Search

Your search keyword '"Dhamdhere, Mayura"' showing total 12 results
Start Over Author "Dhamdhere, Mayura"
12 results on '"Dhamdhere, Mayura"'

3. Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression

Author

Fiziev, Petko, Akdemir, Kadir C, Miller, John P, Keung, Emily Z, Samant, Neha S, Sharma, Sneha, Natale, Christopher A, Terranova, Christopher J, Maitituoheti, Mayinuer, Amin, Samirkumar B, Martinez-Ledesma, Emmanuel, Dhamdhere, Mayura, Axelrad, Jacob B, Shah, Amiksha, Cheng, Christine S, Mahadeshwar, Harshad, Seth, Sahil, Barton, Michelle C, Protopopov, Alexei, Tsai, Kenneth Y, Davies, Michael A, Garcia, Benjamin A, Amit, Ido, Chin, Lynda, Ernst, Jason, and Rai, Kunal

Subjects
Biological Sciences, Human Genome, Cancer, Genetics, Aetiology, 2.1 Biological and endogenous factors, Acetylation, Cell Line, Cell Proliferation, Chromatin, Chromatin Immunoprecipitation, Disease-Free Survival, Epigenomics, Histone Deacetylase Inhibitors, Histone Deacetylases, Histones, Humans, Hydroxamic Acids, Kaplan-Meier Estimate, Melanoma, PTEN Phosphohydrolase, Principal Component Analysis, RNA Interference, RNA, Small Interfering, Signal Transduction, Vorinostat, CBP, ChIP-seq, DUSP5, HDAC, chromatin state, epigenome, histone modifications, melanoma, Biochemistry and Cell Biology, Medical Physiology, Biological sciences
Abstract

The extent and nature of epigenomic changes associated with melanoma progression is poorly understood. Through systematic epigenomic profiling of 35 epigenetic modifications and transcriptomic analysis, we define chromatin state changes associated with melanomagenesis by using a cell phenotypic model of non-tumorigenic and tumorigenic states. Computation of specific chromatin state transitions showed loss of histone acetylations and H3K4me2/3 on regulatory regions proximal to specific cancer-regulatory genes in important melanoma-driving cell signaling pathways. Importantly, such acetylation changes were also observed between benign nevi and malignant melanoma human tissues. Intriguingly, only a small fraction of chromatin state transitions correlated with expected changes in gene expression patterns. Restoration of acetylation levels on deacetylated loci by histone deacetylase (HDAC) inhibitors selectively blocked excessive proliferation in tumorigenic cells and human melanoma cells, suggesting functional roles of observed chromatin state transitions in driving hyperproliferative phenotype. Through these results, we define functionally relevant chromatin states associated with melanoma progression.

Published
2017

4. Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma

Author

Maitituoheti, Mayinuer, Keung, Emily Z., Tang, Ming, Yan, Liang, Alam, Hunain, Han, Guangchun, Singh, Anand K., Raman, Ayush T., Terranova, Christopher, Sarkar, Sharmistha, Orouji, Elias, Amin, Samir B., Sharma, Sneha, Williams, Maura, Samant, Neha S., Dhamdhere, Mayura, Zheng, Norman, Shah, Tara, Shah, Amiksha, Axelrad, Jacob B., Anvar, Nazanin E., Lin, Yu-Hsi, Jiang, Shan, Chang, Edward Q., Ingram, Davis R., Wang, Wei-Lien, Lazar, Alexander, Lee, Min Gyu, Muller, Florian, Wang, Linghua, Ying, Haoqiang, and Rai, Kunal

Published
2020
Full Text
View/download PDF

6. Development of a specific and potent IGF2BP1 inhibitor: A promising therapeutic agent for IGF2BP1-expressing cancers

Author

Singh, Amandeep, primary, Singh, Vikash, additional, Wallis, Nadav, additional, Abis, Giancarlo, additional, Oberman, Froma, additional, Wood, Tyler, additional, Dhamdhere, Mayura, additional, Gershon, Tehila, additional, Ramos, Andres, additional, Yisraeli, Joel, additional, Spiegelman, Vladimir S., additional, and Sharma, Arun K., additional

Published
2023
Full Text
View/download PDF

9. Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma

Author

Maitituoheti, Mayinuer, primary, Keung, Emily Z., additional, Tang, Ming, additional, Yan, Liang, additional, Alam, Hunain, additional, Han, Guangchun, additional, Raman, Ayush T., additional, Terranova, Christopher, additional, Sarkar, Sharmistha, additional, Orouji, Elias, additional, Amin, Samir B., additional, Sharma, Sneha, additional, Williams, Maura, additional, Samant, Neha S., additional, Dhamdhere, Mayura, additional, Zheng, Norman, additional, shah, tara, additional, Shah, Amiksha, additional, Axelrad, Jacob B., additional, Anvar, Nazanin E., additional, Lin, Yu-Hsi, additional, Jiang, Shan, additional, Chang, Edward Q., additional, Wang, Wei-Lien, additional, Ingram, Davis R., additional, Lazar, Alexander, additional, Lee, Min Gyu, additional, Muller, Florian, additional, Wang, Linghua, additional, Ying, Haoqiang, additional, and Rai, Kunal, additional

Published
2020
Full Text
View/download PDF

10. Enhancer Reprogramming Confers Dependence on Glycolysis and IGF signaling in KMT2D Mutant Melanoma

Author

Maitituoheti, Mayinuer, primary, Keung, Emily Z., additional, Tang, Ming, additional, Yan, Liang, additional, Alam, Hunain, additional, Han, Guangchun, additional, Raman, Ayush T., additional, Terranova, Christopher, additional, Sarkar, Sharmistha, additional, Orouji, Elias, additional, Amin, Samir B., additional, Sharma, Sneha, additional, Williams, Maura, additional, Samant, Neha S., additional, Dhamdhere, Mayura, additional, Zheng, Norman, additional, Shah, Tara, additional, Shah, Amiksha, additional, Axelrad, Jacob B., additional, Anvar, Nazanin E., additional, Lin, Yu-Hsi, additional, Jiang, Shan, additional, Chang, Edward Q., additional, Ingram, Davis R., additional, Wang, Wei-Lien, additional, Lazar, Alexander, additional, Lee, Min Gyu, additional, Muller, Florian, additional, Wang, Linghua, additional, Ying, Haoqiang, additional, and Rai, Kunal, additional

Published
2018
Full Text
View/download PDF

12. Abstract 4314: Chromatin state alterations during melanoma progression

Author

Rai, Kunal, primary, Terranova, Christopher, additional, Maitituoheti, Mayinuer, additional, Tang, Ming, additional, Akdemir, Kadir, additional, Orouji, Elias, additional, Chin, Lynda, additional, Fiziev, Petko, additional, Dhamdhere, Mayura, additional, Samant, Neha S., additional, Shah, Amikhsha, additional, Sharma, Sneha, additional, and Ernst, Jason, additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results