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3. Association of intensity of ventilation with 28-day mortality in COVID-19 patients with acute respiratory failure: insights from the PRoVENT-COVID study

Author

Schuijt, Michiel T. U., Schultz, Marcus J., Paulus, Frederique, Serpa Neto, Ary, van Akkeren, J. P., Algera, A. G., Algoe, C. K., van Amstel, R. B., Baur, O. L., van de Berg, P., Bergmans, D. C. J. J., van den Bersselaar, D. I., Bertens, F. A., Bindels, A. J. G. H., de Boer, M. M., Boer, S. den, Boers, L. S., Bogerd, M., Bos, L. D. J., Botta, M., Breel, J. S., de Bruin, H., de Bruin, S., Bruna, C. L., Buiteman-Kruizinga, L. A., Cremer, O., Determann, R. M., Dongelmans, D. A., de Graaff, M. J., Hol, L., Hollmann, M. W., Horn, J., Juffermans, N. P., Kho, E., de Klerk, E. S., Kuiper, M. A., van Meenen, D. M., Mazzinari, Guido, van Mourik, N., Paulus, F., Pillay, J., Pisani, L., Purmer, I. M., Schultz, M. J., Neto, A. Serpa, Spronk, P. E., Stilma, W., Tuinman, P. R., Vlaar, A. P. J., van Velzen, P., Group, PRoVENT–COVID Collaborative, Critical Care, Intensive Care Medicine, ACS - Pulmonary hypertension & thrombosis, Nursing, AII - Infectious diseases, Graduate School, AII - Amsterdam institute for Infection and Immunity, ACS - Heart failure & arrhythmias, Anesthesiology, APH - Quality of Care, ANS - Neuroinfection & -inflammation, AII - Inflammatory diseases, 06 Operations Centre and intensive care, ARD - Amsterdam Reproduction and Development, Center of Experimental and Molecular Medicine, ACS - Microcirculation, APH - Global Health, ACS - Diabetes & metabolism, RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Arts Assistenten IC (9), Intensive Care, MUMC+: MA Medische Staf IC (9), Pulmonary medicine, and Intensive care medicine

Subjects
Male, ARDS, CLINICAL-COURSE, ademnood syndroom, Critical Care and Intensive Care Medicine, Acute respiratory failure, Cohort Studies, Clinical endpoint, Medicine, OUTCOMES, Respiratory Distress Syndrome, COVID-19/mortality, Coronavirus disease 2019, Delta P, Respiration, Tidal Volume/physiology, Medical emergencies. Critical care. Intensive care. First aid, Middle Aged, Mortality/trends, Cohort, Driving pressure, Breathing, Cardiology, Female, NEW-YORK-CITY, Cohort study, Respiratory Distress Syndrome/mortality, ΔP, medicine.medical_specialty, Critical Illness, Mechanical power of ventilation, Artificial/mortality, Internal medicine, sterfte, INJURY, Tidal Volume, Humans, kunstmatige beademing, Mortality, Aged, Retrospective Studies, Mechanical power, RC86-88.9, business.industry, Proportional hazards model, Research, COVID-19, Retrospective cohort study, medicine.disease, respiration, artificial/mortality, Respiration, Artificial, Confidence interval, MECHANICAL VENTILATION, Invasive ventilation, Critical Illness/mortality, ICU, business
Abstract

Background The intensity of ventilation, reflected by driving pressure (ΔP) and mechanical power (MP), has an association with outcome in invasively ventilated patients with or without acute respiratory distress syndrome (ARDS). It is uncertain if a similar association exists in coronavirus disease 2019 (COVID-19) patients with acute respiratory failure. Methods We aimed to investigate the impact of intensity of ventilation on patient outcome. The PRoVENT-COVID study is a national multicenter observational study in COVID-19 patients receiving invasive ventilation. Ventilator parameters were collected a fixed time points on the first calendar day of invasive ventilation. Mean dynamic ΔP and MP were calculated for individual patients at time points without evidence of spontaneous breathing. A Cox proportional hazard model, and a double stratification analysis adjusted for confounders were used to estimate the independent associations of ΔP and MP with outcome. The primary endpoint was 28-day mortality. Results In 825 patients included in this analysis, 28-day mortality was 27.5%. ΔP was not independently associated with mortality (HR 1.02 [95% confidence interval 0.88–1.18]; P = 0.750). MP, however, was independently associated with 28-day mortality (HR 1.17 [95% CI 1.01–1.36]; P = 0.031), and increasing quartiles of MP, stratified on comparable levels of ΔP, had higher risks of 28-day mortality (HR 1.15 [95% CI 1.01–1.30]; P = 0.028). Conclusions In this cohort of critically ill invasively ventilated COVID-19 patients with acute respiratory failure, we show an independent association of MP, but not ΔP with 28-day mortality. MP could serve as one prognostic biomarker in addition to ΔP in these patients. Efforts aiming at limiting both ΔP and MP could translate in a better outcome. Trial registration Clinicaltrials.gov (study identifier NCT04346342).

Published
2022
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6. One thousand plant transcriptomes and the phylogenomics of green plants

Author

Leebens, Mack J.H., Graham, S.W, Wong, G.K-S., DeGironimo, L., Edger, P.P., Jordon-Thaden, I.E., Joya, S., Melkonian, B., Miles, N.W., Pokorny Montero, L., Quigley, C., Thomas, P., Villarreal, J.C., Augustin, M.M., Barrett, M.D., Baucom, R.S., Beerling, D.J., Benstein, R.M., Biffin, E., Brockington, S.F., Burge, D.O., Burris, J.N., Burris, K.P., Burtet-Sarramegna, V., Caicedo, A.L., Cannon, S.B., Çebi, Z., Chang, Y., Chater, C., Cheeseman, J.M., Chen, T., Clarke, N.D., Clayton, H., Covshoff, S., Crandall-Stotler, B.J., Cross, H., Determann, R., Dickson, R.C., Di Stilio, V.S., Ellis, S., Fast, E., Feja, N., Field, K.J., Filatov, D.A., Finnegan, P.M., Floyd, S.K., Fogliani, B., GarcÍa, N., Gâteblé, G., Godden, G.T., Goh, Q., Greiner, S., Harkess, A., Heaney, Mike J., Helliwell, K.E., Heyduk, K., Hibberd, J.M., Hodel, R.G.J., Hollingsworth, P.M., Johnson, M.T.J., Jost, R., Joyce, B., Kapralov, M.V., Kazamia, E., Kellogg, E.A., Koch, M.A., Von Konrat, M., Könyves, K., Kutchan, T.M., Lam, V., Larsson, A., Leitch, A.R., Lentz, R., Li, F.-W., Lowe, A.J., Ludwig, M., Manos, P.S., Mavrodiev, E., McCormick, M.K., McKain, M, McLellan, T., McNeal, J., Miller, R., Nelson, M.N., Peng, Y., Ralph, P., Real, D., Riggins, C.W., Ruhsam, M., Sage, R.F., Sakai, A.K., Scascitella, M., Schilling, E.E., Schlösser, E., Sederoff, H., Servick, S., Shaw, A.J., Shaw, S.W., Sigel, E.M., Skema, C., Smith, A.G., Smithson, A., NeilStewart, C., Stinchcombe, J.R., Szövényi, P., Tate, J.A., Tiebel, H., Trapnell, D., Villegente, M., Wang, C., Weller, S.G., Wenzel, M., Weststrand, S., Westwood, J.H., Whigham, D.F., Wulff, A.S., Yang, Y., Zhu, D., Zhuang, C., Zuidof, J., Chase, M.W., Deyholos, M.K., Graham, S.W., Pires, J. Chris, Rothfels, C.J., Chen, C., Chen, L., Cheng, S., Li, J., Li, R., Li, X., Lu, H., Ou, Y., Tan, X., Tang, J., Tian, Z., Wang, F., Wang, J., Wei, X., Wong, G. K.-S., Xu, X., Yan, Z., Yang, F., Zhong, X., Zhou, F., Zhu, Y., Zhang, Y., Yu, J., Barkman, T. J., Carpenter, E. J., Liu, T., Sun, X., Wu, S., Mirarab, S., Nguyen, N., Gitzendanner, M. A., Ayyampalayam, S., Der, J., Matasci, N., Sayyari, E., Soltis, D. E., Soltis, P. S., Stevenson, D. W., Wafula, E. K., Walls, R., Wickett, N. J., De Pamphilis, C. W., Graham, S. W, Leebens-Mack, J. H., Warnow, T., Li, Z., An, H., Arrigo, N., Baniaga, A. E., Galuska, S., Jorgensen, S. A., Kidder, T. I., Kong, H., Lu-Irving, P., Marx, H. E., Qi, X., Reardon, C. R., Sessa, E. B., Sutherland, B. L., Tiley, G. P., Welles, S. R., Yu, R., Zhan, S., Barker, M. S., Porsch, M., Ullrich, K. K., Gramzow, L., Melkonian, M., Nelson, D. R., Theißen, G., Wong, G. K. S., Grosse, I., Rensing, S. A., Quint, M., Institut de sciences exactes et appliquées (ISEA), Université de la Nouvelle-Calédonie (UNC), Apollo - University of Cambridge Repository, National Key Research and Development Program (China), Ministry of Science and Technology of the People's Republic of China, Filatov, D, One Thousand Plant Transcriptomes Initiative, and School of Plant and Environmental Sciences

