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Double emulsion consists of two interfacial layers which can encapsulate both hydrophilic and lipophilic substances within a single carrier. Besides encapsulation, double emulsion has also been used to modify the sensorial properties of food products. However, at the same time, double emulsion is susceptible to destabilization under environmental stresses and long-term storage. In this paper, recent articles on double emulsion were critically highlighted in terms of production, composition, and stabilization. With current existing fundamental knowledge about double emulsion, this paper aims to review the utilization of double emulsion for food application to bring potential benefits, stability, and future application. The stability of double emulsion during production and storage was affected by the production method, composition, and temperature control. In terms of food application, double emulsion has been successfully applied in fat-reducing products, food encapsulation, fortification, preservation, edible food packaging, etc. The recent insights in forming stable storage of double emulsion with food-grade emulsifiers have also been discussed in this review paper. In the future, the efforts in mitigating the destabilization behaviour of double emulsion might be beneficial in boosting the applications of double emulsion in bigger markets. [ABSTRACT FROM AUTHOR]

As we all observe, Europeans and Romanian citizens, today's world is in a state of chaos and geopolitical turbulence unprecedented since the end of the Cold War. The main destabilizing factor in Europe and elsewhere in the world is the Russian Federation, ruled with an iron hand by Dictator Vladimir Vladimirovi Putin, surrounded by a clique of loyalists from the Army, FSB, SVR, GRU and supported by a bunch of oligarchs loyal to the Kremlin. There are hundreds of books, studies and articles in which the authors analyze, with credible arguments, the aggressive behavior of the Kremlin. In this context, the book "Russia's war with the world and how it affects us" attracted my attention, author Keir Giles, also published in Romanian by Niculescu Publishing House, in 2023. I think it would be beneficial for Romania if the politicians at the head of the state and military men of all ranks would find time to read (study) it; could find many ways to resist the hostile actions carried out by Russia on a daily basis, including against Romania.

When performing osteosynthesis for spinal instability after traumatic injury, diagnostic difficulties arise due to the migration of metal structure components to distant “atypical” anatomical areas, which is associated with the risk of neurological deficit and life-threatening conditions. This article presents a casuistic case of migration of a metal structure component through an iatrogenic opening in the occipital bone into the posterior cranial fossa in a patient who had previously undergone instrumental correction for comminuted fractures of the cervical vertebrae. It should be noted that there are no data on “spontaneous” perforation of the occipital bone by metal osteosynthesis elements in the domestic literature.

The paper describes the continuous attacks on the socialist Republic of Bosnia and Herzegovina and its political leadership during the eighties of the last century. The destabilization of the B&H communist leadership was conducted from the power centers in Belgrade - primarily from the intellectual centers and through the media. The leadership of this republic is described as extremely repressive, and Bosnia and Herzegovina is the so-called dark province, in which intellectual creativity and any criticism of the system and government is prohibited. At that time, Yugoslavia was in an extremely unfavorable economic position, but in the Serbian media, BiH was presented as an exception compared to most other republics in the Federation. In addition, BiH was presented as a non-national republic, and there were frequent stereotypes and negative content about Muslims, who were the majority people of this republic. Numerous events were turned into affairs, which weakened the leadership and destroyed the Bosnian society.

The aim of this article is to point out the staged nature of the instrumentalization of migrants by analyzing and defining the process and using examples from the Cold War and post-Cold War periods. Accordingly, the following hypotheses are posited: H1-The instrumentalization of migrants is a step-by-step process aimed at achieving specific political, economic and military objectives or introducing destabilization in the target state. HK1-Target destabilization refers to an increase in the level of crime and terrorist threat, insecurity among the citizens of a country. The article consists of two parts. The first analyses the issue of the instrumentalization of migrants from the perspective of political science and administration, while the second analyses it from the perspective of legal science. The duality of research methods is acknowledged in the publication. In the course of preparing the article, desk research methods were applied. These include the method of analysis of written sources, which is a consequence of the application of qualitative content analysis. They allowed the collection of data necessary to solve the research problem, gathered in databases of the Border Guard, state statistical offices, data available in the literature on the subject, articles published in mass media.

The purpose of the study is to clarify the possibility of destabilizing a mediumsized state through information warfare, taking into account its vulnerability to such actions and measuring the strength of them. The solution to the research problem was to identify a methodology for assessing this vulnerability, based on the external and internal conditions of the entity under study. The proposed solution allows assessing the vulnerability of a medium-sized state to information activities based on segmentation of its environment and strengths and weaknesses in terms of security. The article makes it possible to fill a certain research niche in terms of an interdisciplinary approach to the issue at hand.

