1,872 results on '"Diabetes Insipidus, Neurogenic"'
Search Results
2. Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)
- Author
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Instituto de Salud Carlos III
- Published
- 2024
3. Identification and Clinical Relevance of an Oxytocin Deficient State (Melatonin Study)
- Published
- 2024
4. Identification and Clinical Relevance of an Oxytocin Deficient State (CRH Study)
- Author
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Instituto de Salud Carlos III
- Published
- 2024
5. Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus (OxyTUTION)
- Published
- 2024
6. Plasma Copeptin in Response to Oral Urea in Healthy Adults and Patients With Polyuria-polydipsia Syndrome (URANOS)
- Published
- 2023
7. Electrophysiology of the Human Pituitary Gland
- Author
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wrvanfurth, MD, PhD
- Published
- 2023
8. Effects of Intranasal Oxytocin in Patients With Central Diabetes Insipidus
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Elizabeth Austen Lawson, Associate Professor of Medicine, Harvard Medical School; Director, Interdisciplinary Oxytocin Research Program, Neuroendocrine Unit, Massachusetts General Hospital
- Published
- 2022
9. Copeptin as a Biomarker for Central Diabetes Insipidus Development Following Pituitary Surgery
- Author
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Dana Erickson, Associate Professor of Medicine
- Published
- 2022
10. Seoul National University Pituitary Disease Cohort Study (SNU-PIT)
- Author
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Jung Hee Kim, Principal Investigator
- Published
- 2020
11. Vasopressin Deficiency in Hemorrhagic Shock
- Published
- 2018
12. Central Diabetes Insipidus in an Extremely-Low-Birth-Weight Preterm Infant with Suspected Ectopic Posterior Lobe of the Pituitary Gland
- Author
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Yung Zu Park, Inseong Hwang, Sung-Ha Kim, Sook Min Hwang, Tae-Jung Sung, and Hye Jin Lee
- Subjects
diabetes insipidus, neurogenic ,pituitary gland, posterior ,extremely low birth weight ,infant, newborn ,hypernatremia ,Pediatrics ,RJ1-570 - Abstract
Central diabetes insipidus (CDI) is extremely rare in neonates, especially in extremely-low-birth-weight infants, and most cases are secondary to conditions, such as ischemic or hemorrhagic brain damage. Here, we report a case of CDI in a 530-g infant born at 23+3 weeks of gestation, with suspected ectopic posterior pituitary gland. Hypernatremia was noticed at 33+6 weeks of postmenstrual age, and it persisted with in creased volumes of diluted urine, despite adequate sodium intake. Serum and urine osmolality returned to the normal range after administration of a desmopressin injection. The bright spot of the posterior pituitary was absent, and brain magnetic resonance imaging suggested an ectopic posterior pituitary gland. At the time of writing this manuscript, the patient was on oral desmopressin medication without complications at the corrected age of 8 months. Through this report, we emphasize that although CDI is extremely rare in premature infants, it should be suspected when hypernatremia and polyuria that are unexplained by other causes are noted.
