhythmia, led to dose reductions or discontinuation. The toxicity profile of ibrutinib can be attributed to the inhibition of additional kinases that are structurally related to BTK. Therefore, the next-generation highly selective zanubrutinib was developed to address the concerns regarding toxicity and tolerance related to ibrutinib therapy. Based on the results of the randomized, open-label Phase 3 ASPEN (NCT03053440) trial, the Food and Drug Administration (FDA) approved zanubrutinib for treating WM. This trial directly compared zanubrutinib to ibrutinib in patients with treatment-naïve or relapsed/refractory WM, and the results showed stronger responses with zanubrutinib. More importantly, patients responded strongly to zanubrutinib therapy regardless of CXCR4 mutation status. Additionally, zanubrutinib was associated with fewer grade 3 or higher toxicities and was generally better tolerated. Another Phase 1/2 study has been conducted with just zanubrutinib in WM showcasing high efficacy with few toxicities as well. Even though zanubrutinib has been the third and last BTK inhibitor to currently penetrate the market for B-cell lymphoproliferative malignancies, we highlight the emergence of zanubrutinib as a key player in the forefront of the therapeutic landscape in WM.Keywords: zanubrutinib, Waldenström macroglobulinemia, Bruton tyrosine kinase inhibitor, ibrutinib, rituximab, efficacy, safety, atrial fibrillation
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- 2022
3. Urinary Antigen Testing for Respiratory Infections: Current Perspectives on Utility and Limitations
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Kim P, Deshpande A, and Rothberg MB
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urinary antigen test ,streptococcus pneumoniae ,legionella pneumophila ,pneumonia ,impact ,Infectious and parasitic diseases ,RC109-216 - Abstract
Priscilla Kim,1 Abhishek Deshpande,2 Michael B Rothberg2 1Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA; 2Center for Value-Based Care Research, Cleveland Clinic, Cleveland, Ohio, USACorrespondence: Michael B Rothberg, Center for Value-Based Care Research, Cleveland Clinic, 9500 Euclid Ave, Mail Code G10, Cleveland, OH, 44195, USA, Tel +1 216-445-5556, Email rothbem@ccf.orgAbstract: Pneumonia is a leading cause of hospitalization and death due to infection worldwide. Streptococcus pneumoniae and Legionella pneumophila remain among the most commonly identified bacterial pathogens. Unfortunately, more than half of all pneumonia cases today lack an etiologic diagnosis due to limitations in traditional microbiological methods like blood and sputum cultures, which are affected by poor sample collection, prior antibiotic administration, and delayed processing. Urinary antigen tests (UATs) for S. pneumoniae and L. pneumophila have emerged as powerful tools for improving the diagnosis of bacterial respiratory infections, enabling physicians to administer early directed therapy and improve antimicrobial stewardship. UATs are simple, rapid, and non-invasive diagnostic tests with high specificity (> 90%) and moderate sensitivity (< 80%). The potential impact of urinary antigen testing is especially significant for respiratory infections caused by Legionella. While all recommended community-acquired pneumonia (CAP) therapies are adequate for treating pneumococcal pneumonia, only certain antibiotics are effective against Legionella. Delayed therapy for Legionella is associated with worse clinical outcomes, which underscores the importance of rapid diagnostic methods like UATs. Despite their potential impact, current American Thoracic Society and Infectious Diseases Society of America (ATS/IDSA) guidelines argue against the routine use of urinary antigen testing for S. pneumoniae and L. pneumophila, except in patients with severe CAP and those with epidemiological risk factors for Legionella. Further research is necessary to evaluate the impact of early targeted treatment due to positive UAT results, as well as optimal strategies for UAT utilization. The purpose of this review is to summarize the UATs available for bacterial respiratory infections, describe current guidelines on their usage, and assess their impact on clinical outcomes and targeted therapy.Keywords: urinary antigen test, Streptococcus pneumoniae, Legionella pneumophila, pneumonia, impact
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- 2022
4. Child, Parent, and Play – An Insight into These Dimensions Among Children with and without Receptive Expressive Language Disorder Using Video-Based Analysis
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Mohan M, Bajaj G, Deshpande A, Anakkathil Anil M, and Bhat JS
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receptive expressive language disorder ,pre-linguistic skills ,communication stages ,play behaviors ,parental communication roles ,parent-child interaction ,Psychology ,BF1-990 ,Industrial psychology ,HF5548.7-5548.85 - Abstract
Megha Mohan,1 Gagan Bajaj,1 Apramita Deshpande,2 Malavika Anakkathil Anil,1 Jayashree S Bhat1 1Department of Audiology & Speech-Language Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India; 2Wabi Sabi Speech and Language Clinic, Vadodara, IndiaCorrespondence: Gagan BajajDepartment of Audiology & Speech-Language Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, IndiaTel +91-9886461351Email gagan.bajaj@manipal.eduPurpose: Language development in children aged 3– 6 years is shaped by their pre-linguistic abilities, communication patterns and play behaviors along with parental communicative roles. Little is known about how these aspects are distributed among children with receptive expressive language disorder (CWRELD) in comparison to typically developing children (CWTDL). The present research explores these differences between the two groups using a video-based analysis with a belief that an understanding of these aspects may facilitate age-appropriate speech and language acquisition in children with language delay.Methods: A video-based analysis of parent–child interactions was carried out for 10 children each with receptive expressive language disorder and typical language development, respectively. The two groups were compared for the child’s turn-taking skills, eye contact span, autonomous instances, communication patterns, play behaviors and parental communication roles.Results: Children with receptive expressive language disorder exhibited significantly fewer proportion of turns and autonomous instances along with a greater proportion of eye contact to objects than the parent. Majority of the children with language delay were at the “Requester” or “Early communicators” stage and demonstrated either “Exploratory” or “Functional play” behaviors. Most of the typically developing children were at the “Partner stage” of communication and exhibited “Functional”, “Constructive” or “Symbolic Play”. Parents of children with language delay mostly exhibited “Helper” type communicative roles while parents from typically developing groups showed “Partner” type communicative profile.Conclusion: A quantitative planning and monitoring of pre-linguistic skills, determination of communicative patterns and play behaviors is important for clinicians working with children having a language delay. Assessing and modifying parental communicative roles are also crucial. Understanding the distribution of these research variables among CWRELD in comparison to CWTDL may help clinicians in planning precise treatment goals, monitoring specific linguistic progress, ensuring better parental participation and delivering better outcomes during language therapy.Keywords: receptive expressive language disorder, pre-linguistic skills, communication stages, play behaviors, parental communication roles, parent–child interaction
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- 2021
5. Tuning the superconducting dome in granular aluminum thin films
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Deshpande, Aniruddha, Pusskeiler, Jan, Prange, Christian, Rogge, Uwe, Dressel, Martin, and Scheffler, Marc
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Condensed Matter - Superconductivity - Abstract
Granular aluminum, which consists of nanometer-sized aluminum grains separated by aluminum oxide, is a peculiar superconductor. Its phase diagram as function of normal-state resistivity features a superconducting dome with a maximum critical temperature Tc well above the Tc = 1.2 K of pure aluminum. Here we show how the maximum Tc of this superconducting dome grows if the substrate temperature during deposition is lowered from 300 K to cooling with liquid nitrogen (150 K and 100 K) and liquid helium (25 K). The highest Tc we observe is 3.27 K. These results highlight that granular aluminum is a model system for complex phase diagrams of superconductors and demonstrate its potential in the context of high kinetic inductance applications. This is augmented by our observation of comparably sharp superconducting transitions of high-resistivity samples grown at cryogenic temperatures and by a thickness dependence even for films substantially thicker than the grain size., Comment: 8 pages, 6 figures
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- 2024
6. Streamwise energy-transfer mechanisms in zero- and adverse-pressure-gradient turbulent boundary layers
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Deshpande, Rahul and Vinuesa, Ricardo
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Physics - Fluid Dynamics - Abstract
The present study investigates streamwise ($\overline{u^2}$) energy-transfer mechanisms in the inner and outer regions of turbulent boundary layers (TBLs). Particular focus is placed on the $\overline{u^2}$-production, its inter-component and wall-normal transport as well as dissipation, all of which become statistically significant in the outer region with increasing friction Reynolds number ($Re_{\tau}$). These properties are analyzed using published data sets of zero, weak and moderately strong adverse-pressure-gradient (APG) TBLs across a decade of $Re_{\tau}$, revealing similarity in energy-transfer pathways for all these TBLs. It is found that both the inner and outer peaks of $\overline{u^2}$ are always associated with local maxima in the $\overline{u^2}$-production and its inter-component transport, and the regions below/above each of these peaks are always dominated by wall-ward/away-from-wall transport of $\overline{u^2}$, thereby classifying the $\overline{u^2}$-profiles into four distinct regimes. This classification reveals existence of phenomenologically similar energy-transfer mechanisms in the `inner' and `outer' regions of moderately strong APG TBLs, which meet at an intermediate location coinciding with the minimum in $\overline{u^2}$ profiles. Given that the wall-ward/away-from-wall transport of $\overline{u^2}$ is governed by the $\rm Q_4$(sweeps)/$\rm Q_2$(ejections) quadrants of the Reynolds shear stress, it is argued that the emergence of the $\overline{u^2}$ outer peak corresponds with the statistical dominance of $\rm Q_4$ events in the outer region. Besides unravelling the dynamical significance of $\rm Q_2$ and $\rm Q_4$ events in the outer region of turbulent boundary layers, the present analysis also proposes new phenomenological arguments for testing on canonical wall-turbulence data at very high $Re_{\tau}$., Comment: Manuscript accepted in the Journal of Fluid Mechanics, with 22 pages and 8 figures
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- 2024
7. Measurement of inclusive jet cross section and substructure in $p$$+$$p$ collisions at $\sqrt{s_{_{NN}}}=200$ GeV