In the Wadi Nugrus area, south Eastern Desert of Egypt, A-type granite is highly deformed in a prominent NW-SE trending shear zone, likely related to the Najd shear system. Deformation of this post-collisional leucogranite allows the propagation of hydrothermal alterations due to fluid circulation inside the so-called “Nugrus Shear Zone (NSZ)”. This results in the remarkable destabilization of the magmatic dissemination of rare-metal and U-Th minerals in the granite. Relict magmatic minerals that survived destabilization are represented by (1) ferrocolumbite with 14–63–16.39 wt% FeOt, (2) fresh igneous zircon, and (3) thorite. The destabilized ore minerals (hydrothermal) dominate over the fresh magmatic relict minerals. The former comprises the following: (1) altered columbite in the form of three distinct phases of niobates (fergusonite–petscheckite–uranopyrochlore), (2) altered thorite (Ce-bearing and P-F-rich), (3) betafite, (4) altered uranothorite, and (5) sulfides (mainly pyrite). It is evident that the destabilization of magmatic thorite can be distinguished into three stages of hydrothermal alteration, namely low-Zr Ce-bearing thorite (stage I), moderate-Zr Ce-bearing thorite (stage II), and high-Zr U-Nb-Y-bearing thorite (stage III). The two varieties of Ce-bearing thorite are sodic with 1.33–2.28 wt% and 1.51–1.80 wt% Na2O, respectively, whereas the U-Nb-Y-bearing thorite is Na2O-poor (0.06–0.07 wt%). Similarly, thorite in stages I and II are Ca-, P-, F-, and S-rich. Considerable P2O5 content (up to ~17 wt%) is reported in stage II Ce-bearing thorite, whereas stage III thorite is Si-rich (14.56–18.79 wt% SiO2). Upon hydrothermal destabilization, the three niobate minerals replacing the dissemination of magmatic ferrocolumbite become enriched in UO2 (up to 15.24 wt%, 7.86 wt%, and 10.88 wt%, respectively), and similarly, ThO2 (up to 7.13 wt%, 5.71 wt%, and 9.52 wt%, respectively). Hydrothermal destabilization results in the complete dissolution of magmatic fluorite and phosphate minerals at pH = 2–7. This furnishes a source of Ca, P, Ce, Y, F, and Cl in the hydrothermal solution to destabilize/collapse the structure of magmatic ore minerals, particularly ferrocolumbite and thorite. Free elements in the hydrothermal solution are responsible for the crystallization of P- and F-rich Ce-bearing thorite minerals in three stages, as well as abnormal Y2O3 enrichment in three resulting niobates that contain up to 6.03 wt%, 2.93 wt%, and 2.65 wt%, respectively. The fresh undeformed Nugrus leucogranite is sulfide-poor. In contrast, sulfides are enriched in the deformed leucogranite inside the NSZ. Also, the intimate relationship of sulfides with destabilized rare-element minerals indicates the destabilization of these minerals during the hydrothermal stage under reduced conditions. Finally, the proposed paragenetic sequence suggests that most ore minerals are magmatic or hydrothermal primarily. In contrast, supergene minerals such as goethite, Fe-oxyhydroxide, altered betafite, and altered uranothorite are the least abundant.

The purpose of the article is to explain the mechanism of forced migration and its impact on the security of the invaded state, using contemporary Poland as an example. In order to introduce the phenomenon of coercive engineered migration, the author cites historical examples of its use by the authorities of totalitarian states, especially the Soviet Union. The main part of the article is devoted to the analysis of various forms of threats to Poland's security generated by Russia and Belarus, and the possibility of escalation of these threats. The analysis of the geopolitical situation shows that the biggest threat to Poland is the migratory pressure caused by the wars in the Middle East, and on the other hand by the creation of a new migration route through the territory of Ukraine. The author was critical of the level of threat recognition, also pointing out the limited possibilities of counteracting both migratory pressure and unfavorable processes on the territory of Ukraine, which will be a consequence of the reduction of aid from the West to this country, as well as the escalation of conflicts in the Islamic region.

This analysis finds that the impact of elections on risks of armed insurrections is not statistically significant, whereas unarmed uprisings/nonviolent revolutions are more likely to occur in the election year. It is also shown that the influence of elections on unarmed revolutionary destabilization had tended to grow with time. The election year became a significant factor of nonviolent revolutionary destabilization only after the end of the Cold War, and the impact of elections on the probability of unarmed revolutions has become particularly strong in this century (when elections in the given year increase the probability of an unarmed uprising more than three times). At the same time, holding elections primarily increases the risks of revolutionary destabilization in intermediate regimes (anocracies). But even among anocracies, open anocracies/partial democracies stand out, as here elections increase the probability of unarmed uprisings in an especially dramatic way. [ABSTRACT FROM AUTHOR]

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This article questions why violence carried out by men toward their female romantic partners remains so prevalent today by examining how it has been understood and talked about over time. The aim here is twofold: the first is to historically map the changes in how male partner violence has been addressed in society—and to what effect. The second is to examine subtle dynamics within this historical map in order to suggest how language could be used to destabilize its fixture in society. [ABSTRACT FROM AUTHOR]

