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18 results on '"Di Trapani, Mariano"'

2. Rational of targeting WNT/beta-catenin signaling in acute myeloid leukemia (AML)

Author

Paul Takam Kamga, Adriana Cassaro, Bassi, Giulio, Giada Dal Collo, Adamo, Annalisa, Gatti, Alessandro, MARTINA MIDOLO, Carusone, Roberta, Di Trapani, Mariano, Resci, Federica, Massimiliano BONIFACIO, and Krampera, Mauro

Subjects
chemotherapy resistance, acute myeloid leukemia, WNT/beta catenin signaling, microenvironment, chemotherapy resistance, acute myeloid leukemia, microenvironment, WNT/beta catenin signaling
Published
2016

4. Inhibition of GSK-3 Signalling Enhances Sensitivity of Non-Promyelocitic Acute Myeloid Leukemia (AML) Cell to Chemotherapy

Author

Takam Kamga, Paul, primary, Dal Collo, Giada, additional, Cassaro, Adriana, additional, Adamo, Annalisa, additional, Gatti, Alessandro, additional, Carusone, Roberta, additional, Di Trapani, Mariano, additional, Midolo, Martina, additional, Resci, Federica, additional, Bonifacio, Massimiliano, additional, and Krampera, Mauro, additional

Published
2016
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7. Notch signalling drives bone marrow stromal cell-mediated chemoresistance in acute myeloid leukemia

Author

Kamga, Paul Takam, primary, Bassi, Giulio, additional, Cassaro, Adriana, additional, Midolo, Martina, additional, Di Trapani, Mariano, additional, Gatti, Alessandro, additional, Carusone, Roberta, additional, Resci, Federica, additional, Perbellini, Omar, additional, Gottardi, Michele, additional, Bonifacio, Massimiliano, additional, Kamdje, Armel Hervé Nwabo, additional, Ambrosetti, Achille, additional, and Krampera, Mauro, additional

Published
2016
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8. Effects of a Ceramic Biomaterial on Immune Modulatory Properties and Differentiation Potential of Human Mesenchymal Stromal Cells of Different Origin

Author

Bassi, Giulio, primary, Guilloton, Fabien, additional, Menard, Cedric, additional, Di Trapani, Mariano, additional, Deschaseaux, Frederic, additional, Sensebé, Luc, additional, Schrezenmeier, Hubert, additional, Giordano, Rosaria, additional, Bourin, Philippe, additional, Dominici, Massimo, additional, Tarte, Karin, additional, and Krampera, Mauro, additional

Published
2015
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10. Effects Of a Novel Ceramic Biomaterial On Immune Modulatory Properties and Differentiation Potential Of Mesenchymal Stromal Cells

Author

Bassi, Giulio, primary, Menard, Cedric, additional, Guilloton, Fabien, additional, Pacelli, Luciano, additional, Carusone, Roberta, additional, Di Trapani, Mariano, additional, Zanoncello, Jasmina, additional, Bifari, Francesco, additional, Sensebé, Luc, additional, Deschaseaux, Fredric, additional, Baroth, Serge, additional, Schrezenmeier, Hubert, additional, Rojewski, Markus, additional, Layrolle, Pierre, additional, Giordano, Rosaria, additional, Lorenza, Lazzari, additional, Lavazza, Cristiana, additional, Bourin, Philippe, additional, Tarte, Karin, additional, and Krampera, Mauro, additional

Published
2013
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11. Immune Regulatory Properties Are a Common Feature Of Stem Cells

Author

Di Trapani, Mariano, primary, Bassi, Giulio, additional, Ricciardi, Mario, additional, Fontana, Emanuela, additional, Bifari, Francesco, additional, Pacelli, Luciano, additional, Giacomello, Luca, additional, Pozzobon, Michela, additional, Feron, Francois, additional, De Coppi, Paolo, additional, Anversa, Piero, additional, Fumagalli, Guido, additional, Decimo, Ilaria, additional, Menard, Cedric, additional, Tarte, Karin, additional, and Krampera, Mauro, additional

Published
2013
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12. Comparative Study of Immune Regulatory Properties of Stem Cells Derived from Different Tissues

Author

Di Trapani, Mariano, primary, Bassi, Giulio, additional, Ricciardi, Mario, additional, Fontana, Emanuela, additional, Bifari, Francesco, additional, Pacelli, Luciano, additional, Giacomello, Luca, additional, Pozzobon, Michela, additional, Féron, Francois, additional, De Coppi, Paolo, additional, Anversa, Piero, additional, Fumagalli, Guido, additional, Decimo, Ilaria, additional, Menard, Cedric, additional, Tarte, Karin, additional, and Krampera, Mauro, additional

Published
2013
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14. Immune Regulatory Properties of CD117pos Amniotic Fluid Stem Cells Vary According to Gestational Age.

