Search

Your search keyword '"Dexheimer, Phillip"' showing total 242 results
Start Over Author "Dexheimer, Phillip"
242 results on '"Dexheimer, Phillip"'

1. Pediatric cardiomyopathy illustrates the importance of reinterpreting the significance of genetic variants

Author

Lee, Teresa M., Miller, Erin, Sridhar, Arthi, Fan, Xiao, Dexheimer, Phillip J., Bansal, Neha, Godown, Justin, Hsu, Daphne T., Kantor, Paul, Kirmani, Sonya, Lal, Ashwin K., Rossano, Joseph W., Towbin, Jeffrey A., Webber, Steven A., Shi, Ling, Hamza, Taye H., Aronow, Bruce J., Bhatnaghar, Surbhi, Martin, Lisa J., Schubert, Jeffrey, Ware, Stephanie M., Chung, Wendy K., Wilkinson, James D., and Lipshultz, Steven E.

Published
2024
Full Text
View/download PDF

2. Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer

Author

Bedard, Mary C., Chihanga, Tafadzwa, Carlile, Adrean, Jackson, Robert, Brusadelli, Marion G., Lee, Denis, VonHandorf, Andrew, Rochman, Mark, Dexheimer, Phillip J., Chalmers, Jeffrey, Nuovo, Gerard, Lehn, Maria, Williams, David E. J., Kulkarni, Aditi, Carey, Molly, Jackson, Amanda, Billingsley, Caroline, Tang, Alice, Zender, Chad, Patil, Yash, Wise-Draper, Trisha M., Herzog, Thomas J., Ferris, Robert L., Kendler, Ady, Aronow, Bruce J., Kofron, Matthew, Rothenberg, Marc E., Weirauch, Matthew T., Van Doorslaer, Koenraad, Wikenheiser-Brokamp, Kathryn A., Lambert, Paul F., Adam, Mike, Steven Potter, S., and Wells, Susanne I.

Published
2023
Full Text
View/download PDF

3. Mucosal Inflammatory and Wound Healing Gene Programs Reveal Targets for Stricturing Behavior in Pediatric Crohn's Disease.

Author

Haberman, Yael, Minar, Phillip, Karns, Rebekah, Dexheimer, Phillip J, Ghandikota, Sudhir, Tegge, Samuel, Shapiro, Daniel, Shuler, Brianne, Venkateswaran, Suresh, Braun, Tzipi, Ta, Allison, Walters, Thomas D, Baldassano, Robert N, Noe, Joshua D, Rosh, Joel, Markowitz, James, Dotson, Jennifer L, Mack, David R, Kellermayer, Richard, Griffiths, Anne M, Heyman, Melvin B, Baker, Susan S, Moulton, Dedrick, Patel, Ashish S, Gulati, Ajay S, Steiner, Steven J, LeLeiko, Neal, Otley, Anthony, Oliva-Hemker, Maria, Ziring, David, Gokhale, Ranjana, Kim, Sandra, Guthery, Stephen L, Cohen, Stanley A, Snapper, Scott, Aronow, Bruce J, Stephens, Michael, Gibson, Greg, Dillman, Jonathan R, Dubinsky, Marla, Hyams, Jeffrey S, Kugathasan, Subra, Jegga, Anil G, and Denson, Lee A

Subjects
Crohn's Disease, Pediatric, Clinical Research, Genetics, Digestive Diseases, Inflammatory Bowel Disease, Paediatric Crohn disease, ileum, small molecule, surgery, transcriptome, pediatric Crohn Disease, Clinical Sciences, Gastroenterology & Hepatology
Abstract

Ileal strictures are the major indication for resective surgery in Crohn's disease (CD). We aimed to define ileal gene programs present at diagnosis linked with future stricturing behavior during five year follow-up, and to identify potential small molecules to reverse these gene signatures. Antimicrobial serologies and pre-treatment ileal gene expression were assessed in a representative subset of 249 CD patients within the RISK multicenter pediatric CD inception cohort study, including 113 that are unique to this report. These data were used to define genes associated with stricturing behavior and for model testing to predict stricturing behavior. A bioinformatics approach to define small molecules which may reverse the stricturing gene signature was applied. 19 of the 249 patients developed isolated B2 stricturing behavior during follow-up, while 218 remained B1 inflammatory. Using deeper RNA sequencing than in our prior report, we have now defined an inflammatory gene signature including an oncostatin M co-expression signature, tightly associated with extra-cellular matrix (ECM) gene expression in those who developed stricturing complications. We further computationally prioritize small molecules targeting macrophage and fibroblast activation and angiogenesis which may reverse the stricturing gene signature. A model containing ASCA and CBir1 serologies and a refined eight ECM gene set was significantly associated with stricturing development by year five after diagnosis (AUC (95th CI) = 0.82 (0.7-0.94)). An ileal gene program for macrophage and fibroblast activation is linked to stricturing complications in treatment naïve pediatric CD, and may inform novel small molecule therapeutic approaches.

Published
2021

4. Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis

Author

Haberman, Yael, Schirmer, Melanie, Dexheimer, Phillip J, Karns, Rebekah, Braun, Tzipi, Kim, Mi-Ok, Walters, Thomas D, Baldassano, Robert N, Noe, Joshua D, Rosh, Joel, Markowitz, James, Crandall, Wallace V, Mack, David R, Griffiths, Anne M, Heyman, Melvin B, Baker, Susan S, Kellermayer, Richard, Moulton, Dedrick, Patel, Ashish S, Gulati, Ajay S, Steiner, Steven J, LeLeiko, Neal, Otley, Anthony, Oliva-Hemker, Maria, Ziring, David, Kirschner, Barbara S, Keljo, David J, Guthery, Stephen L, Cohen, Stanley A, Snapper, Scott, Evans, Jonathan, Dubinsky, Marla, Aronow, Bruce, Hyams, Jeffrey S, Kugathasan, Subra, Huttenhower, Curtis, Xavier, Ramnik J, and Denson, Lee A

Subjects
Biomedical and Clinical Sciences, Immunology, Prevention, Genetics, Inflammatory Bowel Disease, Clinical Research, Digestive Diseases, Pediatric, Aetiology, 2.1 Biological and endogenous factors, Adolescent, Age Factors, Aging, Child, Child, Preschool, Cohort Studies, Crohn Disease, Dysbiosis, Female, Gene Expression Regulation, Humans, Ileum, Male, Peyer's Patches, Puberty, Risk, Th1 Cells, alpha-Defensins, Biological Sciences, Medical and Health Sciences
Abstract

