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2. Is Systemic Chemotherapy Useful in Patients Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Colorectal Peritoneal Metastases? A Propensity-Score Analysis

Author

Tonello, Marco, Baratti, Dario, Sammartino, Paolo, Di Giorgio, Andrea, Robella, Manuela, Sassaroli, Cinzia, Framarini, Massimo, Valle, Mario, Macrì, Antonio, Graziosi, Luigina, Coccolini, Federico, Lippolis, Piero Vincenzo, Gelmini, Roberta, Deraco, Marcello, Biacchi, Daniele, Santullo, Francesco, Vaira, Marco, Di Lauro, Katia, D’Acapito, Fabrizio, Carboni, Fabio, Milone, Erica, Donini, Annibale, Fugazzola, Paola, Faviana, Pinuccia, Sorrentino, Lorena, Pizzolato, Elisa, Cenzi, Carola, Del Bianco, Paola, and Sommariva, Antonio

Published
2024
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3. Enhanced recovery after surgery (ERAS) implementation in cytoreductive surgery (CRS) and hyperthermic IntraPEritoneal chemotherapy (HIPEC): Insights from Italian peritoneal surface malignancies expert centers

Author

Robella, Manuela, Vaira, Marco, Ansaloni, Luca, Asero, Salvatore, Bacchetti, Stefano, Borghi, Felice, Casella, Francesco, Coccolini, Federico, De Cian, Franco, di Giorgio, Andrea, Framarini, Massimo, Gelmini, Roberta, Graziosi, Luigina, Kusamura, Shigeki, Lippolis, Piero, Lo Dico, Rea, Macrì, Antonio, Marrelli, Daniele, Sammartino, Paolo, Sassaroli, Cinzia, Scaringi, Stefano, Tonello, Marco, Valle, Mario, and Sommariva, Antonio

Published
2024
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5. ASO Visual Abstract: Is Systemic Chemotherapy Useful in Patients Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Colorectal Peritoneal Metastases? A Propensity-Score Analysis

Author

Tonello, Marco, Baratti, Dario, Sammartino, Paolo, Di Giorgio, Andrea, Robella, Manuela, Sassaroli, Cinzia, Framarini, Massimo, Valle, Mario, Macrì, Antonio, Graziosi, Luigina, Coccolini, Federico, Lippolis, Piero Vincenzo, Gelmini, Roberta, Deraco, Marcello, Biacchi, Daniele, Santullo, Francesco, Vaira, Marco, Di Lauro, Katia, D’Acapito, Fabrizio, Carboni, Fabio, Milone, Erica, Donini, Annibale, Fugazzola, Paola, Faviana, Pinuccia, Sorrentino, Lorena, Pizzolato, Elisa, Cenzi, Carola, Del Bianco, Paola, and Sommariva, Antonio

Published
2024
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6. Standardizing eligibility and patient selection for Pressurized Intraperitoneal Aerosol Chemotherapy: A Delphi consensus statement

Author

Afifi, Adnane, Alyami, Mohammad, Mortensen, Michael Bau, Bhatt, Aditi, Brandl, Andreas, Brigand, Cécile, Casella, Francesco, Chia, Claramae Shulyn, Coget, Julien, Delgadillo, Xavier, Dellinger, Thanh, Di Giorgio, Andrea, Escayola, Cecilia, Ezanno, Anne-Cécile, Geboes, Karen, Giger-Pabst, Urs, Gockel, Ines, Graversen, Martin, Jäger, Tarkan, Jones, Sadie, Katdare, Ninad, Kepenekian, Vahan, Khomiakov, Vladimir, Kothonidis, Konstantinos, Lavoue, Vincent, Lehmann, Kuno, Lordick, Florian, Lynch, Craig, Mulier, Stefaan, Paquette, Brice, Yong, Wei Peng, Prenen, Hans, Raoof, Mustafa, Rau, Beat, Ris, Frederic, Robella, Manuela, Somashekhar, Sampige Prasanna, Sourrouille, Isabelle, Steffen, Thomas, Sundar, Raghav, Thieme, René, Torkington, Jared, Ukegjini, Kristjan, Van der Speeten, Kurt, Villeneuve, Laurent, Tozzi, Francesca, Rashidian, Nikdokht, Ceelen, Wim, Callebout, Eduard, Hübner, Martin, Sgarbura, Olivia, and Willaert, Wouter

Published
2024
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8. External validation of COMPASS and BIOSCOPE prognostic scores in colorectal peritoneal metastases treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)

Author

Tonello, Marco, Baratti, Dario, Sammartino, Paolo, Di Giorgio, Andrea, Robella, Manuela, Sassaroli, Cinzia, Framarini, Massimo, Valle, Mario, Macrì, Antonio, Graziosi, Luigina, Fugazzola, Paola, Lippolis, Piero Vincenzo, Gelmini, Roberta, Biacchi, Daniele, Kasamura, Shigeki, Deraco, Marcello, Cenzi, Carola, Del Bianco, Paola, Vaira, Marco, and Sommariva, Antonio

Published
2023
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9. Benefit of a multimodal approach combining chemotherapy and surgery in oligometastatic gastric cancer: experience from a tertiary referral center

Author

Maratta, Maria Grazia, primary, Vitale, Antonio, additional, Basso, Michele, additional, Vivolo, Raffaella, additional, Di Monte, Elena, additional, Biondi, Alberto, additional, Di Giorgio, Andrea, additional, Rosa, Fausto, additional, Tondolo, Vincenzo, additional, Agnes, Annamaria, additional, Tortora, Giampaolo, additional, Strippoli, Antonia, additional, and Pozzo, Carmelo, additional

Published
2024
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10. Microsatellite and RAS/RAF Mutational Status as Prognostic Factors in Colorectal Peritoneal Metastases Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

