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2. Safety of COVID-19 Vaccines Among the Paediatric Population: Analysis of the European Surveillance Systems and Pivotal Clinical Trials

Author

Ahmadizar F., Luxi N., Raethke M., Schmikli S., Riefolo F., Saraswati P. W., Bucsa C., Osman A., Liddiard M., Maques F. B., Petrelli G., Sonderlichova S., Thurin N. H., Villalobos F., Trifiro G., Sturkenboom M., Moretti U., Bellitto C., Ciccimarra F., Gonella L. A., Arzenton E., Chiamulera C., Lora R., Bellantuono D., Sabaini A., Firenze A., Zodda D., Guidotti F., Zappone M., Alagna B., Cutroneo P. M., Minore C., Costantino C., Vitale F., D'Alessandro G., Morreale I., Marsala L., Farinella D., Bavetta S., Fantini M. P., Reno C., Raschi E., Poluzzi E., Sapigni E., Potenza A. M., Podetti D., Nikitina V., Ricciardelli R., Mogheiseh N., Croce S., Paltrinieri B., Castellani S., Sangiorgi E., Selleri M., Lucchesi S., Catucci G., Savini D., Sacripanti C., Faccioli M., Romio M. S., Rossi L., Radici S., Negri G., Fares L., Ajolfi C., Fadda A., Chiarello A., Pieraccini F., Gavioli B., Palazzi S., Tuccori M., Vannacci A., Bonaiuti R., Ravaldi C., Lombardi N., Crescioli G., Gori F., Tessari R., Zandona E., Zanoni G., Senna G., Crivellaro M. A., Cancian M., Venturini F., Ferri M., Leonardi L., Orzetti S., Caccin E., Baldo P., Capuano A., Rafaniello C., Ferrajolo C., Pagliaro C., Mercaldo M., di Giorgio A., Tari M., Manna S., Farina G., Di Mauro C., De Carlo I., Senesi I., Pileggi C., Palleria C., Gallelli L., De Sarro G., de Sarro C., Verduci C., Papadopoli R., Trabace L., Morgese M., Schiavone S., Tucci P., Bove M., Lapi F., Cricelli C., Racagni G., Tonolo S., Fava G., Giuffrida S., Amato V., Gambera M., Montresor V., Mastropasqua D., Ahmadizar F., Luxi N., Raethke M., Schmikli S., Riefolo F., Saraswati P.W., Bucsa C., Osman A., Liddiard M., Maques F.B., Petrelli G., Sonderlichova S., Thurin N.H., Villalobos F., Trifiro G., Sturkenboom M., Moretti U., Bellitto C., Ciccimarra F., Gonella L.A., Arzenton E., Chiamulera C., Lora R., Bellantuono D., Sabaini A., Firenze A., Zodda D., Guidotti F., Zappone M., Alagna B., Cutroneo P.M., Minore C., Costantino C., Vitale F., D'Alessandro G., Morreale I., Marsala L., Farinella D., Bavetta S., Fantini M.P., Reno C., Raschi E., Poluzzi E., Sapigni E., Potenza A.M., Podetti D., Nikitina V., Ricciardelli R., Mogheiseh N., Croce S., Paltrinieri B., Castellani S., Sangiorgi E., Selleri M., Lucchesi S., Catucci G., Savini D., Sacripanti C., Faccioli M., Romio M.S., Rossi L., Radici S., Negri G., Fares L., Ajolfi C., Fadda A., Chiarello A., Pieraccini F., Gavioli B., Palazzi S., Tuccori M., Vannacci A., Bonaiuti R., Ravaldi C., Lombardi N., Crescioli G., Gori F., Tessari R., Zandona E., Zanoni G., Senna G., Crivellaro M.A., Cancian M., Venturini F., Ferri M., Leonardi L., Orzetti S., Caccin E., Baldo P., Capuano A., Rafaniello C., Ferrajolo C., Pagliaro C., Mercaldo M., di Giorgio A., Tari M., Manna S., Farina G., Di Mauro C., De Carlo I., Senesi I., Pileggi C., Palleria C., Gallelli L., De Sarro G., de Sarro C., Verduci C., Papadopoli R., Trabace L., Morgese M., Schiavone S., Tucci P., Bove M., Lapi F., Cricelli C., Racagni G., Tonolo S., Fava G., Giuffrida S., Amato V., Gambera M., Montresor V., and Mastropasqua D.