Subjects
0106 biological sciences, Genome evolution, Nuclear gene, 631/208/212/2306, [SDV]Life Sciences [q-bio], Viridiplantae, 01 natural sciences, Genome, Article, Evolution, Molecular, 03 medical and health sciences, Plant evolution, Phylogenomics, Databases, Genetic, Glaucophyta, 631/449/2669, 631/181/735, Plastid, Phylogeny, 45/90, 030304 developmental biology, 45/91, Adaptive radiation, 0303 health sciences, 631/181/759/2467, Multidisciplinary, biology, Archaeplastida, fungi, Botany, food and beverages, Botanik, 15. Life on land, biology.organism_classification, Biological Evolution, Evolutionary biology, Molecular evolution, Transcriptome, Genome, Plant, 010606 plant biology & botany
Abstract

Green plants (Viridiplantae) include around 450,000–500,000 species1,2 of great diversity and have important roles in terrestrial and aquatic ecosystems. Here, as part of the One Thousand Plant Transcriptomes Initiative, we sequenced the vegetative transcriptomes of 1,124 species that span the diversity of plants in a broad sense (Archaeplastida), including green plants (Viridiplantae), glaucophytes (Glaucophyta) and red algae (Rhodophyta). Our analysis provides a robust phylogenomic framework for examining the evolution of green plants. Most inferred species relationships are well supported across multiple species tree and supermatrix analyses, but discordance among plastid and nuclear gene trees at a few important nodes highlights the complexity of plant genome evolution, including polyploidy, periods of rapid speciation, and extinction. Incomplete sorting of ancestral variation, polyploidization and massive expansions of gene families punctuate the evolutionary history of green plants. Notably, we find that large expansions of gene families preceded the origins of green plants, land plants and vascular plants, whereas whole-genome duplications are inferred to have occurred repeatedly throughout the evolution of flowering plants and ferns. The increasing availability of high-quality plant genome sequences and advances in functional genomics are enabling research on genome evolution across the green tree of life., The One Thousand Plant Transcriptomes Initiative provides a robust phylogenomic framework for examining green plant evolution that comprises the transcriptomes and genomes of diverse species of green plants.

Published
2019
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8. Associations between positive end-expiratory pressure and outcome of patients without ARDS at onset of ventilation: a systematic review and meta-analysis of randomized controlled trials

Author

Neto, A.S., Rabello, R., Cherpanath, T.G.V., Determann, R., Dongelmans, D. A., Paulus, F., Tuinman, P. R., Pelosi, P., de Abreu, M.G., Schultz, M.J., Investigators, Prove Network, Intensive care medicine, ICaR - Circulation and metabolism, Graduate School, Intensive Care Medicine, AII - Amsterdam institute for Infection and Immunity, and Other Research

Subjects
medicine.medical_specialty, ARDS, medicine.medical_treatment, Hyperinflation, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, law.invention, Hypoxemia, 03 medical and health sciences, 0302 clinical medicine, Mechanical ventilation, Randomized controlled trial, law, Acute respiratory distress syndrome, Atelectasis, Intensive care unit, Meta-analysis, Positive end-expiratory pressure, medicine, 030212 general & internal medicine, business.industry, Research, respiratory system, medicine.disease, Confidence interval, respiratory tract diseases, Anesthesia, Breathing, Physical therapy, medicine.symptom, business, circulatory and respiratory physiology
Abstract

Background The aim of this investigation was to compare ventilation at different levels of positive end-expiratory pressure (PEEP) with regard to clinical important outcomes of intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) at onset of ventilation. Methods Meta-analysis of randomized controlled trials (RCTs) comparing a lower level of PEEP with a higher level of PEEP was performed. The primary outcome was in-hospital mortality. Results Twenty-one RCTs (1393 patients) were eligible. PEEP ranged from 0 to 10 cmH2O and from 5 to 30 cmH2O in the lower PEEP and the higher PEEP arms of included RCTs, respectively. In-hospital mortality was not different between the two PEEP arms in seven RCTs (risk ratio [RR] 0.87; 95% confidence interval [CI] 0.62–1.21; I 2 = 26%, low quality of evidence [QoE]), as was duration of mechanical ventilation in three RCTs (standardized mean difference [SMD] 0.68; 95% CI −0.24 to 1.61; I 2 = 82%, very low QoE). PaO2/FiO2 was higher in the higher PEEP arms in five RCTs (SMD 0.72; 95% CI 0.10–1.35; I 2 = 86%, very low QoE). Development of ARDS and the occurrence of hypoxemia (2 RCTs) were lower in the higher PEEP arms in four RCTs and two RCTs, respectively (RR 0.43; 95% CI 0.21–0.91; I 2 = 56%, low QoE; RR 0.42; 95%–CI 0.19–0.92; I 2 = 19%, low QoE). There was no association between the level of PEEP and any hemodynamic parameter (four RCTs). Conclusion Ventilation with higher levels of PEEP in ICU patients without ARDS at onset of ventilation was not associated with lower in-hospital mortality or shorter duration of ventilation, but with a lower incidence of ARDS and hypoxemia, as well as higher PaO2/FiO2. These findings should be interpreted with caution, as heterogeneity was moderate to high, the QoE was low to very low, and the available studies prevented us from addressing the effects of moderate levels of PEEP. Electronic supplementary material The online version of this article (doi:10.1186/s13613-016-0208-7) contains supplementary material, which is available to authorized users.