Author

Tonello, Marco, Baratti, Dario, Sammartino, Paolo, Di Giorgio, Andrea, Robella, Manuela, Sassaroli, Cinzia, Framarini, Massimo, Valle, Mario, Macrì, Antonio, Graziosi, Luigina, Coccolini, Federico, Lippolis, Piero Vincenzo, Gelmini, Roberta, Deraco, Marcello, Biacchi, Daniele, Santullo, Francesco, Vaira, Marco, Di Lauro, Katia, D’Acapito, Fabrizio, Carboni, Fabio, Giuffrè, Giuseppe, Donini, Annibale, Fugazzola, Paola, Faviana, Pinuccia, Sorrentino, Lorena, Scapinello, Antonio, Del Bianco, Paola, and Sommariva, Antonio

Published
2022
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11. Feasibility and safety of PIPAC combined with additional surgical procedures: PLUS study

Author

Villeneuve, Laurent, Cortés-Guiral, Delia, Nowacki, Maciej, So, Jimmy, Abba, Julio, Afifi, Adnane, Mortensen, Michael Bau, Brandl, Andreas, Ceelen, Wim, Coget, Julien, Courvoiser, Thomas, de Hingh, Ignace H., Delhorme, Jean-Baptiste, Dumont, Frederic, Escayola, Cecilia, Eveno, Clarisse, Ezanno, Anne-Cécile, Gagnière, Johan, Galindo, Julio, Glatz, Torben, Glehen, Olivier, Jäger, Tarkan, Kepenekian, Vahan, Kothonidis, Konstantinos, Lehmann, Kuno, Lynch, Craig, Mehta, Sanket, Moldovan, Bogdan, Nissan, Aviram, Orry, David, Pérez, Gloria Ortega, Paquette, Brice, Paskonis, Marius, Piso, Pompiliu, Pocard, Marc, Rau, Beat, Singh, Shivendra, Somashekhar, S.P., Soravia, Claudio, Taibi, Abelkader, Torkington, Jared, Vizzielli, Giuseppe, Robella, Manuela, Hubner, Martin, Sgarbura, Olivia, Reymond, Marc, Khomiakov, Vladimir, di Giorgio, Andrea, Bhatt, Aditi, Bakrin, Naoual, Willaert, Wouter, Alyami, Mohammad, Teixeira, Hugo, Kaprin, Andrey, Ferracci, Federica, De Meeus, Guillaume, Berchialla, Paola, and Vaira, Marco

Published
2022
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12. Body composition and immunonutritional status in patients treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC) for gastrointestinal peritoneal metastases: a prospective single-center analysis

Author

Rotolo Stefano, Di Giorgio Andrea, Cintoni Marco, Rinninella Emanuele, Palombaro Marta, Pulcini Gabriele, Schena Carlo Alberto, Chiantera Vito, Vizzielli Giuseppe, Gasbarrini Antonio, Pacelli Fabio, and Mele Maria Cristina

Subjects
body composition, clinical nutrition, pressurized intraperitoneal chemotherapy, prognostic nutritional index, skeletal muscle index, Medicine, Specialties of internal medicine, RC581-951
Abstract

Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel drug administration method with promising efficacy for the treatment of peritoneal metastases (PM). This study aimed to evaluate the prognostic value of an immunonutritional assessment on the feasibility, safety, and survival in this setting.

Published
2022
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13. Consensus statement for treatment protocols in pressurized intraperitoneal aerosol chemotherapy (PIPAC)

Author

Sgarbura Olivia, Eveno Clarisse, Alyami Mohammad, Bakrin Naoual, Guiral Delia Cortes, Ceelen Wim, Delgadillo Xavier, Dellinger Thanh, Di Giorgio Andrea, Kefleyesus Amaniel, Khomiakov Vladimir, Mortensen Michael Bau, Murphy Jamie, Pocard Marc, Reymond Marc, Robella Manuela, Rovers Koen P., So Jimmy, Somashekhar S.P., Tempfer Clemens, Van der Speeten Kurt, Villeneuve Laurent, Yong Wei Peng, and Hübner Martin

Subjects
cisplatin, doxorubicin, oxaliplatin, peritoneal metastasis, pipac, standardisation, treatment protocol, Medicine, Specialties of internal medicine, RC581-951
Abstract

Safe implementation and thorough evaluation of new treatments require prospective data monitoring and standardization of treatments. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a promising alternative for the treatment of patients with peritoneal disease with an increasing number of suggested drug regimens. The aim was to reach expert consensus on current PIPAC treatment protocols and to define the most important research topics.

Published
2022
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14. Consensus guidelines for pressurized intraperitoneal aerosol chemotherapy: Technical aspects and treatment protocols

Author

Abba, Julio, Afifi, Adnane, Mortensen, Michael Bau, Bhatt, Aditi, Brandl, Andreas, Ceelen, Wim, Coget, Julien, Courvoiser, Thomas, de Hingh, Ignace H., Delhorme, Jean-Baptiste, di Giorgio, Andrea, Dumont, Frederic, Escayola, Cecilia, Eveno, Clarisse, Ezanno, Anne-Cécile, Gagnière, Johan, Galindo, Julio, Glatz, Torben, Glehen, Olivier, Jäger, Tarkan, Kepenekian, Vahan, Khomyakov, Vladimir M., Kothonidis, Konstantinos, Lehmann, Kuno, Lynch, Craig, Mehta, Sanket, Moldovan, Bogdan, Nissan, Aviram, Orry, David, Pérez, Gloria Ortega, Paquette, Brice, Paskonis, Marius, Piso, Pompiliu, Pocard, Marc, Rau, Beat, Robella, Manuela, Singh, Shivendra, Somashekhar, S.P., Soravia, Claudio, Taibi, Abelkader, Torkington, Jared, Vizzielli, Giuseppe, Willaert, Wouter, Hübner, Martin, Alyami, Mohammad, Villeneuve, Laurent, Cortés-Guiral, Delia, Nowacki, Maciej, So, Jimmy, and Sgarbura, Olivia