- Published
- 2020
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13. Lymphocytic panhypophysitis and anti-rabphilin-3A antibody with pulmonary sarcoidosis
- Author
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Yuka Takahashi, Hiraku Kameda, Aika Miya, Hiroshi Nomoto, Kyu Yong Cho, Akinobu Nakamura, Hiroki Nishimura, Hirokazu Kimura, Masaru Suzuki, Satoshi Konno, Ai Shimizu, Yoshihiro Matsuno, Michinari Okamoto, Hiroaki Motegi, Naoko Iwata, Haruki Fujisawa, Atsushi Suzuki, Yoshihisa Sugimura, Hideaki Miyoshi, and Tatsuya Atsumi
- Subjects
Male ,Anti-rabphilin-3a antibody ,Sarcoidosis ,Endocrinology, Diabetes and Metabolism ,Middle Aged ,Hypopituitarism ,Diabetes Insipidus, Neurogenic ,Endocrinology ,Sarcoidosis, Pulmonary ,Pituitary Gland ,Lymphocytic panhypophysitis ,Humans ,Autoimmune Hypophysitis ,Panhypopituitarism - Abstract
Purpose To explore the clinical significance of anti-rabphillin-3A antibody for the differential diagnosis of lymphocytic panhypophysitis. Methods and results A 58-year-old Japanese man developed uveitis of unknown cause in 2017. In 2019, he became aware of polyuria. In August 2020, he noticed transient diplopia and was diagnosed with right abducens nerve palsy. At the same time, he complained of fatigue and loss of appetite. Head magnetic resonance imaging demonstrated enlargement of the pituitary stalk and pituitary gland, corresponding to hypophysitis. Hormone stimulation tests showed blunted responses with respect to all anterior pituitary hormones. Central diabetes insipidus was diagnosed on the basis of a hypertonic saline loading test. Taking these findings together, a diagnosis of panhypopituitarism was made. Computed tomography showed enlargement of hilar lymph nodes. Biopsies of the hilar lymph nodes revealed non-caseating epithelioid cell granulomas that were consistent with sarcoidosis. Biopsy of the anterior pituitary revealed mild lymphocyte infiltration in the absence of IgG4-positive cells, non-caseating granulomas, or neoplasia. Western blotting revealed the presence of anti-rabphilin-3A antibody, supporting a diagnosis of lymphocytic panhypophysitis. Because the patient had no visual impairment or severe uveitis, we continued physiological hormone replacement therapy and topical steroid therapy for the uveitis. Conclusion To the best of our knowledge, this is the first case of anti-rabphilin 3A antibody positive lymphocytic panhypophysitis comorbid with sarcoidosis, diagnosed by both pituitary and hilar lymph node biopsy. The utility of anti-rabphilin-3A antibody for the differential diagnosis of hypophysitis like this case should be clarified with further case studies.
- Published
- 2023
14. Immune checkpoint inhibitor-induced central diabetes insipidus in the course of panhypophysitis.
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Cylke-Falkowska K, Czajka-Oraniec I, Stelmachowska-Banaś M, and Zgliczyński W
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- Humans, Immune Checkpoint Inhibitors, Retrospective Studies, Diabetes Insipidus, Neurogenic, Diabetes Mellitus
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- 2024
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15. Importance of Intraoperative Factors in Postoperative Arginine Vasopressin Deficiency After Pituitary Adenoma Surgery.
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Alidaei N, Sharifi G, and Davoudi Z
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- Humans, Retrospective Studies, Cerebrospinal Fluid Leak etiology, Cerebrospinal Fluid Leak surgery, Arginine, Postoperative Complications epidemiology, Treatment Outcome, Pituitary Neoplasms complications, Diabetes Insipidus, Neurogenic, Adenoma complications
- Abstract
Objective: Pituitary adenoma (PA) is the most frequent tumor in the sellar region. Arginine vasopressin deficiency (AVP-D), formerly known as central diabetes insipidus, is a common complication after pituitary surgeries. In this study, we reviewed patients with PAs after endoscopic transsphenoidal surgery, evaluated the incidence of postoperative AVP-D, and determined associated risk factors., Methods: We retrospectively studied 520 patients who underwent endoscopic transsphenoidal surgery for PAs and evaluated perioperative risk factors and their associations with postoperative AVP-D. Patients who developed AVP-D were categorized in 3 groups: (1) early AVP-D, (2) transient AVP-D, and (3) permanent AVP-D., Results: Of the 520 patients, 24.8% experienced early AVP-D, and 1.9% (n = 10) had transient AVP-D. Permanent AVP-D was observed in only 6 patients (1.1%). Gross total resection, hormonal remission, pituitary stalk manipulation, and intraoperative cerebrospinal fluid leak were significantly associated with a higher incidence of AVP-D (P = .027, P = .002, P < .001 and P < .001, respectively). All patients who developed permanent AVP-D had somatotroph adenomas. AVP-D was not found to be related with tumor size. The length of hospital stay was prolonged by AVP-D on average by 1.5 days (P = .018)., Conclusion: The reported incidence of AVP-D has a considerably wide range. A consistent definition and grading for AVP-D will increase consistency and comparability among studies. Nonetheless, most patients experience AVP-D on a temporary basis, and only a few require long-term treatment. Cerebrospinal fluid leak, gross total resection, and hormonal remission were identified as risk factors for postoperative AVP-D. We believe that the intraoperative risk factors play the main role in postoperative AVP-D. The course of surgery and operative findings help us plan selective postoperative patient monitoring and care., Competing Interests: Disclosure The authors have no conflicts of interest to disclose., (Copyright © 2023 AACE. Published by Elsevier Inc. All rights reserved.)