Although 4Ce4YSZ has high corrosion resistance, it faces challenges concerning its sinterability and ionic conductivity. Therefore, we studied destabilization behavior caused by corrosion and oxygen vacancy ordering according to ZnO doping. Powders of (4Ce4YSZ)1−x(ZnO)x (x = 0.5, 1, 2, 4 mol%) were synthesized using the sol-gel method. With the addition of ZnO, the cubic phase increased, and secondary phases were not observed. The (111) peak showed a higher angle shift in ZnO-doped 4Ce4YSZ compared to 4Ce4YSZ, and TEM-SAED revealed a reduction in the spacing of the (011)t plane, suggesting lattice contraction due to the substitution of the smaller Zn2+ (60 Å) for Zr4+ (84 Å) in the lattice. The local atomic structure analysis was conducted using EXAFS to investigate the oxygen vacancy ordering behavior. Zr K-edge Fourier transform data revealed a decrease in the Zr-O1 peak intensity with an increasing amount of ZnO doping, indicating an increase in oxygen vacancies. The Zr-O1 peak position shifted to the right, leading to an increase in the Zr-O1 interatomic distance. In the Y K-edge Fourier transform data, the Y-O1 peak intensity did not decrease, and there was little variation in the Y-O1 interatomic distance. These results suggest that the oxygen vacancies formed due to ZnO doping are located in the neighboring oxygen shell of Zn, rather than in the neighboring oxygen shells of Y and Zr. Impedance measurements were conducted to measure the conductivity, and as the amount of ZnO doping increased, the total conductivity increased, while the activation energy decreased. The increase in oxygen vacancies by ZnO doping contributed to the enhancement of conductivity, and it is considered that these created oxygen vacancies did not interact with Zn2+ and did not form defect associations. Fluoride-based molten salts were introduced to the specimens to assess the corrosion behavior in a molten salt environment. Yttrium depletion layers (YDLs) were formed on the surfaces of all specimens due to the leaching of yttrium. However, Ce remained relatively stable at the interface according to EDS line scans, suggesting a reduction in the phase transformation (cubic, tetragonal to monoclinic) typically associated with yttrium leaching in YSZ. [ABSTRACT FROM AUTHOR]

Is there a relationship between education and the type of revolutionary action – violent or nonviolent? Past studies found a positive relationship between the education and nonviolence, but the influence that education produces on the form that revolution takes has not yet been explored. We show several possible mechanisms that push the educated population to choose nonviolent tactic: (1) education changes people's preferences toward peaceful solutions and increases support for civil liberties; (2) it enhances human capital that makes it feasible to use unarmed tactics successfully and (3) it increases the relative costs of engaging in armed action. Thus, it is reasonable to assume that the higher education in a country, the higher the probability that revolution will be nonviolent. This paper examines it at a cross-national level with an analysis of 470 NAVCO 'maximalist campaigns' and 265 revolutionary events recorded between 1950 and 2020. Overall, we find robust evidence that the higher the level of education in a country, the lower chance that the revolution there would take a violent/armed form. [ABSTRACT FROM AUTHOR]

We study the destabilization of synchronous periodic solutions for general patch-models with cross-diffusion-like couplings, where the underlying kinetic systems have stable periodic solutions bifurcating from double homoclinic loops. We first reduce the stability problem of synchronous periodic solutions for patch models into that for lower-dimensional systems, then analyze the destabilization by using the Floquet theory and solving a class of boundary value problems. After establishing the Fredholm alternative properties for an auxiliary linear operator, we give the characteristic function to determine the Floquet spectra for the reduced systems, and then the conditions for the destabilization. Finally, we apply the main results to a patch model with a two-dimensional kinetic system. [ABSTRACT FROM AUTHOR]

Flooding transforms the soil environment, impacting small-scale controls on mineral associated carbon (C), nitrogen (N) and phosphorus (P) persistence and mobilization. Yet during flood events, mineral associated C, N, and P may not respond in the same way, such that soluble C, N, and P concentrations and stoichiometry may change potentially impacting microbial activity. Using a laboratory incubation approach, we investigated how flooding impacts C, N, and P pool distribution and microbial activity across a 1-week flood event and after drying. We found that all three mineral associated pools responded dynamically to flooding, increasing and decreasing throughout the flood with a 5.9% increase in mineral associated C and 32.5% decrease in residual P post flood. However, mineral associated C, N, and P each shifted at different temporal points, indicating that they are likely responding to separate destabilization mechanisms working at different temporal scales. Soluble C increased by 57% and soluble N decreased by 72% at the beginning of the flood which remained post-flood. However, soluble P behaved more similarly to the mineral associated pool, shifting throughout the flood period. The microbial community maintained and even increased their exo-cellular activity throughout the flood period. Our research demonstrates that the mineral associated pool can shift with short-term flooding altering the composition and quantity of the soluble pool and microbial activity. [ABSTRACT FROM AUTHOR]

Cannibalism, or intraspecific predation, is the act of an organism consuming another organism of the same species. In predator-prey relationships, there is experimental evidence to support the existence of cannibalism among juvenile prey. In this work, we propose a stage-structured predator-prey system where cannibalism occurs only in the juvenile prey population. We show that cannibalism has both a stabilizing and destabilizing effect depending on the choice of parameters. We perform stability analysis of the system and also show that the system experiences a supercritical Hopf, saddle-node, Bogdanov-Takens and cusp bifurcation. We perform numerical experiments to further support our theoretical findings. We discuss the ecological implications of our results.