Published
2022
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15. The prognostic value of skeletal muscle index on clinical and survival outcomes after cytoreduction and HIPEC for peritoneal metastases from colorectal cancer: A systematic review and meta-analysis

Author

Di Giorgio, Andrea, Rotolo, Stefano, Cintoni, Marco, Rinninella, Emanuele, Pulcini, Gabriele, Schena, Carlo Alberto, Ferracci, Federica, Grassi, Futura, Raoul, Pauline, Moroni, Rossana, Pacelli, Fabio, Gasbarrini, Antonio, and Mele, Maria Cristina

Published
2022
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16. How to Implement Pressurized Intraperitoneal Aerosol Chemotherapy into a National Health System Scenario: A Single-Center Retrospective Analysis of Costs and Economic Sustainability at a High-Volume Italian Hospital.

Author

Aulicino, Matteo, Orsini, Cecilia, D'Annibale, Giorgio, Barberis, Lorenzo, Catania, Paolo, Abatini, Carlo, Attalla El Halabieh, Miriam, Ferracci, Federica, Lodoli, Claudio, Santullo, Francesco, Pacelli, Fabio, and Di Giorgio, Andrea

Subjects
NATIONAL health services, INTRAPERITONEAL injections, HEALTH insurance reimbursement, ACADEMIC medical centers, AEROSOLS, HOSPITAL care, EVALUATION of human services programs, DESCRIPTIVE statistics, RETROSPECTIVE studies, ONCOLOGY, CANCER chemotherapy, PERITONEAL cancer, MEDICAL records, ACQUISITION of data, ECONOMIC impact, PERITONEUM tumors, LENGTH of stay in hospitals, MEDICAL care costs
Abstract

Simple Summary: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new surgical procedure used in the treatment of peritoneal surface malignancies (PSMs). Despite encouraging clinical results, the high costs of PIPAC and the need to repeat the treatment multiple times make the procedure difficult to sustain economically. A retrospective study was conducted in order to evaluate the cost of hospitalization for patients undergoing PIPAC treatment at a high-volume center in Italy. Currently, the Italian National Health System only partially covers the hospitals' costs. Therefore, there is an urgent need for an economical redefinition of this procedure, by creating dedicated reimbursement codes. PIPAC is a new surgical procedure and a viable treatment option for PSM patients, due to promising therapeutic outcomes, minimal invasiveness, limited surgical morbidity, and systemic toxicity side effects. However, its implementation throughout hospitals is hard to obtain due to its fragile economical sustainability. A retrospective health economic analysis was conducted in order to evaluate the cost of hospitalization for patients undergoing PIPAC treatment at Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, in Rome. The average cost of a PIPAC procedure was defined based on the cost of surgery (cost of surgical material, operating room, intraperitoneal chemotherapy), hospital stay, diagnostic examinations, and drugs used during the stay. A total of 493 PIPAC procedures were performed on 222 patients with peritoneal metastases or primary peritoneal cancer from 2017 to 2023. Since the mean remuneration for each PIPAC hospitalization is €5916 and the mean expenditure per hospitalization is €6538, this results in an operating profit per PIPAC hospitalization of −€622. The reimbursement of PIPAC treatment by the Italian National Health System currently only partially covers the hospital's costs. Development of specific codes and adequate reimbursement for PIPAC by recognizing this procedure as a proper treatment for peritoneal carcinomatosis is essential. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Gastric Cancer with Synchronous Peritoneal Metastases: Multicenter Study of ‘Italian Peritoneal Surface Malignancies Oncoteam—S.I.C.O.’

Author

Marano, Luigi, Marrelli, Daniele, Sammartino, Paolo, Biacchi, Daniele, Graziosi, Luigina, Marino, Elisabetta, Coccolini, Federico, Fugazzola, Paola, Valle, Mario, Federici, Orietta, Baratti, Dario, Deraco, Marcello, Di Giorgio, Andrea, Macrì, Antonio, Pasqual, Enrico Maria, Framarini, Massimo, Vaira, Marco, and Roviello, Franco

Published
2021
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18. Treatment Response After Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) for Peritoneal Metastases of Colorectal Originf

Author

Martin Hübner, MD, S. P. Somashekhar, MD, Hugo Teixeira Farinha, MD, Julio Abba, MD, Ramya G. Rao, PhD, Mohammad Alyami, MD, Wouter Willaert, MD, PhD, on behalf of the PIPAC study group, Brigand Cecile, MD, Delhorme Jean-Baptiste, MD, PhD, Romain Benoit, MD, PhD, Charleux-Muller Diane, MD, Bertin Jean-Baptiste, MD, Rohr Serge, MD, Jager Tarkan, MD, Neureiter Daniel, MD, Schredl Philipp, MD, Weiss Lukas, MD, Klieser Eckhard, MD, Emmanuel Klaus, MD, Sgarbura Olivia, MD, PhD, Bouillin Alix, MD, Khellaf Lakhdar, MD, Nougaret Stephanie, MD, PhD, Samalin Emmanuelle, MD, Mazard Thibault, MD, PhD, Glehen Olivier, MD, PhD, Kepenekian Vahan, MD, PhD, Villeneuve Laurent, PhD, Hubner Martin, Demartines Nicolas, MD, Teixeira-Farinha Hugo, MD, Clerc Daniel, MD, Dromain Clarisse, MD, Sempoux Christine, MD, PhD, Robella Manuela, MD, Vaira Marco, MD, De Simone Michele, MD, Di Giorgio Andrea, MD, Ferracci Federica, MD, Rotolo Stefano, MD, Schena Carlo Alberto, MD, Inzani Frediano, MD, Bagala Cinzia, MD, Babucke Maximilian, MD, Piso Pompiliu, PhD, MD, Somashekhar s p, MD, Ashwin KR, DNB, Rohit Kumar, DNB, Susmita Rakshit, MBBS, MD, Amit Rauthan, DM, Bhatt Aditi, MS, MCh., Shaikh Sakina, BH,MS, MBA, Parikh Loma, MD, Sheth Sandeep, MD, Panchal Amee, MD, Thakkar Shweta, MD, Ezzano Anne-Cecile, MD, Aime Adeline, MD, Eveno Clarisse, MD, PhD, Noiret Barbara, MD, Khomiakov Vladimir, PhD, Ryabov Andrey, PhD, Utkina Anna, PhD, Aksenov Sergey, MD, Bolotina Larisa, PhD, Kaprin Andrey, PhD, Willaert Wouter, MD, PhD, Cosyns Sarah, PhD, MSc, Akhayad Soumaya, BSN, Ceelen Wim, MD, PhD, Gockel Ines, MD, Jansen-Winkeln Boris, MD, Thieme Rene, PhD, Schierle Katrin, MD, Moulla Yusef, MD, Mehdorn Matthias, MD, Abba Julio, MD, Trilling Bertrand, MD, PhD, Tidadini Fatah, MSc, Bonne Aline, MD, Arvieux Catherine, MD, PhD, Orry David, MD, Basso Valeria, MD, Ghiringhelli Francois, MD, PhD, Escayola Cecilia, MD, Torrent Juan Jose, MD, Alyami Mohammad, MD, Alqannas Mashhour, MD, Cortes Guiral Delia, MD, PhD, Alammari samer, MD, Bashanfer Galal, MD, Alshukami Anwar, MD, Reymond Marc A., MD, Solass Wiebke, MD, and Nadiradze Giorgi, MD