Published
2016
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9. Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study

Author

Neto, A, Barbas, C, Simonis, F, Artigas-Raventos, A, Canet, J, Determann, R, Anstey, J, Hedenstierna, G, Hemmes, S, Hermans, G, Hiesmayr, M, Hollmann, M, Jaber, S, Martin-Loeches, I, Mills, G, Pearse, R, Putensen, C, Schmid, W, Severgnini, P, Smith, R, Treschan, T, Tschernko, E, Melo, M, Wrigge, H, de Abreu, M, Pelosi, P, Schultz, M, Russotto, V, Neto, AS, Barbas, CSV, Simonis, FD, Determann, RM, Hemmes, SNT, Hollmann, MW, Mills, GH, Pearse, RM, Treschan, TA, Tschernko, EM, Melo, MFV, de Abreu, MG, Schultz, MJ, Neto, A, Barbas, C, Simonis, F, Artigas-Raventos, A, Canet, J, Determann, R, Anstey, J, Hedenstierna, G, Hemmes, S, Hermans, G, Hiesmayr, M, Hollmann, M, Jaber, S, Martin-Loeches, I, Mills, G, Pearse, R, Putensen, C, Schmid, W, Severgnini, P, Smith, R, Treschan, T, Tschernko, E, Melo, M, Wrigge, H, de Abreu, M, Pelosi, P, Schultz, M, Russotto, V, Neto, AS, Barbas, CSV, Simonis, FD, Determann, RM, Hemmes, SNT, Hollmann, MW, Mills, GH, Pearse, RM, Treschan, TA, Tschernko, EM, Melo, MFV, de Abreu, MG, and Schultz, MJ

Abstract

Background Scant information exists about the epidemiological characteristics and outcome of patients in the intensive care unit (ICU) at risk of acute respiratory distress syndrome (ARDS) and how ventilation is managed in these individuals. We aimed to establish the epidemiological characteristics of patients at risk of ARDS, describe ventilation management in this population, and assess outcomes compared with people at no risk of ARDS. Methods PRoVENT (PRactice of VENTilation in critically ill patients without ARDS at onset of ventilation) is an international, multicentre, prospective study undertaken at 119 ICUs in 16 countries worldwide. All patients aged 18 years or older who were receiving mechanical ventilation in participating ICUs during a 1-week period between January, 2014, and January, 2015, were enrolled into the study. The Lung Injury Prediction Score (LIPS) was used to stratify risk of ARDS, with a score of 4 or higher defining those at risk of ARDS. The primary outcome was the proportion of patients at risk of ARDS. Secondary outcomes included ventilatory management (including tidal volume [VT] expressed as mL/kg predicted bodyweight [PBW], and positive end-expiratory pressure [PEEP] expressed as cm H2O), development of pulmonary complications, and clinical outcomes. The PRoVENT study is registered at ClinicalTrials.gov, NCT01868321. The study has been completed. Findings Of 3023 patients screened for the study, 935 individuals fulfilled the inclusion criteria. Of these critically ill patients, 282 were at risk of ARDS (30%, 95% CI 27–33), representing 0·14 cases per ICU bed over a 1-week period. VT was similar for patients at risk and not at risk of ARDS (median 7·6 mL/kg PBW [IQR 6·7–9·1] vs 7·9 mL/kg PBW [6·8–9·1]; p=0·346). PEEP was higher in patients at risk of ARDS compared with those not at risk (median 6·0 cm H2O [IQR 5·0–8·0] vs 5·0 cm H2O [5·0–7·0]; p<0·0001). The prevalence of ARDS in patients at risk of ARDS was higher than in individuals

Published
2016

10. A man with 'black fingers'. Cold agglutinin disease (CAD)

Author

de Witte, M. A., Determann, R. M., Zeerleder, S. S., Amsterdam institute for Infection and Immunity, Intensive Care Medicine, Amsterdam Cardiovascular Sciences, and Clinical Haematology