Age-of-diagnosis associated variation in disease location and antimicrobial sero-reactivity has suggested fundamental differences in pediatric Crohn Disease (CD) pathogenesis. This variation may be related to pubertal peak incidence of ileal involvement and Peyer's patches maturation, represented by IFNγ-expressing Th1 cells. However, direct mucosal evidence is lacking. We characterize the global pattern of ileal gene expression and microbial communities in 525 treatment-naive pediatric CD patients and controls (Ctl), stratifying samples by their age-of-diagnosis. We show a robust ileal gene signature notable for higher expression of specific immune genes including GM-CSF and INFγ, and reduced expression of antimicrobial Paneth cell α-defensins, in older compared to younger patients. Reduced α-defensin expression in older patients was associated with higher IFNγ expression. By comparison, the CD-associated ileal dysbiosis, characterized by expansion of Enterobacteriaceae and contraction of Lachnospiraceae and Ruminococcaceae, was already established within the younger group and did not vary systematically with increasing age-of-diagnosis. Multivariate analysis considering individual taxa, however did demonstrate negative associations between Lachnospiraceae and IFNγ, and positive associations between Bacteroides and α-defensin expression. These data provide evidence for maturation of mucosal Th1 immune responses and loss of epithelial antimicrobial α-defensins which are associated with specific taxa with increasing age-of-diagnosis in pediatric CD.

Published
2019

5. Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

Author

Haberman, Yael, Karns, Rebekah, Dexheimer, Phillip J, Schirmer, Melanie, Somekh, Judith, Jurickova, Ingrid, Braun, Tzipi, Novak, Elizabeth, Bauman, Laura, Collins, Margaret H, Mo, Angela, Rosen, Michael J, Bonkowski, Erin, Gotman, Nathan, Marquis, Alison, Nistel, Mason, Rufo, Paul A, Baker, Susan S, Sauer, Cary G, Markowitz, James, Pfefferkorn, Marian D, Rosh, Joel R, Boyle, Brendan M, Mack, David R, Baldassano, Robert N, Shah, Sapana, Leleiko, Neal S, Heyman, Melvin B, Grifiths, Anne M, Patel, Ashish S, Noe, Joshua D, Aronow, Bruce J, Kugathasan, Subra, Walters, Thomas D, Gibson, Greg, Thomas, Sonia Davis, Mollen, Kevin, Shen-Orr, Shai, Huttenhower, Curtis, Xavier, Ramnik J, Hyams, Jeffrey S, and Denson, Lee A

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Immunology, Nutrition, Inflammatory Bowel Disease, Clinical Research, Autoimmune Disease, Digestive Diseases, Genetics, Biotechnology, 4.1 Discovery and preclinical testing of markers and technologies, Aetiology, 2.1 Biological and endogenous factors, Detection, screening and diagnosis, Oral and gastrointestinal, Good Health and Well Being, Adolescent, Adult, Anti-Inflammatory Agents, Non-Steroidal, Child, Colitis, Ulcerative, Feces, Female, Gene Expression Profiling, Genes, Mitochondrial, Glucocorticoids, Humans, Integrins, Intestinal Mucosa, Male, Mesalamine, Microbiota, Mitochondria, Mitochondrial Diseases, Precision Medicine, Prospective Studies, Rectum, Remission Induction, Sequence Analysis, RNA, Severity of Illness Index, Transcriptome, Treatment Outcome, Tumor Necrosis Factor-alpha
Abstract

Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients receiving standardised therapy. We validate our key findings in adult and paediatric UC cohorts of 408 participants. We observe a marked suppression of mitochondrial genes and function across cohorts in active UC, and that increasing disease severity is notable for enrichment of adenoma/adenocarcinoma and innate immune genes. A subset of severity genes improves prediction of corticosteroid-induced remission in the discovery cohort; this gene signature is also associated with response to anti-TNFα and anti-α4β7 integrin in adults. The severity and therapeutic response gene signatures were in turn associated with shifts in microbes previously implicated in mucosal homeostasis. Our data provide insights into UC pathogenesis, and may prioritise future therapies for nonresponders to current approaches.

Published
2019

6. Whole-exome sequencing uncovers oxidoreductases DHTKD1 and OGDHL as linkers between mitochondrial dysfunction and eosinophilic esophagitis.

Author

Sherrill, Joseph D, Kc, Kiran, Wang, Xinjian, Wen, Ting, Chamberlin, Adam, Stucke, Emily M, Collins, Margaret H, Abonia, J Pablo, Peng, Yanyan, Wu, Qiang, Putnam, Philip E, Dexheimer, Phillip J, Aronow, Bruce J, Kottyan, Leah C, Kaufman, Kenneth M, Harley, John B, Huang, Taosheng, and Rothenberg, Marc E

Subjects
T-Lymphocytes, Mitochondria, Fibroblasts, Epithelial Cells, Humans, Ketoglutarate Dehydrogenase Complex, Oxidoreductases, Ketone Oxidoreductases, Oxidoreductases Acting on CH-CH Group Donors, Proteins, RNA, Small Interfering, Interleukin-13, Cytokines, Up-Regulation, Mutation, Adult, Child, Female, Male, Eosinophilic Esophagitis, Exome Sequencing, Allergy, Cellular immune response, Immunology, Inflammation, Human Genome, Food Allergies, Clinical Research, Genetics, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Whole Exome Sequencing
Abstract

Eosinophilic esophagitis (EoE) is an allergic inflammatory esophageal disorder with a complex underlying genetic etiology often associated with other comorbidities. Using whole-exome sequencing (WES) of 63 patients with EoE and 60 unaffected family members and family-based trio analysis, we sought to uncover rare coding variants. WES analysis identified 5 rare, damaging variants in dehydrogenase E1 and transketolase domain-containing 1 (DHTKD1). Rare variant burden analysis revealed an overabundance of putative, potentially damaging DHTKD1 mutations in EoE (P = 0.01). Interestingly, we also identified 7 variants in the DHTKD1 homolog oxoglutarate dehydrogenase-like (OGDHL). Using shRNA-transduced esophageal epithelial cells and/or patient fibroblasts, we further showed that disruption of normal DHTKD1 or OGDHL expression blunts mitochondrial function. Finally, we demonstrated that the loss of DHTKD1 expression increased ROS production and induced the expression of viperin, a gene previously shown to be involved in production of Th2 cytokines in T cells. Viperin had increased expression in esophageal biopsies of EoE patients compared with control individuals and was upregulated by IL-13 in esophageal epithelial cells. These data identify a series of rare genetic variants implicating DHTKD1 and OGDHL in the genetic etiology of EoE and underscore a potential pathogenic role for mitochondrial dysfunction in EoE.

Published
2018

7. Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease.