Subjects
Surgery, RD1-811
Abstract

Objective:. The objective of this study is to analyze oncological outcomes of patients with peritoneal metastases (PM) of colorectal origin treated with Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC). Background:. PIPAC has been demonstrated to be a feasible and safe novel treatment for patients with PM of various origins. Only small series reports on survival after PIPAC by disease entity. Methods:. International retrospective cohort study of consecutive patients with PM of colorectal origin. Outcome measures were overall survival (OS), radiological response according to Response Evaluation Criteria in Solid Tumors (RECIST), histological response (peritoneal regression grading score [PRGS]: complete response: 1–4: no response), change of peritoneal cancer index (PCI), and symptom control. Results:. Seventeen eligible centers compiled 256 non-selected patients (mean age 61 [50.6–69.2], 43% female) and 606 procedures. Sixty-three percent were treated after 2 lines of chemotherapy, median PCI at PIPAC1 was 18 (interquartile range [IQR] = 10–27). Median OS was 19.00 months (IQR = 12.9–29.8) from diagnosis and 9.4 months (IQR = 4.5–16.8) from PIPAC1. One hundred and four of 256 patients (40.6%) had ≥3 procedures (per protocol [pp]) with the following outcomes at PIPAC3: RECIST: 59.3% partial response/stable, 40.7% progression; mean PRGS: 2.1 ± 0.9. Median PCI was 21 (IQR = 15–29) at baseline and 20 (IQR = 12–27) at PIPAC3 (P = 0.02). Fifty-six (54%) and 48 (46%) patients were symptomatic at baseline and PIPAC3, respectively (P = 0.267). Median OS for the pp cohort was 11.9 months (IQR = 10.7–15.0) from PIPAC1. Independent predictors for survival were radiological response (HR = 3.0; 95% CI = 1.6–5.7) and no symptoms (HR = 4.5, 95% CI = 2.2–9.1) at PIPAC3. Conclusions:. Objective treatment response and encouraging survival were demonstrated after PIPAC for colorectal PM. Prospective registry data and comparative studies are now needed in to confirm these data.

Published
2022
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21. Current practice of pressurized intraperitoneal aerosol chemotherapy (PIPAC): Still standardized or on the verge of diversification?

Author

Abba, Julio, Afifi, Adnane, Mortensen, Michael Bau, Bharath, G., Bhatt, Aditi, Yan So, Jimmy Bok, Brandl, Andreas, Ceelen, Wim, Cortes-Guiral, Delia, Courvoiser, Thomas, Coget, Julien, de Hingh, Ignace H., Delhorme, Jean-Baptiste, Deo, Suryanarayana S.V., di Giorgio, Andrea, Dumont, Frederic, Escayola, Cecilia, Ezanno, Anne-Cécile, Gagnière, Johan, Galindo, Julio, Glatz, Torben, Jäger, Tarkan, Jarra, Maximilian, Katdare, Ninad, Kepenekian, Vahan, Khomyakov, Vladimir M., Kothonidis, Konstantinos, Laplace, Nathalie, Lavoue, Vincent, Lehmann, Kuno, Lynch, Craig, Mehta, Sanket, Moldovan, Bogdan, Nissan, Aviram, Nowacki, Maciej, Orry, David, Pérez, Gloria Ortega, Pabst, Urs G., Paquette, Brice, Paskonis, Marius, Piso, Pompiliu, Pocard, Marc, Rau, Beate, Reymond, Marc, Ris, Frederic, Robella, Manuela, Silvestre-Rodriguez, José, Singh, Shivendra, Somashekhar, S.P., Soravia, Claudio, Sourrouille, Isabelle, Taibi, Abelkader, Tempfer, Clemens, Torkington, Jared, Vizzielli, Giuseppe, Willaert, Wouter, Sgarbura, Olivia, Villeneuve, Laurent, Alyami, Mohammad, Bakrin, Naoual, Torrent, Juan José, Eveno, Clarisse, and Hübner, Martin

Published
2021
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22. Diagnostic and therapeutic algorithm for colorectal peritoneal metastases. A consensus of the peritoneal surface malignancies onco-team of the Italian society of surgical oncology

Author

Sommariva, Antonio, Ansaloni, Luca, Baiocchi, Gian Luca, Cascinu, Stefano, Cirocchi, Roberto, Coccolini, Federico, Deraco, Marcello, Fiorentini, Gianmaria, Gelmini, Roberta, Di Giorgio, Andrea, Lippolis, Piero Vincenzo, Pasqual, Enrico Maria, Sassaroli, Cinzia, Macrì, Antonio, Sammartino, Paolo, Scaringi, Stefano, Valle, Mario, and Vaira, Marco

Published
2021
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23. Efficacy of Cytoreductive Surgery (CRS) + HIPEC in Gastric Cancer with Peritoneal Metastasis: Systematic Review and Meta-Analysis.

