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36 results on '"Detrisac, Carol J."'

14. Varanid herpesvirus 1: a novel herpesvirus associated with proliferative stomatitis in green tree monitors (Varanus prasinus)

Author

Wellehan, James F.X., primary, Johnson, April J., additional, Latimer, Kenneth S., additional, Whiteside, Douglas P., additional, Crawshaw, Graham J., additional, Detrisac, Carol J., additional, Terrell, Scott P., additional, Heard, Darryl J., additional, Childress, April, additional, and Jacobson, Elliott R., additional

Published
2005
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15. Periocular sarcoid in a horse

Author

Komaromy, Andras M., primary, Andrew, Stacy E., additional, Brooks, Dennis E., additional, Detrisac, Carol J., additional, and Gelatt, Kirk N., additional

Published
2004
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20. West Nile Virus encephalomyelitis in horses: 46 cases (2001)

Author

Porter, Michael B., primary, Long, Maureen T., additional, Getman, Liberty M., additional, Giguère, Steeve, additional, MacKay, Robert J., additional, Lester, Guy D., additional, Alleman, A. Richard, additional, Wamsley, Heather L., additional, Franklin, Robert P., additional, Jacks, Stephanie, additional, Buergelt, Claus D., additional, and Detrisac, Carol J., additional

Published
2003
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28. RESIDENT's CORNER Periocular sarcoid in a horse.

Author

Komáromy, András M., Andrew, Stacy E., Brooks, Dennis E., Detrisac, Carol J., and Gelatt, Kirk N.

Subjects
EYELID diseases, THOROUGHBRED horse, HORSE breeds, TOMOGRAPHY, BACILLUS (Bacteria), ANESTHESIA
Abstract

A periocular nodular sarcoid of the right upper and lower eyelids was diagnosed in an 11year-old Thoroughbred mare. Computed tomography scan revealed the extent of the tumor. The mass was surgically debulked under general anesthesia, and the affected periocular region was injected intralesionally with Bacillus of Calmette and Guerin (BCG). An emulsion of cell wall fractions was used, which has been modified to reduce the toxic and allergic effect, but retain the antitumor activity. In total, five injections were performed at 2-week intervals. At follow-up 7 months after the last BCG injection, the tumor was completely resolved. Two years after the last treatment, the horse remains tumor-free. [ABSTRACT FROM AUTHOR]

Published
2004
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30. Clinicopathologic Findings Associated with Lagenidiumsp. Infection in 6 Dogs: Initial Description of an Emerging Oomycosis

Author

Grooters, Amy M., Hodgin, E. Clay, Bauer, Rudy W., Detrisac, Carol J., Znajda, Nadine R., and Thomas, Randall C.

Abstract

An oomycotic pathogen in the genus Lagenidiumwas isolated from tissues obtained from 6 dogs with progressive cutaneous disease. Initial clinical findings in 5 dogs included multifocal cutaneous lesions, subcutaneous lesions, or both associated with regional lymphadenopathy; the 6th dog initially was presented for evaluation of mandibular lymphadenopathy. Cutaneous lesions were ulcerated, exudative regions (often with necrosis and draining tracts) or multiple firm dermal or subcutaneous nodules. Two dogs subsequently developed hemoabdomen from great vessel rupture and died acutely. Four dogs were euthanized because of progression of subcutaneous lesions or lymphadenopathy. On postmortem examination, regional granulomatous lymphadenitis was found in all 6 dogs, great vessel invasion in 3 dogs, pulmonary lesions in 2 dogs, ureteral obstruction in 1 dog, mediastinal lymphadenitis in 1 dog, and hilar lymphadenitis with invasion of the distal esophagus and trachea in 1 dog. Histologically, lesions were similar to those associated with pythiosis and zygomycosis and were characterized by severe eosinophilic granulomatous inflammation (often with numerous large multinucleated giant cells) centered around broad (7–25 /L), infrequently septate hyphae. Immunoblot analysis of the serologic response of 4 dogs to a soluble mycelial extract of Lagenidium giganteumindicated that each dog's serum recognized at least 10 different antigens of L giganteum.Culture of infected tissues yielded rapid growth of colorless to white submerged colonies. Microscopically, mature hyphae in culture were broad (25–40 /L),segmented, and occasionally branching and produced motile laterally biflagellate zoospores in water culture. This report is the 1st description of infection caused by an oomycete other than Pythium insidiosumin any mammalian species.