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PHENIX Collaboration, Abdulameer, N. J., Acharya, U., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Alexander, J., Alfred, M., Andrieux, V., Antsupov, S., Aoki, K., Apadula, N., Asano, H., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bai, X., Bandara, N. S., Bannier, B., Bannikov, E., Barish, K. N., Bathe, S., Baublis, V., Baumann, C., Baumgart, S., Bazilevsky, A., Beaumier, M., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Black, D., Blankenship, B., Blau, D. S., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Butsyk, S., Campbell, S., Cervantes, R., Chen, C. -H., Chen, D., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Choi, S., Christiansen, P., Chujo, T., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Corliss, R., Cronin, N., Crossette, N., Csanád, M., Csörgő, T., D'Orazio, L., Danley, T. W., Datta, A., Daugherity, M. S., David, G., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Ding, L., Dion, A., Dixit, D., Doomra, V., Do, J. H., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., En'yo, H., Engelmore, T., Enokizono, A., Esha, R., Eyser, K. O., Fadem, B., Fan, W., Feege, N., Fields, D. E., Finger, Jr., M., Finger, M., Firak, D., Fitzgerald, D., Fleuret, F., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukao, Y., Fukuda, Y., Fusayasu, T., Gainey, K., Gallus, P., Gal, C., Garg, P., Garishvili, A., Garishvili, I., Ge, H., Giordano, F., Glenn, A., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, T., Guragain, H., Gu, Y., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamilton, H. F., Hanks, J., Han, S. Y., Hasegawa, S., Haseler, T. O. S., Hashimoto, K., Hayano, R., Hemmick, T. K., Hester, T., He, X., Hill, J. C., Hill, K., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Hoshino, T., Hotvedt, N., Huang, J., Ichihara, T., Ikeda, Y., Imai, K., Imazu, Y., Inaba, M., Iordanova, A., Isenhower, D., Isinhue, A., Ivanishchev, D., Jeon, S. J., Jezghani, M., Jiang, X., Ji, Z., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kamin, J., Kanda, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapukchyan, D., Kapustinsky, J., Karthas, S., Kawall, D., Kazantsev, A. V., Key, J. A., Khachatryan, V., Khandai, P. K., Khanzadeev, A., Kijima, K. M., Kim, C., Kim, D. J., Kim, E. -J., Kim, M., Kim, Y. -J., Kim, Y. K., Kincses, D., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Kofarago, M., Komkov, B., Koster, J., Kotchetkov, D., Kotov, D., Kovacs, L., Krizek, F., Kudo, S., Kurita, K., Kurosawa, M., Kwon, Y., Lai, Y. S., Lajoie, J. G., Lebedev, A., Lee, D. M., Lee, G. H., Lee, J., Lee, K. B., Lee, K. S., Lee, S., Lee, S. H., Leitch, M. J., Leitgab, M., Leung, Y. H., Lewis, B., Lim, S. H., Liu, M. X., Li, X., Loggins, V. -R., Lokos, S., Loomis, D. A., Lovasz, K., Lynch, D., Maguire, C. F., Majoros, T., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Meles, A., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Mitsuka, G., Miyasaka, S., Mizuno, S., Mohanty, A. K., Mohapatra, S., Montuenga, P., Moon, T., Morrison, D. P., Moskowitz, M., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagae, T., Nagai, K., Nagamiya, S., Nagashima, K., Nagashima, T., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Netrakanti, P. K., Nihashi, M., Niida, T., Nouicer, R., Novitzky, N., Novák, T., Nukazuka, G., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Oide, H., Okada, K., Koop, J. D. Orjuela, Orosz, M., Osborn, J. D., Oskarsson, A., Ottino, G. J., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, I. H., Park, J. S., Park, S., Park, S. K., Patel, L., Patel, M., Pate, S. F., Peng, J. -C., Perepelitsa, D. V., Perera, G. D. N., Peressounko, D. Yu., PerezLara, C. E., Perry, J., Petti, R., Phipps, M., Pinkenburg, C., Pisani, R. P., Potekhin, M., Purschke, M. L., Qu, H., Rak, J., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Richford, D., Rinn, T., Riveli, N., Roach, D., Rolnick, S. D., Rosati, M., Rowan, Z., Ryu, M. S., Safonov, A. S., Sahlmueller, B., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Sawada, S., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seele, J., Seidl, R., Sekiguchi, Y., Seleznev, A., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shaver, A., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shioya, T., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Skolnik, M., Slunečka, M., Smith, K. L., Snowball, M., Solano, S., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Steinberg, P., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Stone, M. R., Sugitate, T., Sukhanov, A., Sumita, T., Sun, J., Sun, Z., Sziklai, J., Takahara, A., Taketani, A., Tanaka, Y., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarnai, G., Tennant, E., Tieulent, R., Timilsina, A., Todoroki, T., Tomášek, M., Torii, H., Towell, C. L., Towell, R. S., Tserruya, I., Ueda, Y., Ujvari, B., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Virius, M., Vrba, V., Vukman, N., Vznuzdaev, E., Vértesi, R., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Whitaker, S., Wolin, S., Woody, C. L., Wysocki, M., Xia, B., Xue, L., Xu, C., Xu, Q., Yalcin, S., Yamaguchi, Y. L., Yamamoto, H., Yanovich, A., Yokkaichi, S., Yoon, I., Yoo, J. H., Younus, I., You, Z., Yushmanov, I. E., Yu, H., Zajc, W. A., Zelenski, A., Zhou, S., and Zou, L.
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High Energy Physics - Experiment ,Nuclear Experiment - Abstract
The jet cross-section and jet-substructure observables in $p$$+$$p$ collisions at $\sqrt{s}=200$ GeV were measured by the PHENIX Collaboration at the Relativistic Heavy Ion Collider (RHIC). Jets are reconstructed from charged-particle tracks and electromagnetic-calorimeter clusters using the anti-$k_{t}$ algorithm with a jet radius $R=0.3$ for jets with transverse momentum within $8.0
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- 2024
8. LCDN: Providing Network Determinism with Low-Cost Switches
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Diederich, Philip, Deshpande, Yash, Becker, Laura, and Kellerer, Wolfgang
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Computer Science - Networking and Internet Architecture - Abstract
The demands on networks are increasing at a fast pace. In particular, real-time applications have very strict network requirements. However, building a network that hosts real-time applications is a cost-intensive endeavor, especially for experimental systems such as testbeds. Systems that provide guaranteed real-time networking capabilities usually work with expensive software-defined switches. In contrast, real-time networking systems based on low-cost hardware face the limitation of lower link speeds. This paper fills this gap and presents Low-Cost Deterministic Networking (LCDN), a system designed to work with inexpensive, common off-the-shelf switches and devices. LCDN works at Gigabit speed and enables powerful testbeds to host real-time applications with strict delay guarantees. This paper also provides an evaluation of the determinism of the switch and a Raspberry Pi used as an end device to demonstrate the applicability of LCDN on inexpensive low-power reduced capacity apparatus.
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- 2024
9. Multi--charged geometries with cosmological constant
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Deshpande, Rhucha and Lunin, Oleg
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High Energy Physics - Theory - Abstract
Motivated by gauged supergravities, we consider gravitational systems coupled to arbitrary numbers of fluxes and scalar fields. We show that simple ansatze for asymptotically AdS solutions in these systems fully determine the potential for the scalars, and we construct the black hole geometries which generalize the solutions known in gauged supergravities to an arbitrary number of dimensions. We also construct branes and brane intersections supported by an arbitrary number of higher--form fluxes and a correlated number of scalars., Comment: 64 pages
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- 2024
10. A Bayesian Classification Trees Approach to Treatment Effect Variation with Noncompliance
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Fisher, Jared D., Puelz, David W., and Deshpande, Sameer K.
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Statistics - Applications ,Statistics - Methodology ,Statistics - Machine Learning - Abstract
Estimating varying treatment effects in randomized trials with noncompliance is inherently challenging since variation comes from two separate sources: variation in the impact itself and variation in the compliance rate. In this setting, existing flexible machine learning methods are highly sensitive to the weak instruments problem, in which the compliance rate is (locally) close to zero. Our main methodological contribution is to present a Bayesian Causal Forest model for binary response variables in scenarios with noncompliance. By repeatedly imputing individuals' compliance types, we can flexibly estimate heterogeneous treatment effects among compliers. Simulation studies demonstrate the usefulness of our approach when compliance and treatment effects are heterogeneous. We apply the method to detect and analyze heterogeneity in the treatment effects in the Illinois Workplace Wellness Study, which not only features heterogeneous and one-sided compliance but also several binary outcomes of interest. We demonstrate the methodology on three outcomes one year after intervention. We confirm a null effect on the presence of a chronic condition, discover meaningful heterogeneity impact of the intervention on metabolic parameters though the average effect is null in classical partial effect estimates, and find substantial heterogeneity in individuals' perception of management prioritization of health and safety., Comment: 24 pages, 8 figures
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- 2024
11. Search for baryon junctions in e+A collisions at the Electron Ion Collider
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Magdy, Niseem, Deshpande, Abhay, Lacey, Roy, Li, Wenliang, Tribedy, Prithwish, and Xu, Zhangbu
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment ,Nuclear Experiment ,Nuclear Theory - Abstract
Constituent quarks in a nucleon are the essential elements in the standard ``quark model" associated with the electric charge, spin, mass, and baryon number of a nucleon. Quantum Chromodynamics (QCD) describes nucleon as a composite object containing current quarks (valence quarks and sea (anti-)quarks) and gluons. These subatomic elements and their interactions are known to contribute in complex ways to the overall nucleon spin and mass. In the early development of QCD theory in the 1970s, an alternative hypothesis postulated that the baryon number might manifest itself through a non-perturbative configuration of gluon fields forming a Y-shaped topology known as the gluon junction. In this work, we propose to test such hypothesis by measuring (i) the Regge intercept of the net-baryon distributions for $e$+($p$)Au collisions, (ii) baryon and charge transport in the isobaric ratio between $e$+Ru and $e$+Zr collisions, and (iii) target flavor dependence of proton and antiproton yields at large rapidity, transported from the hydrogen and deuterium targets in $e+p$(d) collisions. Our study indicates that these measurements at the EIC can help determine what carries the baryon number., Comment: 6 pages, 7 figures, submitted for publication
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- 2024
12. PersonaGym: Evaluating Persona Agents and LLMs
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Samuel, Vinay, Zou, Henry Peng, Zhou, Yue, Chaudhari, Shreyas, Kalyan, Ashwin, Rajpurohit, Tanmay, Deshpande, Ameet, Narasimhan, Karthik, and Murahari, Vishvak
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Persona agents, which are LLM agents that act according to an assigned persona, have demonstrated impressive contextual response capabilities across various applications. These persona agents offer significant enhancements across diverse sectors, such as education, healthcare, and entertainment, where model developers can align agent responses to different user requirements thereby broadening the scope of agent applications. However, evaluating persona agent performance is incredibly challenging due to the complexity of assessing persona adherence in free-form interactions across various environments that are relevant to each persona agent. We introduce PersonaGym, the first dynamic evaluation framework for assessing persona agents, and PersonaScore, the first automated human-aligned metric grounded in decision theory for comprehensive large-scale evaluation of persona agents. Our evaluation of 6 open and closed-source LLMs, using a benchmark encompassing 200 personas and 10,000 questions, reveals significant opportunities for advancement in persona agent capabilities across state-of-the-art models. For example, Claude 3.5 Sonnet only has a 2.97% relative improvement in PersonaScore than GPT 3.5 despite being a much more advanced model. Importantly, we find that increased model size and complexity do not necessarily imply enhanced persona agent capabilities thereby highlighting the pressing need for algorithmic and architectural invention towards faithful and performant persona agents., Comment: 21 pages, 5 figures
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- 2024
13. TwinRAN: Twinning the 5G RAN in Azure Cloud
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Deshpande, Yash, Sulkaj, Eni, and Kellerer, Wolfgang
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Computer Science - Networking and Internet Architecture - Abstract
The proliferation of 5G technology necessitates advanced network management strategies to ensure optimal performance and reliability. Digital Twins (DTs) have emerged as a promising paradigm for modeling and simulating complex systems like the 5G Radio Access Network (RAN). In this paper, we present TwinRAN, a DT of the 5G RAN built leveraging the Azure DT platform. TwinRAN is built on top of the Open RAN (O-RAN) architecture and is agnostic to the vendor of the underlying equipment. We demonstrate three applications using TwinRAN and evaluate the required resources and their performance for a network with 800 users and 8 gNBs. We first evaluate the performance and limitations of the Azure DT platform, measuring the latency under different conditions. The results from this evaluation allow us to optimize TwinRAN to the DT platform it uses. Then, we present the system's architectural design, emphasizing its components and interactions. We propose that two types of twin graphs be simultaneously maintained on the cloud. The first one is for intercell operations, keeping a broad overview of all the cells in the network. The second twin graph is where each cell is spawned in a separate Azure DT instance for more granular operation and monitoring of intracell tasks. We evaluate the performance and operating costs of TwinRAN for each of the three applications. The TwinRAN DT in the cloud can keep track of its physical twin within a few hundred milliseconds, extending its utility to many 5G network management tasks - some of which are shown in this paper. The novel framework for building and maintaining a DT of the 5G RAN presented in this paper offers network operators enhanced capabilities, empowering efficient deployments and management.