Subjects
COVID-19 Vaccines, safety, Surveillance Systems, Pivotal Clinical Trials
Abstract

Background and Objectives: The European Medicine Agency extended the use of Comirnaty, Spikevax, and Nuvaxovid in paediatrics; thus, these vaccines require additional real-world safety evidence. Herein, we aimed to monitor the safety of COVID-19 vaccines through Covid-19 Vaccine Monitor (CVM) and EudraVigilance surveillance systems and the published pivotal clinical trials. Methods: In a prospective cohort of vaccinees aged between 5 and 17 years, we measured the frequency of commonly reported (local/systemic solicited) and serious adverse drug events (ADRs) following the first and second doses of COVID-19 vaccines in Europe using data from the CVM cohort until April 2022. The results of previous pivotal clinical trials and data in the EudraVigilance were also analysed. Results: The CVM study enrolled 658 first-dose vaccinees (children aged 5–11 years; n = 250 and adolescents aged 12–17 years; n = 408). Local/systemic solicited ADRs were common, whereas serious ADRs were uncommon. Among Comirnaty first and second dose recipients, 28.8% and 17.1% of children and 54.2% and 52.2% of adolescents experienced at least one ADR, respectively; injection-site pain (29.2% and 20.7%), fatigue (16.1% and 12.8%), and headache (22.1% and 19.3%) were the most frequent local and systemic ADRs. Results were consistent but slightly lower than in pivotal clinical trials. Reporting rates in Eudravigilance were lower by a factor of 1000. Conclusions: The CVM study showed high frequencies of local solicited reactions after vaccination but lower rates than in pivotal clinical trials. Injection-site pain, fatigue, and headache were the most commonly reported ADRs for clinical trials, but higher than spontaneously reported data.

Published
2023

5. Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases (vol 47, pg 1, 2021)

Author

Duse, M, Santamaria, F, Verga, M, Bergamini, M, Simeone, G, Leonardi, L, Tezza, G, Bianchi, A, Capuano, A, Cardinale, F, Cerimoniale, G, Landi, M, Malventano, M, Tosca, M, Varricchio, A, Zicari, A, Alfaro, C, Barberi, S, Becherucci, P, Bernardini, R, Biasci, P, Caffarelli, C, Caldarelli, V, Capristo, C, Castronuovo, S, Chiappini, E, Cutrera, R, De Castro, G, De Franciscis, L, Decimo, F, Iacono, I, Diaferio, L, Di Cicco, M, Di Mauro, C, Di Mauro, D, Di Mauro, F, Di Mauro, G, Doria, M, Falsaperla, R, Ferraro, V, Fanos, V, Galli, E, Ghiglioni, D, Indinnimeo, L, Kantar, A, Lamborghini, A, Licari, A, Lubrano, R, Luciani, S, Macri, F, Marseglia, G, Martelli, A, Masini, L, Midulla, F, Minasi, D, Miniello, V, Del Giudice, M, Morandini, S, Nardini, G, Nocerino, A, Novembre, E, Pajno, G, Paravati, F, Piacentini, G, Piersantelli, C, Pozzobon, G, Ricci, G, Spanevello, V, Turra, R, Zanconato, S, Borrelli, M, Villani, A, Corsello, G, and Peroni, D

