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3,029 results on '"Dhaliwal, A. S."'

9. Somatic mutational landscape across Indian breast cancer cases by whole exome sequencing

Author

Kumar, Rahul, Awasthi, Supriya, Pradhan, Dibyabhaba, Kumar, Rakesh, Goel, Harsh, Singh, Jay, Haider, Imran, Deo, S. V. S., Kumar, Chitresh, Srivastava, Anurag, Bhatnagar, Amar, Kumar, Rakesh, Lakshmi, S., Augustine, Paul, Ranjan, Amar, Chopra, Anita, Gogia, Ajay, Batra, Atul, Mathur, Sandeep, Rath, Goura Kishor, Kaur, Tanvir, Dhaliwal, R. S., Mathew, Aleyamma, Agrawal, Usha, Hussain, Showket, and Tanwar, Pranay

Published
2024
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16. Sex Differences in Outcomes of Percutaneous Pulmonary Artery Thrombectomy in Patients With Pulmonary Embolism.

Author

Agarwal, Manyoo A, Dhaliwal, Jasmeet S, Yang, Eric H, Aksoy, Olcay, Press, Marcella, Watson, Karol, Ziaeian, Boback, Fonarow, Gregg C, Moriarty, John M, Saggar, Rajan, and Channick, Richard

Subjects
Pulmonary Artery, Humans, Pulmonary Embolism, Treatment Outcome, Thrombectomy, Retrospective Studies, Cross-Sectional Studies, Sex Characteristics, United States, Female, Male, disparities, hospitalizations, outcomes, pulmonary embolism, sex, sex differences, thrombectomy, Lung, Patient Safety, Cardiovascular, Clinical Trials and Supportive Activities, Clinical Research, Aging, Good Health and Well Being, &nbsp, differences, Clinical Sciences, Respiratory System
Abstract

BackgroundThe sex differences in use, safety outcomes, and health-care resource use of patients with pulmonary embolism (PE) undergoing percutaneous pulmonary artery thrombectomy are not well characterized.Research questionWhat are the sex differences in outcomes for patients diagnosed with PE who undergo percutaneous pulmonary artery thrombectomy?Study design and methodsThis retrospective cross-sectional study used national inpatient claims data to identify patients in the United States with a discharge diagnosis of PE who underwent percutaneous thrombectomy between January 2016 and December 2018. We evaluated the demographics, comorbidities, safety outcomes (in-hospital mortality), and health-care resource use (discharge to home, length of stay, and hospital charges) of patients with PE undergoing percutaneous thrombectomy.ResultsAmong 1,128,904 patients with a diagnosis of PE between 2016 and 2018, 5,160 patients (0.5%) underwent percutaneous pulmonary artery thrombectomy. When compared with male patients, female patients showed higher procedural bleeding (16.9% vs 11.2%; P < .05), required more blood transfusions (11.9% vs 5.7%; P < .05), and experienced more vascular complications (5.0% vs 1.5%; P < .05). Women experienced higher in-hospital mortality (16.9% vs 9.3%; adjusted OR, 1.9; 95% CI, 1.2-3.0; P = .003) when compared with men. Although length of stay and hospital charges were similar to those of men, women were less likely to be discharged home after surviving hospitalization (47.9% vs 60.3%; adjusted OR, 0.7; 95% CI, 0.50-0.99; P = .04).InterpretationIn this large nationwide cohort, women with PE who underwent percutaneous thrombectomy showed higher morbidity and in-hospital mortality compared with men.

Published
2023

21. Accuracy of energy and nutrient intake estimation versus observed intake using 4 technology-assisted dietary assessment methods: a randomized crossover feeding study

Author

Whitton, Clare, Collins, Clare E, Mullan, Barbara A, Rollo, Megan E, Dhaliwal, Satvinder S, Norman, Richard, Boushey, Carol J, Delp, Edward J, Zhu, Fengqing, McCaffrey, Tracy A, Kirkpatrick, Sharon I, Pollard, Christina M, Healy, Janelle D, Hassan, Amira, Garg, Shivangi, Atyeo, Paul, Mukhtar, Syed Aqif, and Kerr, Deborah A

Published
2024
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36. Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons.