Author

Langellotti, Lodovica, Fiorillo, Claudio, D'Annibale, Giorgio, Panza, Edoardo, Pacelli, Fabio, Alfieri, Sergio, Di Giorgio, Andrea, and Santullo, Francesco

Subjects
STOMACH tumors, PERITONEUM, THERMOTHERAPY, CYTOREDUCTIVE surgery, TREATMENT effectiveness, META-analysis, DESCRIPTIVE statistics, METASTASIS, ADJUVANT chemotherapy, SYSTEMATIC reviews, MEDLINE, DRUG efficacy, ONLINE information services, COMPARATIVE studies
Abstract

Simple Summary: Peritoneal disease in gastric cancer has a poor prognosis, with a median survival of 3–6 months and a 5-year survival rate of 0%. Despite multiple advancements in therapeutics, the National Comprehensive Cancer Network (NCCN) guidelines recommend systemic chemotherapy or best supportive care for GC with peritoneal dissemination. According to several studies, CRS + HIPEC could provide survival advantages in gastric cancer peritoneal metastasis compared to pSC. Background: Peritoneal carcinomatosis is one of deadliest metastatic patterns of gastric cancer, being associated with a median overall survival (OS) of 4 months. Up to now, palliative systemic chemotherapy (pSC) has been the only recommended treatment. The aim of this study is to evaluate a potential survival benefit after CRS + HIPEC compared to pSC. Methods: A systematic review was conducted according to the PRISMA guidelines in March 2024. Manuscripts reporting patients with peritoneal carcinomatosis from gastric cancer treated with CRS + HIPEC were included. A meta-analysis was performed, comparing the survival results between the CRS + HIPEC and pSC groups, and the primary outcome was the comparison in terms of OS. We performed random-effects meta-analysis of odds ratios (ORs). We assessed heterogeneity using the Q2 statistic. Results: Out of the 24 papers included, 1369 patients underwent CRS + HIPEC, with a median OS range of 9.8–28.2 months; and 103 patients underwent pSC, with a median OS range of 4.9–8 months. CRS + HIPEC was associated with significantly increased survival compared to palliative systemic chemotherapy (−1.8954 (95% CI: −2.5761 to −1.2146; p < 0.001). Conclusions: CRS + HIPEC could provide survival advantages in gastric cancer peritoneal metastasis compared to pSC. [ABSTRACT FROM AUTHOR]

Published
2024
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25. ASO Visual Abstract: Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) Applied to Platinum-Resistant Recurrence of Ovarian Tumor—A Single-Institution Experience (ID:PARROT Trial)

Author

Vizzielli, Giuseppe, primary, Giudice, Maria Teresa, additional, Nardelli, Federica, additional, Costantini, Barbara, additional, Salutari, Vanda, additional, Inzani, Frediano Socrate, additional, Zannoni, Gian Franco, additional, Chiantera, Vito, additional, Di Giorgio, Andrea, additional, Pacelli, Fabio, additional, Fagotti, Anna, additional, and Scambia, Giovanni, additional

Published
2023
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26. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) Applied to Platinum-Resistant Recurrence of Ovarian Tumor: A Single-Institution Experience (ID: PARROT Trial)

Author

Vizzielli, Giuseppe, primary, Giudice, Maria Teresa, additional, Nardelli, Federica, additional, Costantini, Barbara, additional, Salutari, Vanda, additional, Inzani, Frediano Socrate, additional, Zannoni, Gian Franco, additional, Chiantera, Vito, additional, Di Giorgio, Andrea, additional, Pacelli, Fabio, additional, Fagotti, Anna, additional, and Scambia, Giovanni, additional

Published
2023
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27. ASO Visual Abstract: Microsatellite and RAS/RAF Mutational Status as Prognostic Factors in Colorectal Peritoneal Metastases Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Author

Tonello, Marco, Baratti, Dario, Sammartino, Paolo, Di Giorgio, Andrea, Robella, Manuela, Sassaroli, Cinzia, Framarini, Massimo, Valle, Mario, Macrì, Antonio, Graziosi, Luigina, Coccolini, Federico, Lippolis, Piero Vincenzo, Gelmini, Roberta, Deraco, Marcello, Biacchi, Daniele, Santullo, Francesco, Vaira, Marco, Di Lauro, Katia, D’Acapito, Fabrizio, Carboni, Fabio, Giuffrè, Giuseppe, Donini, Annibale, Fugazzola, Paola, Faviana, Pinuccia, Sorrentino, Lorena, Scapinello, Antonio, Del Bianco, Paola, and Sommariva, Antonio

Published
2022
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29. Correction: Microsatellite and RAS/RAF Mutational Status as Prognostic Factors in Colorectal Peritoneal Metastases Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

Author

Tonello, Marco, Baratti, Dario, Sammartino, Paolo, Di Giorgio, Andrea, Robella, Manuela, Sassaroli, Cinzia, Framarini, Massimo, Valle, Mario, Macrì, Antonio, Graziosi, Luigina, Coccolini, Federico, Lippolis, Piero Vincenzo, Gelmini, Roberta, Deraco, Marcello, Biacchi, Daniele, Santullo, Francesco, Vaira, Marco, Di Lauro, Katia, D’Acapito, Fabrizio, Carboni, Fabio, Giuffrè, Giuseppe, Donini, Annibale, Fugazzola, Paola, Faviana, Pinuccia, Sorrentino, Lorena, Scapinello, Antonio, Del Bianco, Paola, and Sommariva, Antonio