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- 2024
14. Optimal Strategies in Ranked Choice Voting
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Deshpande, Sanyukta, Garg, Nikhil, and Jacobson, Sheldon
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Computer Science - Computer Science and Game Theory - Abstract
Ranked Choice Voting (RCV) and Single Transferable Voting (STV) are widely valued; but are complex to understand due to intricate per-round vote transfers. Questions like determining how far a candidate is from winning or identifying effective election strategies are computationally challenging as minor changes in voter rankings can lead to significant ripple effects - for example, lending support to a losing candidate can prevent their votes from transferring to a more competitive opponent. We study optimal strategies - persuading voters to change their ballots or adding new voters - both algorithmically and theoretically. Algorithmically, we develop efficient methods to reduce election instances while maintaining optimization accuracy, effectively circumventing the computational complexity barrier. Theoretically, we analyze the effectiveness of strategies under both perfect and imperfect polling information. Our algorithmic approach applies to the ranked-choice polling data on the US 2024 Republican Primary, finding, for example, that several candidates would have been optimally served by boosting another candidate instead of themselves.
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- 2024
15. Robust Quantum Control via Multipath Interference for Thousandfold Phase Amplification in a Resonant Atom Interferometer
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Wang, Yiping, Glick, Jonah, Deshpande, Tejas, DeRose, Kenneth, Saraf, Sharika, Sachdeva, Natasha, Jiang, Kefeng, Chen, Zilin, and Kovachy, Tim
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Quantum Physics ,Physics - Atomic Physics - Abstract
We introduce a novel technique for enhancing the robustness of light-pulse atom interferometers against the pulse infidelities that typically limit their sensitivities. The technique uses quantum optimal control to favorably harness the multipath interference of the stray trajectories produced by imperfect atom-optics operations. We apply this method to a resonant atom interferometer and achieve thousand-fold phase amplification, representing a fifty-fold improvement over the performance observed without optimized control. Moreover, we find that spurious interference can arise from the interplay of spontaneous emission and many-pulse sequences and demonstrate optimization strategies to mitigate this effect. Given the ubiquity of spontaneous emission in quantum systems, these results may be valuable for improving the performance of a diverse array of quantum sensors. We anticipate our findings will significantly benefit the performance of matter-wave interferometers for a variety of applications, including dark matter, dark energy, and gravitational wave detection.
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- 2024
16. Gaussian process regression + deep neural network autoencoder for probabilistic surrogate modeling in nonlinear mechanics of solids
- Author
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Deshpande, Saurabh, Rappel, Hussein, Hobbs, Mark, Bordas, Stéphane P. A., and Lengiewicz, Jakub
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Computer Science - Computational Engineering, Finance, and Science - Abstract
Many real-world applications demand accurate and fast predictions, as well as reliable uncertainty estimates. However, quantifying uncertainty on high-dimensional predictions is still a severely under-invested problem, especially when input-output relationships are non-linear. To handle this problem, the present work introduces an innovative approach that combines autoencoder deep neural networks with the probabilistic regression capabilities of Gaussian processes. The autoencoder provides a low-dimensional representation of the solution space, while the Gaussian process is a Bayesian method that provides a probabilistic mapping between the low-dimensional inputs and outputs. We validate the proposed framework for its application to surrogate modeling of non-linear finite element simulations. Our findings highlight that the proposed framework is computationally efficient as well as accurate in predicting non-linear deformations of solid bodies subjected to external forces, all the while providing insightful uncertainty assessments.
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- 2024
17. Centrality dependence of L\'evy-stable two-pion Bose-Einstein correlations in $\sqrt{s_{_{NN}}}=200$ GeV Au$+$Au collisions
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PHENIX Collaboration, Abdulameer, N. J., Acharya, U., Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Ta'ani, H., Alexander, J., Angerami, A., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Aschenauer, E. C., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bannier, B., Barish, K. N., Bassalleck, B., Bathe, S., Baublis, V., Baumgart, S., Bazilevsky, A., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Blankenship, B., Blau, D. S., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Buesching, H., Bumazhnov, V., Butsyk, S., Campbell, S., Castera, P., Chen, C. -H., Chen, D., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Choi, S., Choudhury, R. K., Christiansen, P., Chujo, T., Chvala, O., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Corliss, R., Csanád, M., Csörgő, T., D'Orazio, L., Dairaku, S., Datta, A., Daugherity, M. S., David, G., Denisov, A., Deshpande, A., Desmond, E. J., Dharmawardane, K. V., Dietzsch, O., Ding, L., Dion, A., Donadelli, M., Doomra, V., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Edwards, S., Efremenko, Y. V., Engelmore, T., Enokizono, A., Esha, R., Eyser, K. O., Fadem, B., Fields, D. E., Finger, Jr., M., Finger, M., Firak, D., Fitzgerald, D., Fleuret, F., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukao, Y., Fusayasu, T., Gainey, K., Gal, C., Garishvili, A., Garishvili, I., Glenn, A., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, L., Guo, T., Gustafsson, H. -Å., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hanks, J., Hashimoto, K., Haslum, E., Hayano, R., Hemmick, T. K., Hester, T., He, X., Hill, J. C., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Ichihara, T., Iinuma, H., Ikeda, Y., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Issah, M., Ivanishchev, D., Jacak, B. V., Javani, M., Jiang, X., Ji, Z., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kamin, J., Kaneti, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Karatsu, K., Kasai, M., Kasza, G., Kawall, D., Kazantsev, A. V., Kempel, T., Khanzadeev, A., Kijima, K. M., Kim, B. I., Kim, C., Kim, D. J., Kim, E. -J., Kim, H. J., Kim, K. -B., Kim, Y. -J., Kim, Y. K., Kinney, E., Kiss, Á., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Komatsu, Y., Komkov, B., Koster, J., Kotchetkov, D., Kotov, D., Kovacs, L., Krizek, F., Král, A., Kunde, G. J., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Kyle, G. S., Lai, Y. S., Lajoie, J. G., Lebedev, A., Lee, B., Lee, D. M., Lee, J., Lee, K. B., Lee, K. S., Lee, S. H., Lee, S. R., Leitch, M. J., Leite, M. A. L., Leitgab, M., Lewis, B., Lim, S. H., Levy, L. A. Linden, Liu, M. X., Lökös, S., Loomis, D. A., Love, B., Maguire, C. F., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., Masumoto, S., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Miyachi, Y., Miyasaka, S., Mohanty, A. K., Mohapatra, S., Moon, H. J., Morrison, D. P., Motschwiller, S., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagae, T., Nagamiya, S., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Nederlof, A., Nihashi, M., Nouicer, R., Novák, T., Novitzky, N., Nukazuka, G., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Okada, K., Orosz, M., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, B. H., Park, I. H., Park, J. S., Park, S., Park, S. K., Patel, L., Pate, S. F., Pei, H., Peng, J. -C., Pereira, H., Peressounko, D. Yu., Petti, R., Pinkenburg, C., Pisani, R. P., Potekhin, M., Proissl, M., Purschke, M. L., Qu, H., Rak, J., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Richford, D., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Sahlmueller, B., Saito, N., Sakaguchi, T., Samsonov, V., Sano, M., Sarsour, M., Sawada, S., Sedgwick, K., Seidl, R., Sen, A., Seto, R., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Sukhanov, A., Sun, J., Sun, Z., Sziklai, J., Takagui, E. M., Takahara, A., Taketani, A., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tennant, E., Themann, H., Todoroki, T., Tomášek, L., Tomášek, M., Torii, H., Towell, R. S., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Ujvari, B., Vale, C., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Virius, M., Vossen, A., Vrba, V., Vznuzdaev, E., Vértesi, R., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Wei, R., White, S. N., Winter, D., Wolin, S., Woody, C. L., Wysocki, M., Xia, B., Yamaguchi, Y. L., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., Younus, I., You, Z., Yushmanov, I. E., Zajc, W. A., and Zelenski, A.
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Nuclear Experiment - Abstract
The PHENIX experiment measured the centrality dependence of two-pion Bose-Einstein correlation functions in $\sqrt{s_{_{NN}}}=200$~GeV Au$+$Au collisions at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory. The data are well represented by L\'evy-stable source distributions. The extracted source parameters are the correlation-strength parameter $\lambda$, the L\'evy index of stability $\alpha$, and the L\'evy-scale parameter $R$ as a function of transverse mass $m_T$ and centrality. The $\lambda(m_T)$ parameter is constant at larger values of $m_T$, but decreases as $m_T$ decreases. The L\'evy scale parameter $R(m_T)$ decreases with $m_T$ and exhibits proportionality to the length scale of the nuclear overlap region. The L\'evy exponent $\alpha(m_T)$ is independent of $m_T$ within uncertainties in each investigated centrality bin, but shows a clear centrality dependence. At all centralities, the L\'evy exponent $\alpha$ is significantly different from that of Gaussian ($\alpha=2$) or Cauchy ($\alpha=1$) source distributions. Comparisons to the predictions of Monte-Carlo simulations of resonance-decay chains show that in all but the most peripheral centrality class (50%-60%), the obtained results are inconsistent with the measurements, unless a significant reduction of the in-medium mass of the $\eta'$ meson is included. In each centrality class, the best value of the in-medium $\eta'$ mass is compared to the mass of the $\eta$ meson, as well as to several theoretical predictions that consider restoration of $U_A(1)$ symmetry in hot hadronic matter., Comment: 401 authors from 75 institutions, 20 pages, 15 figures, 2 tables. v1 is version submitted to Physical Review C. HEPdata tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html
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- 2024
18. Engineering morphogenesis of cell clusters with differentiable programming
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Deshpande, Ramya, Mottes, Francesco, Vlad, Ariana-Dalia, Brenner, Michael P., and Co, Alma dal
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Quantitative Biology - Cell Behavior ,Computer Science - Machine Learning - Abstract
Understanding the rules underlying organismal development is a major unsolved problem in biology. Each cell in a developing organism responds to signals in its local environment by dividing, excreting, consuming, or reorganizing, yet how these individual actions coordinate over a macroscopic number of cells to grow complex structures with exquisite functionality is unknown. Here we use recent advances in automatic differentiation to discover local interaction rules and genetic networks that yield emergent, systems-level characteristics in a model of development. We consider a growing tissue with cellular interactions are mediated by morphogen diffusion, differential cell adhesion and mechanical stress. Each cell has an internal genetic network that it uses to make decisions based on its local environment. We show that one can simultaneously learn parameters governing the cell interactions and the genetic network for complex developmental scenarios, including the symmetry breaking of an embryo from an initial cell, the creation of emergent chemical gradients,homogenization of growth via mechanical stress, programmed growth into a prespecified shape, and the ability to repair from damage. When combined with recent experimental advances measuring spatio-temporal dynamics and gene expression of cells in a growing tissue, the methodology outlined here offers a promising path to unravelling the cellular basis of development., Comment: 8 pages, 6 figures