Author

Ji, Daisy X, Witt, Kristen C, Kotov, Dmitri I, Margolis, Shally R, Louie, Alexander, Chevée, Victoria, Chen, Katherine J, Gaidt, Moritz M, Dhaliwal, Harmandeep S, Lee, Angus Y, Nishimura, Stephen L, Zamboni, Dario S, Kramnik, Igor, Portnoy, Daniel A, Darwin, K Heran, and Vance, Russell E

Subjects
immunology, inflammation, legionella pneumophila, mouse, mycobacterium tuberculosis, type i interferon, Biochemistry and Cell Biology
Abstract

Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important question is how type I IFNs are strongly induced during viral infections, and yet are appropriately restrained during bacterial infections. The Super susceptibility to tuberculosis 1 (Sst1) locus in mice confers resistance to diverse bacterial infections. Here we provide evidence that Sp140 is a gene encoded within the Sst1 locus that represses type I IFN transcription during bacterial infections. We generated Sp140-/- mice and found that they are susceptible to infection by Legionella pneumophila and Mycobacterium tuberculosis. Susceptibility of Sp140-/- mice to bacterial infection was rescued by crosses to mice lacking the type I IFN receptor (Ifnar-/-). Our results implicate Sp140 as an important negative regulator of type I IFNs that is essential for resistance to bacterial infections.

Published
2021

38. Picture-Naming Test for a Linguistically Diverse Population with Cognitive Impairment and Dementia

Author

Paplikar, Avanthi, Varghese, Feba, Alladi, Suvarna, Vandana, V. P., Darshini, K. J., Iyer, Gowri K., Kandukuri, Rajmohan, Divyaraj, Gollahalli, Sharma, Meenakshi, Dhaliwal, R. S., Kaul, Subhash, Saroja, Aralikatte Onkarappa, Ghosh, Amitabha, Sunitha, J., Khan, Arfa Banu, Mathew, Robert, Mekala, Shailaja, Menon, Ramshekhar, Nandi, Ranita, Narayanan, Jwala, Nehra, Ashima, Padma, M. V., Pauranik, Apoorva, Ramakrishnan, Subasree, Sarath, Lekha, Shah, Urvashi, Tripathi, Manjari, Sylaja, P. N., Varma, Ravi Prasad, Verma, Mansi, and Vishwanath, Yeshaswini

Abstract

Background: Picture-naming tests (PNTs) evaluate linguistic impairment in dementia due to semantic memory impairment, impaired lexical retrieval or perceptual deficits. They also assess the decline in naming impairment at various stages of dementia and mild cognitive impairment (MCI) that occurs due to progressive cognitive impairment. With the increasing numbers of people with dementia globally, it is necessary to have validated naming tests and norms that are culturally and linguistically appropriate. Aims: In this cross-sectional study we harmonized a set of 30 images applicable to the Indian context across five languages and investigated the picture-naming performance in patients with MCI and dementia. Methods & Procedures: A multidisciplinary expert group formed by the Indian Council of Medical Research (ICMR) collaborated towards developing and adapting a picture naming test (PNT) known as the ICMR-PNT in five Indian languages: Hindi, Bengali, Telugu, Kannada and Malayalam. Based on cross-cultural adaptation guidelines and item-wise factor analysis and correlations established separately across five languages, the final version of the ICMR-PNT test was developed. A total of 368 controls, 123 dementia and 128 MCI patients were recruited for the study. Psychometric properties of the adapted version of the ICMR-PNT were examined, and sensitivity and specificity were examined. Outcomes & Results The ICMR-PNT scores in all languages combined were higher in controls compared with patients with dementia and MCI (F[subscript 2], [subscript 615] = 139.85; p < 0.001). Furthermore, PNT scores for MCI was higher in comparison with patients with dementia in all languages combined (p < 0.001). The area under the curve across the five languages ranged from 0.81 to 1.00 for detecting dementia. There was a negative correlation between Clinical Dementia Rating (CDR) and ICMR-PNT scores and a positive correlation between Addenbrooke's Cognitive Examination--III (ACE-III) and ICMR-PNT scores in control and patient groups. Conclusions & Implications: The ICMR-PNT was developed by following cross-cultural adaptation guidelines and establishing correlations using item-wise factor analysis across five languages. This adapted PNT was found to be a reliable tool when assessing naming abilities effectively in mild to moderate dementia in a linguistically diverse context.

Published
2022
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