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3. The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis

Author

Alameda, Luis, Rodriguez, Victoria, Di Forti, Marta, Spinazzola, Edoardo, Trotta, Giulia, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, de Haan, Lieuwe, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Sideli, Lucia, Jones, Peter B., Kirkbride, James B., La Cascia, Caterina, Tripoli, Giada, Ferraro, Laura, La Barbera, Daniele, Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, van Os, Jim, Rutten, Bart P., Santos, Jose Luis, Sanjuán, Julio, Selten, Jean-Paul, Szöke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, Velthorst, Eva, Jongsma, Hannah E., Vassos, Evangelos, Quattrone, Diego, Murray, Robin M., and Aas, Monica

Published
2024
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4. Structural brain abnormalities and aggressive behaviour in schizophrenia: Mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium

Author

Lamsma, Jelle, Raine, Adrian, Kia, Seyed M, Cahn, Wiepke, Arold, Dominic, Banaj, Nerisa, Barone, Annarita, Brosch, Katharina, Brouwer, Rachel, Brunetti, Arturo, Calhoun, Vince D, Chew, Qian H, Choi, Sunah, Chung, Young-Chul, Ciccarelli, Mariateresa, Cobia, Derin, Cocozza, Sirio, Dannlowski, Udo, Dazzan, Paola, de Bartolomeis, Andrea, Di Forti, Marta, Dumais, Alexandre, Edmond, Jesse T, Ehrlich, Stefan, Evermann, Ulrika, Flinkenflügel, Kira, Georgiadis, Foivos, Glahn, David C, Goltermann, Janik, Green, Melissa J, Grotegerd, Dominik, Guerrero-Pedraza, Amalia, Ha, Minji, Hong, Elliot L, Pol, Hilleke Hulshoff, Iasevoli, Felice, Kaiser, Stefan, Kaleda, Vasily, Karuk, Andriana, Kim, Minah, Kircher, Tilo, Kirschner, Matthias, Kochunov, Peter, Kwon, Jun Soo, Lebedeva, Irina, Lencer, Rebekka, Marques, Tiago R, Meinert, Susanne, Murray, Robin, Nenadić, Igor, Nguyen, Dana, Pearlson, Godfrey, Piras, Fabrizio, Pomarol-Clotet, Edith, Pontillo, Giuseppe, Potvin, Stéphane, Preda, Adrian, Quidé, Yann, Rodrigue, Amanda, Rootes-Murdy, Kelly, Salvador, Raymond, Skoch, Antonin, Sim, Kang, Spalletta, Gianfranco, Spaniel, Filip, Stein, Frederike, Thomas-Odenthal, Florian, Tikàsz, Andràs, Tomecek, David, Tomyshev, Alexander, Tranfa, Mario, Tsogt, Uyanga, Turner, Jessica A, van Erp, Theo GM, van Haren, Neeltje EM, van Os, Jim, Vecchio, Daniela, Wang, Lei, Wroblewski, Adrian, and Nickl-Jockschat, Thomas

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Schizophrenia, Brain Disorders, Neurosciences, Biomedical Imaging, Serious Mental Illness, Mental Health, Mental Illness, Mental health
Abstract

BACKGROUND: Schizophrenia is associated with an increased risk of aggressive behaviour, which may partly be explained by illness-related changes in brain structure. However, previous studies have been limited by group-level analyses, small and selective samples of inpatients and long time lags between exposure and outcome. METHODS: This cross-sectional study pooled data from 20 sites participating in the international ENIGMA-Schizophrenia Working Group. Sites acquired T1-weighted and diffusion-weighted magnetic resonance imaging scans in a total of 2095 patients with schizophrenia and 2861 healthy controls. Measures of grey matter volume and white matter microstructural integrity were extracted from the scans using harmonised protocols. For each measure, normative modelling was used to calculate how much patients deviated (in z-scores) from healthy controls at the individual level. Ordinal regression models were used to estimate the associations of these deviations with concurrent aggressive behaviour (as odds ratios [ORs] with 99% confidence intervals [CIs]). Mediation analyses were performed for positive symptoms (i.e., delusions, hallucinations and disorganised thinking), impulse control and illness insight. Aggression and potential mediators were assessed with the Positive and Negative Syndrome Scale, Scale for the Assessment of Positive Symptoms or Brief Psychiatric Rating Scale. RESULTS: Aggressive behaviour was significantly associated with reductions in total cortical volume (OR [99% CI] = 0.88 [0.78, 0.98], p = .003) and global white matter integrity (OR [99% CI] = 0.72 [0.59, 0.88], p = 3.50 × 10-5) and additional reductions in dorsolateral prefrontal cortex volume (OR [99% CI] = 0.85 [0.74, 0.97], p =.002), inferior parietal lobule volume (OR [99% CI] = 0.76 [0.66, 0.87], p = 2.20 × 10-7) and internal capsule integrity (OR [99% CI] = 0.76 [0.63, 0.92], p = 2.90 × 10-4). Except for inferior parietal lobule volume, these associations were largely mediated by increased severity of positive symptoms and reduced impulse control. CONCLUSIONS: This study provides evidence that the co-occurrence of positive symptoms, poor impulse control and aggressive behaviour in schizophrenia has a neurobiological basis, which may inform the development of therapeutic interventions.