Abstract

No abstract available

Published
2014

11. The Amborella Genome and the Evolution of Flowering Plants

Author

Albert, Va, Barbazuk, Wb, Depamphilis, Cw, Der, Jp, Leebens Mack, J, Ma, H, Palmer, Jd, Rounsley, S, Sankoff, D, Schuster, Sc, Soltis, De, Soltis, Ps, Wessler, Sr, Wing, Ra, Ammiraju, Js, Chamala, S, Chanderbali, As, Determann, R, Ralph, P, Talag, J, Tomsho, L, Walts, B, Wanke, S, Chang, Th, Lan, T, Arikit, S, Axtell, Mj, Ayyampalayam, S, Burnette JM 3rd, DE PAOLI, Emanuele, Estill, Jc, Farrell, Np, Harkess, A, Jiao, Y, Liu, K, Mei, W, Meyers, Bc, Shahid, S, Wafula, E, Zhai, J, Zhang, X, Carretero Paulet, L, Lyons, E, Tang, H, Zheng, C, Altman, Ns, Chen, F, Chen, Jq, Chiang, V, De Paoli, E, Fogliani, B, Guo, C, Harholt, J, Job, C, Job, D, Kim, S, Kong, H, Li, G, Li, L, Liu, J, Park, J, Qi, X, Rajjou, L, Burtet Sarramegna, V, Sederoff, R, Sun, Yh, Ulvskov, P, Villegente, M, Xue, Jy, Yeh, Tf, Yu, X, Acosta, Jj, Bruenn, Ra, de Kochko, A, Herrera Estrella LR, Ibarra Laclette, E, Kirst, M, Pissis, Sp, Poncet, V, Tomsho, L., Department of Biological Sciences, University at Buffalo [SUNY] (SUNY Buffalo), State University of New York (SUNY)-State University of New York (SUNY), Department of Biology, University of Florida [Gainesville], University of Florida Genetics Institute, Huck Institutes of the Life Sciences [University Park], Intercollege Plant Biology Graduate Program, Pennsylvania State University (Penn State), Penn State System-Penn State System, Center for Comparative Genomics and Bioinformatics, Penn State Univ, Ctr Comparat Genom & Bioinformat, University Pk, PA 16802 USA, Université Paris Diderot - Paris 7 (UPD7), Department of Plant Biology [Athens], University of Georgia [USA], Penn State Univ, Huck Inst Life Sci, University Pk, PA 16802 USA, Penn State Univ, Dept Biol, University Pk, PA 16802 USA, Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China, Fudan Univ, Inst Genet, Inst Plant Biol, Ctr Evolutionary Biol,Inst Biomed Sci, Shanghai 200433, Peoples R China, Indiana Univ, Dept Biol, Bloomington, IN 47405 USA, Univ Arizona, Inst Collaborat Res BIO5, Tucson, AZ 85721 USA, Dow AgroSci, Indianapolis, IN 46268 USA, Univ Arizona, Sch Biol Sci, Tucson, AZ 85721 USA, Department of Mathematics and Statistics, University of Ottawa [Ottawa] (uOttawa), Singapore Ctr Environm Life Sci Engn, Singapore, Singapore, Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA, Florida Museum of Natural History, Department of Botany and Plant Sciences [Riverside], University of California [Riverside] (UCR), University of California-University of California, Univ Arizona, Arizona Genom Inst, Tucson, AZ 85721 USA, Atlanta Bot Garden, Atlanta, GA 30309 USA, Univ Florida, Dept Biol, Gainesville, FL 32611 USA, Tech Univ Dresden, Inst Bot, D-01062 Dresden, Germany, SUNY Buffalo, Dept Biol Sci, Buffalo, NY 14260 USA, Chongqing Univ Sci & Technol, Dept Biol, Chongqing 4000042, Peoples R China, Univ Delaware, Delaware Biotechnol Inst, Newark, DE 19711 USA, Univ Georgia, Dept Plant Biol, Athens, GA 30602 USA, Univ Udine, Dipartimento Sci Agr & Ambientali, I-33100 Udine, Italy, Penn State Univ, Intercoll Plant Biol Grad Program, University Pk, PA 16802 USA, Univ Arizona, iPlant Collaborat, Tucson, AZ 85721 USA, J Craig Venter Inst, Rockville, MD 20850 USA, Univ Ottawa, Dept Math & Stat, Ottawa, ON K1N 6N5, Canada, Penn State Univ, Dept Stat, University Pk, PA 16802 USA, Univ Tennessee, Dept Plant Sci, Knoxville, TN 37996 USA, Nanjing Univ, Sch Life Sci, Nanjing 210093, Jiangsu, Peoples R China, N Carolina State Univ, Dept Forestry & Environm Resources, Raleigh, NC 27695 USA, Institut Agronomique Néo-Calédonien (IAC), Univ New Caledonia, Lab Insulaire Vivant & Environm, Noumea 98851, New Caledonia, Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China, Univ Copenhagen, Dept Plant & Environm Sci, DK-1871 Frederiksberg C, Denmark, Univ Claude Bernard Lyon, Inst Natl Sci Appl Bayer CropSci Joint Lab UMR524, CNRS, Bayer CropSci, F-69263 Lyon 9, France, Sungshin Womens Univ, Basic Sci Res Inst, Seoul 142732, South Korea, Sungshin Womens Univ, Sch Biol Sci & Chem, Seoul 142732, South Korea, Zhejiang Univ, Coll Life Sci, Lab Systemat & Evolutionary Bot & Biodivers, Hangzhou 310058, Zhejiang, Peoples R China, Zhejiang Univ, Coll Life Sci, Key Lab Conservat Biol Endangered Wildlife, Minist Educ, Hangzhou 310058, Zhejiang, Peoples R China, Institut Jean-Pierre Bourgin (IJPB), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Natl Chung Hsing Univ, Dept Forestry, Taichung 40227, Taiwan, Natl Taiwan Univ, Sch Forestry & Resource Conservat, Taipei 10617, Taiwan, Univ Florida, Sch Forest Resources & Conservat, Gainesville, FL 32611 USA, Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA, Diversité, adaptation, développement des plantes (UMR DIADE), Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Lab Nacl Genom Biodiversidad, Irapuato 36821, Mexico, Univ Florida, Genet Inst, Gainesville, FL 32610 USA, Univ Florida, Florida Museum Nat Hist, Gainesville, FL 32611 USA, Heidelberg Inst Theoret Studies, Sci Comp Grp, D-69118 Heidelberg, Germany, NSF Plant Genome Research Program [0922742], NSF, University of Florida [Gainesville] (UF), University of Florida Genetics Institute (UFGI), Center for Comparative Genomics and Bioinformatics (CCBB), Department of Biology [PennState], State Key Laboratory of Genetic Engineering, Fudan University [Shanghai], Institute of Plant Biology [Shanghai], Department of Biology [Bloomington], Indiana University [Bloomington], Indiana University System-Indiana University System, BIO5 - Institute for Collaborative Bioresearch, University of Arizona, Dow AgroSciences LLC, School of Plant Sciences [Tucson], Department of Mathematics and Statistics [Ottawa], University of Ottawa [Ottawa], Singapore Centre for Environmental Life Sciences Engineering [Singapore] (SCELSE), Nanyang Technological University [Singapour], Department of Biochemistry and Molecular Biology [PennState], Arizona Genomics Institute [Tucson], Atlanta Botanical Garden, Department of Biology [Gainesville] (UF|Biology), Institut für Botanik [Dresden], Technische Universität Dresden = Dresden University of Technology (TU Dresden), Department of Biological Sciences [Buffalo], Department of Biology [Chongqing], Chongqing University of Science & Technology, Plant Genome Mapping Laboratory (PGML), Dipartimento di Scienze Agrarie e Ambientali (DiSA), Università degli Studi di Udine - University of Udine [Italie], iPlant Collaborative, J. Craig Venter Institute, Department of Statistics [PennState], Department of Plant Sciences [Knoxville], The University of Tennessee [Knoxville], School of Life Sciences [Nanjing] (SLiS), Nanjing University (NJU), Department of Forestry and Environmental Resources [Raleigh] (FER), North Carolina State University [Raleigh] (NC State), University of North Carolina System (UNC)-University of North Carolina System (UNC), Université de la Nouvelle-Calédonie (UNC), State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany [Beijing] (IB-CAS), Chinese Academy of Sciences [Beijing] (CAS)-Chinese Academy of Sciences [Beijing] (CAS), Department of Plant and Environmental Sciences [Frederiksberg], University of Copenhagen = Københavns Universitet (KU), Microbiologie, adaptation et pathogénie (MAP), Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Génomique fonctionnelle des champignons pathogènes des plantes (FungiPath), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Basic Science Research Institute [Seoul], Sungshin Women's University, School of Biological Sciences and Chemistry [Seoul], Laboratory of Systematic & Evolutionary Botany and Biodiversity, Zhejiang University, Key Laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education, Department of Forestry [Taichung], National Chung Hsing University (NCHU), School of Forestry and Resource Conservation [Taiwan], National Taïwan University (NTU), School of Forest Resources and Conservation [Gainesville] (UF|IFAS|FFGS), Institute of Food and Agricultural Sciences [Gainesville] (UF|IFAS), University of Florida [Gainesville] (UF)-University of Florida [Gainesville] (UF), Department of Plant and Microbial Biology [Berkeley], University of California [Berkeley], Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigacion y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Florida Museum of Natural History [Gainesville], Heidelberg Institute for Theoretical Studies (HITS ), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL)

Subjects
0106 biological sciences, Most recent common ancestor, Genetics, Transposable element, 0303 health sciences, education.field_of_study, Multidisciplinary, Lineage (evolution), [SDV]Life Sciences [q-bio], Population, fungi, food and beverages, Biology, 01 natural sciences, Genome, 03 medical and health sciences, Gene duplication, Gene family, education, Gene, 030304 developmental biology, 010606 plant biology & botany
Abstract

Shaping Plant Evolution Amborella trichopoda is understood to be the most basal extant flowering plant and its genome is anticipated to provide insights into the evolution of plant life on Earth (see the Perspective by Adams ). To validate and assemble the sequence, Chamala et al. (p. 1516 ) combined fluorescent in situ hybridization (FISH), genomic mapping, and next-generation sequencing. The Amborella Genome Project (p. 10.1126/science.1241089 ) was able to infer that a whole-genome duplication event preceded the evolution of this ancestral angiosperm, and Rice et al. (p. 1468 ) found that numerous genes in the mitochondrion were acquired by horizontal gene transfer from other plants, including almost four entire mitochondrial genomes from mosses and algae.