Published
2022
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30. ASO Visual Abstract: Is Systemic Chemotherapy Useful in Patients Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Colorectal Peritoneal Metastases? A Propensity-Score Analysis

Author

Tonello, Marco, primary, Baratti, Dario, additional, Sammartino, Paolo, additional, Di Giorgio, Andrea, additional, Robella, Manuela, additional, Sassaroli, Cinzia, additional, Framarini, Massimo, additional, Valle, Mario, additional, Macrì, Antonio, additional, Graziosi, Luigina, additional, Coccolini, Federico, additional, Lippolis, Piero Vincenzo, additional, Gelmini, Roberta, additional, Deraco, Marcello, additional, Biacchi, Daniele, additional, Santullo, Francesco, additional, Vaira, Marco, additional, Di Lauro, Katia, additional, D’Acapito, Fabrizio, additional, Carboni, Fabio, additional, Milone, Erica, additional, Donini, Annibale, additional, Fugazzola, Paola, additional, Faviana, Pinuccia, additional, Sorrentino, Lorena, additional, Pizzolato, Elisa, additional, Cenzi, Carola, additional, Del Bianco, Paola, additional, and Sommariva, Antonio, additional

Published
2023
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31. Is Systemic Chemotherapy Useful in Patients Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Colorectal Peritoneal Metastases? A Propensity-Score Analysis

Author

Tonello, Marco, primary, Baratti, Dario, additional, Sammartino, Paolo, additional, Di Giorgio, Andrea, additional, Robella, Manuela, additional, Sassaroli, Cinzia, additional, Framarini, Massimo, additional, Valle, Mario, additional, Macrì, Antonio, additional, Graziosi, Luigina, additional, Coccolini, Federico, additional, Lippolis, Piero Vincenzo, additional, Gelmini, Roberta, additional, Deraco, Marcello, additional, Biacchi, Daniele, additional, Santullo, Francesco, additional, Vaira, Marco, additional, Di Lauro, Katia, additional, D’Acapito, Fabrizio, additional, Carboni, Fabio, additional, Milone, Erica, additional, Donini, Annibale, additional, Fugazzola, Paola, additional, Faviana, Pinuccia, additional, Sorrentino, Lorena, additional, Pizzolato, Elisa, additional, Cenzi, Carola, additional, Del Bianco, Paola, additional, and Sommariva, Antonio, additional

Published
2023
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32. Descriptive review of current practices and prognostic factors in patients with ovarian cancer treated by pressurized intraperitoneal aerosol chemotherapy (PIPAC): a multicentric, retrospective, cohort of 234 patients

Author

Kefleyesus, Amaniel, primary, Bhatt, Aditi, additional, Escayola, Cecilia, additional, Khomyakov, Vladimir, additional, Hübner, Martin, additional, Reymond, Marc A., additional, Thieme, René, additional, Sgarbura, Olivia, additional, Willaert, Wouter, additional, Ceelen, Wim, additional, Di Giorgio, Andrea, additional, Vizzielli, Giuseppe, additional, Glehen, Olivier, additional, Robella, Manuela, additional, and Bakrin, Naoual, additional

Published
2023
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36. 10 Years of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC): A Systematic Review and Meta-Analysis

Author

Di Giorgio, Andrea, primary, Macrì, Antonio, additional, Ferracci, Federica, additional, Robella, Manuela, additional, Visaloco, Mario, additional, De Manzoni, Giovanni, additional, Sammartino, Paolo, additional, Sommariva, Antonio, additional, Biacchi, Daniele, additional, Roviello, Franco, additional, Pastorino, Roberta, additional, Pires Marafon, Denise, additional, Rotolo, Stefano, additional, Casella, Francesco, additional, and Vaira, Marco, additional

Published
2023
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38. Rare recurrence of malignant mesothelioma spreading to the perineum

Author

Marra, Angelo Alessandro, Di Giorgio, Andrea, Ratto, Carlo, Marra A. A. (ORCID:0000-0001-8384-5081), Di Giorgio A., Ratto C. (ORCID:0000-0002-0556-0037), Marra, Angelo Alessandro, Di Giorgio, Andrea, Ratto, Carlo, Marra A. A. (ORCID:0000-0001-8384-5081), Di Giorgio A., and Ratto C. (ORCID:0000-0002-0556-0037)

Abstract

Malignant mesothelioma is a rare aggressive tumour of the mesothelium with a propensity to spread locally and, rarely, to distant organs. The latest advances in its diagnosis and treatment have led to an increase in unusual disease presentations. Although a direct invasion of the perineum has been previously described in a men, a malignant mesothelioma spreading to the perianal region was never reported in a women. We presented a rare case of malignant mesothelioma recurrence spreading from the peritoneal cavity to the perineum through the rectovaginal space.