Published
2024

5. Cortical morphology in patients with the deficit and non-deficit syndrome of schizophrenia: a worldwide meta- and mega-analyses.

Author

Banaj, Nerisa, Vecchio, Daniela, Piras, Fabrizio, De Rossi, Pietro, Bustillo, Juan, Ciufolini, Simone, Dazzan, Paola, Di Forti, Marta, Dickie, Erin, Ford, Judith, Fuentes-Claramonte, Paola, Gruber, Oliver, Guerrero-Pedraza, Amalia, Hamilton, Holly, Howells, Fleur, Kraemer, Bernd, Lawrie, Stephen, Radua, Joaquim, Richter, Anja, Salvador, Raymond, Sawa, Akira, Scheffler, Freda, Sim, Kang, Spaniel, Filip, Stein, Dan, Temmingh, Henk, Thomopoulos, Sophia, Tomecek, David, Uhlmann, Anne, Voineskos, Aristotle, Yang, Kun, Jahanshad, Neda, Thompson, Paul, Murray, Robin, Pomarol-Clotet, Edith, Turner, Jessica, Spalletta, Gianfranco, Piras, Federica, Mathalon, Daniel, Potkin, Steven, Van Erp, Theodorus, and Preda, Adrian

Subjects
Humans, Schizophrenia, Magnetic Resonance Imaging, Neuroimaging, Parietal Lobe, Syndrome, Cerebral Cortex
Abstract

Converging evidence suggests that schizophrenia (SZ) with primary, enduring negative symptoms (i.e., Deficit SZ (DSZ)) represents a distinct entity within the SZ spectrum while the neurobiological underpinnings remain undetermined. In the largest dataset of DSZ and Non-Deficit (NDSZ), we conducted a meta-analysis of data from 1560 individuals (168 DSZ, 373 NDSZ, 1019 Healthy Controls (HC)) and a mega-analysis of a subsampled data from 944 individuals (115 DSZ, 254 NDSZ, 575 HC) collected across 9 worldwide research centers of the ENIGMA SZ Working Group (8 in the mega-analysis), to clarify whether they differ in terms of cortical morphology. In the meta-analysis, sites computed effect sizes for differences in cortical thickness and surface area between SZ and control groups using a harmonized pipeline. In the mega-analysis, cortical values of individuals with schizophrenia and control participants were analyzed across sites using mixed-model ANCOVAs. The meta-analysis of cortical thickness showed a converging pattern of widespread thinner cortex in fronto-parietal regions of the left hemisphere in both DSZ and NDSZ, when compared to HC. However, DSZ have more pronounced thickness abnormalities than NDSZ, mostly involving the right fronto-parietal cortices. As for surface area, NDSZ showed differences in fronto-parietal-temporo-occipital cortices as compared to HC, and in temporo-occipital cortices as compared to DSZ. Although DSZ and NDSZ show widespread overlapping regions of thinner cortex as compared to HC, cortical thinning seems to better typify DSZ, being more extensive and bilateral, while surface area alterations are more evident in NDSZ. Our findings demonstrate for the first time that DSZ and NDSZ are characterized by different neuroimaging phenotypes, supporting a nosological distinction between DSZ and NDSZ and point toward the separate disease hypothesis.

Published
2023

7. Associations Between Cannabis Use, Polygenic Liability for Schizophrenia, and Cannabis-related Experiences in a Sample of Cannabis Users

Author

Johnson, Emma C, Colbert, Sarah MC, Jeffries, Paul W, Tillman, Rebecca, Bigdeli, Tim B, Karcher, Nicole R, Chan, Grace, Kuperman, Samuel, Meyers, Jacquelyn L, Nurnberger, John I, Plawecki, Martin H, Degenhardt, Louisa, Martin, Nicholas G, Kamarajan, Chella, Schuckit, Marc A, Murray, Robin M, Dick, Danielle M, Edenberg, Howard J, D’Souza, Deepak Cyril, Di Forti, Marta, Porjesz, Bernice, Nelson, Elliot C, and Agrawal, Arpana

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Pediatric Research Initiative, Clinical Research, Cannabinoid Research, Brain Disorders, Substance Misuse, Serious Mental Illness, Schizophrenia, Genetics, Mental Health, Prevention, Aetiology, 2.1 Biological and endogenous factors, 2.3 Psychological, social and economic factors, Mental health, Good Health and Well Being, Humans, Female, Male, Cannabis, Alcoholism, Genetic Predisposition to Disease, Risk Factors, Multifactorial Inheritance, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences
Abstract