Published
2013
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19. Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia.

Author

van Baarle, F. L. F., van de Weerdt, E. K., van der Velden, W. J. F. M., Ruiterkamp, R. A., Tuinman, P. R., Ypma, P. F., van den Bergh, W. M., Demandt, A. M. P., Kerver, E. D., Jansen, A. J. G., Westerweel, P. E., Arbous, S. M., Determann, R. M., van Mook, W. N. K. A., Koeman, M., Mäkelburg, A. B. U., van Lienden, K. P., Binnekade, J. M., Biemond, B. J., and Vlaar, A. P. J.

Subjects
*BLOOD platelet transfusion, *CENTRAL venous catheterization, *THROMBOCYTOPENIA, *INTENSIVE care units, *CATHETERIZATION, *PLATELET count
Abstract

BACKGROUND Transfusion guidelines regarding platelet-count thresholds before the placement of a central venous catheter (CVC) offer conflicting recommendations because of a lack of good-quality evidence. The routine use of ultrasound guidance has decreased CVC-related bleeding complications. METHODS In a multicenter, randomized, controlled, noninferiority trial, we randomly assigned patients with severe thrombocytopenia (platelet count, 10,000 to 50,000 per cubic millimeter) who were being treated on the hematology ward or in the intensive care unit to receive either one unit of prophylactic platelet transfusion or no platelet transfusion before ultrasound-guided CVC placement. The primary outcome was catheter-related bleeding of grade 2 to 4; a key secondary outcome was grade 3 or 4 bleeding. The noninferiority margin was an upper boundary of the 90% confidence interval of 3.5 for the relative risk. RESULTS We included 373 episodes of CVC placement involving 338 patients in the perprotocol primary analysis. Catheter-related bleeding of grade 2 to 4 occurred in 9 of 188 patients (4.8%) in the transfusion group and in 22 of 185 patients (11.9%) in the no-transfusion group (relative risk, 2.45; 90% confidence interval [CI], 1.27 to 4.70). Catheter-related bleeding of grade 3 or 4 occurred in 4 of 188 patients (2.1%) in the transfusion group and in 9 of 185 patients (4.9%) in the no-transfusion group (relative risk, 2.43; 95% CI, 0.75 to 7.93). A total of 15 adverse events were observed; of these events, 13 (all grade 3 catheter-related bleeding [4 in the transfusion group and 9 in the no-transfusion group]) were categorized as serious. The net savings of withholding prophylactic platelet transfusion before CVC placement was $410 per catheter placement. CONCLUSIONS The withholding of prophylactic platelet transfusion before CVC placement in patients with a platelet count of 10,000 to 50,000 per cubic millimeter did not meet the predefined margin for noninferiority and resulted in more CVC-related bleeding events than prophylactic platelet transfusion. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study