Author

Di Trapani, Mariano, Bassi, Giulio, Fontana, Emanuela, Giacomello, Luca, Pozzobon, Michela, Guillot, Pascale V., De Coppi, Paolo, and Krampera, Mauro

Subjects
*AMNIOTIC liquid, *C-kit protein, *GESTATIONAL age, *CELL-mediated cytotoxicity, *KILLER cells, *CELL proliferation, *STEM cells
Abstract

Amniotic Fluid Stem (AFS) cells are broadly multipotent fetal stem cells derived from the positive selection and ex vivo expansion of amniotic fluid CD117/c-kitpos cells. Considering the differentiation potential in vitro toward cell lineages belonging to the three germ layers, AFS cells have raised great interest as a new therapeutic tool, but their immune properties still need to be assessed. We analyzed the in vitro immunological properties of AFS cells from different gestational age in coculture with T, B, and natural killer (NK) cells. Nonactivated (resting) first trimester-AFS cells showed lower expression of HLA class-I molecules and NK-activating ligands than second and third trimester-AFS cells, whose features were associated with lower sensitivity to NK cell-mediated lysis. Nevertheless, inflammatory priming with interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) enhanced resistance of all AFS cell types to NK cytotoxicity. AFS cells modulated lymphocyte proliferation in a different manner according to gestational age: first trimester-AFS cells significantly inhibited T and NK cell proliferation, while second and third trimester-AFS cells were less efficient. In addition, only inflammatory-primed second trimester-AFS cells could suppress B cell proliferation, which was not affected by the first and third trimester-AFS cells. Indolamine 2,3 dioxygenase pathway was significantly involved only in T cell suppression mediated by second and third trimester-AFS cells. Overall, this study shows a number of significant quantitative differences among AFS cells of different gestational age that have to be considered in view of their clinical application. [ABSTRACT FROM AUTHOR]

Published
2015
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16. Notch singalling inhibition as a multi-target therapy to overcome bone marrow microenvironment-mediated drug resistance in AML

Author

Paul Takam Kamga, Bassi, Giulio, Adriana Cassaro, Adamo, Annalisa, Gatti, Alessandro, Giada Dal Collo, MARTINA MIDOLO, Carusone, Roberta, Di Trapani, Mariano, Massimiliano BONIFACIO, and Krampera, Mauro

Subjects
chemotherapy resistance, acute myeloid leukemia, Notch signaling, microenvironment, chemotherapy resistance, acute myeloid leukemia, microenvironment, Notch signaling

17. Inhibition of Notch signalling overcomes bone marrow stromal-mediated anti-apoptotic and chemoresistance effects in AML

Author

Paul Takam Kamga, Bassi, Giulio, Adriana Cassaro, MARTINA MIDOLO, Di Trapani, Mariano, Canella, Francesca, Carusone, Roberta, Gatti, Alessandro, Resci, Federica, Perbellini, O., Gottardi, M., Massimiliano BONIFACIO, Nwabo Kamdje, Armel Herve, Ambrosetti, Achille, and Krampera, Mauro

Subjects
Acute Myeloid Leukemia, Notch signalling, Mesenchimal Stem Cells, Acute Myeloid Leukemia, Mesenchimal Stem Cells, Notch signalling

18. Notch signalling drives bone marrow stromal cell-mediated chemoresistance in acute myeloid leukemia.

Author

Takam Kamga P, Bassi G, Cassaro A, Midolo M, Di Trapani M, Gatti A, Carusone R, Resci F, Perbellini O, Gottardi M, Bonifacio M, Nwabo Kamdje AH, Ambrosetti A, and Krampera M

Subjects
Acute Disease, Adult, Aged, Cell Differentiation, Cell Line, Tumor, Cells, Cultured, Coculture Techniques, Drug Resistance, Neoplasm drug effects, Female, HL-60 Cells, Humans, K562 Cells, Leukemia, Myeloid pathology, Male, Middle Aged, Oligopeptides pharmacology, Receptors, Notch antagonists & inhibitors, Tumor Cells, Cultured, U937 Cells, Bone Marrow Cells metabolism, Leukemia, Myeloid metabolism, Mesenchymal Stem Cells metabolism, Receptors, Notch metabolism, Signal Transduction
Abstract

Both preclinical and clinical investigations suggest that Notch signalling is critical for the development of many cancers and for their response to chemotherapy. We previously showed that Notch inhibition abrogates stromal-induced chemoresistance in lymphoid neoplasms. However, the role of Notch in acute myeloid leukemia (AML) and its contribution to the crosstalk between leukemia cells and bone marrow stromal cells remain controversial. Thus, we evaluated the role of the Notch pathway in the proliferation, survival and chemoresistance of AML cells in co-culture with bone marrow mesenchymal stromal cells expanded from both healthy donors (hBM-MSCs) and AML patients (hBM-MSCs*). As compared to hBM-MSCs, hBM-MSCs* showed higher level of Notch1, Jagged1 as well as the main Notch target gene HES1. Notably, hBM-MSCs* induced expression and activation of Notch signalling in AML cells, supporting AML proliferation and being more efficientin inducing AML chemoresistance than hBM-MSCs*. Pharmacological inhibition of Notch using combinations of Notch receptor-blocking antibodies or gamma-secretase inhibitors (GSIs), in presence of chemotherapeutic agents, significant lowered the supportive effect of hBM-MSCs and hBM-MSCs* towards AML cells, by activating apoptotic cascade and reducing protein level of STAT3, AKT and NF-κB.These results suggest that Notch signalling inhibition, by overcoming the stromal-mediated promotion of chemoresistance,may represent a potential therapeutic targetnot only for lymphoid neoplasms, but also for AML., Competing Interests: The authors report no potential conflict of interest.

Published
2016
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