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- 2024
19. Are Large Language Models Consistent over Value-laden Questions?
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Moore, Jared, Deshpande, Tanvi, and Yang, Diyi
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
Large language models (LLMs) appear to bias their survey answers toward certain values. Nonetheless, some argue that LLMs are too inconsistent to simulate particular values. Are they? To answer, we first define value consistency as the similarity of answers across (1) paraphrases of one question, (2) related questions under one topic, (3) multiple-choice and open-ended use-cases of one question, and (4) multilingual translations of a question to English, Chinese, German, and Japanese. We apply these measures to a few large ($>=34b$), open LLMs including llama-3, as well as gpt-4o, using eight thousand questions spanning more than 300 topics. Unlike prior work, we find that models are relatively consistent across paraphrases, use-cases, translations, and within a topic. Still, some inconsistencies remain. Models are more consistent on uncontroversial topics (e.g., in the U.S., "Thanksgiving") than on controversial ones ("euthanasia"). Base models are both more consistent compared to fine-tuned models and are uniform in their consistency across topics, while fine-tuned models are more inconsistent about some topics ("euthanasia") than others ("women's rights") like our human subjects (n=165)., Comment: 8 pages, 9 figures
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- 2024
20. Investigations into the Mould Variability of Process Parameters in Green Sand Moulds for Mould Characterization in the Casting Process
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Pandit Harshwardhan and Deshpande Anand
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green sand moulding ,time temperature dependencies ,casting defect ,process parameters ,Environmental sciences ,GE1-350 - Abstract
In this study, the time-temperature behaviour of selected process parameters is established. The paper describes a new approach to understanding the defect generation phenomena in castings by considering the uniqueness of individual green sand moulds. It also explains the changing values of process parameters by experimental investigation. Foundry is the science of experiments. The aim is to achieve the right quality, quantity, and cost with minimum rejections. The casting quality results from several interconnected, dynamic, and complicated processes that are part of a foundry operation. Quality castings are produced by exercising proper control over several process parameters involved in the casting process. Despite taking several control measures regarding proper casting design, methoding and processing, casting defects are still observed. Defect reduction continues to be the primary goal in sand casting foundries due to the same. This paper investigates the essential parameters of the Green Sand casting process for understanding the influence over the generation of the casting defect in green sand moulding grey cast iron components. This study also adopts the time series method of recording the process parameters and finding the values of process parameter sets for individual moulds. The results showed a systematic predictive behaviour of the selected process parameters. By recording the process parameters under given conditions, it is found that they are time and temperature-dependent. Values can be obtained by building regression equations. It has been found that values of per cent moisture and green compressive strength reduce, whereas permeability and mould hardness increase.
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- 2023
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21. Saltwater intrusion and human health risks for coastal populations under 2050 climate scenarios.
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Mueller, William, Zamrsky, Daniel, Essink, Gualbert, Fleming, Lora, Deshpande, Aniruddha, Makris, Konstantinos, Wheeler, Benedict, Newton, John, Narayan, K, Naser, Abu, and Gribble, Matthew
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Climate change ,Low- and middle-income countries ,Salinity ,Sea level rise ,Humans ,Climate Change ,Drinking Water ,Groundwater ,Water Supply ,Hypertension - Abstract
Populations consuming saline drinking water are at greater risk of high blood pressure and potentially other adverse health outcomes. We modelled data and used available datasets to identify countries of higher vulnerability to future saltwater intrusion associated with climate change in 2050 under Representative Concentration Pathways (RCP)4.5 and RCP8.5. We developed three vulnerability criteria to capture geographies with: (1) any coastal areas with projected inland saltwater intrusion of ≥ 1 km inland, (2) > 50% of the population in coastal secondary administrative areas with reliance on groundwater for drinking water, and 3) high national average sodium urinary excretion (i.e., > 3 g/day). We identified 41 nations across all continents (except Antarctica) with ≥ 1 km of inland saltwater intrusion by 2050. Seven low- and middle-income countries of higher vulnerability were all concentrated in South/Southeast Asia. Based on these initial findings, future research should study geological nuances at the local level in higher-risk areas and co-produce with local communities contextually appropriate solutions to secure equitable access to clean drinking water.
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- 2024
22. Extant and extinct bilby genomes combined with Indigenous knowledge improve conservation of a unique Australian marsupial.
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Hogg, Carolyn, Edwards, Richard, Farquharson, Katherine, Silver, Luke, Brandies, Parice, Peel, Emma, Escalona, Merly, Jaya, Frederick, Thavornkanlapachai, Rujiporn, Batley, Kimberley, Bradford, Tessa, Chang, J, Chen, Zhiliang, Deshpande, Nandan, Dziminski, Martin, Ewart, Kyle, Griffith, Oliver, Marin Gual, Laia, Moon, Katherine, Travouillon, Kenny, Waters, Paul, Whittington, Camilla, Wilkins, Marc, Helgen, Kristofer, Lo, Nathan, Ho, Simon, Ruiz Herrera, Aurora, Paltridge, Rachel, Marshall Graves, Jennifer, Renfree, Marilyn, Shapiro, Beth, Ottewell, Kym, and Belov, Katherine
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Animals ,Conservation of Natural Resources ,Marsupialia ,Genome ,Australia ,Polymorphism ,Single Nucleotide ,Extinction ,Biological - Abstract
Ninu (greater bilby, Macrotis lagotis) are desert-dwelling, culturally and ecologically important marsupials. In collaboration with Indigenous rangers and conservation managers, we generated the Ninu chromosome-level genome assembly (3.66 Gbp) and genome sequences for the extinct Yallara (lesser bilby, Macrotis leucura). We developed and tested a scat single-nucleotide polymorphism panel to inform current and future conservation actions, undertake ecological assessments and improve our understanding of Ninu genetic diversity in managed and wild populations. We also assessed the beneficial impact of translocations in the metapopulation (N = 363 Ninu). Resequenced genomes (temperate Ninu, 6; semi-arid Ninu, 6; and Yallara, 4) revealed two major population crashes during global cooling events for both species and differences in Ninu genes involved in anatomical and metabolic pathways. Despite their 45-year captive history, Ninu have fewer long runs of homozygosity than other larger mammals, which may be attributable to their boom-bust life history. Here we investigated the unique Ninu biology using 12 tissue transcriptomes revealing expression of all 115 conserved eutherian chorioallantoic placentation genes in the uterus, an XY1Y2 sex chromosome system and olfactory receptor gene expansions. Together, we demonstrate the holistic value of genomics in improving key conservation actions, understanding unique biological traits and developing tools for Indigenous rangers to monitor remote wild populations.
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- 2024
23. The present and future of QCD
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Achenbach, P, Adhikari, D, Afanasev, A, Afzal, F, Aidala, CA, Al-bataineh, A, Almaalol, DK, Amaryan, M, Androić, D, Armstrong, WR, Arratia, M, Arrington, J, Asaturyan, A, Aschenauer, EC, Atac, H, Avakian, H, Averett, T, Gayoso, C Ayerbe, Bai, X, Barish, KN, Barnea, N, Basar, G, Battaglieri, M, Baty, AA, Bautista, I, Bazilevsky, A, Beattie, C, Behera, SC, Bellini, V, Bellwied, R, Benesch, JF, Benmokhtar, F, Bernardes, CA, Bernauer, JC, Bhatt, H, Bhatta, S, Boer, M, Boettcher, TJ, Bogacz, SA, Bossi, HJ, Brandenburg, JD, Brash, EJ, Briceño, RA, Briscoe, WJ, Brodsky, SJ, Brown, DA, Burkert, VD, Caines, H, Cali, IA, Camsonne, A, Carman, DS, Caylor, J, Cerci, DS, Cerci, S, Llatas, M Chamizo, Chatterjee, S, Chen, JP, Chen, Y, Chen, Y-C, Chien, Y-T, Chou, P-C, Chu, X, Chudakov, E, Cline, E, Cloët, IC, Cole, PL, Connors, ME, Constantinou, M, Cosyn, W, Dusa, S Covrig, Cruz-Torres, R, D'Alesio, U, da Silva, C, Davoudi, Z, Dean, CT, Dean, DJ, Demarteau, M, Deshpande, A, Detmold, W, Deur, A, Devkota, BR, Dhital, S, Diefenthaler, M, Dobbs, S, Döring, M, Dong, X, Dotel, R, Dow, KA, Downie, EJ, Drachenberg, JL, Dumitru, A, Dunlop, JC, Dupre, R, Durham, JM, Dutta, D, Edwards, RG, Ehlers, RJ, Fassi, L El, Elaasar, M, and Elouadrhiri, L
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Nuclear and Plasma Physics ,Physical Sciences ,Astronomical and Space Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Quantum Physics ,Nuclear & Particles Physics ,Astronomical sciences ,Nuclear and plasma physics ,Particle and high energy physics - Abstract
This White Paper presents an overview of the current status and future perspective of QCD research, based on the community inputs and scientific conclusions from the 2022 Hot and Cold QCD Town Meeting. We present the progress made in the last decade toward a deep understanding of both the fundamental structure of the sub-atomic matter of nucleon and nucleus in cold QCD, and the hot QCD matter in heavy ion collisions. We identify key questions of QCD research and plausible paths to obtaining answers to those questions in the near future, hence defining priorities of our research over the coming decades.
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- 2024
24. RAVEN: Multitask Retrieval Augmented Vision-Language Learning
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Rao, Varun Nagaraj, Choudhary, Siddharth, Deshpande, Aditya, Satzoda, Ravi Kumar, and Appalaraju, Srikar
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Information Retrieval - Abstract
The scaling of large language models to encode all the world's knowledge in model parameters is unsustainable and has exacerbated resource barriers. Retrieval-Augmented Generation (RAG) presents a potential solution, yet its application to vision-language models (VLMs) is under explored. Existing methods focus on models designed for single tasks. Furthermore, they're limited by the need for resource intensive pre training, additional parameter requirements, unaddressed modality prioritization and lack of clear benefit over non-retrieval baselines. This paper introduces RAVEN, a multitask retrieval augmented VLM framework that enhances base VLMs through efficient, task specific fine-tuning. By integrating retrieval augmented samples without the need for additional retrieval-specific parameters, we show that the model acquires retrieval properties that are effective across multiple tasks. Our results and extensive ablations across retrieved modalities for the image captioning and VQA tasks indicate significant performance improvements compared to non retrieved baselines +1 CIDEr on MSCOCO, +4 CIDEr on NoCaps and nearly a +3\% accuracy on specific VQA question types. This underscores the efficacy of applying RAG approaches to VLMs, marking a stride toward more efficient and accessible multimodal learning.