Author

Haberman, Yael, BenShoshan, Marina, Di Segni, Ayelet, Dexheimer, Phillip J, Braun, Tzipi, Weiss, Batia, Walters, Thomas D, Baldassano, Robert N, Noe, Joshua D, Markowitz, James, Rosh, Joel, Heyman, Melvin B, Griffiths, Anne M, Crandall, Wallace V, Mack, David R, Baker, Susan S, Kellermayer, Richard, Patel, Ashish, Otley, Anthony, Steiner, Steven J, Gulati, Ajay S, Guthery, Stephen L, LeLeiko, Neal, Moulton, Dedrick, Kirschner, Barbara S, Snapper, Scott, Avivi, Camila, Barshack, Iris, Oliva-Hemker, Maria, Cohen, Stanley A, Keljo, David J, Ziring, David, Anikster, Yair, Aronow, Bruce, Hyams, Jeffrey S, Kugathasan, Subra, and Denson, Lee A

Subjects
Biotechnology, Autoimmune Disease, Prevention, Crohn's Disease, Inflammatory Bowel Disease, Digestive Diseases, Genetics, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Adolescent, Caco-2 Cells, Child, Crohn Disease, Down-Regulation, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Gene Regulatory Networks, Hepatocyte Nuclear Factor 4, Humans, Ileum, Male, Oligonucleotide Array Sequence Analysis, RNA, Long Noncoding, RNA, Messenger, Up-Regulation, Crohn disease, long ncRNA, RNAseq, RNA expression, Clinical Sciences, Gastroenterology & Hepatology
Abstract

BackgroundLong noncoding RNAs (lncRNA) are key regulators of gene transcription and many show tissue-specific expression. We previously defined a novel inflammatory and metabolic ileal gene signature in treatment-naive pediatric Crohn disease (CD). We now extend our analyses to include potential regulatory lncRNA.MethodsUsing RNAseq, we systematically profiled lncRNAs and protein-coding gene expression in 177 ileal biopsies. Co-expression analysis was used to identify functions and tissue-specific expression. RNA in situ hybridization was used to validate expression. Real-time polymerase chain reaction was used to test lncRNA regulation by IL-1β in Caco-2 enterocytes.ResultsWe characterize widespread dysregulation of 459 lncRNAs in the ileum of CD patients. Using only the lncRNA in discovery and independent validation cohorts showed patient classification as accurate as the protein-coding genes, linking lncRNA to CD pathogenesis. Co-expression and functional annotation enrichment analyses across several tissues and cell types 1showed that the upregulated LINC01272 is associated with a myeloid pro-inflammatory signature, whereas the downregulated HNF4A-AS1 exhibits association with an epithelial metabolic signature. We confirmed tissue-specific expression in biopsies using in situ hybridization, and validated regulation of prioritized lncRNA upon IL-1β exposure in differentiated Caco-2 cells. Finally, we identified significant correlations between LINC01272 and HNF4A-AS1 expression and more severe mucosal injury.ConclusionsWe systematically define differentially expressed lncRNA in the ileum of newly diagnosed pediatric CD. We show lncRNA utility to correctly classify disease or healthy states and demonstrate their regulation in response to an inflammatory signal. These lncRNAs, after mechanistic exploration, may serve as potential new tissue-specific targets for RNA-based interventions.

Published
2018

8. Filaggrin loss-of-function variants are associated with atopic dermatitis phenotypes in a diverse, early life prospective cohort

Author

Virolainen, Samuel J., primary, Satish, Latha, additional, Biagini, Jocelyn M., additional, Chaib, Hassan, additional, Chang, Wan Chi, additional, Dexheimer, Phillip J., additional, Dixon, Michael R., additional, Dunn, Katelyn A., additional, Fletcher, David, additional, Forney, Carmy, additional, Granitto, Marissa, additional, Hestand, Matthew S., additional, Hurd, Makenna, additional, Kaufman, Kenneth, additional, Lawson, Lucinda P., additional, Martin, Lisa J., additional, Peña, Loren D.M., additional, Phelan, Kieran J., additional, Shook, Molly S., additional, Weirauch, Matthew T., additional, Khurana Hershey, Gurjit K., additional, and Kottyan, Leah C., additional

Published
2024
Full Text
View/download PDF

9. AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria

Author

McDaniel, Cameron T., Panmanee, Warunya, Winsor, Geoffrey L., Gill, Erin, Bertelli, Claire, Schurr, Michael J., Dongare, Prateek, Paul, Andrew T., Ko, Seung-Hyun B., Lau, Gee W., Dasgupta, Nupur, Bogue, Amy L., Miller, William E., Mortensen, Joel E., Haslam, David B., Dexheimer, Phillip, Muruve, Daniel A., Aronow, Bruce J., Forbes, Malcolm D. E., Danilczuk, Marek, Brinkman, Fiona S. L., Hancock, Robert E. W., Meyer, Thomas J., and Hassett, Daniel J.

Published
2020

12. Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

Author

Haberman, Yael, Tickle, Timothy L, Dexheimer, Phillip J, Kim, Mi-Ok, Tang, Dora, Karns, Rebekah, Baldassano, Robert N, Noe, Joshua D, Rosh, Joel, Markowitz, James, Heyman, Melvin B, Griffiths, Anne M, Crandall, Wallace V, Mack, David R, Baker, Susan S, Huttenhower, Curtis, Keljo, David J, Hyams, Jeffrey S, Kugathasan, Subra, Walters, Thomas D, Aronow, Bruce, Xavier, Ramnik J, Gevers, Dirk, and Denson, Lee A

Subjects
Prevention, Digestive Diseases, Genetics, Inflammatory Bowel Disease, Crohn's Disease, Autoimmune Disease, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Adolescent, Apolipoprotein A-I, Case-Control Studies, Child, Cohort Studies, Colitis, Ulcerative, Crohn Disease, Dual Oxidases, Female, Gene Expression Profiling, Humans, Ileum, Male, Microbiota, NADPH Oxidases, Proteobacteria, Transcriptome, Medical and Health Sciences, Immunology
Abstract

Interactions between the host and gut microbial community likely contribute to Crohn disease (CD) pathogenesis; however, direct evidence for these interactions at the onset of disease is lacking. Here, we characterized the global pattern of ileal gene expression and the ileal microbial community in 359 treatment-naive pediatric patients with CD, patients with ulcerative colitis (UC), and control individuals. We identified core gene expression profiles and microbial communities in the affected CD ilea that are preserved in the unaffected ilea of patients with colon-only CD but not present in those with UC or control individuals; therefore, this signature is specific to CD and independent of clinical inflammation. An abnormal increase of antimicrobial dual oxidase (DUOX2) expression was detected in association with an expansion of Proteobacteria in both UC and CD, while expression of lipoprotein APOA1 gene was downregulated and associated with CD-specific alterations in Firmicutes. The increased DUOX2 and decreased APOA1 gene expression signature favored oxidative stress and Th1 polarization and was maximally altered in patients with more severe mucosal injury. A regression model that included APOA1 gene expression and microbial abundance more accurately predicted month 6 steroid-free remission than a model using clinical factors alone. These CD-specific host and microbe profiles identify the ileum as the primary inductive site for all forms of CD and may direct prognostic and therapeutic approaches.