Subjects
Settore MED/38
Published
2022

6. Analysis of fatal adverse drug events recorded in several Italian emergency departments (the MEREAFaPS study)

Author

Pagani, S., Lombardi, N., Crescioli, G., Vighi, G. V., Spada, G., Romoli, I., Andreetta, P., Capuano, A., Marrazzo, E., Marra, A., Leoni, O., Vannacci, A., Venegoni, M., Vighi, G. D., Bettoni, D., Blandizzi, C., Bonaiuti, R., Borsi, V., Cecchi, E., Convertino, I., Del Lungo, M., Di Mauro, C., Farina, G., Ferraro, S., Fucile, A., Galfrascoli, E., Geninatti, E., Giovannetti, L., Leonardi, L., Liccardo, R., Monina, G., Mugelli, A., Parrilli, M., Rafaniello, C., Rossi, F., Rostan, S., Ruocco, M., Sironi, M., Sportiello, L., Tuccori, M., Pagani, S., Lombardi, N., Crescioli, G., Vighi, G. V., Spada, G., Romoli, I., Andreetta, P., Capuano, A., Marrazzo, E., Marra, A., Leoni, O., Vannacci, A., Venegoni, M., Vighi, G. D., Bettoni, D., Blandizzi, C., Bonaiuti, R., Borsi, V., Cecchi, E., Convertino, I., Del Lungo, M., Di Mauro, C., Farina, G., Ferraro, S., Fucile, A., Galfrascoli, E., Geninatti, E., Giovannetti, L., Leonardi, L., Liccardo, R., Monina, G., Mugelli, A., Parrilli, M., Rafaniello, C., Rossi, F., Rostan, S., Ruocco, M., Sironi, M., Sportiello, L., and Tuccori, M.

Subjects
Drug, Male, medicine.medical_specialty, Drug-Related Side Effects and Adverse Reactions, media_common.quotation_subject, Adverse drug reaction, 030204 cardiovascular system & hematology, 03 medical and health sciences, Appropriateness of drug use, Pharmacovigilance, 0302 clinical medicine, Older patients, Internal Medicine, Medicine, Humans, 030212 general & internal medicine, Adverse effect, Drug safety, media_common, Aged, Medication error, business.industry, Public health, Anticoagulants, Mean age, medicine.disease, Italy, Concomitant, Emergency medicine, Emergency Medicine, Female, business, Emergency Service, Hospital, Algorithms, Platelet Aggregation Inhibitors
Abstract

Fatal Adverse Events (FADEs) are a major public health problem, and some FADEs could be preventable. The aim of the present study is to describe the frequency, the drugs involved and the preventability in the FADEs collected through the MEREAFaPS Study between 2012 and 2018. All cases including the outcome “death” have been examined. We excluded cases with vaccine-related ADEs, overdose or suicide, and ADEs occurred during the hospitalisation. Two trained assessors evaluated all cases fulfilling the inclusion criteria. ADEs’ preventability was evaluated applying the Schumock and Thornton algorithm. During the study period, we observed 429 cases of death, 92 of which were excluded. The remaining 337 cases involved 187 women and 150 men, with a mean age of 79 and of 77years, respectively. For each report, the suspected drugs and concomitant ones were 1.26 and 4.20, respectively. Anticoagulants and antiplatelet agents account for more than 40% of FADE cases and the most frequent reactions are haemorrhages (37.5%). The 25% of the FADEs were preventable. This study confirms that FADEs are still a relevant clinical occurrence, and are often caused by widely used old drugs associated with adverse events. The death of one in four patients was preventable. Further efforts should be done to improve the appropriateness of the therapy, especially in older patients who are treated with anticoagulants.

Published
2021

7. COVID-19 Vaccination in Pregnancy, Paediatrics, Immunocompromised Patients, and Persons with History of Allergy or Prior SARS-CoV-2 Infection: Overview of Current Recommendations and Pre- and Post-Marketing Evidence for Vaccine Efficacy and Safety