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- 2024
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16. Serum copeptin levels at day two after pituitary surgery and ratio to baseline predict postoperative central diabetes insipidus
- Author
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Han Na Jang, Ho Kang, Yoo Hyung Kim, Hwan Sub Lim, Mi-Kyeong Lee, Kyoung-Ryul Lee, Yong Hwy Kim, and Jung Hee Kim
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Diabetes Insipidus, Neurogenic ,Postoperative Complications ,Endocrinology ,Pituitary Diseases ,Pituitary Gland ,Endocrinology, Diabetes and Metabolism ,Glycopeptides ,Diabetes Mellitus ,Humans - Abstract
Central diabetes insipidus is a complication that may occur after pituitary surgery and has been difficult to predict. This study aimed to identify the cutoff levels of serum copeptin and its optimal timing for predicting the occurrence of central diabetes insipidus in patients who underwent transsphenoidal surgery.This was a prospective observational study of patients who underwent transsphenoidal surgery for pituitary gland or stalk lesions. Copeptin levels were measured before surgery, 1 h after extubation, and on postoperative days 1, 2, 7, and 90.Among 73 patients, 14 (19.2%) and 13 (17.8%) patients developed transient and permanent central diabetes insipidus, respectively. There was no significant difference in copeptin levels before surgery and 1 h after extubation; copeptin levels on postoperative days 1, 2, 7, and 90 were significantly lower in patients with permanent central diabetes insipidus than in those without central diabetes insipidus. Copeptin measurement on postoperative day 2 exhibited the highest performance for predicting permanent central diabetes insipidus among postoperative days 1, 2, and 7 (area under the curve [95% confidence interval] = 0.754 [0.632-0.876]). Serum copeptin level at postoperative day 2( 3.1 pmol/L) showed a sensitivity of 92.3% and a negative predictive value of 97.1%. The ratio of copeptin at postoperative day 2 to baseline ( 0.94) presented a sensitivity of 84.6% and a negative predictive value of 94.9%. The copeptin levels 3.4 and 7.5 pmol/L at postoperative day 2 and 7 may have ruled out the occurrence of CDI with a negative predictive value of 100%.The copeptin level at postoperative day 2 and its ratio to baseline can predict the occurrence of permanent central diabetes insipidus after pituitary surgery.
- Published
- 2022
17. Machine learning-based algorithm as an innovative approach for the differentiation between diabetes insipidus and primary polydipsia in clinical practice
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Uri Nahum, Julie Refardt, Irina Chifu, Wiebke K Fenske, Martin Fassnacht, Gabor Szinnai, Mirjam Christ-Crain, and Marc Pfister
- Subjects
Saline Solution, Hypertonic ,Polyuria ,Endocrinology, Diabetes and Metabolism ,Sodium ,Glycopeptides ,General Medicine ,Diabetes Insipidus, Neurogenic ,Machine Learning ,Glucose ,Endocrinology ,Diabetes Mellitus ,Humans ,Polydipsia, Psychogenic ,Polydipsia ,Prospective Studies ,Diabetes Insipidus ,Algorithms - Abstract
Objective Differentiation between central diabetes insipidus (cDI) and primary polydipsia (PP) remains challenging in clinical practice. Although the hypertonic saline infusion test led to high diagnostic accuracy, it is a laborious test requiring close monitoring of plasma sodium levels. As such, we leverage machine learning (ML) to facilitate differential diagnosis of cDI. Design We analyzed data of 59 patients with cDI and 81 patients with PP from a prospective multicenter study evaluating the hypertonic saline test as new test approach to diagnose cDI. Our primary outcome was the diagnostic accuracy of the ML-based algorithm in differentiating cDI from PP patients. Methods The data set used included 56 clinical, biochemical, and radiological covariates. We identified a set of five covariates which were crucial for differentiating cDI from PP patients utilizing standard ML methods. We developed ML-based algorithms on the data and validated them with an unseen test data set. Results Urine osmolality, plasma sodium and glucose, known transsphenoidal surgery, or anterior pituitary deficiencies were selected as input parameters for the basic ML-based algorithm. Testing it on an unseen test data set resulted in a high area under the curve (AUC) score of 0.87. A further improvement of the ML-based algorithm was reached with the addition of MRI characteristics and the results of the hypertonic saline infusion test (AUC: 0.93 and 0.98, respectively). Conclusion The developed ML-based algorithm facilitated differentiation between cDI and PP patients with high accuracy even if only clinical information and laboratory data were available, thereby possibly avoiding cumbersome clinical tests in the future.