Published
2014

13. Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight‐loss‐independent manner

Author

Myronovych, Andriy, Kirby, Michelle, Ryan, Karen K, Zhang, Wujuan, Jha, Pinky, Setchell, Kenneth DR, Dexheimer, Phillip J, Aronow, Bruce, Seeley, Randy J, and Kohli, Rohit

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Nutrition, Liver Disease, Obesity, Digestive Diseases, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Animals, Bile Acids and Salts, Caloric Restriction, Cholic Acid, Diet, High-Fat, Down-Regulation, Fatty Liver, Gastroplasty, Gene Expression Profiling, Gene Expression Regulation, Lipogenesis, Liver, Male, Mice, Mice, Inbred C57BL, Non-alcoholic Fatty Liver Disease, Postprandial Period, Random Allocation, Taurochenodeoxycholic Acid, Triglycerides, Up-Regulation, Weight Loss, Endocrinology & Metabolism
Abstract

ObjectiveOur objective was to investigate the role of bile acids in hepatic steatosis reduction after vertical sleeve gastrectomy (VSG).Design and methodsHigh fat diet (HFD)-induced obese C57Bl/6 mice were randomized to VSG, Sham operation (Sham), Sham operation with pair feeding to VSG (Sham-PF), or nonsurgical controls (Naïve). All mice were on HFD until sacrifice. Mice were observed postsurgery and data for body weight, body composition, metabolic parameters, serum bile acid level and composition were collected. Further hepatic gene expression by mRNA-seq and RT-PCR analysis was assessed.ResultsVSG and Sham-PF mice lost equal weight postsurgery while VSG mice had the lowest hepatic triglyceride content at sacrifice. The VSG mice had elevated serum bile acid levels that positively correlated with maximal weight loss. Serum bile composition in the VSG group had increased cholic and tauroursodeoxycholic acid. These bile acid composition changes in VSG mice explained observed downregulation of hepatic lipogenic and bile acid synthetic genes.ConclusionVSG in obese mice results in greater hepatic steatosis reduction than seen with caloric restriction alone. VSG surgery increases serum bile acids that correlate with weight lost postsurgery and changes serum bile composition that could explain suppression of hepatic genes responsible for lipogenesis.

Published
2014

16. A Critical Role of RUNX1 in Governing Megakaryocyte-Primed Hematopoietic Stem Cell Differentiation

Author

Wang, Chen, primary, Tu, Zhaowei, additional, Cai, Xiongwei, additional, Wang, Weinan, additional, Davis, Ashley Kuenzi, additional, Nattamai, Kalpana J, additional, Paranjpe, Aditi, additional, Dexheimer, Phillip, additional, Wu, Jianqiang, additional, Huang, L. Frank, additional, Geiger, Hartmut, additional, Huang, Gang, additional, and Zheng, Yi, additional

Published
2023
Full Text
View/download PDF

19. Abstract 16673: Exome Sequencing in a Pediatric Cardiomyopathy Cohort: Findings From the Pediatric Cardiomyopathy Registry

Author

Ware, Stephanie M, Wilkinson, James D, Tariq, Muhammad, Schubert, Jeffrey A, Sridhar, Arthi, Colan, Steven D, Shi, Ling, Canter, Charles E, Hsu, Daphne T, Webber, Steven A, Dodd, Debra A, Everitt, Melanie D, Kantor, Paul F, Addonizio, Linda J, Jefferies, John L, Rossano, Joseph W, Pahl, Elfriede, Rusconi, Paolo, Chung, Wendy K, Lee, Teresa M, Towbin, Jeffrey A, Lal, Ashwin K, Bhatnagar, Surbhi, Aronow, Bruce J, Dexheimer, Phillip, Martin, Lisa J, Miller, Erin M, Razoky, Hiedy, Czachor, Jason D, and Lipshultz, Steven E

Published
2017

21. Characteristics of children ≤36 months of age with DIPG: A report from the international DIPG registry

Author

Bartlett, Allison L, primary, Lane, Adam, additional, Chaney, Brooklyn, additional, Escorza, Nancy Yanez, additional, Black, Katie, additional, Cochrane, Anne, additional, Minturn, Jane, additional, Bartels, Ute, additional, Warren, Kathy, additional, Hansford, Jordan, additional, Ziegler, David, additional, Diez, Blanca, additional, Goldman, Stewart, additional, Packer, Roger, additional, Kieran, Mark, additional, DeWire-Schottmiller, Mariko, additional, Erker, Craig, additional, Monje-Deisseroth, Michelle, additional, Wagner, Lars, additional, Koschmann, Carl, additional, Dorris, Kathleen, additional, Shih, Chie-Schin, additional, Hassall, Tim, additional, Samson, Yvan, additional, Fisher, Paul, additional, Wang, Stacie S, additional, Tsui, Karen, additional, Sevlever, Gustavo, additional, Zhu, Xiaoting, additional, Dexheimer, Phillip, additional, Asher, Anthony, additional, Fuller, Christine, additional, Drissi, Rachid, additional, Jones, Blaise, additional, Leach, James, additional, and Fouladi, Maryam, additional

Published
2022
Full Text
View/download PDF

23. The genetic architecture of pediatric cardiomyopathy

Author

Ware, Stephanie M., primary, Bhatnagar, Surbhi, additional, Dexheimer, Phillip J., additional, Wilkinson, James D., additional, Sridhar, Arthi, additional, Fan, Xiao, additional, Shen, Yufeng, additional, Tariq, Muhammad, additional, Schubert, Jeffrey A., additional, Colan, Steven D., additional, Shi, Ling, additional, Canter, Charles E., additional, Hsu, Daphne T., additional, Bansal, Neha, additional, Webber, Steven A., additional, Everitt, Melanie D., additional, Kantor, Paul F., additional, Rossano, Joseph W., additional, Pahl, Elfriede, additional, Rusconi, Paolo, additional, Lee, Teresa M., additional, Towbin, Jeffrey A., additional, Lal, Ashwin K., additional, Chung, Wendy K., additional, Miller, Erin M., additional, Aronow, Bruce, additional, Martin, Lisa J., additional, and Lipshultz, Steven E., additional