Author

Luxi N., Giovanazzi A., Capuano A., Crisafulli S., Cutroneo P. M., Fantini M. P., Ferrajolo C., Moretti U., Poluzzi E., Raschi E., Ravaldi C., Reno C., Tuccori M., Vannacci A., Zanoni G., Trifiro G., Petrelli G., Girotti S., Arzenton E., Magro L., Lora R., Bellantuono D., Sabaini A., Firenze A., Zodda D., Guidotti F., Zappone M., Alagna B., Spina E., Minore C., Costantino C., Conforto A., Vitale F., Morreale I., Marsala L., Farinella D., Bavetta S., Sapigni E., Potenza A. M., Podetti D., Nikitina V., Ricciardelli R., Mogheiseh N., Croce S., Paltrinieri B., Castellani S., Sangiorgi E., Selleri M., Lucchesi S., Catucci G., Savini D., Sacripanti C., Faccioli M., Romio M. S., Rossi L., Radici S., Negri G., Fares L., Ajolfi C., Fadda A., Chiarello A., Pieraccini F., Pappalardo F., Bonaiuti R., Lombardi N., Crescioli G., Tessari R., Zandona E., Marchiori F., Chiamulera C., Senna G., Crivellaro M. A., Cancian M., Venturini F., Ferri M., Leonardi L., Orzetti S., Caccin E., Baldo P., Rafaniello C., Pagliaro C., Mercaldo M., Fucile A., di Giorgio A., Tari M., Manna S., Farina G., Di Mauro C., De Carlo I., Senesi I., Pileggi C., Palleria C., Gallelli L., De Sarro G., Trabace L., Morgese M., Schiavone S., Tucci P., Bove M., Lapi F., Cricelli C., Racagni G., Tonolo S., Leopardi E., Fava G., Giuffrida S., Amato V., Gambera M., Montresor V., Luxi N., Giovanazzi A., Capuano A., Crisafulli S., Cutroneo P.M., Fantini M.P., Ferrajolo C., Moretti U., Poluzzi E., Raschi E., Ravaldi C., Reno C., Tuccori M., Vannacci A., Zanoni G., Trifiro G., Luxi, N., Giovanazzi, A., Capuano, A., Crisafulli, S., Cutroneo, P. M., Fantini, M. P., Ferrajolo, C., Moretti, U., Poluzzi, E., Raschi, E., Ravaldi, C., Reno, C., Tuccori, M., Vannacci, A., Zanoni, G., Trifiro, G., Petrelli G., Girotti S., Arzenton E., Magro L., Lora R., Bellantuono D., Sabaini A., Firenze A., Zodda D., Guidotti F., Zappone M., Alagna B., Spina E., Minore C., Costantino C., Conforto A., Vitale F., Morreale I., Marsala L., Farinella D., Bavetta S., Sapigni E., Potenza A.M., Podetti D., Nikitina V., Ricciardelli R., Mogheiseh N., Croce S., Paltrinieri B., Castellani S., Sangiorgi E., Selleri M., Lucchesi S., Catucci G., Savini D., Sacripanti C., Faccioli M., Romio M.S., Rossi L., Radici S., Negri G., Fares L., Ajolfi C., Fadda A., Chiarello A., Pieraccini F., Pappalardo F., Bonaiuti R., Lombardi N., Crescioli G., Tessari R., Zandona E., Marchiori F., Chiamulera C., Senna G., Crivellaro M.A., Cancian M., Venturini F., Ferri M., Leonardi L., Orzetti S., Caccin E., Baldo P., Rafaniello C., Pagliaro C., Mercaldo M., Fucile A., di Giorgio A., Tari M., Manna S., Farina G., Di Mauro C., De Carlo I., Senesi I., Pileggi C., Palleria C., Gallelli L., De Sarro G., Trabace L., Morgese M., Schiavone S., Tucci P., Bove M., Lapi F., Cricelli C., Racagni G., Tonolo S., Leopardi E., Fava G., Giuffrida S., Amato V., Gambera M., and Montresor V.