A worldwide pandemic that started in China in late 2019 was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a single-stranded RNA virus belonging to the family Coronaviridae. Due to its structural variability and mutability, this virus continues to evolve and pose a major health threat around the world. Its characteristics, such as transmissibility, antigenicity, and resistance to drugs and vaccines, are continually altered through mutations. Examining mutational hotspots and their structural repercussions can thus aid in the development of more-effective vaccinations and treatment plans. In this study, we used full genome sequences of SARS-CoV-2 variants to predict structural changes in viral proteins. These sequences were obtained from the Global Initiative on Sharing Avian Influenza Data (GISAID), and a set of significant mutations were identified in each of the non-structural proteins (NSP1-16) and structural proteins, including the envelope, nucleocapsid, membrane, and spike proteins. The mutations were characterized as stabilizing or destabilizing based on their effect on protein dynamics and stability, and their impact on structure and function was evaluated. Among all of the proteins, NSP6 stands out as especially variable. The results of this study augment our understanding of how mutational events influence virus pathogenicity and evolution. [ABSTRACT FROM AUTHOR]

If myth is vital to a community, its memory must be kept alive. But how, is the question? Is it always prudent to remain faithful to the 'original' version of the received myth, or is it desirable to tamper with, or destabilize, the source myth? In India, mainstream versions of the Ramayana and the Mahabharata have long been disrupted by folk, feminist, and queer adaptations. Reversions of these oral, transhistorical master narratives of Hinduism have made a resurgence in a post-independence India that is precariously perched between tradition and modernity, and hence more acutely desirous that its children veer closer to their roots, or so the flourishing market for myth retellings for children suggests. Amongst this incandescent body of literature is Sudha Murty's series of five books that revisits popular stories about the gods and goddesses of the Hindu pantheon -- The Serpent's Revenge: Unusual Tales from the Mahabharata (2016), The Man from the Egg: Unusual Tales about the Trinity (2017), The Upside Down King: Unusual Tales about Rama and Krishna (2018), The Daughter from a Wishing Tree: Unusual Tales about Women in Mythology (2019), and The Sage with Two Horns: Unusual Tales from Mythology (2021). This paper explores how these tales of antiquity, refracted and reconstructed through the author's own personal memory, intersect with the more public and collective myth memory of the community. In reviewing Murty's retrieval of myths by reimagining and re-situating the 'evidentiary traces' of myth in the here and now for the children of today, it interrogates how, if at all, the retold myths counter the metanarratives of gender, religion, culture and perhaps, history too. Finally, it argues that the genre of myth retelling must go beyond simply reviving myth memory to destabilizing myth by 'fiddling 'with the sacred, especially when adapted for children. [ABSTRACT FROM AUTHOR]

[Display omitted] Colloidal particles can be used to generate water-in-oil (W/O) emulsions resistant against coalescence. Demulsification is possible with addition of low molecular weight surfactants to the emulsion continuous oil phase. Whether surfactants demulsify particle-stabilized W/O emulsions depends on their ability to modify the wettability of interfacially-bound particles. Crystals of glycerol monostearate (GMS) were prepared followed by water addition to generate GMS-stabilized W/O emulsions. The surfactants sorbitan monooleate (SMO), sorbitan monolaurate (SML), citric acid esters of monoglycerides (CITREM), sorbitan trioleate (STO), propylene glycol monolaurate (PgML), and polyglycerol polyricinoleate (PGPR) were added to the emulsion oil phase. Emulsion microstructure was characterized by light microscopy and cryo-scanning electron microscopy. Surfactant activity and crystal wetting were characterized by interfacial tension and three-phase contact angle measurements. Salt release from within the emulsions was used to assess demulsifier efficacy. Emulsions stabilized by platelet-like GMS crystals were generated. Of the six surfactants, SMO, SML, and CITREM were effective demulsifiers whereas STO, PgML, and PGPR were ineffective. The former three sufficiently modified the wettability of GMS crystals on the droplet surface, as they adsorbed to both the oil–water interface and GMS crystal surface. Emulsion destabilization was associated with faster NaCl release from the emulsion internal phase. [ABSTRACT FROM AUTHOR]