Published
2022
Full Text
View/download PDF

24. Characteristics of patients ≥10 years of age with diffuse intrinsic pontine glioma: a report from the International DIPG/DMG Registry

Author

Erker, Craig, Lane, Adam, Chaney, Brooklyn, Leary, Sarah, Minturn, Jane E, Bartels, Ute, Packer, Roger J, Dorris, Kathleen, Gottardo, Nicholas G, Warren, Katherine E, Broniscer, Alberto, Kieran, Mark W, Zhu, Xiaoting, White, Peter, Dexheimer, Phillip J, Black, Katie, Asher, Anthony, DeWire, Mariko, Hansford, Jordan R, Gururangan, Sridharan, Nazarian, Javad, Ziegler, David S, Sandler, Eric, Bartlett, Allison, Goldman, Stewart, Shih, Chie-Schin, Hassall, Tim, Dholaria, Hetal, Bandopadhayay, Pratiti, Samson, Yvan, et al, University of Zurich, and Erker, Craig

Subjects
2728 Neurology (clinical), 10036 Medical Clinic, 610 Medicine & health, 2730 Oncology, 1306 Cancer Research
Published
2022
Full Text
View/download PDF

28. Characteristics of patients ≥10 years of age with diffuse intrinsic pontine glioma: a report from the International DIPG/DMG Registry

Author

Erker, Craig, primary, Lane, Adam, additional, Chaney, Brooklyn, additional, Leary, Sarah, additional, Minturn, Jane E, additional, Bartels, Ute, additional, Packer, Roger J, additional, Dorris, Kathleen, additional, Gottardo, Nicholas G, additional, Warren, Katherine E, additional, Broniscer, Alberto, additional, Kieran, Mark W, additional, Zhu, Xiaoting, additional, White, Peter, additional, Dexheimer, Phillip J, additional, Black, Katie, additional, Asher, Anthony, additional, DeWire, Mariko, additional, Hansford, Jordan R, additional, Gururangan, Sridharan, additional, Nazarian, Javad, additional, Ziegler, David S, additional, Sandler, Eric, additional, Bartlett, Allison, additional, Goldman, Stewart, additional, Shih, Chie-Schin, additional, Hassall, Tim, additional, Dholaria, Hetal, additional, Bandopadhayay, Pratiti, additional, Samson, Yvan, additional, Monje, Michelle, additional, Fisher, Paul G, additional, Dodgshun, Andrew, additional, Parkin, Sarah, additional, Chintagumpala, Murali, additional, Tsui, Karen, additional, Gass, David, additional, Larouche, Valerie, additional, Broxson, Emmett, additional, Garcia Lombardi, Mercedes, additional, Wang, Stacie Shiqi, additional, Ma, Jie, additional, Hawkins, Cynthia, additional, Hamideh, Dima, additional, Wagner, Lars, additional, Koschmann, Carl, additional, Fuller, Christine, additional, Drissi, Rachid, additional, Jones, Blaise V, additional, Leach, James, additional, and Fouladi, Maryam, additional

Published
2021
Full Text
View/download PDF

29. Su094 IMMUNE AND METABOLIC PATHOGENESIS OF ENVIRONMENTAL ENTERIC DYSFUNCTION IN CHILDHOOD UNDERNUTRITION: A BIRTH INCEPTION COHORT

Author

Haberman, Yael, primary, Iqbal, Najeeha T., additional, Ghandikota, Sudhir, additional, Mallawaarachchi, Indika, additional, Braun, Tzipi, additional, Dexheimer, Phillip J., additional, Rehman, Najeeb U., additional, Hadar, Rotem, additional, Sadiq, Kamran, additional, Ahmad, Zubair, additional, Idrees, Romana, additional, Iqbal, Junaid, additional, Ahmed, Sheraz, additional, Hotwani, Aneeta, additional, Umrani, Fayaz A., additional, Ehsan, Lubaina, additional, Medlock, Greg, additional, Syed, Sana, additional, Moskaluk, Christopher A., additional, Ma, Jennie Z., additional, Jegga, Anil, additional, Moore, Sean, additional, Ali, Asad, additional, and Denson, Lee A., additional

Published
2021
Full Text
View/download PDF

30. Mucosal Inflammatory and Wound Healing Gene Programs Reveal Targets for Stricturing Behavior in Pediatric Crohn's Disease.

Author

Haberman, Yael, Haberman, Yael, Minar, Phillip, Karns, Rebekah, Dexheimer, Phillip J, Ghandikota, Sudhir, Tegge, Samuel, Shapiro, Daniel, Shuler, Brianne, Venkateswaran, Suresh, Braun, Tzipi, Ta, Allison, Walters, Thomas D, Baldassano, Robert N, Noe, Joshua D, Rosh, Joel, Markowitz, James, Dotson, Jennifer L, Mack, David R, Kellermayer, Richard, Griffiths, Anne M, Heyman, Melvin B, Baker, Susan S, Moulton, Dedrick, Patel, Ashish S, Gulati, Ajay S, Steiner, Steven J, LeLeiko, Neal, Otley, Anthony, Oliva-Hemker, Maria, Ziring, David, Gokhale, Ranjana, Kim, Sandra, Guthery, Stephen L, Cohen, Stanley A, Snapper, Scott, Aronow, Bruce J, Stephens, Michael, Gibson, Greg, Dillman, Jonathan R, Dubinsky, Marla, Hyams, Jeffrey S, Kugathasan, Subra, Jegga, Anil G, Denson, Lee A, Haberman, Yael, Haberman, Yael, Minar, Phillip, Karns, Rebekah, Dexheimer, Phillip J, Ghandikota, Sudhir, Tegge, Samuel, Shapiro, Daniel, Shuler, Brianne, Venkateswaran, Suresh, Braun, Tzipi, Ta, Allison, Walters, Thomas D, Baldassano, Robert N, Noe, Joshua D, Rosh, Joel, Markowitz, James, Dotson, Jennifer L, Mack, David R, Kellermayer, Richard, Griffiths, Anne M, Heyman, Melvin B, Baker, Susan S, Moulton, Dedrick, Patel, Ashish S, Gulati, Ajay S, Steiner, Steven J, LeLeiko, Neal, Otley, Anthony, Oliva-Hemker, Maria, Ziring, David, Gokhale, Ranjana, Kim, Sandra, Guthery, Stephen L, Cohen, Stanley A, Snapper, Scott, Aronow, Bruce J, Stephens, Michael, Gibson, Greg, Dillman, Jonathan R, Dubinsky, Marla, Hyams, Jeffrey S, Kugathasan, Subra, Jegga, Anil G, and Denson, Lee A