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- 2024
25. Active and inactive contributions to the wall pressure and wall-shear stress in turbulent boundary layers
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Deshpande, Rahul, Vinuesa, Ricardo, Klewicki, Joseph, and Marusic, Ivan
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Physics - Fluid Dynamics - Abstract
A phenomenological description is presented to explain the intermediate and low-frequency/large-scale contributions to the wall-shear-stress (${\tau}_w$) and wall-pressure (${p}_w$) spectra of canonical turbulent boundary layers, which are well known to increase with Reynolds number. The explanation is based on the concept of active and inactive motions (Townsend, J. Fluid Mech., vol. 11, 1961) associated with the attached-eddy hypothesis. Unique data sets of simultaneously acquired ${\tau}_w$, ${p}_w$ and velocity fluctuation time series in the log region are considered, across friction-Reynolds-number ($Re_{\tau}$) range of $\mathcal{O}$($10^3$) $\lesssim$ $Re_{\tau}$ $\lesssim$ $\mathcal{O}$($10^6$). A recently proposed energy-decomposition methodology (Deshpande et al., J. Fluid Mech., vol. 914, 2021) is implemented to reveal the active and inactive contributions to the ${\tau}_w$- and $p_w$-spectra. Empirical evidence is provided in support of Bradshaw's (J. Fluid Mech., vol. 30, 1967) hypothesis that the inactive motions are responsible for the non-local wall-ward transport of the large-scale inertia-dominated energy, which is produced in the log region by active motions. This explains the large-scale signatures in the ${\tau}_w$-spectrum, which grow with $Re_{\tau}$ despite the statistically weak signature of large-scale turbulence production, in the near-wall region. For wall pressure, active and inactive motions respectively contribute to the intermediate and large scales of the $p_w$-spectrum. Both these contributions are found to increase with increasing $Re_{\tau}$ owing to the broadening and energization of the wall-scaled (attached) eddy hierarchy. This potentially explains the rapid $Re_{\tau}$-growth of the $p_w$-spectra relative to ${\tau}_w$, given the dependence of the latter only on the inactive contributions., Comment: Preprint submitted for review to the Journal of Fluid Mechanics, with 18 pages and 7 figures
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- 2024
26. Graph Representation Learning Strategies for Omics Data: A Case Study on Parkinson's Disease
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de Lope, Elisa Gómez, Deshpande, Saurabh, Torné, Ramón Viñas, Liò, Pietro, Glaab, Enrico, and Bordas, Stéphane P. A.
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computational Engineering, Finance, and Science ,Quantitative Biology - Biomolecules ,Quantitative Biology - Molecular Networks - Abstract
Omics data analysis is crucial for studying complex diseases, but its high dimensionality and heterogeneity challenge classical statistical and machine learning methods. Graph neural networks have emerged as promising alternatives, yet the optimal strategies for their design and optimization in real-world biomedical challenges remain unclear. This study evaluates various graph representation learning models for case-control classification using high-throughput biological data from Parkinson's disease and control samples. We compare topologies derived from sample similarity networks and molecular interaction networks, including protein-protein and metabolite-metabolite interactions (PPI, MMI). Graph Convolutional Network (GCNs), Chebyshev spectral graph convolution (ChebyNet), and Graph Attention Network (GAT), are evaluated alongside advanced architectures like graph transformers, the graph U-net, and simpler models like multilayer perceptron (MLP). These models are systematically applied to transcriptomics and metabolomics data independently. Our comparative analysis highlights the benefits and limitations of various architectures in extracting patterns from omics data, paving the way for more accurate and interpretable models in biomedical research., Comment: Submitted to Machine Learning in Computational Biology 2024 as an extended abstract, 2 pages + 1 appendix
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- 2024
27. GNOME: Generating Negotiations through Open-Domain Mapping of Exchanges
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Deshpande, Darshan, Sinha, Shambhavi, Kumar, Anirudh Ravi, Pal, Debaditya, and May, Jonathan
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Computer Science - Computation and Language - Abstract
Language Models have previously shown strong negotiation capabilities in closed domains where the negotiation strategy prediction scope is constrained to a specific setup. In this paper, we first show that these models are not generalizable beyond their original training domain despite their wide-scale pretraining. Following this, we propose an automated framework called GNOME, which processes existing human-annotated, closed-domain datasets using Large Language Models and produces synthetic open-domain dialogues for negotiation. GNOME improves the generalizability of negotiation systems while reducing the expensive and subjective task of manual data curation. Through our experimental setup, we create a benchmark comparing encoder and decoder models trained on existing datasets against datasets created through GNOME. Our results show that models trained on our dataset not only perform better than previous state of the art models on domain specific strategy prediction, but also generalize better to previously unseen domains.
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- 2024
28. Jet modification via $\pi^0$-hadron correlations in Au$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV
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PHENIX Collaboration, Abdulameer, N. J., Acharya, U., Adare, A., Afanasiev, S., Aidala, C., Ajitanand, N. N., Akiba, Y., Al-Bataineh, H., Alexander, J., Alfred, M., Aoki, K., Apadula, N., Aphecetche, L., Asai, J., Asano, H., Atomssa, E. T., Averbeck, R., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Baksay, G., Baksay, L., Baldisseri, A., Bandara, N. S., Bannier, B., Barish, K. N., Barnes, P. D., Bassalleck, B., Basye, A. T., Bathe, S., Batsouli, S., Baublis, V., Baumann, C., Bazilevsky, A., Beaumier, M., Beckman, S., Belikov, S., Belmont, R., Bennett, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Bickley, A. A., Blankenship, B., Blau, D. S., Boissevain, J. G., Bok, J. S., Borel, H., Borisov, V., Boyle, K., Brooks, M. L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Bunce, G., Butsyk, S., Camacho, C. M., Campbell, S., Chang, B. S., Chang, W. C., Charvet, J. L., Chen, C. -H., Chen, D., Chernichenko, S., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Choudhury, R. K., Chujo, T., Chung, P., Churyn, A., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Constantin, P., Corliss, R., Csanád, M., Csörgő, T., d'Enterria, D., Dahms, T., Dairaku, S., Danley, T. W., Das, K., Datta, A., Daugherity, M. S., David, G., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Dietzsch, O., Dion, A., Diss, P. B., Donadelli, M., Doomra, V., Do, J. H., Drapier, O., Drees, A., Drees, K. A., Dubey, A. K., Durham, J. M., Durum, A., Dutta, D., Dzhordzhadze, V., Efremenko, Y. V., Ellinghaus, F., En'yo, H., Engelmore, T., Enokizono, A., Esha, R., Eyser, K. O., Fadem, B., Feege, N., Fields, D. E., Finger, Jr., M., Finger, M., Firak, D., Fitzgerald, D., Fleuret, F., Fokin, S. L., Fraenkel, Z., Frantz, J. E., Franz, A., Frawley, A. D., Fujiwara, K., Fukao, Y., Fusayasu, T., Gallus, P., Gal, C., Garg, P., Garishvili, I., Ge, H., Giordano, F., Glenn, A., Gong, H., Gonin, M., Gosset, J., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, T., Gustafsson, H. -Å., Hachiya, T., Henni, A. Hadj, Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamilton, H. F., Hanks, J., Han, R., Han, S. Y., Hartouni, E. P., Haruna, K., Hasegawa, S., Haseler, T. O. S., Hashimoto, K., Haslum, E., Hayano, R., Heffner, M., Hemmick, T. K., Hester, T., He, X., Hill, J. C., Hodges, A., Hohlmann, M., Hollis, R. S., Holzmann, W., Homma, K., Hong, B., Horaguchi, T., Hornback, D., Hoshino, T., Hotvedt, N., Huang, J., Ichihara, T., Ichimiya, R., Iinuma, H., Ikeda, Y., Imai, K., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Ishihara, M., Isobe, T., Issah, M., Isupov, A., Ivanishchev, D., Jacak, B. V., Jezghani, M., Jiang, X., Jin, J., Ji, Z., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kajihara, F., Kametani, S., Kamihara, N., Kamin, J., Kanda, S., Kang, J. H., Kapustinsky, J., Kawall, D., Kazantsev, A. V., Kempel, T., Key, J. A., Khachatryan, V., Khanzadeev, A., Kijima, K. M., Kikuchi, J., Kimelman, B., Kim, B. I., Kim, C., Kim, D. H., Kim, D. J., Kim, E., Kim, E. -J., Kim, G. W., Kim, M., Kim, S. H., Kinney, E., Kiriluk, K., Kiss, Á., Kistenev, E., Kitamura, R., Klatsky, J., Klay, J., Klein-Boesing, C., Kleinjan, D., Kline, P., Koblesky, T., Kochenda, L., Komkov, B., Konno, M., Koster, J., Kotov, D., Kovacs, L., Kozlov, A., Kravitz, A., Král, A., Kunde, G. J., Kurgyis, B., Kurita, K., Kurosawa, M., Kweon, M. J., Kwon, Y., Kyle, G. S., Lai, Y. S., Lajoie, J. G., Layton, D., Lebedev, A., Lee, D. M., Lee, K. B., Lee, S., Lee, S. H., Lee, T., Leitch, M. J., Leite, M. A. L., Lenzi, B., Liebing, P., Lim, S. H., Litvinenko, A., Liu, H., Liu, M. X., Liška, T., Li, X., Lokos, S., Loomis, D. A., Love, B., Lynch, D., Maguire, C. F., Makdisi, Y. I., Makek, M., Malakhov, A., Malik, M. D., Manion, A., Manko, V. I., Mannel, E., Mao, Y., Masui, H., Matathias, F., Mašek, L., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Means, N., Meles, A., Mendoza, M., Meredith, B., Miake, Y., Mignerey, A. C., Mikeš, P., Miki, K., Milov, A., Mishra, D. K., Mishra, M., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Miyasaka, S., Mizuno, S., Mohanty, A. K., Montuenga, P., Moon, T., Morino, Y., Morreale, A., Morrison, D. P., Moukhanova, T. V., Mukhopadhyay, D., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagamiya, S., Nagashima, K., Nagle, J. L., Naglis, M., Nagy, M. I., Nakagawa, I., Nakagomi, H., Nakamiya, Y., Nakamura, T., Nakano, K., Nattrass, C., Netrakanti, P. K., Newby, J., Nguyen, M., Niida, T., Nishimura, S., Nouicer, R., Novitzky, N., Novák, T., Nukazuka, G., Nyanin, A. S., O'Brien, E., Oda, S. X., Ogilvie, C. A., Okada, K., Oka, M., Onuki, Y., Koop, J. D. Orjuela, Orosz, M., Osborn, J. D., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Palounek, A. P. T., Pantuev, V., Papavassiliou, V., Park, J., Park, J. S., Park, S., Park, W. J., Patel, M., Pate, S. F., Pei, H., Peng, J. -C., Pereira, H., Perepelitsa, D. V., Perera, G. D. N., Peresedov, V., Peressounko, D. Yu., Perry, J., Petti, R., Pinkenburg, C., Pinson, R., Pisani, R. P., Potekhin, M., Purschke, M. L., Purwar, A. K., Qu, H., Rakotozafindrabe, A., Rak, J., Ramson, B. J., Ravinovich, I., Read, K. F., Rembeczki, S., Reygers, K., Reynolds, D., Riabov, V., Riabov, Y., Richford, D., Rinn, T., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Rosendahl, S. S. E., Rosnet, P., Rowan, Z., Rubin, J. G., Rukoyatkin, P., Ružička, P., Rykov, V. L., Sahlmueller, B., Saito, N., Sakaguchi, T., Sakai, S., Sakashita, K., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Sato, T., Sawada, S., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seele, J., Seidl, R., Semenov, A. Yu., Semenov, V., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Silvestre, C., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Snowball, M., Soldatov, A., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Staley, F., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Suire, C., Sukhanov, A., Sumita, T., Sun, J., Sun, Z., Sziklai, J., Takagui, E. M., Taketani, A., Tanabe, R., Tanaka, Y., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarján, P., Themann, H., Thomas, T. L., Tieulent, R., Timilsina, A., Todoroki, T., Togawa, M., Toia, A., Tomita, Y., Tomášek, L., Tomášek, M., Torii, H., Towell, C. L., Towell, R., Towell, R. S., Tram, V-N., Tserruya, I., Tsuchimoto, Y., Ujvari, B., Vale, C., Valle, H., van Hecke, H. W., Veicht, A., Velkovska, J., Vinogradov, A. A., Virius, M., Vrba, V., Vznuzdaev, E., Vértesi, R., Wang, X. R., Watanabe, Y., Watanabe, Y. S., Wei, F., Wessels, J., White, A. S., White, S. N., Winter, D., Woody, C. L., Wysocki, M., Xia, B., Xie, W., Xue, L., Yalcin, S., Yamaguchi, Y. L., Yamaura, K., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., Yoon, I., Yoo, J. H., Young, G. R., Younus, I., Yushmanov, I. E., Yu, H., Zajc, W. A., Zaudtke, O., Zelenski, A., Zhang, C., Zhou, S., Zolin, L., and Zou, L.