During the leather tanning process, chromium (Cr) can interact with different macromolecular organics to generate mixed ligand complexes. The removal of organochromium complexes is one of the main difficulties in the treatment of tannery wastewater. In this study, a gelatin-gallic ac-id-Cr(III) (G-GA-Cr) mixed ligand complex was used to examine the effects of ultrasonic on chromium destabilization and removal from the dissolved complexes. To investigate organic destruction and chromium liberation, alkali precipitation or chelating precipitation assisted with ultrasound were conducted, respectively. The findings demonstrate that ultrasonic-assisted alkali precipitation and chelating precipitation, respectively, removed over 50% and 93% of Cr from the complexes. According to the data, ultrasonication weakened the bonds that bound macromolecular ligands together, and depolymerization took place to the point where Cr could interact directly with hydroxide ions or chelating agents. In addition, by applying ultrasonic-assisted chelating precipitation, the chromium concentration could meet the discharge standard and the amount of precipitation was also noticeably decreased. [ABSTRACT FROM AUTHOR]

This essay aims to identify vulnerabilities and exploitation means necessary to use destabilization to support a military, and ultimately political, objective in a potential conflict between China and the governments supporting a liberal rules-based order. Japanese efforts during the Russo-Japanese War of 1904-1905 showed destabilizing a regime as a credible way to support military objectives during a conflict and provided some key insights by which destabilization efforts function. Based on the historical case and contemporary analysis of China, this essay makes recommendations to decision makers in a conflict on how to best execute and support destabilization efforts. [ABSTRACT FROM AUTHOR]

Microemulsions for heavy metal separation show advantages of fast separation rate, high separation efficiency and extraction capacity. However, it remains challenging in destabilizing microemulsions for back-extraction due to their thermodynamic stability. This study describes an effective strategy to construct pH-responsive microemulsion by adding N,N-dimethylethanolamine (DMEA) during back-extraction to avoid the negative impact of responsive materials on the extraction, meanwhile the back-extraction can be realized through a mild pH stimulus compared to traditional strong acid demulsifier. Cetyltrimethylammonium bromide (CTAB)-stabilized microemulsion was formulated and optimized for the selective Co(II) extraction reaching 95.4 %, while extraction efficiency of Ni(II) kept low at 10.5 %. The back-extraction efficiency of Co(II) reached 99.53 %. The responsive mechanism was studied by measuring the dynamic interfacial tension and interfacial dilatational rheology of CTAB solution in heptane under the effects of NaCl, DMEA and pH. By pH stimulus, DMEA protonated and increased the ionic strength, consequently inducing a "salting-out" effect and deactivating CTAB at oil-water interface, ultimately destabilizing the microemulsion. This study proposes a new approach for constructing responsive microemulsions for recovering heavy metals and also provides useful information on its responsive mechanisms by establishing a relationship between interfacial property and macroscopic stability of microemulsions. [Display omitted] • pH-responsive microemulsion was used for the first time in metal recovery. • CTAB-stabilized microemulsion was optimized for the selective Co(II) extraction. • pH-responsiveness was realized by introducing DMEA after metal extraction. • The formulated microemulsion had excellent selectivity of Co(II) over coexisting ions. • The responsiveness is due to the salting-out effect induced by the protonated DMEA. [ABSTRACT FROM AUTHOR]

Introduction. The article is devoted to identifying and interpreting the reasons and forms of protest activity of representatives of the youth cohort in the context of the institutionalization of modern digital society and digital policy. The common and specific features of the protest activity of Russian and foreign youth in the context of the content and level of their digital culture are characterized. The attention is focused on the dominant trends in the transformation of the practices of protest behavior in online and offline formats, taking into account the restrictive measures caused by the spread of COVID-19. Methods. The work was prepared within the framework of political science discourse using modern scientific theories and concepts. The authors rely on the main provisions of the activity-activist approach (A. Giddens, V. Yadov), the concept of “traumatic changes” (P. Sztompka) and “network society” (M. Castells). At the same time, the characterization of digital transformations and innovations (society, politics, culture) is carried out in the context of the ideas of “digital counterculture” (C. Gere), domestic researchers analyzing the consumer behavior of youth in the digital environment (T. Beregovskaya, S. Grishaeva). The work uses theoretical and empirical methods for analyzing the results obtained by leading domestic and foreign research centers, as well as with the direct participation of the authors in the implementation of grant activities. Results. An attempt is made to conduct political science analysis of the modern approaches to understanding the phenomenon of youth protest activity, its dominant forms in the context of the institutionalization of digital policy and the transformation of value orientations in the new structure of “digital culture”. The relationship between the protest activity of representatives of domestic and foreign youth, the practices of their destructive/constructive protest behavior using digital technologies in order to legitimize/ delegitimize the political regime is traced. Highlighted the real and potential resources of the authorities and administration, civil society institutions to minimize destructive factors that contribute to the strengthening of protest (civil, political, etc.) activity of various groups of young people in the context of the spread of the global pandemic. The results of theoretical and empirical studies that reveal the regional specifics of institutional forms of protest activity in modern Russia are interpreted. Discussion. The question of the forms and technologies of transformation of protest activity, taking into account the substantive characteristics of the digital culture of youth, its inclusion in the system for ensuring the stable and safe development of the Russian Federation, remains poorly studied. Authors’ contributions. S.A. Pankratov developed the theoretical basis of the research and carried out the general scientific edition of the article. S.I. Morozov analyzed the dominant tendencies of youth protest activity. S.D. Gavrilov interpreted the results of theoretical and empirical studies characterizing the process of institutionalization of digital policy.