Author

Ary Serpa Neto, Carmen S V Barbas, Fabienne D Simonis, Antonio Artigas-Raventós, Jaume Canet, Rogier M Determann, James Anstey, Goran Hedenstierna, Sabrine N T Hemmes, Greet Hermans, Michael Hiesmayr, Markus W Hollmann, Samir Jaber, Ignacio Martin-Loeches, Gary H Mills, Rupert M Pearse, Christian Putensen, Werner Schmid, Paolo Severgnini, Roger Smith, Tanja A Treschan, Edda M Tschernko, Marcos F V Melo, Hermann Wrigge, Marcelo Gama de Abreu, Paolo Pelosi, Marcus J Schultz, Adam Bell, Agreta Gecaj-Gashi, Ahmet Dilek, Ahmet Sukru Denker, Akut Aytulun, Peter Kienbaum, Alastair Rose, Alessandro Bacuzzi, Alexandre Biasi Cavalcanti, Alexandre Chan, Alexandre Molin, Alison Ghosh, Alistair Roy, Amanda Cowton, Amanda Skinner, Amanda Whileman, Amy McInerney, Ana Carolina Peçanha, Andrea Cortegiani, Andrej Sribar, Andrew Bentley, Andrew Corner, Angela Pinder, Anil Hormis, Anna Walker, Barry Dixon, Ben Creagh-Brown, Carlo Alberto Volta, Carlos Munhoz, Carly Brown, Carmen Scott, Caroline Wreybrown, Catherine Plowright, Charlotte Downes, Cheryl Padilla-Harris, Chloe Hughes, Christian Frey, Christian Schlegel, Christine Boyd, Christine Ryan, Christoph Muench, Christopher Smalley, Çiler Zincircioglu, Clair Harris, Claire Kaloo, Claire Matthews, Claire Miller, Claire Pegg, Clare Bullock, Clare Mellis, Claudio Piras, Colette Seasman, Cristina Santos, Daniel Beraldo, Daniel Collins, Daniel Hadfield, Daniel Hull, Daniel Prado, David Pogson, David Rogerson, David Shaw, Davide D'Antini, Dawn Trodd Denise Griffin, Debbie Weller, Deborah Smith, Deborah Wilson, Demet Aydin, Denise Donaldson, Donatella Mestria, Eduardo Di Lauro, Eliane Bernadete Caser, Elisa Seghelini, Emanuel Cirstea, Eoin Young, Erna Alberts, Evren Senturk, Farooq Brohi, Fatma Ulger, Feda Kahveci, Fernando José da Silva Ramos, Frank Van Haren, Güldem Turan, Gabriele Sales, Gayle Clifford, Gilda Cinnella, Giovana Colozza Mecatti, Giuseppe Melchionda, Gulay Eren, Hannah Crowther, Hazel Spencer, Heather Blaylock, Helen Green, Helen Robertson, Helen Rodgers, Helen Talbot, Helen Wong, Helena Barcraft-Barnes, Helga Ceunen, Henrik Reschreiter, Hulya Ulusoy, Huseyin Toman, Iain McCullagh, Ian White, Ingeborg Welters, Ingrid van den Hul, Isabela Ambrósio Gava, Isabelle Reed, Isil Kose, Israel Maia, James Limb, Jan Máca, Jane Adderly, Jane Hunt, Jane Martin, Jane Montgomery, Jane Snell, Jean Salgado, Jenny Ritzema, Jeremy Bewley, Joanne Howe, Johan Decruyenaere, Johanna Mouland, Johanna Stickley, Johannes Mellinghoff, John Criswell, John Knighton, Jonathan Cooper, Jonathan Harrison, Jonathan Paddle, Jose Augusto Santos Pellegrini, Joseph Needleman, Julian Giles, Julie Camsooksai, Julie Furneval, Julie Toms, Karen Burt, Karen Simeson, Karen Williams, Karl Blenk, Kate Turner, Katie Lynch, Katie Sweet, Keith Hugill, Kelly Matthews, Kessia Ruas, Kevin Clarkson, Kobus Preller, Kristen Joyce, Laura Ortiz-Ruiz, Laura Youds, Lee Tbaily, Lisa Barrell, Lisa Grimmer, Lokman Soyoral, Lorenzo Peluso, Lorna Murray, Lotta Niska, Louise Tonks, Lousie Fasting, Luc DeCrop, Luca Brazzi, Lucia Mirabella, Lucy Cooper, Luis Fernando Falcão, Lynn Everett, Malcolm Watters, Mandy Carnahan, Marc Bourgeois, Marcelo Luz Pereira Romano, Marco Botteri, Marcos F Vidal Melo, Maria Faulkner, Marijana Krkusek, Marina Bahl, Mark Holliday, Mark Kol, Mark Pulletz, Marta Kozlowski, Matea Bogdanovic Dvorscak, Matija Jurjevic, Matty Koopmans, Mauricio Morales, Maximilian Schaefer, Melinda Brazier, Meredith Harris, Michael Devile, Michael Kuiper, Michael Parris, Michael Sharman, Milan Kratochvil, Mohamed Ramali, Moreno Calcagnotto dos Santos, Natalie Bynorth, Natalie Wilson, Nathalie Anquez, Nathan Huneke, Nazim Dogan, Nenad Karanovic, Nicholas Tarmey, Nicolás Carreño, Nicola Fisher, Nicola Lamb, Nicola Venner, Nigel Hollister, Nur Akgun, Osman Ekinci, Owen Boyd, Pardeep Gill, Pasquale Raimondo, Pasquale Verrastro, Paul Pulak, Pauline Fitzell, Paulo Dark, Pedro Alzugaray, Perihan Ergin Özcan, Peter MacNaughton, Petr Stourac, Phil Hopkins, Pieter Roel Tuinman, Rachel Pearson, Rachel Walker, Rafaella Souza dos Santos, Raffaele Caione, Ramprasad Matsa, Rebecca Oliver, Reni Jacob, Richard Howard-Griffin, Robert BP de Wilde, Robert Plant, Robin Hollands, Rodrigo Biondi, Rola Jaafar, Rossana Avendaño, Ruth Salt, Ryan Humphries, Sérgio Felix Pinto, Sallyane Pearson, Sam Hendry, Sandeep Lakhani, Sarah Beavis, Sarah Moreton, Sarah Prudden, Sarah Thornthwaite, Savino Spadaro, Sedat Saylan, Shailaja Chenna, Shammer Gopal, Shanaz James, Sheeba Suresh, Sian Birch, Sonja Skilijic, Stefania Aguirre, Stella Metherell, Stephanie Bell, Stephanie Janes, Stephen Wright, Steve Rose, Steve Windebank, Sue Glenn, Susan Melbourne, Susan Tyson, Susannah Leaver, Tasmin Patel, Tatjana Simurina, Terri-Ann Sewell, Tiago Macruz, Tom Hatton, Tracey Evans, Ugur Goktas, Una Poultney, Unase Buyukkocak, Vanessa Linnett, Vanessa Oliveira, Vincenzo Russotto, Vlasta Klaric, Yavuz Orak, Zerrin Demirtürk, Neto, Ary Serpa, Barbas, Carmen S V, Simonis, Fabienne D, Artigas-Raventós, Antonio, Canet, Jaume, Determann, Rogier M, Anstey, Jame, Hedenstierna, Goran, Hemmes, Sabrine N T, Hermans, Greet, Hiesmayr, Michael, Hollmann, Markus W, Jaber, Samir, Martin-Loeches, Ignacio, Mills, Gary H, Pearse, Rupert M, Putensen, Christian, Schmid, Werner, Severgnini, Paolo, Smith, Roger, Treschan, Tanja A, Tschernko, Edda M, Melo, Marcos F V, Wrigge, Hermann, de Abreu, Marcelo Gama, Pelosi, Paolo, Schultz, Marcus J, Bell A, Gecaj-Gashi A, Dilek A, Denker AS, Aytulun A, Kienbaum P, Rose A, Bacuzzi A, Cavalcanti AB, Chan A, Molin A, Ghosh A, Roy A, Cowton A, Skinner A, Whileman A, McInerney A, Peçanha AC, Cortegiani A, Sribar A, Bentley A, Corner A, Pinder A, Hormis A, Walker A, Artigas-Raventós A, Neto AS, Dixon B, Creagh-Brown B, Volta CA, Munhoz C, Brown C, Barbas CSV, Scott C, Wreybrown C, Plowright C, Downes C, Padilla-Harris C, Hughes C, Frey C, Putensen C, Schlegel C, Boyd C, Ryan C, Muench C, Smalley C, Zincircioglu Ç, Harris C, Kaloo C, Matthews C, Miller C, Pegg C, Bullock C, Mellis C, Piras C, Seasman C, Santos C, Beraldo D, Collins D, Hadfield D, Hull D, Prado D, Pogson D, Rogerson D, Shaw D, D'Antini D, Griffin DTD, Weller D, Smith D, Wilson D, Aydin D, Donaldson D, Mestria D, Tschernko EM, Lauro ED, Caser EB, Seghelini E, Cirstea E, Young E, Alberts E, Senturk E, Simonis FD, Brohi F, Ulger F, Kahveci F, da Silva Ramos FJ, Van Haren F, Turan G, Sales G, Mills GH, Mills GH, Clifford G, Cinnella G, Mecatti GC, Melchionda G, Hedenstierna G, Hermans G, Hermans G, Eren G, Crowther H, Spencer H, Blaylock H, Green H, Robertson H, Rodgers H, Talbot H, Wong H, Barcraft-Barnes H, Ceunen H, Reschreiter H, Wrigge H, Wrigge H, Ulusoy H, Toman H, McCullagh I, White I, Martin-Loeches I, Welters I, van den Hul I, Gava IA, Reed I, Kose I, Maia I, Limb J, Máca J, Adderly J, Hunt J, Martin J, Montgomery J, Snell J, Canet J, Salgado J, Ritzema J, Bewley J, Howe J, Decruyenaere J, Mouland J, Stickley J, Mellinghoff J, Criswell J, Knighton J, Cooper J, Harrison J, Paddle J, Pellegrini JAS, Needleman J, Giles J, Camsooksai J, Furneval J, Toms J, Burt K, Simeson K, Williams K, Blenk K, Turner K, Lynch K, Sweet K, Hugill K, Matthews K, Ruas K, Clarkson K, Preller K, Joyce K, Ortiz-Ruiz L, Youds L, Tbaily L, Barrell L, Grimmer L, Soyoral L, Peluso L, Murray L, Niska L, Tonks L, Fasting L, DeCrop L, Brazzi L, Mirabella L, Cooper L, Falcão LF, Everett L, Watters M, Carnahan M, Bourgeois M, Abreu MG, Romano MLP, Botteri M, Melo MFV, Melo MFV, Schultz MJ, Schultz MJ, Faulkner M, Krkusek M, Bahl M, Holliday M, Kol M, Pulletz M, Hollmann MW, Kozlowski M, Dvorscak MB, Jurjevic M, Koopmans M, Morales M, Schaefer M, Brazier M, Harris M, Devile M, Hiesmayr M, Kuiper M, Parris M, Sharman M, Kratochvil M, Ramali M, Dos Santos MC, Bynorth N, Wilson N, Anquez N, Huneke N, Dogan N, Karanovic N, Tarmey N, Carreño N, Fisher N, Lamb N, Venner N, Hollister N, Akgun N, Ekinci O, Boyd O, Pelosi P, Pelosi P, Severgnini P, Severgnini P, Gill P, Raimondo P, Verrastro P, Pulak P, Fitzell P, Dark P, Alzugaray P, Özcan PE, MacNaughton P, Stourac P, Hopkins P, Tuinman PR, Pearson R, Walker R, Santos RSD, Caione R, Matsa R, Oliver R, Jacob R, Howard-Griffin R, Wilde RB, Plant R, Hollands R, Biondi R, Smith R, Smith R, Determann RM, Jaafar R, Avendaño R, Pearse RM, Salt R, Humphries R, Pinto SF, Hemmes SNT, Pearson S, Hendry S, Jaber S, Lakhani S, Beavis S, Moreton S, Prudden S, Thornthwaite S, Spadaro S, Saylan S, Chenna S, Gopal S, James S, Suresh S, Birch S, Skilijic S, Aguirre S, Metherell S, Bell S, Janes S, Wright S, Rose S, Windebank S, Glenn S, Melbourne S, Tyson S, Leaver S, Treschan TA, Treschan TA, Patel T, Simurina T, Sewell TA, Macruz T, Hatton T, Evans T, Goktas U, Poultney U, Buyukkocak U, Linnett V, Oliveira V, Russotto V, Klaric V, Schmid W, Orak Y, Demirtürk Z., Neto, A, Barbas, C, Simonis, F, Artigas-Raventos, A, Canet, J, Determann, R, Anstey, J, Hedenstierna, G, Hemmes, S, Hermans, G, Hiesmayr, M, Hollmann, M, Jaber, S, Martin-Loeches, I, Mills, G, Pearse, R, Putensen, C, Schmid, W, Severgnini, P, Smith, R, Treschan, T, Tschernko, E, Melo, M, Wrigge, H, de Abreu, M, Pelosi, P, Schultz, M, Russotto, V, Intensive Care Medicine, Other departments, and Anesthesiology