Abstract

Ileal strictures are the major indication for resective surgery in Crohn's disease (CD). We aimed to define ileal gene programs present at diagnosis linked with future stricturing behavior during five year follow-up, and to identify potential small molecules to reverse these gene signatures. Antimicrobial serologies and pre-treatment ileal gene expression were assessed in a representative subset of 249 CD patients within the RISK multicenter pediatric CD inception cohort study, including 113 that are unique to this report. These data were used to define genes associated with stricturing behavior and for model testing to predict stricturing behavior. A bioinformatics approach to define small molecules which may reverse the stricturing gene signature was applied. 19 of the 249 patients developed isolated B2 stricturing behavior during follow-up, while 218 remained B1 inflammatory. Using deeper RNA sequencing than in our prior report, we have now defined an inflammatory gene signature including an oncostatin M co-expression signature, tightly associated with extra-cellular matrix (ECM) gene expression in those who developed stricturing complications. We further computationally prioritize small molecules targeting macrophage and fibroblast activation and angiogenesis which may reverse the stricturing gene signature. A model containing ASCA and CBir1 serologies and a refined eight ECM gene set was significantly associated with stricturing development by year five after diagnosis (AUC (95th CI) = 0.82 (0.7-0.94)). An ileal gene program for macrophage and fibroblast activation is linked to stricturing complications in treatment naïve pediatric CD, and may inform novel small molecule therapeutic approaches.

Published
2020

34. Mucosal Inflammatory and Wound Healing Gene Programmes Reveal Targets for Stricturing Behaviour in Paediatric Crohn’s Disease

Author

Haberman, Yael, primary, Minar, Phillip, additional, Karns, Rebekah, additional, Dexheimer, Phillip J, additional, Ghandikota, Sudhir, additional, Tegge, Samuel, additional, Shapiro, Daniel, additional, Shuler, Brianne, additional, Venkateswaran, Suresh, additional, Braun, Tzipi, additional, Ta, Allison, additional, Walters, Thomas D, additional, Baldassano, Robert N, additional, Noe, Joshua D, additional, Rosh, Joel, additional, Markowitz, James, additional, Dotson, Jennifer L, additional, Mack, David R, additional, Kellermayer, Richard, additional, Griffiths, Anne M, additional, Heyman, Melvin B, additional, Baker, Susan S, additional, Moulton, Dedrick, additional, Patel, Ashish S, additional, Gulati, Ajay S, additional, Steiner, Steven J, additional, LeLeiko, Neal, additional, Otley, Anthony, additional, Oliva-Hemker, Maria, additional, Ziring, David, additional, Gokhale, Ranjana, additional, Kim, Sandra, additional, Guthery, Stephen L, additional, Cohen, Stanley A, additional, Snapper, Scott, additional, Aronow, Bruce J, additional, Stephens, Michael, additional, Gibson, Greg, additional, Dillman, Jonathan R, additional, Dubinsky, Marla, additional, Hyams, Jeffrey S, additional, Kugathasan, Subra, additional, Jegga, Anil G, additional, and Denson, Lee A, additional

Published
2020
Full Text
View/download PDF

35. 935 PRE-TREATMENT MUCOSAL INFLAMMATORY AND WOUND HEALING GENE PROGRAMS REVEAL MECHANISMS ASSOCIATED WITH FUTURE STRICTURING BEHAVIOR DURING FIVE YEAR FOLLOW-UP IN PEDIATRIC CROHN'S DISEASE

Author

Haberman, Yael, primary, Minar, Phillip P., additional, Karns, Rebekah, additional, Dexheimer, Phillip J., additional, Ghandikota, Sudhir, additional, Tegge, Samuel, additional, Shapiro, Daniel, additional, Shuler, Brianne, additional, Venkateswaran, Suresh, additional, Braun, Tzipi, additional, Walters, Thomas D., additional, Baldassano, Robert N., additional, Noe, Joshua D., additional, Kellermayer, Richard, additional, Markowitz, James, additional, Dotson, Jennifer L., additional, Mack, David R., additional, Griffiths, Anne M., additional, Heyman, Melvin B., additional, Baker, Susan S., additional, Moulton, Dedrick E., additional, Patel, Ashish S., additional, Gulati, Ajay S., additional, Steiner, Steven J., additional, Leleiko, Neal S., additional, Otley, Anthony, additional, Oliva-Hemker, Maria, additional, Ziring, David, additional, Gokhale, Ranjana R., additional, Kim, Sandra C., additional, Guthery, Stephen, additional, Cohen, Stanley A., additional, Snapper, Scott B., additional, Aronow, Bruce J., additional, Stephens, Michael C., additional, Gibson, Greg, additional, Dubinsky, Marla C, additional, Hyams, Jeffrey S., additional, Kugathasan, Subra, additional, Jegga, Anil, additional, and Denson, Lee A., additional

Published
2020
Full Text
View/download PDF

36. NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation

Author

Yu, Yanan, primary, Choi, Kwangmin, additional, Wu, Jianqiang, additional, Andreassen, Paul R., additional, Dexheimer, Phillip J., additional, Keddache, Mehdi, additional, Brems, Hilde, additional, Spinner, Robert J., additional, Cancelas, Jose A., additional, Martin, Lisa J., additional, Wallace, Margaret R., additional, Legius, Eric, additional, Vogel, Kristine S., additional, and Ratner, Nancy, additional

Published
2019
Full Text
View/download PDF

38. Tu1756 – The Treatment Naive Rectal Transcriptome Identifies Pathways Underlying Response to Induction Corticosteroid Therapy in Ulcerative Colitis

Author

Haberman, Yael, primary, Karns, Rebekah, additional, Dexheimer, Phillip J., additional, Schirmer, Melanie, additional, Jurickova, Ingrid, additional, Collins, Margaret H., additional, Mo, Angela, additional, Rosen, Michael J., additional, Bonkowski, Erin, additional, Gotman, Nathan, additional, Marquis, Alison, additional, Rufo, Paul A., additional, Baker, Susan S., additional, Sauer, Cary G., additional, Markowitz, James, additional, Pfefferkorn, Marian D., additional, Rosh, Joel R., additional, Boyle, Brendan M., additional, Mack, David R., additional, Baldassano, Robert N., additional, Shah, Sapana.shah, additional, Leleiko, Neal S., additional, Heyman, Melvin B., additional, Griffiths, Anne M., additional, Patel, Ashish S., additional, Noe, Joshua D., additional, Aronow, Bruce J., additional, Kugathasan, Subra, additional, Walters, Thomas D., additional, Gibson, Greg, additional, Thomas, Sonia Davis Thomas Davis, additional, Mollen, Kevin, additional, Huttenhower, Curtis, additional, Xavier, Ramnik, additional, Hyams, Jeffrey S., additional, and Denson, Lee A., additional