Background and hypothesisRisk for cannabis use and schizophrenia is influenced in part by genetic factors, and there is evidence that genetic risk for schizophrenia is associated with subclinical psychotic-like experiences (PLEs). Few studies to date have examined whether genetic risk for schizophrenia is associated with cannabis-related PLEs.Study designWe tested whether measures of cannabis involvement and polygenic risk scores (PRS) for schizophrenia were associated with self-reported cannabis-related experiences in a sample ascertained for alcohol use disorders (AUDs), the Collaborative Study on the Genetics of Alcoholism (COGA). We analyzed 4832 subjects (3128 of European ancestry and 1704 of African ancestry; 42% female; 74% meeting lifetime criteria for an AUD).Study resultsCannabis use disorder (CUD) was prevalent in this analytic sample (70%), with 40% classified as mild, 25% as moderate, and 35% as severe. Polygenic risk for schizophrenia was positively associated with cannabis-related paranoia, feeling depressed or anhedonia, social withdrawal, and cognitive difficulties, even when controlling for duration of daily cannabis use, CUD, and age at first cannabis use. The schizophrenia PRS was most robustly associated with cannabis-related cognitive difficulties (β = 0.22, SE = 0.04, P = 5.2e-7). In an independent replication sample (N = 1446), associations between the schizophrenia PRS and cannabis-related experiences were in the expected direction and not statistically different in magnitude from those in the COGA sample.ConclusionsAmong individuals who regularly use cannabis, genetic liability for schizophrenia-even in those without clinical features-may increase the likelihood of reporting unusual experiences related to cannabis use.

Published
2023

10. The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study

Author

Sideli, Lucia, Aas, Monica, Quattrone, Diego, La Barbera, Daniele, La Cascia, Caterina, Ferraro, Laura, Alameda, Luis, Velthorst, Eva, Trotta, Giulia, Tripoli, Giada, Schimmenti, Adriano, Fontana, Andrea, Gayer-Anderson, Charlotte, Stilo, Simona, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Berardi, Domenico, D’Andrea, Giuseppe, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Sanjuán, Julio, Santos, Jose Luis, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Jongsma, Hannah E., Jones, Peter B., Kirkbride, James B., Llorca, Pierre-Michel, Tortelli, Andrea, Pignon, Baptiste, de Haan, Lieuwe, Selten, Jean-Paul, Van Os, Jim, Rutten, Bart P., Bentall, Richard, Di Forti, Marta, Murray, Robin M., Morgan, Craig, and Fisher, Helen L.

Published
2023
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11. Genetic variants associated with longitudinal changes in brain structure across the lifespan

Author

Brouwer, Rachel M, Klein, Marieke, Grasby, Katrina L, Schnack, Hugo G, Jahanshad, Neda, Teeuw, Jalmar, Thomopoulos, Sophia I, Sprooten, Emma, Franz, Carol E, Gogtay, Nitin, Kremen, William S, Panizzon, Matthew S, Olde Loohuis, Loes M, Whelan, Christopher D, Aghajani, Moji, Alloza, Clara, Alnæs, Dag, Artiges, Eric, Ayesa-Arriola, Rosa, Barker, Gareth J, Bastin, Mark E, Blok, Elisabet, Bøen, Erlend, Breukelaar, Isabella A, Bright, Joanna K, Buimer, Elizabeth EL, Bülow, Robin, Cannon, Dara M, Ciufolini, Simone, Crossley, Nicolas A, Damatac, Christienne G, Dazzan, Paola, de Mol, Casper L, de Zwarte, Sonja MC, Desrivières, Sylvane, Díaz-Caneja, Covadonga M, Doan, Nhat Trung, Dohm, Katharina, Fröhner, Juliane H, Goltermann, Janik, Grigis, Antoine, Grotegerd, Dominik, Han, Laura KM, Harris, Mathew A, Hartman, Catharina A, Heany, Sarah J, Heindel, Walter, Heslenfeld, Dirk J, Hohmann, Sarah, Ittermann, Bernd, Jansen, Philip R, Janssen, Joost, Jia, Tianye, Jiang, Jiyang, Jockwitz, Christiane, Karali, Temmuz, Keeser, Daniel, Koevoets, Martijn GJC, Lenroot, Rhoshel K, Malchow, Berend, Mandl, René CW, Medel, Vicente, Meinert, Susanne, Morgan, Catherine A, Mühleisen, Thomas W, Nabulsi, Leila, Opel, Nils, de la Foz, Víctor Ortiz-García, Overs, Bronwyn J, Paillère Martinot, Marie-Laure, Redlich, Ronny, Marques, Tiago Reis, Repple, Jonathan, Roberts, Gloria, Roshchupkin, Gennady V, Setiaman, Nikita, Shumskaya, Elena, Stein, Frederike, Sudre, Gustavo, Takahashi, Shun, Thalamuthu, Anbupalam, Tordesillas-Gutiérrez, Diana, van der Lugt, Aad, van Haren, Neeltje EM, Wardlaw, Joanna M, Wen, Wei, Westeneng, Henk-Jan, Wittfeld, Katharina, Zhu, Alyssa H, Zugman, Andre, Armstrong, Nicola J, Bonfiglio, Gaia, Bralten, Janita, Dalvie, Shareefa, Davies, Gail, Di Forti, Marta, Ding, Linda, Donohoe, Gary, Forstner, Andreas J, and Gonzalez-Peñas, Javier