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Nuclear Experiment - Abstract
High-momentum two-particle correlations are a useful tool for studying jet-quenching effects in the quark-gluon plasma. Angular correlations between neutral-pion triggers and charged hadrons with transverse momenta in the range 4--12~GeV/$c$ and 0.5--7~GeV/$c$, respectively, have been measured by the PHENIX experiment in 2014 for Au$+$Au collisions at $\sqrt{s_{_{NN}}}=200$~GeV. Suppression is observed in the yield of high-momentum jet fragments opposite the trigger particle, which indicates jet suppression stemming from in-medium partonic energy loss, while enhancement is observed for low-momentum particles. The ratio and differences between the yield in Au$+$Au collisions and $p$$+$$p$ collisions, $I_{AA}$ and $\Delta_{AA}$, as a function of the trigger-hadron azimuthal separation, $\Delta\phi$, are measured for the first time at the Relativistic Heavy Ion Collider. These results better quantify how the yield of low-$p_T$ associated hadrons is enhanced at wide angle, which is crucial for studying energy loss as well as medium-response effects., Comment: 534 authors from 83 institutions, 12 pages, 7 figures. v1 is version submitted to Physical Review C. HEPdata tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html
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- 2024
29. High precision measurements of alpha_s at the future EIC
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Kutz, T., Pybus, J. R., Upton, D. W., Cotton, C., Deshpande, A., Deur, A., Li, W. B., Nguyen, D., Nycz, M., and Zhen, X.
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Nuclear Theory ,Nuclear Experiment - Abstract
We present a projection study for the first moments of the inclusive spin structure function for the proton and neutron from simulated doubly-polarized e+p and e+3He collision data expected from the Electron-Ion collider. For detection and extraction of the neutron spin asymmetries from e+3He collisions, we used the double-tagging method which significantly reduces the uncertainty over the traditional inclusive method. Using the Bjorken sum rule, the projected results allow us to determine that the QCD coupling at the Z-pole alpha_s can be measured with a relative precision of 1.3%. This underscores the significance of the EIC for achieving precision determinations of alpha_s.
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- 2024
30. On the Power of Randomization in Fair Classification and Representation
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Agarwal, Sushant and Deshpande, Amit
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Computer Science - Machine Learning - Abstract
Fair classification and fair representation learning are two important problems in supervised and unsupervised fair machine learning, respectively. Fair classification asks for a classifier that maximizes accuracy on a given data distribution subject to fairness constraints. Fair representation maps a given data distribution over the original feature space to a distribution over a new representation space such that all classifiers over the representation satisfy fairness. In this paper, we examine the power of randomization in both these problems to minimize the loss of accuracy that results when we impose fairness constraints. Previous work on fair classification has characterized the optimal fair classifiers on a given data distribution that maximize accuracy subject to fairness constraints, e.g., Demographic Parity (DP), Equal Opportunity (EO), and Predictive Equality (PE). We refine these characterizations to demonstrate when the optimal randomized fair classifiers can surpass their deterministic counterparts in accuracy. We also show how the optimal randomized fair classifier that we characterize can be obtained as a solution to a convex optimization problem. Recent work has provided techniques to construct fair representations for a given data distribution such that any classifier over this representation satisfies DP. However, the classifiers on these fair representations either come with no or weak accuracy guarantees when compared to the optimal fair classifier on the original data distribution. Extending our ideas for randomized fair classification, we improve on these works, and construct DP-fair, EO-fair, and PE-fair representations that have provably optimal accuracy and suffer no accuracy loss compared to the optimal DP-fair, EO-fair, and PE-fair classifiers respectively on the original data distribution., Comment: Appeared in ACM FAccT 2022
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- 2024
31. Optimization of a Welding Procedure for Making Critical Aluminum Welds on the LBNF Absorber Core Block
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Anderson, K. E., Deshpande, A., Sidorov, V. I., and Zahurones, J.
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Physics - Accelerator Physics - Abstract
The LBNF Absorber consists of thirteen 6061-T6 aluminum core blocks. The core blocks are water cooled with de-ionized (DI) water which becomes radioactive during beam operations. The cooling water flows through gun-drilled channels in the core blocks. A weld quality optimization was performed to produce National Aeronautical Standard 1514 Class I quality welds on the aluminum core blocks. This was not successful in all cases. An existing Gas Tungsten Arc Welding Procedure Specification was fine tuned to minimize, in most cases, and eliminate detect-able tungsten inclusions in the welds. All the weld coupons, however passed welding inspection as per the piping code: ASME B31.3 Normal Fluid Service. Tungsten electrode diameter, type, and manufacturer were varied. Some of the samples were pre-heated and others were not. It was observed that larger diameter electrodes, 5/32 in., with pre-heated joints resulted in welds with the least number of tungsten inclusions. It is hypothesized that thinner electrodes breakdown easily and get lodged into the weld pool during the welding process. This breakdown is further enhanced by the large temperature differential between the un-preheated sample and the hot electrode., Comment: IPAC'24 - 15th International Particle Accelerator Conference
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- 2024
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32. Pressure Spike in The LBNF Absorber Core s Gun Drilled Cooling Channel from an Accident Beam Pulse
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Deshpande, A., Hurh, P., Hylen, J., Lee, A., Lewis, J., Rakhno, I., Sidorov, V. I., Tang, Z., and Tropin, S. Tariq I.
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Physics - Accelerator Physics - Abstract
The LBNF Absorber consists of thirteen 6061-T6 aluminum core blocks. The core blocks are water cooled with de-ionized (DI) water which becomes radioactive during beam operations. The cooling water flows through gun-drilled channels in the core blocks. The cooling water is supplied by the LBNF Absorber Radioactive Water (RAW) cooling system which is designed as per ASME B31.3 Normal Fluid Service [1]. An uninhibited beam accident pulse striking the water channels was identified as a credible accident scenario. In this study, it is assumed that the beam pulse hits the Absorber directly without interacting with any of the other upstream beamline components. The beam parameters used for the LBNF beam are 120 GeV, 2.4 MW with a 1.2 s cycle time. The accident pulse lasts for 10 {\mu}s. The maximum energy is deposited in the 3rd aluminum core block. For the sake of simplicity, it is assumed that the accident pulse strikes the 1 in. ID water channel directly. The analysis here simulates the pressure rise in the water during and after the beam pulse and its effects on the aluminum piping components that deliver water to the core blocks. The weld strengths as determined by the Load and Resistance Factor Design (LRDF) and the Allowable Strength Design (ASD) are compared to the forces generated in the weld owing to the pressure spike. A transient structural analysis was used to determine the equivalent membrane, peak, and bending stresses and they were com-pared to allowable limits., Comment: IPAC'24 - 15th International Particle Accelerator Conference
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- 2024
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33. Data Efficient Behavior Cloning for Fine Manipulation via Continuity-based Corrective Labels
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Deshpande, Abhay, Ke, Liyiming, Pfeifer, Quinn, Gupta, Abhishek, and Srinivasa, Siddhartha S.
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Computer Science - Robotics - Abstract
We consider imitation learning with access only to expert demonstrations, whose real-world application is often limited by covariate shift due to compounding errors during execution. We investigate the effectiveness of the Continuity-based Corrective Labels for Imitation Learning (CCIL) framework in mitigating this issue for real-world fine manipulation tasks. CCIL generates corrective labels by learning a locally continuous dynamics model from demonstrations to guide the agent back toward expert states. Through extensive experiments on peg insertion and fine grasping, we provide the first empirical validation that CCIL can significantly improve imitation learning performance despite discontinuities present in contact-rich manipulation. We find that: (1) real-world manipulation exhibits sufficient local smoothness to apply CCIL, (2) generated corrective labels are most beneficial in low-data regimes, and (3) label filtering based on estimated dynamics model error enables performance gains. To effectively apply CCIL to robotic domains, we offer a practical instantiation of the framework and insights into design choices and hyperparameter selection. Our work demonstrates CCIL's practicality for alleviating compounding errors in imitation learning on physical robots.
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- 2024
34. 'Golden Ratio Yoshimura' for Meta-Stable and Massively Reconfigurable Deployment
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Deshpande, Vishrut, Phalak, Yogesh, Zhou, Ziyang, Walker, Ian, and Li, Suyi
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Computer Science - Robotics ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Yoshimura origami is a classical folding pattern that has inspired many deployable structure designs. Its applications span from space exploration, kinetic architectures, and soft robots to even everyday household items. However, despite its wide usage, Yoshimura has been fixated on a set of design constraints to ensure its flat-foldability. Through extensive kinematic analysis and prototype tests, this study presents a new Yoshimura that intentionally defies these constraints. Remarkably, one can impart a unique meta-stability by using the Golden Ratio angle to define the triangular facets of a generalized Yoshimura. As a result, when its facets are strategically popped out, a ``Golden Ratio Yoshimura'' boom with $m$ modules can be theoretically reconfigured into $8^m$ geometrically unique and load-bearing shapes. This result not only challenges the existing design norms but also opens up a new avenue to create deployable and versatile structural systems.