Subjects
Allergy, IMPACT, COVID-19 Vaccine, Breastfeeding, Review Article, Toxicology, Settore MED/42 - Igiene Generale E Applicata, CLINICAL CHARACTERISTICS, Pregnancy, Pharmacology (medical), Pregnancy Complications, Infectious, Child, OUTCOMES, education.field_of_study, CANCER, Vaccination, Europe, CORONAVIRUS DISEASE 2019, CLINICAL CHARACTERISTICS, CANCER, RECIPIENTS, SEVERITY, OUTCOMES, IMPACT, RATES, Breast Feeding, Child, Preschool, Practice Guidelines as Topic, Female, 2019-nCoV Vaccine mRNA-1273, Human, Adult, medicine.medical_specialty, COVID-19 Vaccines, Adolescent, BNT162 Vaccine, COVID-19, ChAdOx1 nCoV-19, Humans, Infant, SARS-CoV-2, Hypersensitivity, Immunocompromised Host, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Population, MEDLINE, CORONAVIRUS DISEASE 2019, medicine, RATES, education, Pharmacology, business.industry, medicine.disease, Vaccine efficacy, RECIPIENTS, SEVERITY, Family medicine, Pregnancy Complications, Infectiou, business
Abstract

To date, four vaccines have been authorised for emergency use and under conditional approval by the European Medicines Agency to prevent COVID-19: Comirnaty, COVID-19 Vaccine Janssen, Spikevax (previously COVID-19 Vaccine Moderna) and Vaxzevria (previously COVID-19 Vaccine AstraZeneca). Although the benefit–risk profile of these vaccines was proven to be largely favourable in the general population, evidence in special cohorts initially excluded from the pivotal trials, such as pregnant and breastfeeding women, children/adolescents, immunocompromised people and persons with a history of allergy or previous SARS-CoV-2 infection, is still limited. In this narrative review, we critically overview pre- and post-marketing evidence on the potential benefits and risks of marketed COVID-19 vaccines in the above-mentioned special cohorts. In addition, we summarise the recommendations of the scientific societies and regulatory agencies about COVID-19 primary prevention in the same vaccinee categories. Supplementary Information The online version contains supplementary material available at 10.1007/s40264-021-01131-6.

Published
2021

8. The impact of managerial and organizational aspects on hospital wards' efficiency: Evidence from a case study

Author

Ancarani, A., Di Mauro, C., and Giammanco, M.D.

Subjects
Hospitals -- Case studies, Business, Business, general, Business, international
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ejor.2007.11.046 Byline: A. Ancarani (a), C. Di Mauro (b), M.D. Giammanco (b) Keywords: OR in health services; Organization; Efficiency; Data envelopment analysis; Hospital Abstract: In spite of its acknowledged relevance, the impact of managerial and organizational aspects on hospital wards' efficiency has been so far overlooked by the literature. In order to explore this issue, this paper presents a model of the relations between the decision making process of a hospital ward and its technical efficiency. In order to test the model, a two-step approach has been adopted. In the first step the technical efficiency of wards belonging to a large Italian Hospital Enterprise has been calculated using DEA. In the second step, efficiency scores have been regressed on a set of variables capturing managerial goals and actions internal to the ward, as well as re-organizations imposed by the hospital central management. Responses to a questionnaire administered to the heads of ward were used to build the independent variables. Results show that both decisions internal to the ward and exogenous re-organizations affect the ward's efficiency, and suggest that these variables are more significant in explaining efficiency than environmental ones. Author Affiliation: (a) DICA - Dipartimento di Ingegneria Civile e Ambientale, Sezione di Ingegneria Gestionale, Economica ed Estimativa, Universita di Catania, Viale A. Doria 6, 95125 Catania, Italy (b) Dipartimento di Analisi dei Processi Politici, Sociali ed Istituzionali, Universita di Catania Palazzo Reburdone, Via Vittorio Emanuele 8, 95131 Catania, Italy Article History: Received 2 February 2006; Accepted 19 November 2007

Published
2009

12. Vaccinazione anti-influenzale dei pediatri nella stagione 2014-2015

Author

Falco, P., Bon, A., Di Matteo, T., Guida, I., Lamberti, M., Trapani, A., Liguori, R., Di Mauro, C., Mariniello, A., Pinto, L., VECCHIO, Davide, Falco, P., Bon, A., Di Matteo, T., Guida, I., Lamberti, M., Trapani, A., Vecchio, D., Liguori, R., Di Mauro, C., Mariniello, A., and Pinto, L.

