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78 results on '"Dey, A.B."'

7. Serum FOXO3A: A ray of hope for early diagnosis of Alzheimer’s disease

Author

Pradhan, Rashmita, primary, Yadav, Saroj Kumar, additional, Prem, Naganath Narasimhan, additional, Bhagel, Vivek, additional, Pathak, Mona, additional, Shekhar, Shashank, additional, Gaikwad, S., additional, Dwivedi, S.N., additional, Bal, Chandra Shekhar, additional, Dey, A.B., additional, and Dey, Sharmistha, additional

Published
2020
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9. Circulatory GSK-3β: Blood-Based Biomarker and Therapeutic Target for Alzheimer's Disease.

Author

Kumari, Shiwani, Singh, Ambica, Singh, Abhinay Kumar, Yadav, Yudhishthir, Bajpai, Swati, Kumar, Pramod, Upadhyay, Ashish Datt, Shekhar, Shashank, Dwivedi, Sadanand, Dey, A.B., and Dey, Sharmistha

Subjects
ALZHEIMER'S disease, SURFACE plasmon resonance, MILD cognitive impairment, P53 protein, BIOMARKERS
Abstract

Background: Alzheimer's disease (AD) is the progressive brain disorder which degenerates brain cells connection and causes memory loss. Although AD is irreversible, it is not impossible to arrest or slow down the progression of the disease. However, this would only be possible if the disease is diagnosed at an early stage, and early diagnosis requires clear understanding of the pathogenesis at molecular level. Overactivity of GSK-3β and p53 accounts for tau hyperphosphorylation and the formation of amyloid-β plaques.Objective: Here, we explored GSK-3β and p53 as blood-based biomarkers for early detection of AD.Methods: The levels of GSK-3β, p53, and their phosphorylated states were measured using surface plasmon resonance and verified using western blot in serum from AD, mild cognitive impairment (MCI), and geriatric-control (GC) subjects. The neurotoxic SH-SY5Y cell line was treated with antioxidant Emblica Officinalis (EO) for rescue effect.Results: GSK-3β, p53, and their phosphorylated states were significantly over expressed (p > 0.001) in AD and MCI compared to GC and can differentiate AD and MCI from GC. The expression level of GSK-3β and p53 proteins were found to be downregulated in a dose-dependent manner after the treatment with EO in amyloid-b-induced neurotoxic cells.Conclusion: These proteins can serve as potential blood markers for the diagnosis of AD and EO can suppress their level. This work has translational value and clinical utility in the future. [ABSTRACT FROM AUTHOR]

Published
2022
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14. Development and validation of Cognitive Training Intervention for Alzheimer's disease (CTI-AD): A picture-based interventional program.

Author

Bajpai, Swati, Tripathi, Manjari, Pandey, RM, Dey, A.B, and Nehra, Ashima

Abstract

Introduction: Alzheimer's disease is a gradual and progressive disorder which cripples the person's functionality due to cognitive decline. Many clinicopathological and pharmacological therapy has the potential to slow down the progression of the disease but has limited efficacy. One complimentary approach that has emerged is cognitive training interventions which have shown synergistic effect with the drug therapy. Nevertheless, many cognitive interventions lack on specificities of the intervention due to which its efficacy gets scrutinized. Objective: To describe the foundation, content, and development of Cognitive Training Intervention for Alzheimer's disease (CTI-AD) along with the treatment feasibility based on a pilot study. Materials and methods: A culture-specific picture-based eight weeks cognitive training manual was developed based on extensive review and focused group discussions. It was standardized on 63 older participants (48 healthy controls (HC); 15 early Alzheimer's disease cases). Results: All the tasks were progressive in nature and were found effective in discriminating the cognitive performance of early Alzheimer's disease and HC throughout the intervention period. Moreover, it also improved early Alzheimer's disease performance on the memory (HC: 1st week/8th week = 21.6 ± 5.7/57.3 ± 19.0; early Alzheimer's disease: 1st week/8th week = 48.5 ± 22.9/60.5 ± 21.8); attention (HC: 1st week/8th week = 90.2 ± 18.0/196.9 ± 28.0; early Alzheimer's disease: 1st week/8th week = 216.6 ± 78.2/286.8 ± 87.0) and language (HC: 1st week/8th week = 29.8 ± 9.4/115.3 ± 31.1; early Alzheimer's disease: 1st week/8th week = 211.8 ± 68.4/270.4 ± 104.9) domains, respectively, from the baseline level. Conclusion: The current manual (CTI-AD) is one of the first promising non-pharmacological program developed nationally with a strong theoretical base to cater to the tertiary needs of the older adults with early Alzheimer's disease. [ABSTRACT FROM AUTHOR]

Published
2020
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15. Molecular detection of Mycoplasma pneumoniae by quantitative real-time PCR in patients with community acquired pneumonia

Author

Chaudhry, Rama, Sharma, Sutikshan, Javed, Sabah, Passi, Kapil, Dey, A.B., and Malhotra, Pawan