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- 2024
35. Probing the Relationship between Defects and Enhanced Mobility in MoS2 Monolayers Grown by Mo Foil
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Majumder, Sudipta, Walve, Vaibhav, Chand, Rahul, A., Gokul M., Hwang, Sooyeon, Kumar, G. V. Pavan, Deshpande, Aparna, and Rahman, Atikur
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Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science - Abstract
Atomic vacancies, such as chalcogen vacancies in 2D TMDs, are important in changing the host material's electronic structure and transport properties. We present a straightforward one-step method for growing monolayer MoS2 utilizing oxidized Molybdenum (Mo) foil using CVD and delve into the transport properties of as-grown samples. Devices fabricated from these MoS2 sheets exhibit excellent electrical responses, with the standout device achieving mobility exceeding 100 cm2V-1s-1. Structural analysis and optical signatures unveiled the presence of chalcogen defects within these samples. To decipher the influence of inherent defects on the electronic transport properties, we measured low-temperature transport on two distinct sets of devices exhibiting relatively high or low mobilities. Combining the thermally activated transport model with quantum capacitance calculations, we have shown the existence of shallow states near the conduction band, likely attributed to sulfur vacancies within MoS2. These vacancies are responsible for the hopping conduction of electrons in the device channel. Furthermore, our claims were substantiated through low-temperature scanning tunnelling microscopy measurements, which revealed an abundance of isolated and lateral double sulfur vacancies in Mo foil-grown samples. We found that these vacancies increase the density of states near the conduction band, inducing intrinsic n-type doping in the MoS2 channel. Consequently, this elevated conductivity enhances the field-effect mobility of MoS2 transistors. Our study offers insights into chalcogen vacancies in CVD-grown monolayer MoS2 and highlights their beneficial impact on electronic transport properties.
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- 2024
36. Charge pumping in hBN-encapsulated graphene driven by surface acoustic waves
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Nichols, Dublin M., Berg, Jameson G., Taniguchi, Takashi, Watanabe, Kenji, Dhagat, Pallavi, Deshpande, Vikram, Jander, Albrecht, and Minot, Ethan Davis
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Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Applied Physics - Abstract
Surface acoustic waves (SAWs) on piezoelectric insulators can generate dynamic periodic potentials inside one-dimensional and two-dimensional materials. These periodic potentials have been utilized or proposed for various applications, including acoustoelectric charge pumping. In this study, we investigate acoustoelectric charge pumping in graphene with very low electrostatic disorder. By employing a graphite top gate on boron-nitride-encapsulated graphene, we adjust the graphene carrier concentration over a broad range, enabling us to examine the acoustoelectric signal in both mixed-carrier and single-carrier regimes. We discuss the benefits of hBN-encapsulated graphene for charge pumping applications and introduce a model that describes the acoustoelectric signal across all carrier concentrations, including at the charge neutrality point. This quantitative model will support future SAW-enabled explorations of phenomena in low-dimensional materials and guide the design of novel SAW sensors.
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- 2024
37. The Flux Hypothesis for Odd Transport Phenomena
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Hargus, Cory, Deshpande, Alhad, Omar, Ahmad K., and Mandadapu, Kranthi K.
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Condensed Matter - Statistical Mechanics ,Condensed Matter - Soft Condensed Matter ,Physics - Chemical Physics - Abstract
Onsager's regression hypothesis makes a fundamental connection between macroscopic transport phenomena and the average relaxation of spontaneous microscopic fluctuations. This relaxation, however, is agnostic to odd transport phenomena, in which fluxes run orthogonal to the gradients driving them. To account for odd transport, we generalize the regression hypothesis, postulating that macroscopic linear constitutive laws are, on average, obeyed by microscopic fluctuations, whether they contribute to relaxation or not. From this "flux hypothesis," Green-Kubo and reciprocal relations follow, elucidating the separate roles of broken time-reversal and parity symmetries underlying various odd transport coefficients. As an application, we derive and verify the Green-Kubo relation for odd collective diffusion in chiral active matter, first in an analytically-tractable model and subsequently through molecular dynamics simulations of concentrated active spinners.
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- 2024
38. A study of the nuclear structure of light nuclei at the Electron-Ion Collider
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Magdy, Niseem, Hegazy, Mariam, Rafaat, Aliaa, Li, Wenliang, Deshpande, Abhay, Abdelhady, A. M. H., Ellithi, A. Y., Lacey, Roy A., and Tu, Zhoudunming
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Nuclear Theory ,High Energy Physics - Phenomenology ,Nuclear Experiment - Abstract
The substructure of atomic nuclei resulting from the clustering of nucleons is crucial for understanding nuclear structure and dynamics. Various cluster configurations can emerge depending on excitation energy, the number and types of core clusters, and the presence of excess neutrons. Despite the prevalence of tightly bound cluster formations in low-lying states, understanding the correlation between clusters and their formation mechanisms remains incomplete. This exploring study investigates nuclear clustering at the Electron-Ion Collider (EIC) using simulations based on the modified BeAGLE model. By simulating collisions involving $e$+$^{9}$Be, $e$+$^{12}$C, and $e$+$^{16}$O nuclei, we find that the average energy of particles $\langle E \rangle$ and the system size ratios of particles at forward rapidity exhibit sensitivity to alpha clustering and its various configurations. These findings offer valuable insights into the dynamics of nuclear clustering and its implications for future studies at the EIC., Comment: 7 pages, 7 figures, submitted for publication
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- 2024
39. Influence of Ga-Ge Doping on the Structural and Electrical Properties of Li7La3Zr2O12 Solid Electrolytes For Li ion Battery
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Aote, Muktai, Deshpande, A. V., Khapekar, Anuj, and Parchake, Kajal
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Condensed Matter - Materials Science - Abstract
In order to replace the conventional liquid electrolytes by solid electrolytes, high room temperature ionic conductivity is required. To achieve such high ionic conductivity, the series Li7-3xGaxLa3Zr1.9Ge0.1O12 was prepared by solid-state reaction method. The content of Ge was kept constant at 0.10 a.p.f.u, and the Ga has been varied from 0 to 0.40 a.p.f.u. The conducting cubic phase was identified using X-ray diffraction study, whereas the physical and structural studies were perfomed using density measurements and scanning electron microscopy (SEM) analysis, respectively. Electrical conductivity results reveal that the 0.20 Ga ceramic sample possessed the highest room temperature Li ion conductivity of 5.09 x 10-4 S/cm and minimum activation energy of 0.25 eV. Predominant ionic conduction in 0.20 Ga ceramic sample was confirmed by the DC polarization method. The high room temperature ionic conductivity makes the 0.20 Ga ceramic sample a suitable candidate as a solid electrolyte for all-solid-state lithium-ion batteries (ASSLIBs).
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- 2024
40. Deception in Reinforced Autonomous Agents: The Unconventional Rabbit Hat Trick in Legislation
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Dogra, Atharvan, Deshpande, Ameet, Nay, John, Rajpurohit, Tanmay, Kalyan, Ashwin, and Ravindran, Balaraman
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Computer Science - Computation and Language - Abstract
Recent developments in large language models (LLMs), while offering a powerful foundation for developing natural language agents, raise safety concerns about them and the autonomous agents built upon them. Deception is one potential capability of AI agents of particular concern, which we refer to as an act or statement that misleads, hides the truth, or promotes a belief that is not true in its entirety or in part. We move away from the conventional understanding of deception through straight-out lying, making objective selfish decisions, or giving false information, as seen in previous AI safety research. We target a specific category of deception achieved through obfuscation and equivocation. We broadly explain the two types of deception by analogizing them with the rabbit-out-of-hat magic trick, where (i) the rabbit either comes out of a hidden trap door or (ii) (our focus) the audience is completely distracted to see the magician bring out the rabbit right in front of them using sleight of hand or misdirection. Our novel testbed framework displays intrinsic deception capabilities of LLM agents in a goal-driven environment when directed to be deceptive in their natural language generations in a two-agent adversarial dialogue system built upon the legislative task of "lobbying" for a bill. Along the lines of a goal-driven environment, we show developing deceptive capacity through a reinforcement learning setup, building it around the theories of language philosophy and cognitive psychology. We find that the lobbyist agent increases its deceptive capabilities by ~ 40% (relative) through subsequent reinforcement trials of adversarial interactions, and our deception detection mechanism shows a detection capability of up to 92%. Our results highlight potential issues in agent-human interaction, with agents potentially manipulating humans towards its programmed end-goal.
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- 2024
41. Adolescent sports participation and health in early adulthood: An observational study
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Kokandakar, Ajinkya H., Lin, Yuzhou, Jin, Steven, Weiss, Jordan, Rabinowitz, Amanda R., May, Reuben A. Buford, Small, Dylan, and Deshpande, Sameer K.
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Statistics - Applications - Abstract
We study the impact of teenage sports participation on early-adulthood health using longitudinal data from the National Study of Youth and Religion. We focus on two primary outcomes measured at ages 23--28 -- self-rated health and total score on the PHQ9 Patient Depression Questionnaire -- and control for several potential confounders related to demographics and family socioeconomic status. To probe the possibility that certain types of sports participation may have larger effects on health than others, we conduct a matched observational study at each level within a hierarchy of exposures. Our hierarchy ranges from broadly defined exposures (e.g., participation in any organized after-school activity) to narrow (e.g., participation in collision sports). We deployed an ordered testing approach that exploits the hierarchical relationships between our exposure definitions to perform our analyses while maintaining a fixed family-wise error rate. Compared to teenagers who did not participate in any after-school activities, those who participated in sports had statistically significantly better self-rated and mental health outcomes in early adulthood., Comment: The pre-analysis protocol for this study is available at arXiv:2211.02104
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- 2024
42. MedPromptExtract (Medical Data Extraction Tool): Anonymization and Hi-fidelity Automated data extraction using NLP and prompt engineering
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Srivastava, Roomani, Prasad, Suraj, Bhat, Lipika, Deshpande, Sarvesh, Das, Barnali, and Jadhav, Kshitij
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Computer Science - Artificial Intelligence ,Computer Science - Information Retrieval - Abstract
A major roadblock in the seamless digitization of medical records remains the lack of interoperability of existing records. Extracting relevant medical information required for further treatment planning or even research is a time consuming labour intensive task involving expenditure of valuable time of doctors. In this demo paper we present, MedPromptExtract an automated tool using a combination of semi supervised learning, large language models, natural language processing and prompt engineering to convert unstructured medical records to structured data which is amenable for further analysis., Comment: 4 pages, 3 figures, pre-print sumitted to CIKM 2024
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- 2024
43. Report on the AAPM Grand Challenge on deep generative modeling for learning medical image statistics
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Deshpande, Rucha, Kelkar, Varun A., Gotsis, Dimitrios, Kc, Prabhat, Zeng, Rongping, Myers, Kyle J., Brooks, Frank J., and Anastasio, Mark A.
