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Detection of molecular level biomedical event extraction plays a vital role in creating and visualizing the applications related to natural language processing. Cystic Fibrosis is an inherited genetic and debilitating pathology involving the respiratory and digestive systems. The excessive production of thick sticky mucus on the outside of the cells is the main consequence of such disease. This includes disease prevention and medical search to signify the occurrence and detection of event triggers, which is regarded as a proper step in an event extraction of molecular level in biomedical applications. In this model, use a rich set of extracted features to feed the machine learning classifier that helps in better extraction of events. The study uses an automatic feature selection and a classification model using Radial Belief Neural Network (RBNN) for the optimal detection of molecular biomedical event detection. The Radial Belief Neural Network (RBNN) is the proposed system is implemented and it is the classifier to give accurate result of the disease detection. These three algorithms are used to enhance the generalization performance and scalability of detecting the molecular event triggers. The validation is conducted on the cystic fibrosis event trigger based on the gene ontology bio system using the RBNN model with a lung molecular event-level extraction dataset. The extensive computation shows that the Radial Belief Neural Network (RBNN) is proposed to given the better performance results like Accuracy, Sensitivity, Specificity, F-measure and Execution time., (Copyright © 2020 Elsevier B.V. All rights reserved.)