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16 results on '"Di Geronimo, Natalie"'

7. Efficacy of the Combined Intrastromal Injection of Voriconazole and Amphotericin B in Recalcitrant Fungal Keratitis.

Author

Moramarco, Antonio, Grendele, Arianna, Iannetta, Danilo, Ottoboni, Simone, Gregori, Giulia, di Geronimo, Natalie, Ortalli, Margherita, Lazzarotto, Tiziana, and Fontana, Luigi

Subjects
FUNGAL keratitis, AMPHOTERICIN B, VORICONAZOLE, DISEASE relapse, VISUAL acuity, CANDIDA, ARACHNOID cysts, ANTIFUNGAL agents
Abstract

This study aims to report the efficacy of a combined intrastromal injection in optimizing the outcome of severe mycotic keratitis. Herein, we report a case series of 20 consecutive patients with positive fungal cultures not responding to topical antifungal treatment. Patients received cycles of intrastromal injections of voriconazole (50 µg/0.1 mL) and amphotericin B (2.5 µg/0.1 mL); all patients continued their topical antifungal therapy. The organisms isolated were Fusarium (n = 5), Aspergillus (n = 4), Candida (n = 4), Rhodotorula (n = 2), Penicillium (n = 2), Alternaria (n = 1), Bipolaris (n = 1), and Curvularia (n = 1). The size of the infiltrate varied from 6.5 to 1.5 mm. At presentation, the best corrected visual acuity (BCVA, namely, the best visual acuity achieved with glasses, if needed) was less than 20/400 in all patients, improving to better than 20/400 in eleven patients. Seven patients required surgical intervention; four of them underwent penetrating keratoplasty (PK) à chaud one month after the first intrastromal injection. Patients who underwent surgery achieved a BCVA of 20/40 or better. Combined intrastromal injections before therapeutic penetrating keratoplasty (TPK) effectively reduced ulcer size and graft diameter, preventing infection recurrence. Our results highlight the efficacy of combined intrastromal injections in optimizing outcomes for severe mycotic keratitis undergoing TPK. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Multitarget microangiopathy in a young healthy man with COVID-19 disease: A case report

Author

Matilde, Roda, Alberto, Pazzaglia, Fabio, Guaraldi, Leonardo, Taroni, Di Geronimo, Natalie, Michela, Fresina, and Costantino, Schiavi

Subjects
Methylprednisolone -- Dosage and administration, Blood vessels -- Diseases, Optic neuritis -- Risk factors, Arterial occlusions -- Risk factors -- Diagnosis -- Care and treatment, Health
Abstract

Byline: Roda. Matilde, Pazzaglia. Alberto, Guaraldi. Fabio, Taroni. Leonardo, Natalie. di Geronimo, Fresina. Michela, Schiavi. Costantino A 41-year-old man presented to the emergency department complaining of decrease of vision in [...]

Published
2022

16. Evaluation of peripapillary vascular flow in patients with Thyroid-Associated Ophthalmopathy (TAO) by OCT Angiography

Author

Chiara Del Noce, Matilde Roda, Nicola Valsecchi, Sofia Guandalini, Natalie Di Geronimo, Costantino Schiavi, Carlo Enrico Traverso, Aldo Vagge, Del Noce, Chiara, Roda, Matilde, Valsecchi, Nicola, Guandalini, Sofia, Di Geronimo, Natalie, Schiavi, Costantino, Traverso, Carlo Enrico, and Vagge, Aldo

Subjects
Adult, Male, Choroid, Retinal Vessels, Middle Aged, Sensory Systems, Retina, Graves Ophthalmopathy, Cellular and Molecular Neuroscience, Ophthalmology, Peripapillary vascular flow, Humans, Female, Fluorescein Angiography, Graves’ disease, OCTA, Thyroid-associated ophthalmopathy, Tomography, Optical Coherence, Aged
Abstract

Purpose To evaluate changes in peripapillary vascular blood flow indices (PVBFI) in patients with thyroid-associated ophthalmopathy (TAO) using OCT angiography (OCTA) technology. Methods Patients with TAO and control subjects matched for age and sex were included in the study. Eye examination, Clinical Activity Score (CAS) evaluation and OCTA scan analysis (Topcon ImageNet 6; DRI OCT Triton, Topcon Corporation) were performed. In particular, PVBFI of the superficial capillary plexus (SCP), deep capillary plexus (DCP), outer retina (OR) and choriocapillaris (CC) layers were obtained by OCTA and extracted from 8-bit greyscale OCT images using the ImageJ software package. Results Twenty-six patients with TAO (19 females, mean age 54.7 ± 5.2 and 7 males, mean age 51.4 ± 16.3) were compared with 26 healthy subjects (15 females, mean age 48.2 ± 14.1 and 11 males, mean age 53.1 ± 15.2). Both DCP-PVBF and CC-PVBFI were significantly reduced in TAO patients compared to control eyes (28.6 ± 2.1 vs. 29.7 ± 0.93, p = 0.002; 46.5 ± 1.72 vs. 47.2 ± 1.2, p = 0.019 respectively); on the other hand, no statistically significant differences were found in SCP-PVBFI and OR-PVBFI in TAO patients compared to healthy subjects (p > 0.05). Also, CC-PVBFI was associated with elevated values of CAS (p = 0.018) and ROC curve showed that patients with elevated CC-PVBFI were correlated with active TAO (CAS > 3) (p = 0.012). Conclusions TAO disease may be associated with changes in DCP-PVBFI and CC-PVBFI; also, CC-PVBFI seems to correlate with disease activity.

Published
2021

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