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition ,Physics - Medical Physics - Abstract
The findings of the 2023 AAPM Grand Challenge on Deep Generative Modeling for Learning Medical Image Statistics are reported in this Special Report. The goal of this challenge was to promote the development of deep generative models (DGMs) for medical imaging and to emphasize the need for their domain-relevant assessment via the analysis of relevant image statistics. As part of this Grand Challenge, a training dataset was developed based on 3D anthropomorphic breast phantoms from the VICTRE virtual imaging toolbox. A two-stage evaluation procedure consisting of a preliminary check for memorization and image quality (based on the Frechet Inception distance (FID)), and a second stage evaluating the reproducibility of image statistics corresponding to domain-relevant radiomic features was developed. A summary measure was employed to rank the submissions. Additional analyses of submissions was performed to assess DGM performance specific to individual feature families, and to identify various artifacts. 58 submissions from 12 unique users were received for this Challenge. The top-ranked submission employed a conditional latent diffusion model, whereas the joint runners-up employed a generative adversarial network, followed by another network for image superresolution. We observed that the overall ranking of the top 9 submissions according to our evaluation method (i) did not match the FID-based ranking, and (ii) differed with respect to individual feature families. Another important finding from our additional analyses was that different DGMs demonstrated similar kinds of artifacts. This Grand Challenge highlighted the need for domain-specific evaluation to further DGM design as well as deployment. It also demonstrated that the specification of a DGM may differ depending on its intended use.
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- 2024
44. Characteristics of active and inactive motions in high-Reynolds-number turbulent boundary layers
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Deshpande, Rahul, Vinuesa, Ricardo, and Marusic, Ivan
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Physics - Fluid Dynamics - Abstract
Wall-scaled (attached) eddies play a significant role in the overall drag experienced in high-Reynolds-number turbulent boundary layers (TBLs). This study aims to delve into the underlying mechanisms driving this phenomenon by dissecting the active and inactive components of these attached eddies, as initially proposed by Townsend (1976). Employing a recently introduced energy-decomposition scheme, we analyze TBL datasets covering a wide range of Reynolds numbers ($Re_{\tau}$ $\sim$ $\mathcal{O}$(10$^{3}$)--$\mathcal{O}$(10$^{6}$)). This analysis provides empirical evidence of the distinct contributions of these components to drag generation, and reveals that while active motions are responsible solely for generating Reynolds shear stresses, inactive motions are crucial for transporting streamwise momentum from the logarithmic region to the wall, thus corroborating earlier hypotheses in the literature., Comment: Proceeding accepted for the Thirteenth International Symposium on Turbulence and Shear Flow Phenomena (TSFP13)
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- 2024
45. Retrieval-Augmented Generation with Knowledge Graphs for Customer Service Question Answering
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Xu, Zhentao, Cruz, Mark Jerome, Guevara, Matthew, Wang, Tie, Deshpande, Manasi, Wang, Xiaofeng, and Li, Zheng
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Computer Science - Information Retrieval ,Computer Science - Artificial Intelligence ,Computer Science - Computation and Language ,Computer Science - Machine Learning ,I.2 - Abstract
In customer service technical support, swiftly and accurately retrieving relevant past issues is critical for efficiently resolving customer inquiries. The conventional retrieval methods in retrieval-augmented generation (RAG) for large language models (LLMs) treat a large corpus of past issue tracking tickets as plain text, ignoring the crucial intra-issue structure and inter-issue relations, which limits performance. We introduce a novel customer service question-answering method that amalgamates RAG with a knowledge graph (KG). Our method constructs a KG from historical issues for use in retrieval, retaining the intra-issue structure and inter-issue relations. During the question-answering phase, our method parses consumer queries and retrieves related sub-graphs from the KG to generate answers. This integration of a KG not only improves retrieval accuracy by preserving customer service structure information but also enhances answering quality by mitigating the effects of text segmentation. Empirical assessments on our benchmark datasets, utilizing key retrieval (MRR, Recall@K, NDCG@K) and text generation (BLEU, ROUGE, METEOR) metrics, reveal that our method outperforms the baseline by 77.6% in MRR and by 0.32 in BLEU. Our method has been deployed within LinkedIn's customer service team for approximately six months and has reduced the median per-issue resolution time by 28.6%.
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- 2024
- Full Text
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46. Auto-Generating Weak Labels for Real & Synthetic Data to Improve Label-Scarce Medical Image Segmentation
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Deshpande, Tanvi, Prakash, Eva, Ross, Elsie Gyang, Langlotz, Curtis, Ng, Andrew, and Valanarasu, Jeya Maria Jose
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Computer Science - Computer Vision and Pattern Recognition - Abstract
The high cost of creating pixel-by-pixel gold-standard labels, limited expert availability, and presence of diverse tasks make it challenging to generate segmentation labels to train deep learning models for medical imaging tasks. In this work, we present a new approach to overcome the hurdle of costly medical image labeling by leveraging foundation models like Segment Anything Model (SAM) and its medical alternate MedSAM. Our pipeline has the ability to generate weak labels for any unlabeled medical image and subsequently use it to augment label-scarce datasets. We perform this by leveraging a model trained on a few gold-standard labels and using it to intelligently prompt MedSAM for weak label generation. This automation eliminates the manual prompting step in MedSAM, creating a streamlined process for generating labels for both real and synthetic images, regardless of quantity. We conduct experiments on label-scarce settings for multiple tasks pertaining to modalities ranging from ultrasound, dermatology, and X-rays to demonstrate the usefulness of our pipeline. The code is available at https://github.com/stanfordmlgroup/Auto-Generate-WLs/., Comment: Accepted at MIDL 2024
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- 2024
47. Class-Level Code Generation from Natural Language Using Iterative, Tool-Enhanced Reasoning over Repository
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Deshpande, Ajinkya, Agarwal, Anmol, Shet, Shashank, Iyer, Arun, Kanade, Aditya, Bairi, Ramakrishna, and Parthasarathy, Suresh
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Computer Science - Software Engineering ,Computer Science - Artificial Intelligence - Abstract
LLMs have demonstrated significant potential in code generation tasks, achieving promising results at the function or statement level across various benchmarks. However, the complexities associated with creating code artifacts like classes, particularly within the context of real-world software repositories, remain underexplored. Prior research treats class-level generation as an isolated task, neglecting the intricate dependencies & interactions that characterize real-world software environments. To address this gap, we introduce RepoClassBench, a comprehensive benchmark designed to rigorously evaluate LLMs in generating complex, class-level code within real-world repositories. RepoClassBench includes "Natural Language to Class generation" tasks across Java, Python & C# from a selection of repositories. We ensure that each class in our dataset not only has cross-file dependencies within the repository but also includes corresponding test cases to verify its functionality. We find that current models struggle with the realistic challenges posed by our benchmark, primarily due to their limited exposure to relevant repository contexts. To address this shortcoming, we introduce Retrieve-Repotools-Reflect (RRR), a novel approach that equips LLMs with static analysis tools to iteratively navigate & reason about repository-level context in an agent-based framework. Our experiments demonstrate that RRR significantly outperforms existing baselines on RepoClassBench, showcasing its effectiveness across programming languages & under various settings. Our findings emphasize the critical need for code-generation benchmarks to incorporate repo-level dependencies to more accurately reflect the complexities of software development. Our work shows the benefits of leveraging specialized tools to enhance LLMs' understanding of repository context. We plan to make our dataset & evaluation harness public., Comment: Preprint with additional experiments
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- 2024
48. OpenAirLink: Reproducible Wireless Channel Emulation using Software Defined Radios
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Deshpande, Yash, Wang, Xianglong, and Kellerer, Wolfgang
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Computer Science - Networking and Internet Architecture ,Electrical Engineering and Systems Science - Signal Processing - Abstract
This paper presents OpenAirLink(OAL), an open-source channel emulator for reproducible testing of wireless scenarios. OAL is implemented on off-the-shelf software-defined radios (SDR) and presents a smaller-scale alternative to expensive commercially available channel emulators. Path loss and propagation delay are the fundamental aspects of emulating a wireless channel. OAL provides a simple method to change these aspects in real-time. The emulator is implemented using a finite impulse response (FIR) filter. The FIR filter is written in Verilog and flashed on the SDRs Field Programmable Gate Array (FPGA). Most processing transpires on the FPGA, so OAL does not require high-performance computing hardware and SDRs. We validate the performance of OAL and demonstrate the utility of such a channel emulation tool using two examples. We believe that open-source channel emulators such as OAL can make reproducible wireless experiments accessible to many researchers in the scientific community.
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- 2024
49. RLHF Deciphered: A Critical Analysis of Reinforcement Learning from Human Feedback for LLMs
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Chaudhari, Shreyas, Aggarwal, Pranjal, Murahari, Vishvak, Rajpurohit, Tanmay, Kalyan, Ashwin, Narasimhan, Karthik, Deshpande, Ameet, and da Silva, Bruno Castro
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computation and Language - Abstract
State-of-the-art large language models (LLMs) have become indispensable tools for various tasks. However, training LLMs to serve as effective assistants for humans requires careful consideration. A promising approach is reinforcement learning from human feedback (RLHF), which leverages human feedback to update the model in accordance with human preferences and mitigate issues like toxicity and hallucinations. Yet, an understanding of RLHF for LLMs is largely entangled with initial design choices that popularized the method and current research focuses on augmenting those choices rather than fundamentally improving the framework. In this paper, we analyze RLHF through the lens of reinforcement learning principles to develop an understanding of its fundamentals, dedicating substantial focus to the core component of RLHF -- the reward model. Our study investigates modeling choices, caveats of function approximation, and their implications on RLHF training algorithms, highlighting the underlying assumptions made about the expressivity of reward. Our analysis improves the understanding of the role of reward models and methods for their training, concurrently revealing limitations of the current methodology. We characterize these limitations, including incorrect generalization, model misspecification, and the sparsity of feedback, along with their impact on the performance of a language model. The discussion and analysis are substantiated by a categorical review of current literature, serving as a reference for researchers and practitioners to understand the challenges of RLHF and build upon existing efforts.
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- 2024
50. ROBUST: 221 Bugs in the Robot Operating System
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Timperley, Christopher S., van der Hoorn, Gijs, Santos, André, Deshpande, Harshavardhan, and Wąsowski, Andrzej
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Computer Science - Software Engineering ,Computer Science - Robotics - Abstract
As robotic systems such as autonomous cars and delivery drones assume greater roles and responsibilities within society, the likelihood and impact of catastrophic software failure within those systems is increased.To aid researchers in the development of new methods to measure and assure the safety and quality of robotics software, we systematically curated a dataset of 221 bugs across 7 popular and diverse software systems implemented via the Robot Operating System (ROS). We produce historically accurate recreations of each of the 221 defective software versions in the form of Docker images, and use a grounded theory approach to examine and categorize their corresponding faults, failures, and fixes. Finally, we reflect on the implications of our findings and outline future research directions for the community.
- Published
- 2024
- Full Text
- View/download PDF
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