Background Mutations of adenomatous polyposis coli (APC) and KRAS play essential roles in the development of colorectal cancer (CRC) by forming an abnormal colon morphology. Despite intensive efforts to discover therapeutic strategies to re-transform cancer cells into normal cells, no effective approaches have been reported yet. Methods In this study, we aimed to identify therapeutic strategies for inducing morphological changes of tumor organoids to structures similar to the normal intestine in ApcMin/+/KrasG12DLA2 mice by using KYA1797K, a dual inhibitor of the Wnt/β-catenin and RAS signaling pathways. Results KYA1797K, previously identified as a dual inhibitor of the Wnt/β-catenin and RAS pathways, inhibited the growth of organoids derived from tumor cells of ApcMin/+/KrasG12DLA2 mice, with the transformation of benign tumor structures into normal structures, similar to bone morphogenetic protein 4 (BMP4), an intestinal differentiation signaling inducer. Conclusion Given the anti-cancer effects of KYA1797K and its ability to induce morphological changes similar to those elicited by BMP4 treatment, the dual suppression of Wnt/β-catenin and RAS signaling is a potential therapy for treating CRC.

In May 2020, within the cultural and emotionally regressive chaos of the pandemic, the analyst witnessed a violent Black Lives Matter protest. Myriad unprocessed feelings subsequently impacted her handling the treatment of a patient who abruptly left a session to attend a protest herself. The analyst describes her own personal experience and the cascade of events that affected the treatment. She suggests that analysts can be armed with the awareness that enactments are more likely to happen when the analyst, as well the patient, are under extreme duress as is the case in the time of Covid. She describes some of the forces that were specific to this case and her own personal embroilment. She then broadens the discussion to other analysts' reports of overwhelming pandemic experiences and the corresponding effect on the work. She also elucidates the importance of the frame for therapeutic work. [ABSTRACT FROM AUTHOR]

This paper analyzes flood impact on the historical objects and cultural heritage in Southern and Eastern Serbia. The basic research problem is the lack of systematized databases regarding the flood impact on the cultural heritage, in addition to the lack of official manuals or other types of educational material dealing with the management of the assets with monumental properties in flood situations. The goal of the paper is to indicate this problem to the professional and wider public through systematization and classification of the observed damages on the buildings. The paper first provides a brief overview of the development of flood protection throughout history with particular reference to the research area. In addition, the history of floods in Serbia is also analyzed in order to point to the frequency and scale of this problem in the researched area. Through the research of archival materials in the appropriate institutions as well as direct recording of assets in the field, the degree of flood impact on historical objects in the territories of Southern and Eastern Serbia is determined. It refers to both declared cultural monuments and those that are still undeclared but possess certain monumental properties. Only the material damages on the immovable cultural assets have been analyzed. The protection of the movable cultural assets has not been taken into consideration, although it represents a very important aspect of every flood damage. A classification of the damages observed on these types of buildings, which occur as a direct or indirect consequence of floods, has been carried out. Examples of structural damage are presented in the paper (such as fissures, cracks, bucklings and collapse of parts or overall objects). Examples of the damages that do not threaten the stability of buildings are also presented. Here, they are divided into two groups—moisture-induced damages and biodegradation. The paper also gives examples of the damages induced by direct or indirect impacts of floods. It is from these examples that general lessons can be drawn, namely those that would be applicable to the endangered categories of cultural heritage. The classification is conducted for the purpose of better planning of preventive or rehabilitation strategies and measures for the preservation of architectural cultural heritage. Recommendations for dealing with heritage assets in the case of floods are also given. [ABSTRACT FROM AUTHOR]

The Internet provides a medium for the rapid mobilization of dissatisfied citizens and potentially contributes to various forms of political instability, including terrorism. However, the spread of the Internet may not lead to a higher intensity of terrorist attacks because direct perpetrators rely on close personal offline ties, and the national security agencies derive symmetrical benefits from Internet development as terrorists. In addition, the number of connections proxies a general level of country development, which is associated with less terrorist activity. We analyze the relationship between the number of Internet connections and the intensity of terrorist attacks using time-series cross-sectional data from the Global Terrorism Database from 1970 to 2018. Estimation of negative binomial regression models demonstrates an inverse relationship between Internet proliferation and the number of terrorist attacks, which holds for democracies and is absent for autocracies. Our results suggest that Internet proliferation is not a decisive factor in terrorism activity. Its impact on terrorism depends on the type of political regime and the level of socio-economic development. [ABSTRACT FROM AUTHOR]