Subjects
Male, Pediatrics, ARDS, medicine.medical_treatment, law.invention, Positive-Pressure Respiration, 0302 clinical medicine, law, Risk Factors, Prevalence, ventilator–induced lung injury, Prospective Studies, Hospital Mortality, Prospective cohort study, Tidal volume, education.field_of_study, Respiratory Distress Syndrome, Acute respiratory distress syndrome, tidal volume, ARDS, critically ill, ventilation, Middle Aged, Intensive care unit, Intensive Care Units, Critical Illne, Female, Human, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Critical Illness, Population, Intensive Care Unit, Lung injury, mechanical ventilation, NO, 03 medical and health sciences, Intensive care, medicine, Acute respiratory distress syndrome, mechanical ventilation, ventilator–induced lung injury, tidal volume, positive end–expiratory pressure, Humans, MED/41 - ANESTESIOLOGIA, education, Aged, Mechanical ventilation, business.industry, Risk Factor, Respiratory Distress Syndrome, Adult, 030208 emergency & critical care medicine, medicine.disease, Respiration, Artificial, Mechanical ventilation Acute respiratory failure Acute respiratory distress syndrome, Prospective Studie, 030228 respiratory system, Emergency medicine, positive end–expiratory pressure, business
Abstract

Background Scant information exists about the epidemiological characteristics and outcome of patients in the intensive care unit (ICU) at risk of acute respiratory distress syndrome (ARDS) and how ventilation is managed in these individuals. We aimed to establish the epidemiological characteristics of patients at risk of ARDS, describe ventilation management in this population, and assess outcomes compared with people at no risk of ARDS. Methods PRoVENT (PRactice of VENTilation in critically ill patients without ARDS at onset of ventilation) is an international, multicentre, prospective study undertaken at 119 ICUs in 16 countries worldwide. All patients aged 18 years or older who were receiving mechanical ventilation in participating ICUs during a 1-week period between January, 2014, and January, 2015, were enrolled into the study. The Lung Injury Prediction Score (LIPS) was used to stratify risk of ARDS, with a score of 4 or higher defining those at risk of ARDS. The primary outcome was the proportion of patients at risk of ARDS. Secondary outcomes included ventilatory management (including tidal volume [VT] expressed as mL/kg predicted bodyweight [PBW], and positive end-expiratory pressure [PEEP] expressed as cm H2O), development of pulmonary complications, and clinical outcomes. The PRoVENT study is registered at ClinicalTrials.gov, NCT01868321. The study has been completed. Findings Of 3023 patients screened for the study, 935 individuals fulfilled the inclusion criteria. Of these critically ill patients, 282 were at risk of ARDS (30%, 95% CI 27–33), representing 0·14 cases per ICU bed over a 1-week period. VTwas similar for patients at risk and not at risk of ARDS (median 7·6 mL/kg PBW [IQR 6·7–9·1] vs 7·9 mL/kg PBW [6·8–9·1]; p=0·346). PEEP was higher in patients at risk of ARDS compared with those not at risk (median 6·0 cm H2O [IQR 5·0–8·0] vs 5·0 cm H2O [5·0–7·0]; p

Published
2016

21. Effects of peep on lung injury, pulmonary function, systemic circulation and mortality in animals with uninjured lungs-a systematic review.

Author

Algera AG, Pisani L, Chaves RCF, Amorim TC, Cherpanath T, Determann R, Dongelmans DA, Paulus F, Tuinman PR, Pelosi P, Gama de Abreu M, Schultz MJ, and Serpa Neto A

Abstract

It is well-known that positive end-expiratory pressure (PEEP) can prevent ventilator-induced lung injury (VILI) and improve pulmonary physiology in animals with injured lungs. It's uncertain whether PEEP has similar effects in animals with uninjured lungs. A systematic review of randomized controlled trials (RCTs) comparing different PEEP levels in animals with uninjured lungs was performed. Trials in animals with injured lungs were excluded, as were trials that compared ventilation strategies that also differed with respect to other ventilation settings, e.g., tidal volume size. The search identified ten eligible trials in 284 animals, including rodents and small as well as large mammals. Duration of ventilation was highly variable, from 1 to 6 hours and tidal volume size varied from 7 to 60 mL/kg. PEEP ranged from 3 to 20 cmH 2 O, and from 0 to 5 cmH 2 O, in the 'high PEEP' or 'PEEP' arms, and in the 'low PEEP' or 'no PEEP' arms, respectively. Definitions used for lung injury were quite diverse, as were other outcome measures. The effects of PEEP, at any level, on lung injury was not straightforward, with some trials showing less injury with 'high PEEP' or 'PEEP' and other trials showing no benefit. In most trials, 'high PEEP' or 'PEEP' was associated with improved respiratory system compliance, and better oxygen parameters. However, 'high PEEP' or 'PEEP' was also associated with occurrence of hypotension, a reduction in cardiac output, or development of hyperlactatemia. There were no differences in mortality. The number of trials comparing 'high PEEP' or 'PEEP' with 'low PEEP' or 'no PEEP' in animals with uninjured lungs is limited, and results are difficult to compare. Based on findings of this systematic review it's uncertain whether PEEP, at any level, truly prevents lung injury, while most trials suggest potential harmful effects on the systemic circulation., Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare.

Published
2018
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22. Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).