Subjects
Community-acquired pneumonia (CAP), Base Sequence, lcsh:R, serology, lcsh:Medicine, Quantitative real-time PCR (QRT-PCR), Real-Time Polymerase Chain Reaction, Community-acquired pneumonia ( CAP) - Mycoplasma pneumonia - Quantitative real-time PCR (QRT-PCR) - serology, Mycoplasma pneumoniae, Pneumonia, Bacterial, Humans, Original Article, Mycoplasma pneumonia, DNA Primers
Abstract

Background & objectives: Mycoplasma pneumoniae is the most important and common cause of community-acquired pneumonia (CAP). The conventional detection methods (culture and serology) lack sensitivity. PCR offers a better approach for rapid detection but is prone to carry over contamination during manipulation of amplification products. Quantitative real-time PCR (qRT-PCR) method offers an attractive alternative detection method. In the present study, qRT-PCR, PCR and serology methods were used to detect M. pneumoniae infection in cases of pneumonias and findings compared. Methods: A total of 134 samples consisting of blood (for serology) and respiratory secretions (for PCR and qRT-PCR) from 134 patients were collected. The blood samples were tested for IgG, IgM and IgA using commercially available kits. For standardization of PCR of M. pneumoniae P1 gene was cloned in pGEMTEasy vector. Specific primers and reporter sequence were designed and procured for this fragment. The qRT-PCR assay was performed to prepare the standard curve for M. pneumoniae positive control DNA template and detection in patient samples. Results: Of the 134 patients, 26 (19%) were positive for antibodies against M. pneumoniae. IgG was positive in 14.92 per cent (20) cases, IgM in 4.47 per cent (6) and IgA was positive in 5.22 per cent (7) cases. In the qRT-PCR assay 19 per cent (26) samples were positive. Of the 26 qRT-PCR positive samples, nine could be detected by serology. PCR was positive for 25 samples. An extra sample negative by PCR was detected by qRT-PCR. Thus, real-time PCR assay, PCR and serology in combination could detect M. pneumoniae infection in 43 patients. Interpretation & conclusions: The study shows that 17 patients were detected by serology alone, 17 were detected by qRT-PCR only and nine patients were positive by both serology and real-time PCR. Of the 134 samples tested, 25 were positive by conventional PCR, but qRT-PCR could detect one more sample that was negative by PCR and serology. These results suggest that a combination of two or three methods may be required for reliable identification of CAP due to M. pneumoniae.

Published
2013

16. Density dependent composition of InAs quantum dots extracted from grazing incidence x-ray diffraction measurements

Author

Sharma, M., Sanyal, M.K., Farrer, I., Ritchie, D.A., Dey, A.B., Bhattacharyya, A., Seeck, O.H., Skiba-Szymanska, J., Felle, M., Bennett, A.J., and Shields, A.J.

Subjects
Condensed Matter::Materials Science, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect
Abstract

Epitaxial InAs quantum dots grown on GaAs substrate are being used in several applications ranging from quantum communications to solar cells. The growth mechanism of these dots also helps us to explore fundamental aspects of self-organized processes. Here we show that composition and strain profile of the quantum dots can be tuned by controlling in-plane density of the dots over the substrate with the help of substrate-temperature profile. The compositional profile extracted from grazing incidence x-ray measurements show substantial amount of inter-diffusion of Ga and In within the QD as a function of height in the low-density region giving rise to higher variation of lattice parameters. The QDs grown with high in-plane density show much less spread in lattice parameter giving almost flat density of In over the entire height of an average QD and much narrower photoluminescence (PL) line. The results have been verified with three different amounts of In deposition giving systematic variation of the In composition as a function of average quantum dot height and average energy of PL emission.

Published
2015

34. Emerging leptospirosis, North India. (Letters)

Author

Chaudhry, Rama, Premlatha, M.M., Mohanty, Srujana, Dhawan, Benu, Singh, Kumar Kirti, and Dey, A.B

Abstract

To the Editor: We read with interest the article, The Changing Epidemiology of Leptospirosis in Israel, published in volume 7, no. 6 (1). Leptospirosis, a septicemic zoonosis with multisystemic involvement, [...]

Published
2002

49. LETTERS.

Author

Daniels, Thomas J., Battaly, Gertrude R., Liveris, Dionysios, Falco, Richard C., Schwartz, Ira, Chaudry, Rama, Premlatha, M.M., Mohanty, Srujana, Dhawan, Benu, Singh, Kumar Kirti, and Dey, A.B.

Subjects
LETTERS to the editor, DISEASES, EHRLICHIOSIS, LEPTOSPIROSIS
Abstract

Presents letters to the editor on medical and disease research. Discussion of the potential role of birds in human granulocytic ehrlichiosis ecology; Incidence of human leptospirosis in India.

Published
2002

50. Infections caused by Gemellaspp.: Case Reports from India

Author

Chaudhry, R., Mathur, P., Dhawan, B., Gaur, S., and Dey, A.B.

Abstract

Human infections caused by Gemellaspp. are rare. We report here our experience of the isolation of species of Gemellae from various clinical samples. Careful and complete identification of this organism will prevent diagnostic and therapeutic delays and bring more such cases to light.

Published
2001
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