Memory destabilization and reconsolidation is hypothesized to be a fundamental mnemonic process that can underpin memory updating. Instrumental memories have been shown recently to be destabilized following a reactivation session that involves a change in instrumental reward contingency. However, the acquisition and performance of an instrumental response occurs in the presence of the learning of other reward-related memories. This may influence the ability of a given reactivation session to destabilize the previously learned instrumental memory. Here we present a series of experiments in male rats involving an instrumental memory trained on an FR1 schedule over 10 days, and then reactivated in a session that imposed a VR5 schedule of reinforcement. When MK-801 was injected prior to the VR5 reactivation session, it reliably impaired subsequent instrumental performance at test only when the reactivation session occurred 48 h, and not 24 h, after the end of training. The interposition between the end of training and the reactivation session of a context extinction session, an additional VR5 reactivation session, or indeed the simple experience of being handled and injected with vehicle, resulted in MK-801 no longer having an amnestic effect on test performance. While we do not have a clear account for the process and mechanism underpinning this apparent selectivity of the effect of the VR5 session to destabilize the instrumental memory, it does additionally highlight the need for greater understanding of the conditions that facilitate reactivation-induced memory destabilization. [ABSTRACT FROM AUTHOR]

Memory destabilization and reconsolidation is hypothesized to be a fundamental mnemonic process that can underpin memory updating. Instrumental memories have been shown recently to be destabilized following a reactivation session that involves a change in instrumental reward contingency. However, the acquisition and performance of an instrumental response occurs in the presence of the learning of other reward-related memories. This may influence the ability of a given reactivation session to destabilize the previously learned instrumental memory. Here we present a series of experiments in male rats involving an instrumental memory trained on an FR1 schedule over 10 days, and then reactivated in a session that imposed a VR5 schedule of reinforcement. When MK-801 was injected prior to the VR5 reactivation session, it reliably impaired subsequent instrumental performance at test only when the reactivation session occurred 48 h, and not 24 h, after the end of training. The interposition between the end of training and the reactivation session of a context extinction session, an additional VR5 reactivation session, or indeed the simple experience of being handled and injected with vehicle, resulted in MK-801 no longer having an amnestic effect on test performance. While we do not have a clear account for the process and mechanism underpinning this apparent selectivity of the effect of the VR5 session to destabilize the instrumental memory, it does additionally highlight the need for greater understanding of the conditions that facilitate reactivation-induced memory destabilization.

Hydrogen energy is an excellent carrier for connecting various renewable energy sources and has many advantages. However, hydrogen is flammable and explosive, and its density is low and easy to escape, which brings inconvenience to the storage and transportation of hydrogen. Therefore, hydrogen storage technology has become one of the key steps in the application of hydrogen energy. Solid-state hydrogen storage method has a very high volumetric hydrogen density compared to the traditional compressed hydrogen method. The main issue of solid-state hydrogen storage method is the development of advanced hydrogen storage materials. Metal borohydrides have very high hydrogen density and have received much attention over the past two decades. However, high hydrogen sorption temperature, slow kinetics, and poor reversibility still severely restrict its practical applications. This paper mainly discusses the research progress and problems to be solved of metal borohydride hydrogen storage materials for solid-state hydrogen storage.

3-chloro-4-fluoraniline (FCA) is an important intermediate for the synthesis of antibiotics, herbicides and insecticides, and has significant environmental health hazards. Catalytic hydrogenation technology is widely used in pretreatment of halogenated organics due to its simple process and excellent performance. However, compared with the research of high activity hydrogenation catalyst, the research of efficient utilization of hydrogen source under mild conditions is not sufficient. In this work, micro-nano H 2 bubbles are produced in situ by electrolytic water and active metal replacement, and their apparent properties are studied. The result show that the H 2 bubbles have a size distribution in the range of 150–900 nm, which can rapidly reduce the REDOX potential of the water and maintain it in a hydrogen-rich state for a long time. Under the action of Pd/C catalyst, atomic hydrogen (H•) produced by dissociative adsorption can sequentially hydrogenate FCA to aniline. The H• utilization ratios of the above two hydrogen supply pathways reach 6.20% and 4.94% respectively, and H 2 consumption is reduced by tens of times (≥50 → ≈1.0 mL/min). The research provides technical support for the efficient removal of halogenated refractory pollutants in water and the development of hydrogen economy. [Display omitted] • Micro-nano H 2 bubbles were generated in situ by cathode and hydrogen-rich balls. • Micro-nano H 2 bubbles can remain in the water environment for a long time. • Micro-nano H 2 bubbles can be activated efficiently over Pd/C catalyst. • Mechanism of hydrogenate 3-chloro-4-fluoroaniline under different pH was elucidated. • Oxidizability and biodegradability of targets were improved after dehalogenation. [ABSTRACT FROM AUTHOR]