Subjects
Biological Psychology, Psychology, Neurosciences, Mental Illness, Human Genome, Genetics, Aging, Mental Health, Brain Disorders, 2.1 Biological and endogenous factors, Neurological, Mental health, Brain, Genome-Wide Association Study, Humans, Longevity, Magnetic Resonance Imaging, IMAGEN Consortium, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.

Published
2022

13. Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study

Author

Thygesen, Johan H, Presman, Amelia, Harju-Seppänen, Jasmine, Irizar, Haritz, Jones, Rebecca, Kuchenbaecker, Karoline, Lin, Kuang, Alizadeh, Behrooz Z, Austin-Zimmerman, Isabelle, Bartels-Velthuis, Agna, Bhat, Anjali, Bruggeman, Richard, Cahn, Wiepke, Calafato, Stella, Crespo-Facorro, Benedicto, de Haan, Liewe, de Zwarte, Sonja MC, Di Forti, Marta, Díez-Revuelta, Álvaro, Hall, Jeremy, Hall, Mei-Hua, Iyegbe, Conrad, Jablensky, Assen, Kahn, Rene, Kalaydjieva, Luba, Kravariti, Eugenia, Lawrie, Stephen, Luykx, Jurjen J, Mata, Igancio, McDonald, Colm, McIntosh, Andrew M, McQuillin, Andrew, Muir, Rebecca, Ophoff, Roel, Picchioni, Marco, Prata, Diana P, Ranlund, Siri, Rujescu, Dan, Rutten, Bart PF, Schulze, Katja, Shaikh, Madiha, Schirmbeck, Frederike, Simons, Claudia JP, Toulopoulou, Timothea, van Amelsvoort, Therese, van Haren, Neeltje, van Os, Jim, van Winkel, Ruud, Vassos, Evangelos, Walshe, Muriel, Weisbrod, Matthias, Zartaloudi, Eirini, Bell, Vaughan, Powell, John, Lewis, Cathryn M, Murray, Robin M, and Bramon, Elvira

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Human Genome, Clinical Research, Brain Disorders, Serious Mental Illness, Schizophrenia, Neurosciences, Genetics, Prevention, Mental Health, 2.1 Biological and endogenous factors, 2.3 Psychological, social and economic factors, Aetiology, Mental health, Cognition, DNA Copy Number Variations, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Psychotic Disorders, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

The burden of large and rare copy number genetic variants (CNVs) as well as certain specific CNVs increase the risk of developing schizophrenia. Several cognitive measures are purported schizophrenia endophenotypes and may represent an intermediate point between genetics and the illness. This paper investigates the influence of CNVs on cognition. We conducted a systematic review and meta-analysis of the literature exploring the effect of CNV burden on general intelligence. We included ten primary studies with a total of 18,847 participants and found no evidence of association. In a new psychosis family study, we investigated the effects of CNVs on specific cognitive abilities. We examined the burden of large and rare CNVs (>200 kb,

Published
2021

14. Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis—findings from the EU-GEI study

Author

Alameda, Luis, Liu, Zhonghua, Sham, Pak C., Aas, Monica, Trotta, Giulia, Rodriguez, Victoria, Di Forti, Marta, Stilo, Simona A., Kandaswamy, Radhika, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, de Haan, Lieuwe, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Sideli, Lucia, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B., La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, van Os, Jim, Quattrone, Diego, Rutten, Bart P., Santos, Jose Luis, Sanjuán, Julio, Selten, Jean-Paul, Szöke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, Velthorst, Eva, Morgan, Craig, Dempster, Emma, Hannon, Eilis, Burrage, Joe, Dwir, Daniella, Arumuham, Atheeshaan, Mill, Jonathan, Murray, Robin M., and Wong, Chloe C. Y.