Published
2023

39. Enhanced Recovery after Surgery (ERAS) Program for Patients with Peritoneal Surface Malignancies Undergoing Cytoreductive Surgery with or without HIPEC: A Systematic Review and a Meta-Analysis

Author

Robella, Manuela, primary, Tonello, Marco, additional, Berchialla, Paola, additional, Sciannameo, Veronica, additional, Ilari Civit, Alba Maria, additional, Sommariva, Antonio, additional, Sassaroli, Cinzia, additional, Di Giorgio, Andrea, additional, Gelmini, Roberta, additional, Ghirardi, Valentina, additional, Roviello, Franco, additional, Carboni, Fabio, additional, Lippolis, Piero Vincenzo, additional, Kusamura, Shigeki, additional, and Vaira, Marco, additional

Published
2023
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40. Laparoscopic Cytoreduction Combined with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Peritoneal Surface Malignancies (PSM): Italian PSM Oncoteam Evidence and Literature Review

Author

Sommariva, Antonio, primary, Valle, Mario, additional, Gelmini, Roberta, additional, Tonello, Marco, additional, Carboni, Fabio, additional, De Manzoni, Giovanni, additional, Sorrentino, Lorena, additional, Pasqual, Enrico Maria, additional, Bacchetti, Stefano, additional, Sassaroli, Cinzia, additional, Di Giorgio, Andrea, additional, Framarini, Massimo, additional, Marrelli, Daniele, additional, Casella, Francesco, additional, and Federici, Orietta, additional

Published
2022
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41. Cytoreductive Surgery (CRS) and HIPEC for Advanced Ovarian Cancer with Peritoneal Metastases: Italian PSM Oncoteam Evidence and Study Purposes

Author

Marrelli, Daniele, primary, Ansaloni, Luca, additional, Federici, Orietta, additional, Asero, Salvatore, additional, Carbone, Ludovico, additional, Marano, Luigi, additional, Baiocchi, Gianluca, additional, Vaira, Marco, additional, Coccolini, Federico, additional, Di Giorgio, Andrea, additional, Framarini, Massimo, additional, Gelmini, Roberta, additional, Palopoli, Carmen, additional, Accarpio, Fabio, additional, and Fagotti, Anna, additional

Published
2022
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42. Complications and Mortality Rate of Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy: Italian Peritoneal Surface Malignancies Oncoteam Results Analysis

Author

Carboni, Fabio, primary, Valle, Mario, additional, Vaira, Marco, additional, Sammartino, Paolo, additional, Federici, Orietta, additional, Robella, Manuela, additional, Deraco, Marcello, additional, Framarini, Massimo, additional, Macrì, Antonio, additional, Sassaroli, Cinzia, additional, Lippolis, Piero Vincenzo, additional, Di Giorgio, Andrea, additional, Biacchi, Daniele, additional, Martin-Roman, Lorena, additional, Sperduti, Isabella, additional, and Baratti, Dario, additional

Published
2022
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44. Feasibility and safety of PIPAC combined with additional surgical procedures: PLUS study

Author

Robella, Manuela, primary, Hubner, Martin, additional, Sgarbura, Olivia, additional, Reymond, Marc, additional, Khomiakov, Vladimir, additional, di Giorgio, Andrea, additional, Bhatt, Aditi, additional, Bakrin, Naoual, additional, Willaert, Wouter, additional, Alyami, Mohammad, additional, Teixeira, Hugo, additional, Kaprin, Andrey, additional, Ferracci, Federica, additional, De Meeus, Guillaume, additional, Berchialla, Paola, additional, Vaira, Marco, additional, Villeneuve, Laurent, additional, Cortés-Guiral, Delia, additional, Nowacki, Maciej, additional, So, Jimmy, additional, Abba, Julio, additional, Afifi, Adnane, additional, Mortensen, Michael Bau, additional, Brandl, Andreas, additional, Ceelen, Wim, additional, Coget, Julien, additional, Courvoiser, Thomas, additional, de Hingh, Ignace H., additional, Delhorme, Jean-Baptiste, additional, Dumont, Frederic, additional, Escayola, Cecilia, additional, Eveno, Clarisse, additional, Ezanno, Anne-Cécile, additional, Gagnière, Johan, additional, Galindo, Julio, additional, Glatz, Torben, additional, Glehen, Olivier, additional, Jäger, Tarkan, additional, Kepenekian, Vahan, additional, Kothonidis, Konstantinos, additional, Lehmann, Kuno, additional, Lynch, Craig, additional, Mehta, Sanket, additional, Moldovan, Bogdan, additional, Nissan, Aviram, additional, Orry, David, additional, Pérez, Gloria Ortega, additional, Paquette, Brice, additional, Paskonis, Marius, additional, Piso, Pompiliu, additional, Pocard, Marc, additional, Rau, Beat, additional, Singh, Shivendra, additional, Somashekhar, S.P., additional, Soravia, Claudio, additional, Taibi, Abelkader, additional, Torkington, Jared, additional, and Vizzielli, Giuseppe, additional

Published
2022
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45. External validation of COMPASS and BIOSCOPE prognostic scores in colorectal peritoneal metastases treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)

Author

Tonello, Marco, primary, Baratti, Dario, additional, Sammartino, Paolo, additional, Di Giorgio, Andrea, additional, Robella, Manuela, additional, Sassaroli, Cinzia, additional, Framarini, Massimo, additional, Valle, Mario, additional, Macrì, Antonio, additional, Graziosi, Luigina, additional, Fugazzola, Paola, additional, Lippolis, Piero Vincenzo, additional, Gelmini, Roberta, additional, Biacchi, Daniele, additional, Kasamura, Shigeki, additional, Deraco, Marcello, additional, Cenzi, Carola, additional, Del Bianco, Paola, additional, Vaira, Marco, additional, and Sommariva, Antonio, additional

Published
2022
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46. Prophylactic surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC CO2) versus standard surgery in colorectal carcinoma at high risk of peritoneal carcinomatosis: short-term and long-term outcomes from the CHECK study – protocol for a randomised, multicentre, phase 3 trial

Author

Pacelli, Fabio, primary, Gerardi, Chiara, additional, Rulli, Eliana, additional, Abatini, Carlo, additional, Rotolo, Stefano, additional, Garattini, Silvio, additional, Melotti, Gianluigi, additional, Torri, Valter, additional, Galli, Fabio, additional, Rulli, Erica, additional, and Di Giorgio, Andrea, additional

Published
2022
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48. Selected Patients With Peritoneal Metastases From Breast Cancer May Benefit From Cytoreductive Surgery: The Results of a Multicenter Survey