This paper aims to select the appropriate node(s) to effectively destabilize the terrorist network in order to reduce the terrorist group's effectiveness. Considerations are introduced in this literature as fuzzy soft sets. Using the weighted average combination rule and the D–S theory of evidence, we created an algorithm to determine which node(s) should be isolated from the network in order to destabilize the terrorist network. The paper may also prove that if its power and foot soldiers simultaneously decrease, terrorist groups will collapse. This paper also proposes using entropy-based centrality, vote rank centrality, and resilience centrality to neutralize the network effectively. The terrorist network considered for this study is a network of the 26/11 Mumbai attack created by Sarita Azad. [ABSTRACT FROM AUTHOR]

It was shown that the SAP11 effector of different Candidatus Phytoplasma can destabilize some TEOSINE BRANCHES/CYCLOIDEA/PROLIFERATING CELL FACTORs (TCPs), resulting in plant phenotypes such as witches' broom and crinkled leaves. Some SAP11 exclusively localize in the nucleus, while the others localize in the cytoplasm and the nucleus. The SAP11-like effector of Candidatus Phytoplasma mali strain PM19 (SAP11PM19) localizes in both compartments of plant cells. We show here that SAP11PM19 can destabilize TCPs in both the nucleus and the cytoplasm. However, expression of SAP11PM19 exclusively in the nucleus resulted in the disappearance of leaf phenotypes while still showing the witches' broom phenotype. Moreover, we show that SAP11PM19 can not only destabilize TCPs but also relocalizes these proteins in the nucleus. Interestingly, three different transgenic Nicotiana species expressing SAP11PM19 show all the same witches' broom phenotype but different leaf phenotypes. A possible mechanism of SAP11-TCP interaction is discussed. [ABSTRACT FROM AUTHOR]

Microbial necromass is a large, dynamic and persistent component of soil organic carbon, the dominant terrestrial carbon pool. Quantification of necromass carbon stocks and its susceptibility to global change is becoming standard practice in soil carbon research. However, the typical proxies used for necromass carbon do not reveal the dynamic nature of necromass carbon flows and transformations within soil that ultimately determine necromass persistence. In this review, we define and deconstruct four stages of the necromass continuum: production, recycling, stabilization and destabilization.Current understanding of necromass dynamics is described for each continuum stage. We highlight recent advances, methodological limitations and knowledge gaps which need to be addressed to determine necromass pool sizes and transformations. We discuss the dominant controls on necromass process rates and aspects of soil microscale structure including biofilms and food web interactions. The relative importance of each stage of the continuum is then compared in contrasting ecosystems and for climate change drivers.From the perspective of the continuum, we draw three conclusions to inform future research. First, controls on necromass persistence are more clearly defined when viewed through the lens of the continuum; second, destabilization is the least understood stage of the continuum with recycling also poorly evidenced outside of a few ecosystems; and third, the response of necromass process rates to climate change is unresolved for most continuum stages and ecosystems.Future mechanistic research focused on the role of biotic and abiotic soil microscale structure in determining necromass process rates and the relative importance of organo–mineral and organo–organo interactions can inform necromass persistence in different climate change scenarios. Our review demonstrates that deconstructing the necromass continuum is key to predicting the vulnerability and persistence of necromass carbon in a changing world. Read the free Plain Language Summary for this article on the Journal blog. [ABSTRACT FROM AUTHOR]

The acidizing fracturing flowback fluid with strong corrosion, high viscosity, high oil content and high suspended matter content was treated with "viscosity reduction, neutralization, de-stabilization and filtration". The results show that the optimal viscosity reduction conditions were as follows: pH was 4, the dosing quantity of H2O2 was 2 000 mg/L, the dosing quantity of Fe2+ was 500 mg/L, reaction time was 60 min and the optimal instability conditions were as follows: pH was 8, the dosing quantity of PAFC was 120 mg/L, the dosing quantity of PAM was 1. 2 mg/L. Under the optimized conditions and after comprehensive treatment, the oil content and SS content of the acidizing fracturing flowback fluid were 4. 4 mg/L and 1. 3 mg/L, the average corrosion rate was 0. 035 mm/a, the viscosity was 1. 4 mPa • s. The treated acidizing fracturing flowback fluid was mixed with formation water in any proportion, and the compatibility was good. All indicators meet the standard of re-injection. [ABSTRACT FROM AUTHOR]

As renewable energy sources increasingly outcompete fossil fuels on cost and efficiency, novel questions arise around how, when, and where renewables can displace fossil energy. We need to understand fossil fuel displacement as a sociopolitical and spatial process. In this article, we focus particularly on the scales and practices of legitimation through which fossil fuel displacement occurs. We advance an understanding of how such displacement is conditioned by incumbent multiscalar arrangements and of how these can be overcome. We suggest that there are different practices of displacement that operate across multiple scales—here conceptualized as discursive, financial, institutional, and infrastructural—and use them to develop an analysis of solar rollout and fossil phase-out in Portugal. Our analysis shows that although renewables have partially displaced fossil fuels both discursively and financially, they have not yet displaced the historically large-scale nature of energy generation. Rather, the persistence of fossil fuel geographies and sectoral institutional arrangements keeps the displacements of energy transition at a spatial remove from citizens. [ABSTRACT FROM AUTHOR]