Published
2003
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35. Evaluation of oxidative stress markers for the early diagnosis of allograft rejection in feline renal allotransplant recipients with normal renal function.

Author

Halling KB, Ellison GW, Armstrong D, Aoyagi K, Detrisac CJ, Graham JP, Newell SP, Martin FG, and Van Gilder JM

Subjects
Animals, Biomarkers blood, Cat Diseases surgery, Cats, Creatinine urine, Fever veterinary, Graft Rejection blood, Graft Rejection diagnosis, Kidney blood supply, Kidney diagnostic imaging, Kidney Failure, Chronic surgery, Kidney Failure, Chronic veterinary, Kidney Function Tests methods, Kidney Function Tests veterinary, Lactic Acid blood, Male, Oxidative Stress, Predictive Value of Tests, Specific Pathogen-Free Organisms, Ultrasonography, Creatinine analogs & derivatives, Creatinine blood, Graft Rejection veterinary, Kidney Transplantation veterinary, Thiobarbituric Acid Reactive Substances
Abstract

The purpose of this study was to identify oxidative damage to renal allografts during graft rejection by evaluating changes in oxidative markers and plasma lactate levels in feline renal allotransplant recipients. Heterotopic renal allotransplantations were performed between 8 adult feline cross-matched donors. Following 14 d of immunosuppression, the drugs were discontinued to allow allograft rejection. Baseline and serial postoperative evaluations of serum creatinine, plasma lactate, plasma thiobarbituate reactive substances (TBARS), plasma creatol, urine creatol, and renal sonographic cross-sectional area were performed. When sonographic evaluation revealed the absence of blood flow to the allograft, the rejected kidney was nephrectomized and evaluated histopathologically. Allograft rejection occurred in all cats by day 26. A significant elevation in body temperature occurred during the rejection period. No significant change was observed between any of the time periods for plasma TBARS, creatol, or urine creatol. There was a significant decrease in plasma lactate levels throughout the study. Markers of oxidative stress from venous blood did not reflect renal allograft rejection in cats with a normally functioning native kidney. Renal allograft rejection may be associated with significant increases in body temperature and warrants further investigation.

Published
2004

36. Sonographic and scintigraphic evaluation of acute renal allograft rejection in cats.

Author

Halling KB, Graham JP, Newell SP, Ellison GW, Detrisac CJ, Martin FG, VanGilder JM, and Grossman D

Subjects
Animals, Cats, Glomerular Filtration Rate veterinary, Kidney diagnostic imaging, Kidney Function Tests methods, Kidney Function Tests veterinary, Male, Radionuclide Imaging veterinary, Renal Circulation, Specific Pathogen-Free Organisms, Technetium Tc 99m Pentetate, Ultrasonography veterinary, Graft Rejection veterinary, Kidney blood supply, Kidney Transplantation veterinary
Abstract

The sonographic features of acute renal allograft rejection in humans and dogs are manifested by increase in renal cross-sectional area and reduction in renal cortical blood flow. These changes have not been investigated in cats. The objectives of this study were to evaluate sonographic and scintigraphic changes during acute renal allograft rejection in cats. Eight SPF, intact, adult, male cats received heterotopic renal allotransplantations. Immunosuppressive doses of cyclosporine and prednisolone were administered for 14 days and then discontinued to allow acute allograft rejection to occur. Serial measurements of renal cross-sectional area, resistive index (RI), echogenicity, and glomerular filtration rate (GFR) were performed to evaluate changes during acute rejection. Upon sonographic confirmation of absent diastolic blood flow or a 20% increase in cross-sectional area of the allograft, a nephrectomy and histopathologic evaluation were performed. Acute allograft rejection was confirmed histologically in all cats. Significant increases in renal cross-sectional area (P < 0.001) occurred postoperatively and during rejection. There were no significant changes in RI (P = 0.43) at any time. A subjective increase in medullary echogenicity and a decrease in corticomedullary demarcation were observed in the rejection period. While GFR decreased significantly in the immediate postoperative period (P < 0.001), no further change occurred during rejection (P = 0.42). Changes in RI and GFR do not appear to be sensitive indicators of acute renal allograft rejection in cats. Serial measurements of renal cross-sectional area appear to be a sensitive method for the early diagnosis of allograft rejection in feline renal transplant recipients.

Published
2003
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