Published
2023
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15. Psychosis brain subtypes validated in first-episode cohorts and related to illness remission: results from the PHENOM consortium

Author

Dwyer, Dominic B., Chand, Ganesh B., Pigoni, Alessandro, Khuntia, Adyasha, Wen, Junhao, Antoniades, Mathilde, Hwang, Gyujoon, Erus, Guray, Doshi, Jimit, Srinivasan, Dhivya, Varol, Erdem, Kahn, Rene S., Schnack, Hugo G., Meisenzahl, Eva, Wood, Stephen J., Zhuo, Chuanjun, Sotiras, Aristeidis, Shinohara, Russell T., Shou, Haochang, Fan, Yong, Schaulfelberger, Maristela, Rosa, Pedro, Lalousis, Paris A., Upthegrove, Rachel, Kaczkurkin, Antonia N., Moore, Tyler M., Nelson, Barnaby, Gur, Raquel E., Gur, Ruben C., Ritchie, Marylyn D., Satterthwaite, Theodore D., Murray, Robin M., Di Forti, Marta, Ciufolini, Simone, Zanetti, Marcus V., Wolf, Daniel H., Pantelis, Christos, Crespo-Facorro, Benedicto, Busatto, Geraldo F., Davatzikos, Christos, Koutsouleris, Nikolaos, and Dazzan, Paola

Published
2023
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18. Cognitive performance at first episode of psychosis and the relationship with future treatment resistance: Evidence from an international prospective cohort study

Author

Millgate, Edward, Smart, Sophie E., Pardiñas, Antonio F., Kravariti, Eugenia, Ajnakina, Olesya, Kępińska, Adrianna P., Andreassen, Ole A., Barnes, Thomas R.E., Berardi, Domenico, Crespo-Facorro, Benedicto, D'Andrea, Giuseppe, Demjaha, Arsime, Di Forti, Marta, Doody, Gillian A., Kassoumeri, Laura, Ferchiou, Aziz, Guidi, Lorenzo, Joyce, Eileen M., Lastrina, Ornella, Melle, Ingrid, Pignon, Baptiste, Richard, Jean-Romain, Simonsen, Carmen, Szöke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, Vázquez-Bourgon, Javier, Murray, Robin M., Walters, James T.R., and MacCabe, James H.

Published
2023
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20. Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium

Author

Smart, Sophie E., Agbedjro, Deborah, Pardiñas, Antonio F., Ajnakina, Olesya, Alameda, Luis, Andreassen, Ole A., Barnes, Thomas R.E., Berardi, Domenico, Camporesi, Sara, Cleusix, Martine, Conus, Philippe, Crespo-Facorro, Benedicto, D'Andrea, Giuseppe, Demjaha, Arsime, Di Forti, Marta, Do, Kim, Doody, Gillian, Eap, Chin B., Ferchiou, Aziz, Guidi, Lorenzo, Homman, Lina, Jenni, Raoul, Joyce, Eileen, Kassoumeri, Laura, Lastrina, Ornella, Melle, Ingrid, Morgan, Craig, O'Neill, Francis A., Pignon, Baptiste, Restellini, Romeo, Richard, Jean-Romain, Simonsen, Carmen, Španiel, Filip, Szöke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, Üçok, Alp, Vázquez-Bourgon, Javier, Murray, Robin M., Walters, James T.R., Stahl, Daniel, and MacCabe, James H.

Published
2022
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21. First-episode Psychosis and Migration in Italy : Results from a Study in the Italian Mental Health Services (Pep-Ita Study)

Author

Tarricone, Ilaria, D’Andrea, Giuseppe, Storbini, Viviana, Braca, Mauro, Ferrari, Silvia, Reggianini, Corinna, Rigatelli, Marco, Gramaglia, Carla, Zeppegno, Patrizia, Gambaro, Eleonora, Luciano, Mario, Ceregato, Alessio, Altamura, Mario, Barrasso, Giuseppe, Primavera, Diego, Carpiniello, Bernardo, Todarello, Orlando, Berlincioni, Vanna, Podavini, Francesca, Morgan, Craig, Murray, Robin M., Di Forti, Marta, Muratori, Roberto, and Berardi, Domenico

Published
2021

22. COVID-19 and UK family carers: policy implications

Author

Onwumere, Juliana, Creswell, Cathy, Livingston, Gill, Shiers, David, Tchanturia, Kate, Charman, Tony, Russell, Alisa, Treasure, Janet, Di Forti, Marta, Wildman, Emilie, Minnis, Helen, Young, Allan, Davis, Annette, and Kuipers, Elizabeth

Published
2021
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23. The relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI study

Author

Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Sanchez-Gutierrez, Teresa, Tripoli, Giada, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Sideli, Lucia, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Kirkbride, James B., Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, Rutten, Bart P., Santos, Jose Luis, Sanjuán, Julio, Selten, Jean-Paul, Szöke, Andrei, Tarricone, Ilaria, Muratori, Roberto, Tortelli, Andrea, Velthorst, Eva, Rodriguez, Victoria, Quattrone, Andrea, Jones, Peter B., Van Os, Jim, Vassos, Evangelos, Morgan, Craig, de Haan, Lieuwe, Reininghaus, Ulrich, Cardno, Alastair G., Di Forti, Marta, Murray, Robin M., and Quattrone, Diego

Published
2021
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25. Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings

Author

Velthorst, Eva, Mollon, Josephine, Murray, Robin M., de Haan, Lieuwe, Germeys, Inez Myin, Glahn, David C., Arango, Celso, van der Ven, Els, Di Forti, Marta, Bernardo, Miguel, Guloksuz, Sinan, Delespaul, Philippe, Mezquida, Gisela, Amoretti, Silvia, Bobes, Julio, Saiz, Pilar A., García-Portilla, María Paz, Santos, José Luis, Jiménez-López, Estela, Sanjuan, Julio, Aguilar, Eduardo J., Arrojo, Manuel, Carracedo, Angel, López, Gonzalo, González-Peñas, Javier, Parellada, Mara, Atbaşoğlu, Cem, Saka, Meram Can, Üçok, Alp, Alptekin, Köksal, Akdede, Berna, Binbay, Tolga, Altınyazar, Vesile, Ulaş, Halis, Yalınçetin, Berna, Gümüş-Akay, Güvem, Beyaz, Burçin Cihan, Soygür, Haldun, Cankurtaran, Eylem Şahin, Kaymak, Semra Ulusoy, Maric, Nadja P., Mihaljevic, Marina M., Petrovic, Sanja Andric, Mirjanic, Tijana, Del-Ben, Cristina Marta, Ferraro, Laura, Gayer-Anderson, Charlotte, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B., La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, Morgan, Craig, Quattrone, Diego, Menchetti, Marco, Selten, Jean-Paul, Szöke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, McGuire, Philip, Valmaggia, Lucia, Kempton, Matthew J., van der Gaag, Mark, Riecher-Rössler, Anita, Bressan, Rodrigo A., Barrantes-Vidal, Neus, Nelson, Barnaby, McGorry, Patrick, Pantelis, Chris, Krebs, Marie-Odile, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Alizadeh, Behrooz Z., van Amelsvoort, Therese, Bartels-Velthuis, Agna A., Bruggeman, Richard, van Beveren, Nico J., Luykx, Jurjen J., Cahn, Wiepke, Simons, Claudia J. P., Kahn, Rene S., Schirmbeck, Frederike, van Winkel, Ruud, and Reichenberg, Abraham

Published
2021
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26. Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT).

Author

Farooq, Saeed, Hattle, Miriam, Kingstone, Tom, Ajnakina, Olesya, Dazzan, Paola, Demjaha, Arsime, Murray, Robin M., Di Forti, Marta, Jones, Peter B., Doody, Gillian A., Shiers, David, Andrews, Gabrielle, Milner, Abbie, Nettis, Maria Antonietta, Lawrence, Andrew J., van der Windt, Danielle A., and Riley, Richard D.

Subjects
DECISION making, PROGNOSTIC models, PREDICTION models, MISSING data (Statistics), LOGISTIC regression analysis
Abstract

Background: A clinical tool to estimate the risk of treatment-resistant schizophrenia (TRS) in people with first-episode psychosis (FEP) would inform early detection of TRS and overcome the delay of up to 5 years in starting TRS medication. Aims: To develop and evaluate a model that could predict the risk of TRS in routine clinical practice. Method: We used data from two UK-based FEP cohorts (GAP and AESOP-10) to develop and internally validate a prognostic model that supports identification of patients at high-risk of TRS soon after FEP diagnosis. Using sociodemographic and clinical predictors, a model for predicting risk of TRS was developed based on penalised logistic regression, with missing data handled using multiple imputation. Internal validation was undertaken via bootstrapping, obtaining optimism-adjusted estimates of the model's performance. Interviews and focus groups with clinicians were conducted to establish clinically relevant risk thresholds and understand the acceptability and perceived utility of the model. Results: We included seven factors in the prediction model that are predominantly assessed in clinical practice in patients with FEP. The model predicted treatment resistance among the 1081 patients with reasonable accuracy; the model's C-statistic was 0.727 (95% CI 0.723–0.732) prior to shrinkage and 0.687 after adjustment for optimism. Calibration was good (expected/observed ratio: 0.999; calibration-in-the-large: 0.000584) after adjustment for optimism. Conclusions: We developed and internally validated a prediction model with reasonably good predictive metrics. Clinicians, patients and carers were involved in the development process. External validation of the tool is needed followed by co-design methodology to support implementation in early intervention services. [ABSTRACT FROM AUTHOR]

Published
2024
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27. The Role of Social Deprivation and Cannabis Use in Explaining Variation in the Incidence of Psychotic Disorders: Findings From the EU-GEI Study

