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3. Best methods for identification and treatment of PCOS

Author

PAOLO GIOVANNI ARTINI, Di Berardino, O. M., Simi, G., Papini, F., Ruggiero, M., Monteleone, P., and Cela, V.

Subjects
Hirsutism, Reproductive Techniques, Assisted, Aromatase Inhibitors, Ovary, Spironolactone, Metformin, Clomiphene, Contraceptives, Oral, Hormonal, Diagnosis, Differential, Gonadotropin-Releasing Hormone, PPAR gamma, Ovarian Follicle, Gonadotropins, Pituitary, Androgens, Humans, Female, Obesity, Follicle Stimulating Hormone, Insulin Resistance, Hyperandrogenism, Infertility, Female, Menstruation Disturbances, Polycystic Ovary Syndrome, Ultrasonography
Abstract

The polycystic ovarian syndrome (PCOS) includes a wide spectrum of clinical symptoms and signs. Three different diagnostic classifications have been proposed to define this disease. The first one, published in 1990, known as the "NIH criteria" requires the simultaneous presence of hyperandrogenism and menstrual dysfunction in order to diagnose PCOS. Later on, in 2003, an expert panel met in Rotterdam and added to the previous criteria the presence of polycystic ovarian morphology detected by transvaginal ultrasonography. The later classification broadened the spectrum of PCOS and also included women with oligomenorrhea and PCO without hyperandrogenism or hyperandrogenism and PCO without menstrual dysfunction. Finally, the Androgen Excess Society, published in 2006 new diagnostic criteria which required the presence of clinical or biochemical hyperandrogenism, with either PCO or menstrual dysfunction to diagnose PCOS. This review focuses on the diagnostic techniques and methods of treatment for PCOS patients. Special attention is given to the role of insulin resistance and the potential utility of insulin sensitizers in management of the syndrome. The benefit and utmost importance of lifestyle modification for the long-term health of these women is stressed as well. It is hoped that some clarity in this regard will allow more women to not only be diagnosed and managed properly for their presenting symptoms (hirsutism, irregular menses, etc.), but also to be educated and managed for the continuing health risk of insulin resistance throughout their lives.

Published
2010

4. In vitro effect of myo-inositol on sperm motility in normal and oligoasthenospermia patients undergoing in vitro fertilization.

Author

Artini, P. G., Casarosa, E., Carletti, E., Monteleone, P., Di Noia, A., and Di Berardino, O. M.

Subjects
INOSITOL, SPERM motility, FERTILIZATION in vitro, REACTIVE oxygen species, ANTIOXIDANTS, DNA damage
Abstract

Copyright of Gynecological Endocrinology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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7. Best methods for identification and treatment of PCOS.

Author

Artini PG, Di Berardino OM, Simi G, Papini F, Ruggiero M, Monteleone P, and Cela V

Subjects
Androgens metabolism, Aromatase Inhibitors therapeutic use, Clomiphene therapeutic use, Contraceptives, Oral, Hormonal therapeutic use, Diagnosis, Differential, Female, Follicle Stimulating Hormone therapeutic use, Gonadotropin-Releasing Hormone agonists, Gonadotropins, Pituitary metabolism, Hirsutism etiology, Hirsutism therapy, Humans, Hyperandrogenism etiology, Infertility, Female drug therapy, Infertility, Female etiology, Insulin Resistance, Menstruation Disturbances drug therapy, Menstruation Disturbances etiology, Metformin therapeutic use, Obesity complications, Ovarian Follicle diagnostic imaging, Ovary diagnostic imaging, Ovary surgery, PPAR gamma antagonists & inhibitors, Polycystic Ovary Syndrome complications, Polycystic Ovary Syndrome physiopathology, Polycystic Ovary Syndrome surgery, Reproductive Techniques, Assisted, Spironolactone therapeutic use, Ultrasonography, Polycystic Ovary Syndrome diagnosis, Polycystic Ovary Syndrome drug therapy
Abstract

The polycystic ovarian syndrome (PCOS) includes a wide spectrum of clinical symptoms and signs. Three different diagnostic classifications have been proposed to define this disease. The first one, published in 1990, known as the "NIH criteria" requires the simultaneous presence of hyperandrogenism and menstrual dysfunction in order to diagnose PCOS. Later on, in 2003, an expert panel met in Rotterdam and added to the previous criteria the presence of polycystic ovarian morphology detected by transvaginal ultrasonography. The later classification broadened the spectrum of PCOS and also included women with oligomenorrhea and PCO without hyperandrogenism or hyperandrogenism and PCO without menstrual dysfunction. Finally, the Androgen Excess Society, published in 2006 new diagnostic criteria which required the presence of clinical or biochemical hyperandrogenism, with either PCO or menstrual dysfunction to diagnose PCOS. This review focuses on the diagnostic techniques and methods of treatment for PCOS patients. Special attention is given to the role of insulin resistance and the potential utility of insulin sensitizers in management of the syndrome. The benefit and utmost importance of lifestyle modification for the long-term health of these women is stressed as well. It is hoped that some clarity in this regard will allow more women to not only be diagnosed and managed properly for their presenting symptoms (hirsutism, irregular menses, etc.), but also to be educated and managed for the continuing health risk of insulin resistance throughout their lives.

Published
2010

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