Subjects
Settore MED/38 - Pediatria Generale E Specialistica, Vaccinazione anti-influenzale, pediatria di famiglia, pediatria di comunità
Published
2015

13. Indagine SiPPS sulle opinioni dei pediatri sulle vaccinazioni

Author

Pinto, L., Liguori, R., Basilicata, A., Bon, A., Carbone, M., Di Mauro, C., Falco, P., Aniello, F., Muccio, C., Picozzi, F., Pullano, F., Schiavone Giacco, G., Spagnuolo, M., Sticco, M., Mariniello, A., Di Mauro, G., VECCHIO, Davide, Pinto, L., Liguori, R., Basilicata, A., Bon, A., Carbone, M., Di Mauro, C., Falco, P., Aniello, F., Muccio, C., Picozzi, F., Pullano, F., Schiavone Giacco, G., Spagnuolo, M., Sticco, M., Vecchio, D., Mariniello, A., and Di Mauro, G.

Subjects
Settore MED/38 - Pediatria Generale E Specialistica, Vaccinazioni, salute globale, pediatria
Published
2015

16. A vulnerability model for assessing the impact of multi-hazards on critical infrastructures

Author

Di Mauro, C., Paolo Frattini, Bouchon, S., Lari, S., Di Mauro, C, Frattini, P, Bouchon, S, and Lari, S

Subjects
Vulnerability, Modu, Multirisk intensity scale, Safety, Risk, Reliability and Quality, Critical infrastructure
Abstract

Different natural and anthropogenic hazards can affect critical infrastructures (CI) causing physical damages to infrastructure assets, and the possible interruption of the services provided by these infrastructures. Since CI are recognized, by definition, as vital for the society (Kröger and Zio, 2011), their interruption can lead to serious and heavy socio-economic consequences. CI are complex systems with multiple assets that contribute to the ability to provide a service. These assets are interconnected between each other, so that an impact on an infrastructure can propagate to other interconnected. The processes that can affect CI are very different in nature, magnitude and frequency. The European Project Threvi2 tackles these problems by defining a comprehensive ontology for the infrastructures systems, the interconnections among infrastructures and the hazards that can affect these infrastructures. An important component of this ontology is the vulnerability model, which allows to connect the hazard ontology with the infrastructure ontology by assessing if, how and to what extent a specific hazard can affect an infrastructure system.

Published
2014

17. Phosphatidylinositol 3-kinase (PI3Kα)/AKT axis blockade with taselisib or ipatasertib enhances the efficacy of anti-microtubule drugs in human breast cancer cells

Author

Diana, A., primary, Morgillo, F., additional, Della Corte, C.M., additional, Di Mauro, C., additional, Ciaramella, V., additional, Barra, G., additional, Belli, V., additional, Franzese, E., additional, Bianco, R., additional, Maiello, E., additional, De Vita, F., additional, Ciardiello, F., additional, and Orditura, M., additional

Published
2017
Full Text
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18. Manufacturing Back-Shoring: A Research Agenda for an Emerging Issue in International Business

Author

Fratocchi, L, Nassimbeni, Guido, Zanoni, A, Ancarani, A, Valente, Me, Sartor, Marco, Barbieri, P, Di Mauro, C, Vignoli, M., Fratocchi L., Nassimbeni G., Zanoni A., Ancarani A., Valente M.E., Sartor M., Barbieri P., Di Mauro C., and Vignoli M.

Subjects
Back-shoring, INTERNAZIONALIZATION, Manufacturing Strategy, Off-shoring, Near-shoring, reshoring back-shoring on-shoring in-shoring internationalization manufacturing, SUPPLY CHAIN MANAGEMENT (SCM)
Abstract

The paper is focused on a phenomenon – the so called “back-shoring” (often indicated also as “on-shoring”, “in-shoring”, “re-shoring”, “reverse-shoring”, “international re-concentration”, “reverse-globalization”, even if they are not always considered synonymous) – which is becoming more and more diffused in the last years. Notwithstanding this increasing diffusion, it is still rarely investigated by academics and often discussed only in economic newspapers and white papers by management consulting firms. Manufacturing “back-shoring” is the process by which previously off-shored production are moved back to the domestic location (Kinkel and Maloca, 2009; Leibl, Morefield and Pfeiffer, 2011) an earlier off-shored or off-shore outsourced manufacturing activity is relocated in the firm’s home country. Based on a comprehensive literature review and evidences regarding 87 western companies, the objectives of this paper are: a) to analyze the relevance of such a managerial phenomenon; b) to identify and classify its motivations; c) to highlight some research questions.