Published
2019
Full Text
View/download PDF

41. Complementary RNA amplification methods enhance microarray identification of transcripts expressed in the C. elegans nervous system

Author

Levy Shawn, Spencer W Clay, Von Stetina Stephen E, Wang Shenglong, Watson Joseph D, Dexheimer Phillip J, Kurn Nurith, Heath Joe, and Miller David M

Subjects
Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background DNA microarrays provide a powerful method for global analysis of gene expression. The application of this technology to specific cell types and tissues, however, is typically limited by small amounts of available mRNA, thereby necessitating amplification. Here we compare microarray results obtained with two different methods of RNA amplification to profile gene expression in the C. elegans larval nervous system. Results We used the mRNA-tagging strategy to isolate transcripts specifically from C. elegans larval neurons. The WT-Ovation Pico System (WT-Pico) was used to amplify 2 ng of pan-neural RNA to produce labeled cDNA for microarray analysis. These WT-Pico-derived data were compared to microarray results obtained with a labeled aRNA target generated by two rounds of In Vitro Transcription (IVT) of 25 ng of pan-neural RNA. WT-Pico results in a higher fraction of present calls than IVT, a finding consistent with the proposal that DNA-DNA hybridization results in lower mismatch signals than the RNA-DNA heteroduplexes produced by IVT amplification. Microarray data sets from these samples were compared to a reference profile of all larval cells to identify transcripts with elevated expression in neurons. These results were validated by the high proportion of known neuron-expressed genes detected in these profiles and by promoter-GFP constructs for previously uncharacterized genes in these data sets. Together, the IVT and WT-Pico methods identified 2,173 unique neuron-enriched transcripts. Only about half of these transcripts (1,044), however, are detected as enriched by both IVT and WT-Pico amplification. Conclusion We show that two different methods of RNA amplification, IVT and WT-Pico, produce valid microarray profiles of gene expression in the C. elegans larval nervous system with a low rate of false positives. However, our results also show that each method of RNA amplification detects a unique subset of bona fide neural-enriched transcripts and thus a wider array of authentic neural genes are identified by the combination of these data sets than by the microarray profiles obtained with either method of RNA amplification alone. With its relative ease of implementation and greater sensitivity, WT-Pico is the preferred method of amplification for cases in which sample RNA is limiting.

Published
2008
Full Text
View/download PDF

42. Genome-Driven Therapy for Chemotherapy-Resistant Metastatic CDK6-Amplified Osteosarcoma.

Author

Lazow, Margot A., Johnson, Sheryl L., Johnson, Neil D., Breneman, John C., Dexheimer, Phillip J., Szabo, Sara, and Pressey, Joseph G.

Subjects
HORMONE receptor positive breast cancer, OSTEOSARCOMA, EPIDERMAL growth factor receptors
Abstract

The therapy and prognosis for osteosarcoma have not significantly changed in several decades.[1] [3] Standard treatment includes complete surgical resection of gross disease and systemic multiagent chemotherapy to treat micrometastases.[4] Recent trials have failed to substantially improve outcomes, such that 5-year overall survival rates remain approximately 65% for patients with localized disease and < 30% for patients with metastatic disease, with an especially dismal prognosis associated with unresectable and relapsed disease.[2],[5],[6] Beyond common alterations of I TP53 i , I RB i , and I MDM2/4 i , the osteosarcoma genome is generally characterized by chaotic findings including complex karyotypes, significant copy number variation, and random rearrangements.[7],[8] The lack of recurring point mutations in expressed proteins has considerably hindered the development of novel osteosarcoma therapy; however, targeting of prevalent somatic copy number alterations has been proposed as a potential approach to this heterogeneous, genomically complex disease.[9] The cyclin D-cyclin-dependent kinase (CDK) 4/6-retinoblastoma (Rb) pathway is dysregulated in many cancer types, with resultant uncontrolled cell cycle progression and proliferation.[10],[11] CDK4/6 proteins bind with D-type cyclin subunits to multiphosphorylate the tumor suppressor Rb, thereby inhibiting its function and allowing progression through the G SB 1 sb -S cell cycle checkpoint. Given the dearth of established therapeutic options for treatment-refractory osteosarcoma, investigative strategies exploiting frequently documented copy number alterations with careful clinical monitoring including the acquisition of posttherapy tumor specimen may be worthy of further exploration. [Extracted from the article]

Published
2020
Full Text
View/download PDF

44. DIPG-69. CHARACTERISTICS OF PATIENTS ≥ 10 YEARS OF AGE WITH DIFFUSE INTRINSIC PONTINE GLIOMA: A REPORT FROM THE INTERNATIONAL DIPG REGISTRY

Author

Erker, Craig, primary, Lane, Adam, additional, Chaney, Brooklyn, additional, Escorza, Nancy Yanez, additional, Fuller, Christine, additional, Saab, Raya, additional, Kieran, Mark, additional, Packer, Roger, additional, Nazarian, Javad, additional, Minturn, Jane, additional, Dodgshun, Andrew, additional, Parkin, Sarah, additional, Foreman, Nicholas, additional, Broxson, Emmett, additional, Lombardi, Mercedes Garcia, additional, Goldman, Stewart, additional, Sandler, Eric, additional, Warren, Kathy, additional, Greiner, Robert, additional, Gottardo, Nickolas, additional, Dholaria, Hetal, additional, Shih, Chie-Schin, additional, Hassall, Tim, additional, Hansford, Jordan R, additional, Wang, Shiqi Stacie, additional, Samson, Yvan, additional, Leary, Sarah, additional, Ma, Jie, additional, Bartels, Ute, additional, Broniscer, Alberto, additional, Monje, Michelle, additional, Fisher, Paul, additional, Ziegler, David, additional, Wagner, Lars, additional, Koschmann, Carl, additional, Doughman, Renee, additional, Drissi, Rachid, additional, Jones, Blaise, additional, Leach, James, additional, White, Peter, additional, Dexheimer, Phillip, additional, Hendershot, Jacob, additional, Hawkins, Cynthia, additional, Bandopadhayay, Pratiti, additional, and Fouladi, Maryam, additional

Published
2018
Full Text
View/download PDF

45. DIPG-70. CLINICAL, RADIOLOGICAL, PATHOLOGICAL AND MOLECULAR CHARACTERISTICS OF CHILDREN <3 YEARS WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG): A REPORT FROM THE INTERNATIONAL DIPG REGISTRY