Author

Cozza G, Zanin S, Determann R, Ruzzene M, Kunick C, and Pinna LA

Subjects
Adenosine Triphosphate metabolism, Apoptosis drug effects, Cell Line, Tumor, Cell Membrane Permeability drug effects, Hep G2 Cells, Humans, Carrier Proteins antagonists & inhibitors, Protein Kinase Inhibitors chemical synthesis, Protein Kinase Inhibitors pharmacology, Protein Serine-Threonine Kinases antagonists & inhibitors
Abstract

Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival, whose investigation has been hampered by the lack of specific inhibitors able to dissect its cellular functions. SB203580, a p38 MAP kinase inhibitor, has been used as a tool to inhibit HIPK2 in cells, but here we show that its efficacy as HIPK2 inhibitor is negligible (IC₅₀>40 µM). In contrast by altering the scaffold of the promiscuous CK2 inhibitor TBI a new class of HIPK2 inhibitors has been generated. One of these, TBID, displays toward HIPK2 unprecedented efficacy (IC₅₀ = 0.33 µM) and selectivity (Gini coefficient 0.592 out of a panel of 76 kinases). The two other members of the HIPK family, HIPK1 and HIPK3, are also inhibited by TBID albeit less efficiently than HIPK2. The mode of action of TBID is competitive with respect to ATP, consistent with modelling. We also provide evidence that TBID is cell permeable by showing that HIPK2 activity is reduced in cells treated with TBID, although with an IC₅₀ two orders of magnitude higher (about 50 µM) than in vitro.

Published
2014
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23. A man with "black fingers". Cold agglutinin disease (CAD).

Author

de Witte MA, Determann RM, and Zeerleder SS

Subjects
Aged, Anemia, Hemolytic, Autoimmune blood, Anemia, Hemolytic, Autoimmune complications, Anemia, Hemolytic, Autoimmune immunology, Autoantibodies blood, Blood Specimen Collection standards, Diagnosis, Differential, Humans, Immunoglobulin M blood, Male, Physical Examination, Anemia, Hemolytic, Autoimmune diagnosis, Blood Specimen Collection methods, Cold Temperature, Fingers pathology, Immunoglobulin M immunology
Published
2014

24. 2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines.

Author

Determann R, Dreher J, Baumann K, Preu L, Jones PG, Totzke F, Schächtele C, Kubbutat MH, and Kunick C

Subjects
Antineoplastic Agents chemical synthesis, Cell Line, Tumor, Cell Proliferation drug effects, Humans, Models, Molecular, Protein Conformation, Protein Kinase Inhibitors chemical synthesis, Pyrimidines chemical synthesis, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Protein Kinase Inhibitors chemistry, Protein Kinase Inhibitors pharmacology, Pyrimidines chemistry, Pyrimidines pharmacology
Abstract

2-Anilino-4-(benzimidazol-2-yl)-pyrimidines, synthesized by reaction of a readily available benzimidazole-substituted enaminone with suitable arylguanidines, were shown to inhibit four cancer-related protein kinases (Aurora B, PLK1, FAK, and VEGF-R2). The most potent derivative exhibited antiproliferative activity for several cancer cell lines of the NCI in vitro cell line panel in submicromolar concentrations. Both the anilinopyrimidine structure and the substitution pattern at the aniline ring appear to be important for the protein kinase inhibitory activity., (Copyright © 2012 Elsevier Masson SAS. All rights reserved.)

Published
2012
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25. A Novel Fusarium Species Causes a Canker Disease of the Critically Endangered Conifer, Torreya taxifolia.

Author

Smith JA, O'Donnell K, Mount LL, Shin K, Peacock K, Trulock A, Spector T, Cruse-Sanders J, and Determann R

Abstract

A canker disease of Florida torreya (Torreya taxifolia) has been implicated in the decline of this critically endangered species in its native range of northern Florida and southeastern Georgia. In surveys of eight Florida torreya sites, cankers were present on all dead trees and 71 to 100% of living trees, suggesting that a fungal pathogen might be the causal agent. To identify the causal agent, nuclear ribosomal internal transcribed spacer region (ITS rDNA) sequences were determined for 115 fungi isolated from cankers on 46 symptomatic trees sampled at three sites in northern Florida. BLASTn searches of the GenBank nucleotide database, using the ITS rDNA sequences as the query, indicated that a novel Fusarium species designated Fsp-1 might be the etiological agent. Molecular phylogenetic analyses of partial translation elongation factor 1-alpha (EF-1) and RNA polymerase second largest subunit (RPB2) gene sequences indicate that Fsp-1 represents a novel species representing one of the earliest divergences within the Gibberella clade of Fusarium. Results of pathogenicity experiments established that the four isolates of Fsp-1 tested could induce canker symptoms on cultivated Florida torreya in a growth chamber. Koch's postulates were completed by the recovery and identification of Fsp-1 from cankers of the inoculated plants.

Published
2011
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26. Development and characterization of microsatellite markers in Sarracenia L. (pitcher plant) species.

Author

Rogers WL, Cruse-Sanders JM, Determann R, and Malmberg RL

Abstract

Sarracenia species (pitcher plants) are carnivorous plants which obtain a portion of their nutrients from insects captured in the pitchers. Sarracenia species naturally hybridize with each other, and hybrid swarms have been identified. A number of the taxa within the genus are considered endangered. In order to facilitate evolutionary, ecological and conservation genetic analyses within the genus, we developed 25 microsatellite loci which show variability either within species or between species. Three S. purpurea populations were examined with 10 primer sets which showed within population variability.

Published
2010
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27. Infectious pleural effusions can be identified by sTREM-1 levels.

Author

Determann RM, Achouiti AA, El Solh AA, Bresser P, Vijfhuizen J, Spronk PE, and Schultz MJ

Subjects
Biomarkers analysis, Calcitonin Gene-Related Peptide, Female, Humans, Male, Middle Aged, Pleural Effusion metabolism, ROC Curve, Triggering Receptor Expressed on Myeloid Cells-1, Bacterial Infections diagnosis, C-Reactive Protein analysis, Calcitonin analysis, Membrane Glycoproteins analysis, Pleural Effusion diagnosis, Protein Precursors analysis, Receptors, Immunologic analysis
Abstract

Background and Objective: Conventional methods to establish pleural infection are time-consuming and sometimes inadequate. Biomarkers may aid in making rapid diagnosis of infection. In an observational study we evaluated and compared the diagnostic value of pleural fluid levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), C-reactive protein and procalcitonin in intensive care patients with pleural effusions., Methods: Thirty-six patients with de novo pleural effusions were included and 20 patients with pleural effusions after cardiothoracic surgery and 20 patients with pleural effusions after esophagus surgery acted as controls. Levels of sTREM-1, C-reactive protein and procalcitonin were measured in pleural effusions., Results: Levels of sTREM-1 were highest in empyemas, followed by infectious exudates. Levels of sTREM-1 were low in transudates and non-infectious exudates. C-reactive protein levels were highest in exudates and empyemas, while procalcitonin levels were highest in exudates. Pleural fluid with positive culture results contained higher sTREM-1 and C-reactive protein levels as compared to samples with negative culture results. A cut-off level of 50pg/mlsTREM-1 yielded a sensitivity of 93% and a specificity of 86%, while these were 87% and 67% respectively for a cut-off value of 7.5microg/ml C-reactive protein, and 60% and 64% respectively for a cut-off value of 0.15 ng/ml procalcitonin., Conclusion: sTREM-1 is superior to C-reactive protein and procalcitonin in detecting infection.

Published
2010
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