Author

Brink, Vera, primary, Andleeb, Humma, additional, Gayer-Anderson, Charlotte, additional, Arango, Celso, additional, Arrojo, Manuel, additional, Berardi, Domenico, additional, Bernardo, Miquel, additional, Bobes, Julio, additional, Del-Ben, Cristina Marta, additional, Ferraro, Laura, additional, de Haan, Lieuwe, additional, La Barbera, Daniele, additional, La Cascia, Caterina, additional, Lasalvia, Antonio, additional, Llorca, Pierre-Michel, additional, Menezes, Paolo Rossi, additional, Pignon, Baptiste, additional, Sanjuán, Julio, additional, Santos, José Luis, additional, Selten, Jean-Paul, additional, Tarricone, Ilaria, additional, Tortelli, Andrea, additional, Tripoli, Giada, additional, Velthorst, Eva, additional, Rutten, Bart P F, additional, van Os, Jim, additional, Quattrone, Diego, additional, Murray, Robin M, additional, Jones, Peter B, additional, Morgan, Craig, additional, Di Forti, Marta, additional, Jongsma, Hannah E, additional, and Kirkbride, James B, additional

Published
2024
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28. 455. AI-Derived Neuroanatomical Subtypes of Schizophrenia and Their Expression During Disease Onset and in Unaffected Siblings

Author

Antoniades, Mathilde, primary, Yang, Zhijian, additional, Chand, Ganesh, additional, Schnack, Hugo, additional, Shinohara, Russell T., additional, Kaczkurkin, Antonia N., additional, Moore, Tyler M., additional, Gur, Raquel E., additional, Satterthwaite, Theodore D., additional, Di Forti, Marta, additional, Ciufolini, Simone, additional, Zanetti, Marcus V., additional, Crespo-Facorro, Benedicto, additional, Busatto, Geraldo F., additional, Wolf, Daniel H., additional, Dazzan, Paola, additional, Koutsouleris, Nikolaos, additional, and Davatzikos, Christos, additional

Published
2024
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31. The Role of Social Deprivation and Cannabis Use in Explaining Variation in the Incidence of Psychotic Disorders: Findings From the EU-GEI Study

Author

Hersenen-Medisch 1, Brain, Brink, Vera, Andleeb, Humma, Gayer-Anderson, Charlotte, Arango, Celso, Arrojo, Manuel, Berardi, Domenico, Bernardo, Miquel, Bobes, Julio, Del-Ben, Cristina Marta, Ferraro, Laura, de Haan, Lieuwe, La Barbera, Daniele, La Cascia, Caterina, Lasalvia, Antonio, Llorca, Pierre-Michel, Menezes, Paolo Rossi, Pignon, Baptiste, Sanjuán, Julio, Santos, José Luis, Selten, Jean-Paul, Tarricone, Ilaria, Tortelli, Andrea, Tripoli, Giada, Velthorst, Eva, Rutten, Bart P F, van Os, Jim, Quattrone, Diego, Murray, Robin M, Jones, Peter B, Morgan, Craig, Di Forti, Marta, Jongsma, Hannah E, Kirkbride, James B, Hersenen-Medisch 1, Brain, Brink, Vera, Andleeb, Humma, Gayer-Anderson, Charlotte, Arango, Celso, Arrojo, Manuel, Berardi, Domenico, Bernardo, Miquel, Bobes, Julio, Del-Ben, Cristina Marta, Ferraro, Laura, de Haan, Lieuwe, La Barbera, Daniele, La Cascia, Caterina, Lasalvia, Antonio, Llorca, Pierre-Michel, Menezes, Paolo Rossi, Pignon, Baptiste, Sanjuán, Julio, Santos, José Luis, Selten, Jean-Paul, Tarricone, Ilaria, Tortelli, Andrea, Tripoli, Giada, Velthorst, Eva, Rutten, Bart P F, van Os, Jim, Quattrone, Diego, Murray, Robin M, Jones, Peter B, Morgan, Craig, Di Forti, Marta, Jongsma, Hannah E, and Kirkbride, James B

Published
2024

36. The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study

Author

Amoretti, Silvia, Arrojo, Manuel, Baudin, Grégoire, Beards, Stephanie, Bernardo, Miquel, Bobes, Julio, Bonetto, Chiara, Cabrera, Bibiana, Carracedo, Angel, Charpeaud, Thomas, Costas, Javier, Cristofalo, Doriana, Cuadrado, Pedro, Díaz-Caneja, Covadonga M, Ferchiou, Aziz, Franke, Nathalie, Frijda, Flora, García Bernardo, Enrique, Garcia-Portilla, Paz, González, Emiliano, Hubbard, Kathryn, Jamain, Stéphane, Jiménez-López, Estela, Leboyer, Marion, López Montoya, Gonzalo, Lorente-Rovira, Esther, Marcelino Loureiro, Camila, Marrazzo, Giovanna, Martínez, Covadonga, Matteis, Mario, Messchaart, Elles, Moltó, Ma Dolores, Nacher, Juan, Olmeda, Ma Soledad, Parellada, Mara, González Peñas, Javier, Pignon, Baptiste, Rapado, Marta, Richard, Jean-Romain, Rodríguez Solano, José Juan, Roldán Díaz, Laura, Ruggeri, Mirella, Sáiz, Pilar A., Sánchez, Emilio, Sanjuán, Julio, Sartorio, Crocettarachele, Schürhoff, Franck, Seminerio, Fabio, Shuhama, Rosana, Sideli, Lucia, Stilo, Simona A, Termorshuizen, Fabian, Tosato, Sarah, Tronche, Anne-Marie, van Dam, Daniella, van der Ven, Elsje, Di Forti, Marta, Quattrone, Diego, Freeman, Tom P, Tripoli, Giada, Gayer-Anderson, Charlotte, Quigley, Harriet, Rodriguez, Victoria, Jongsma, Hannah E, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Berardi, Domenico, Szöke, Andrei, Arango, Celso, Tortelli, Andrea, Velthorst, Eva, Bernardo, Miguel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B, Kirkbride, James B, Rutten, Bart PF, de Haan, Lieuwe, Sham, Pak C, van Os, Jim, Lewis, Cathryn M, Lynskey, Michael, Morgan, Craig, and Murray, Robin M

