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4 results on '"Dharini Shashank"'

1. Bacteria-Mediated Oncogenesis and the Underlying Molecular Intricacies: What We Know So Far

Author

Shashanka K. Prasad, Smitha Bhat, Dharini Shashank, Akshatha C. R., Sindhu R., Pornchai Rachtanapun, Devananda Devegowda, Prasanna K. Santhekadur, and Sarana Rose Sommano

Subjects
oncogenesis, chronic inflammation, Helicobacter pylori, bacteria, carcinogen, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Cancers are known to have multifactorial etiology. Certain bacteria and viruses are proven carcinogens. Lately, there has been in-depth research investigating carcinogenic capabilities of some bacteria. Reports indicate that chronic inflammation and harmful bacterial metabolites to be strong promoters of neoplasticity. Helicobacter pylori-induced gastric adenocarcinoma is the best illustration of the chronic inflammation paradigm of oncogenesis. Chronic inflammation, which produces excessive reactive oxygen species (ROS) is hypothesized to cause cancerous cell proliferation. Other possible bacteria-dependent mechanisms and virulence factors have also been suspected of playing a vital role in the bacteria-induced-cancer(s). Numerous attempts have been made to explore and establish the possible relationship between the two. With the growing concerns on anti-microbial resistance and over-dependence of mankind on antibiotics to treat bacterial infections, it must be deemed critical to understand and identify carcinogenic bacteria, to establish their role in causing cancer.

Published
2022
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2. Current therapeutic options for gastric adenocarcinoma

Author

Wanaporn Tapingkae, R. Sindhu, Sarana Rose Sommano, Shashanka K. Prasad, Ratchadawan Cheewangkoon, Dharini Shashank, C.R. Akshatha, and Smitha S. Bhat

Subjects
Oncology, medicine.medical_specialty, QH301-705.5, medicine.medical_treatment, Review, Therapeutics, Disease, Targeted therapy, Trastuzumab, Internal medicine, microRNA, Chemotherapy, Medicine, Epidermal growth factor receptor, Biology (General), Helicobacter pylori, biology, business.industry, Cancer, biology.organism_classification, medicine.disease, MicroRNAs, biology.protein, Gastric cancer, General Agricultural and Biological Sciences, business, medicine.drug
Abstract

Gastric cancer inflicts significant health issues globally despite its declining incidence. The disease is known to be diagnosed at its advanced stages also corresponding with a poor prognosis for patients. The integral therapeutic choices to cure advanced gastric cancer have progressed swiftly in modern days. The preface of molecularly targeted therapeutic techniques would potentiate the personalized approach depending on patient-specific and tumor-specific features, exasperating the advantages of chemotherapy. Here we have reviewed the modern therapeutics such as immune therapy, chemotherapy, m-RNA based therapeutics, alongside evaluating the influence of age, sex and comorbidities-like factors on the occurrence of gastric cancer. Gastric cancer therapy consolidated target agents comprising inhibitors of programmed death-1(PD-1), human epidermal growth factor receptor 2 (HER2), mRNA, and epidermal growth factor receptor (EPGF). A combination of trastuzumab to platinum-mediated chemotherapy evolved has a typical front-line therapy in advanced gastric cancer. An attempt has been made to epitomize the contemporary-modern research on targeted therapy for advanced gastric cancer.

Published
2021
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4. Interacting Models of Amyloid-ß and Tau Proteins: An Approach to Identify Drug Targets in Alzheimer’s Disease

Author

Priya, Khadgawat, Siddesha, J.M., Dharini, Shashank, and Shashanka, K. Prasad

Abstract

Alzheimer’s disease (AD) is the primary cause of dementia affecting millions each year across the world, though still remains incurable. This might be attributed to the lack of knowledge about the associated proteins, their cellular and molecular mechanisms, and the genesis of the disease. The discovery of drugs that earlier revolved around targeting the amyloid-ß cascade has now been reformed with the upgraded knowledge of the cross-seeding ability of tau protein which opens new gateways for therapeutic targets. This article provides a comprehensive review of various direct and indirect connecting pathways between the two main proteins involved in development and progression of AD, enabling us to further expand our repertoire of information regarding the etiology of AD. The current review indicates the need for extensive research in this niche, thus considerable advances can be made in understanding AD which eventually helps to improve the current therapeutics against AD.

Published
2021
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