Author

Bartlett, Allison, primary, Cochrane, Anne, additional, Lane, Adam, additional, Yanez-Escorza, Nancy, additional, Chaney, Brooklyn, additional, Doughman, Renee, additional, DeWire-Schottmiller, Mariko, additional, Goldman, Stewart, additional, Warren, Kathy, additional, Bandopadhayay, Pratiti, additional, Foreman, Nicholas, additional, Shih, Chie-Schin, additional, Minturn, Jane, additional, Bartels, Ute, additional, Packer, Roger, additional, Nazarian, Javad, additional, Hassall, Tim, additional, Samson, Yvan, additional, Monje-Deisseroth, Michelle, additional, Fisher, Paul, additional, Wagner, Lars, additional, Koschmann, Carl, additional, Ziegler, David, additional, Kieran, Mark, additional, Hawkins, Cynthia, additional, White, Peter, additional, Dexheimer, Phillip, additional, Hendershot, Jacob, additional, Drissi, Rachid, additional, Fuller, Christine, additional, Leach, James, additional, Jones, Blaise, additional, and Fouladi, Maryam, additional

Published
2018
Full Text
View/download PDF

46. 589 - The Treatment Naive Rectal Transcriptome Identifies Pathways Mediating Clinical and Endoscopic Severity and Response to Initial Therapy in Pediatric Ulcerative Colitis

Author

Haberman, Yael, primary, Karns, Rebekah, additional, Dexheimer, Phillip J., additional, Bauman, Laura E., additional, Collins, Margaret H., additional, Rosen, Michael J., additional, Bonkowski, Erin, additional, Marquis, Alison, additional, Gotman, Nathan, additional, Rufo, Paul A., additional, Baker, Susan S., additional, Sauer, Cary G., additional, Markowitz, James, additional, Pfefferkorn, Marian D., additional, Rosh, Joel R., additional, Boyle, Brendan M., additional, Mack, David R., additional, Baldassano, Robert N., additional, Keljo, David J., additional, Leleiko, Neal S., additional, Heyman, Melvin B., additional, Griffiths, Anne M., additional, Patel, Ashish S., additional, Noe, Joshua D., additional, Aronow, Bruce J., additional, Kugathasan, Subra, additional, Walters, Thomas D., additional, Davis, Sonia, additional, Hyams, Jeffrey S., additional, and Denson, Lee A., additional

Published
2018
Full Text
View/download PDF

47. Sa2009 - Bioavailable Serum Vitamin D and Rectal Vitamin D Receptor Expression at Diagnosis in Pediatric Ulcerative Colitis: Associations with Disease Severity, Clinical Outcomes, and Rectal Patterns of Gene Expression

Author

Bauman, Laura E., primary, Haberman, Yael, additional, Hao, Li, additional, Patel, Shiven, additional, Tangpricha, Vin, additional, Karns, Rebekah, additional, Dexheimer, Phillip J., additional, Collins, Margaret H., additional, Rosen, Michael J., additional, Bonkowski, Erin, additional, Marquis, Alison, additional, Gotman, Nathan, additional, Rufo, Paul A., additional, Baker, Susan S., additional, Sauer, Cary G., additional, Markowitz, James, additional, Pfefferkorn, Marian D., additional, Rosh, Joel R., additional, Boyle, Brendan M., additional, Mack, David R., additional, Baldassano, Robert N., additional, Keljo, David J., additional, Leleiko, Neal S., additional, Heyman, Melvin B., additional, Griffiths, Anne M., additional, Patel, Ashish S., additional, Noe, Joshua D., additional, Aronow, Bruce J., additional, Kugathasan, Subra, additional, Walters, Thomas D., additional, Davis, Sonia, additional, Hyams, Jeffrey S., additional, and Denson, Lee A., additional

Published
2018
Full Text
View/download PDF

48. 740 - Age-of-Onset Dependent Ileal Immune Maturation and Reduced Alpha-Defensin in Pediatric Crohn Disease with Already Established Dysbiosis

Author

Haberman, Yael, primary, Schirmer, Melanie, additional, Dexheimer, Phillip J., additional, Karns, Rebekah, additional, Braun, Tzipi, additional, Kim, Mi-Ok, additional, Walters, Thomas D., additional, Baldassano, Robert N., additional, Noe, Joshua D., additional, Rosh, Joel R., additional, Markowitz, James, additional, Crandall, Wallace V., additional, Mack, David R., additional, Griffiths, Anne M., additional, Heyman, Melvin B., additional, Baker, Susan S., additional, Kellermayer, Richard, additional, Moulton, Dedrick E., additional, Patel, Ashish S., additional, Gulati, Ajay S., additional, Steiner, Steven J., additional, Leleiko, Neal S., additional, Otley, Anthony, additional, Oliva-Hemker, Maria, additional, Kirschner, Barbara S., additional, Keljo, David J., additional, Guthery, Stephen, additional, Cohen, Stanley, additional, Ziring, David, additional, Evans, Jonathan, additional, Snapper, Scott B., additional, Dubinsky, Marla, additional, Aronow, Bruce J., additional, Hyams, Jeffrey S., additional, Kugathasan, Subra, additional, Huttenhower, Curtis, additional, Xavier, Ramnik, additional, and Denson, Lee A., additional

Published
2018
Full Text
View/download PDF

49. X chromosomal linkage to eosinophilic esophagitis susceptibility

Author

Kottyan, Leah C., primary, Maddox, Avery, additional, Hoffman, Kate, additional, Ray, Leanne, additional, Forney, Carmey, additional, Eby, Michael, additional, Mingler, Melissa K., additional, Kaufman, Kenneth, additional, Dexheimer, Phillip, additional, Lukac, Nina, additional, Caldwell, Julie M., additional, Rochman, Mark, additional, Shoda, Tetsuo, additional, Wen, Ting, additional, Wheeler, Justin C., additional, Hogan, Simon P., additional, Mukkada, Vincent A., additional, Putnam, Philip E., additional, Abonia, Pablo P., additional, Genta, Robert M., additional, Martin, Lisa J., additional, Dellon, Evan S., additional, and Rothenberg, Marc E., additional

Published
2018
Full Text
View/download PDF

50. Foamy Virus Vector Carries a Strong Insulator in Its Long Terminal Repeat Which Reduces Its Genotoxic Potential

Author

Goodman, Michael Aaron, primary, Arumugam, Paritha, additional, Pillis, Devin Marie, additional, Loberg, Anastacia, additional, Nasimuzzaman, Mohammed, additional, Lynn, Danielle, additional, van der Loo, Johannes Christiaan Maria, additional, Dexheimer, Phillip Joseph, additional, Keddache, Mehdi, additional, Bauer, Thomas Roy, additional, Hickstein, Dennis Durand, additional, Russell, David William, additional, and Malik, Punam, additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results