Published
2011

19. Multilocus microsatellite polymorphism analysis to characterize Leishmania infantum strains isolated in Sicily

Author

Reale S., Lupo T., Migliazzo A., Di Mauro C., Ciprì V., Calderone S., Vitale F., MANNA, LAURA, Reale, S., Lupo, T., Migliazzo, A., Di Mauro, C., Ciprì, V., Calderone, S., Manna, Laura, and Vitale, F.

Subjects
Dogs, Polymorphism, Genetic, Animals, Dog Diseases, Leishmania infantum, Sicily, Microsatellite Repeats
Abstract

Different approaches are being developed to improve the differentiation of Leishmania genus using biochemical and molecular methods. In this study, 11 independent polymorphic microsatellites were used for the typing of strains of L. infantum isolated in Sicily. Polymerase chain reaction was employed to amplify the microsatellites contained in 12 DNA regions selected from among more investigated loci. A total of 51 isolates of L. infantum from dogs were tested by using the same locus panel. The products were successively analysed using an automatic sequence detector (ABI PRISM 3130 AB), to discover relevant microsatellite polymorphisms. It was possible to discriminate between MON-1 and non-MON-1 groups. Moreover, the method permitted to distinguish various genotypes of L. infantum isolates within each zymodema. Model- and distance-based analyses of the data set showed comparable results. The frequency of heterozygosity in the alleles analysed varied extremely between the different groups of isolates. As the method exhibits a high level of discrimination, it is suitable for characterization of closely related strains in epidemiological studies.

Published
2010

22. A survival analysis of offshore initiatives

Author

Ancarani, A., Di Mauro, C., Fratocchi, L., Orzes, Guido, and Sartor, Marco

Subjects
back-reshoring, near-reshoring, reshoring, duration, offshoring, manufacturing, offshoring, manufacturing, back-reshoring, near-reshoring, reshoring, duration, offshorin, reshoring, duration
Published
2015

43. Industrial Risk in the Lombardy Region (Italy): What People Perceive and What Are the Gaps to Improve the Risk Communication and the Participatory Processes

Author

Di Mauro, C., Bouchon, S., and Torretta, Vincenzo

Subjects
risk communication, hazardous industries, risk perception, lcsh:Computer engineering. Computer hardware, lcsh:TP155-156, lcsh:TK7885-7895, lcsh:Chemical engineering
Abstract

Risk communication is of vital importance in today’s society, as audiences become ever more questioning about the causes and effects of risk. However, the communication of risk is a complex activity involving many different types of communicators and receivers from scientists, to the media, to government agencies, industry and consumer groups, each of which having its own agendas to fulfil. Such variation across the communication of the same risk can lead to confusion, misunderstandings, misreporting in the media and subsequent conflicts. The goal of risk communication is to produce an informed public. The personal nature of risk issues and the uncertainty associated with estimating risk can provoke considerable anxiety for the public and make adopted risk management strategies less acceptable. Lombardy is one of the most densely populated and industrialized regions in Europe and nearly 280 Seveso sites interest it. The Seveso Directive requires specific measures on risk communication to the population. Nevertheless, the Lombardy Region Authorities consider that the implementation of such provisions is too weak. Therefore an exploratory research has been concluded, in order to estimate the gaps in risk communication and to improve the participation of the population in the emergency preparedness activities. The paper reports the main results of the research and illustrates the potential strategies to improve the risk communication and the population participation and preparedness (ÉupolisLombardia, 2011).

Published
2012

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