Published
2019
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39. Variation of subclinical psychosis across 16 sites in Europe and Brazil: findings from the multi-national EU-GEI study

Author

D'Andrea, Giuseppe, primary, Quattrone, Diego, additional, Malone, Kathryn, additional, Tripoli, Giada, additional, Trotta, Giulia, additional, Spinazzola, Edoardo, additional, Gayer-Anderson, Charlotte, additional, Jongsma, Hannah E, additional, Sideli, Lucia, additional, Stilo, Simona A, additional, La Cascia, Caterina, additional, Ferraro, Laura, additional, Lasalvia, Antonio, additional, Tosato, Sarah, additional, Tortelli, Andrea, additional, Velthorst, Eva, additional, de Haan, Lieuwe, additional, Llorca, Pierre-Michel, additional, Rossi Menezes, Paulo, additional, Santos, Jose Luis, additional, Arrojo, Manuel, additional, Bobes, Julio, additional, Sanjuán, Julio, additional, Bernardo, Miguel, additional, Arango, Celso, additional, Kirkbride, James B, additional, Jones, Peter B, additional, Rutten, Bart P, additional, Van Os, Jim, additional, Selten, Jean-Paul, additional, Vassos, Evangelos, additional, Schürhoff, Franck, additional, Szöke, Andrei, additional, Pignon, Baptiste, additional, O'Donovan, Michael, additional, Richards, Alexander, additional, Morgan, Craig, additional, Di Forti, Marta, additional, Tarricone, Ilaria, additional, and Murray, Robin M, additional

Published
2024
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40. Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking

Author

Johnson, Emma C, primary, Austin-Zimmerman, Isabelle, additional, Thorpe, Hayley HA, additional, Levey, Daniel F, additional, Baranger, David AA, additional, Colbert, Sarah Mary Carlton, additional, Demontis, Ditte, additional, Khokhar, Jibran Y, additional, Davis, Lea K, additional, Edenberg, Howard J, additional, Di Forti, Marta, additional, Sanchez-Roige, Sandra, additional, Gelernter, Joel, additional, and Agrawal, Arpana, additional

Published
2024
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47. Predicting First-Episode Psychosis Associated with Cannabis Use with Artificial Neural Networks and Deep Learning

Author

Stamate, Daniel, Alghamdi, Wajdi, Stahl, Daniel, Pu, Ida, Murtagh, Fionn, Belgrave, Danielle, Murray, Robin, di Forti, Marta, Barbosa, Simone Diniz Junqueira, Series Editor, Chen, Phoebe, Series Editor, Filipe, Joaquim, Series Editor, Kotenko, Igor, Series Editor, Sivalingam, Krishna M., Series Editor, Washio, Takashi, Series Editor, Yuan, Junsong, Series Editor, Zhou, Lizhu, Series Editor, Medina, Jesús, editor, Ojeda-Aciego, Manuel, editor, Verdegay, José Luis, editor, Perfilieva, Irina, editor, Bouchon-Meunier, Bernadette, editor, and Yager, Ronald R., editor

Published
2018
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48. Can Artificial Neural Networks Predict Psychiatric Conditions Associated with Cannabis Use?

Author

Stamate, Daniel, Alghamdi, Wajdi, Stahl, Daniel, Zamyatin, Alexander, Murray, Robin, di Forti, Marta, Rannenberg, Kai, Editor-in-Chief, Sakarovitch, Jacques, Series Editor, Goedicke, Michael, Series Editor, Tatnall, Arthur, Series Editor, Neuhold, Erich J., Series Editor, Pras, Aiko, Series Editor, Tröltzsch, Fredi, Series Editor, Pries-Heje, Jan, Series Editor, Whitehouse, Diane, Series Editor, Reis, Ricardo, Series Editor, Furnell, Steven, Series Editor, Furbach, Ulrich, Series Editor, Winckler, Marco, Series Editor, Rauterberg, Matthias, Series Editor, Iliadis, Lazaros, editor, Maglogiannis, Ilias, editor, and Plagianakos, Vassilis, editor

Published
2018
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