Author

Cardi, Maurizio, primary, Pocard, Marc, additional, Dico, Rea Lo, additional, Fiorentini, Gianmaria, additional, Valle, Mario, additional, Gelmini, Roberta, additional, Vaira, Marco, additional, Pasqual, Enrico Maria, additional, Asero, Salvatore, additional, Baiocchi, Gianluca, additional, Di Giorgio, Andrea, additional, Spagnoli, Alessandra, additional, Di Marzo, Francesco, additional, Sollazzo, Bianca, additional, D’Ermo, Giuseppe, additional, Biacchi, Daniele, additional, Iafrate, Franco, additional, and Sammartino, Paolo, additional

Published
2022
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49. The Road to Technical Proficiency in Cytoreductive Surgery for Peritoneal Carcinomatosis: Risk-Adjusted Cumulative Summation Analysis

Author

Santullo, Francesco, Abatini, Carlo, Attalla El Halabieh, Miriam, Ferracci, Federica, Lodoli, Claudio, Barberis, Lorenzo, Giovinazzo, Francesco, Di Giorgio, Andrea, Pacelli, Fabio, Pacelli, Fabio (ORCID:0000-0002-2013-6525), Santullo, Francesco, Abatini, Carlo, Attalla El Halabieh, Miriam, Ferracci, Federica, Lodoli, Claudio, Barberis, Lorenzo, Giovinazzo, Francesco, Di Giorgio, Andrea, Pacelli, Fabio, and Pacelli, Fabio (ORCID:0000-0002-2013-6525)

Abstract

Background: Cytoreductive surgery (CRS) is a technically demanding procedure, and there is considerable debate about its safe application. This study investigated the learning curve for CRS and the clinical outcomes of consecutive patients treated by a single surgeon at a single institution. Methods: We collected 251 consecutive patients who underwent CRS for peritoneal metastases by a single surgeon at Fondazione Policlinico Universitario A. Gemelli IRCCS, between January 2016 and December 2020. The learning curve was estimated using the cumulative summation analysis (CUSUM) for operative time (OT). Risk-adjusted CUSUM (RA-CUSUM) charts were developed using a composite variable (surgical failure), defined as the occurrence of at least one of the following events: major postoperative complications (Clavien-Dindo grade >= 3), blood loss >= 500 mL, incomplete cytoreduction. Three learning phases were thus derived from the RA-CUSUM analysis, and were compared in terms of perioperative outcomes. Results: CUSUM-OT showed that the operation time improved significantly after the 161(th) case. RA-CUSUM analysis allowed to break the CRS learning curve into three different phases: phase 1, "the learning phase " (cases 1-99), phase 2 "the experienced phase " (cases 100-188), and phase 3, "the mastership phase " (cases 189-251). The rate of major postoperative complications decreased significantly over the three phases (p = 0.019). Operative time decreased significantly as well (p = 0.031) and was significantly shorter in phase 3 with respect to the other two phases (phase 3 vs phase 2: 420 min vs 500 min, p = 0.017; phase 3 vs phase 1: 420 min vs 503 min, p = 0.021). Blood loss consistently decreased throughout the three phases (p = 0.001). The rate of incomplete cytoreduction was significantly lower in phase 3 than in phase 2 (4.8% vs 14.6%, p = 0.043). Conclusion: The CRS failure rate stabilized after the first 99 cases, and the complete surgical proficiency was achiev

Published
2022

50. Body composition and immunonutritional status in patients treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC) for gastrointestinal peritoneal metastases: a prospective single-center analysis

Author

Rotolo, Stefano, Di Giorgio, Andrea, Cintoni, Marco, Rinninella, Emanuele, Palombaro, Marta, Pulcini, Gabriele, Schena, Carlo Alberto, Chiantera, Vito, Vizzielli, Giuseppe, Gasbarrini, Antonio, Pacelli, Fabio, Mele, Maria Cristina, Cintoni, Marco (ORCID:0000-0002-9610-0748), Rinninella, Emanuele (ORCID:0000-0002-9165-2367), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Pacelli, Fabio (ORCID:0000-0002-2013-6525), Mele, Maria Cristina (ORCID:0000-0003-0153-5819), Rotolo, Stefano, Di Giorgio, Andrea, Cintoni, Marco, Rinninella, Emanuele, Palombaro, Marta, Pulcini, Gabriele, Schena, Carlo Alberto, Chiantera, Vito, Vizzielli, Giuseppe, Gasbarrini, Antonio, Pacelli, Fabio, Mele, Maria Cristina, Cintoni, Marco (ORCID:0000-0002-9610-0748), Rinninella, Emanuele (ORCID:0000-0002-9165-2367), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Pacelli, Fabio (ORCID:0000-0002-2013-6525), and Mele, Maria Cristina (ORCID:0000-0003-0153-5819)

Abstract

Objectives Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel drug administration method with promising efficacy for the treatment of peritoneal metastases (PM). This study aimed to evaluate the prognostic value of an immunonutritional assessment on the feasibility, safety, and survival in this setting.Methods Data of PM patients undergoing PIPAC between September 2018 and May 2020 were prospectively recorded. A CT scan-derived body composition assessment was performed for each patient.Results Fifty-one patients were enrolled, of which 30 (58%) underwent multiple PIPAC cycles, with a pathological response rate of 55%. Prognostic nutritional index (PNI) and neutrophil-to-lymphocytes predicted completion of more than one PIPAC cycle, with a cut off of 36.5 and 4.8 respectively. Muscle attenuation and body fat tissues were associated with pathological response. At multivariate Cox regression analysis, only the presence of a low PNI (HR 2.41, 95% CI 1.08-5.46) was significantly associated with a worse OS.Conclusions A pretreatment immunonutritional assessment may provide valuable information for PIPAC patients' selection and survival, while body composition parameters are able to predict pathological response. Further larger studies are needed to validate the role of these biomarkers in tailoring the treatment and monitoring PM patients undergoing PIPAC.

Published
2022

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