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- 2022
18. Management of cranial diabetes insipidus: clinical outcomes and patient perception of care
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M D S A Dilrukshi, Marcus Vickars, Christine J H May, Taffy Makaya, Fiona Ryan, Bahram Jafar-Mohammadi, John A H Wass, Aparna Pal, and Aoife Garrahy
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Adult ,Aged, 80 and over ,Blood Glucose ,Adolescent ,Blood Glucose Self-Monitoring ,Endocrinology, Diabetes and Metabolism ,Sodium ,Nasal Sprays ,General Medicine ,Middle Aged ,Diabetes Insipidus, Neurogenic ,Young Adult ,Endocrinology ,Diabetes Mellitus ,Humans ,Deamino Arginine Vasopressin ,Perception ,Child ,Diabetes Insipidus ,Aged ,Retrospective Studies ,Tablets - Abstract
Objective There is growing recognition of morbidity and mortality that can occur in patients with cranial diabetes insipidus (CDI) during hospitalisation, due to prescribing errors and dysnatraemia, often related to confusion between CDI and diabetes mellitus among non-specialists. We aimed to investigate this. Methods Data for each hospitalisation in patients with CDI attending Oxford University Hospital (OUH) were collected retrospectively. The same cohort were invited to complete a questionnaire by telephone. Results One hundred and nine patients were included, median age was 42 (range: 6–80) years. Route of desmopressin was tablet, melt and nasal spray in 74%, 7% and 17% of patients, respectively, while two patients used a combination of tablet and nasal spray. There were 85 admissions to OUH by 38 patients between 2012 and 2021. Daily measurement of serum sodium was performed in 39% of admissions; hyponatraemia and hypernatraemia occurred in 44 and 15% of admissions, respectively. Endocrine consultation was sought in 63% of admissions post-2018. Forty-five of 78 patients (58%) self-reported ≥1 admission to any hospital since diagnosis. Of these, 53% felt their medical team did not have a good understanding of the management of CDI during hospital admission. Twenty-four per cent reported delay in administration of desmopressin, while 44% reported confusion between CDI and diabetes mellitus, often leading to unnecessary blood glucose monitoring. Conclusion Dysnatraemia is common in hospitalised patients with CDI. More than half of patients perceived their medical team’s understanding of CDI to be poor when admitted with intercurrent illness. A coordinated approach, including early consultation of specialists, frequent serum sodium monitoring, and education of hospital specialists is needed to address this.
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- 2022
19. Diagnosis and tactics of managing a patient with central diabetes insipidus on the example of a clinical case
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N. N. Katamadze, E. A. Pigarova, and L. K. Dzeranova
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Diabetes Insipidus, Neurogenic ,Diagnosis, Differential ,Water Deprivation ,Dehydration ,Endocrinology, Diabetes and Metabolism ,Diabetes Mellitus ,Humans ,Diabetes Insipidus - Abstract
Diagnosis and differential diagnosis of patients with diabetes insipidus is often a difficult task for the endocrinologist. This case report focuses on a patient with a long history of central idiopathic diabetes insipidus who had a substantial decrease in desmopressin requirements during the last year of follow-up. Conducting tests with osmotic stimulation (test with water deprivation, infusion test with hypertonic solution) made it possible to answer the question of the persistence of the disease, as well as to determine a further management plan, taking into account the physiological characteristics of our patient.
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- 2022
20. Evaluation of the etiological and clinical characteristics of pediatric central diabetes insipidus
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Elnare Gasimova, Merih Berberoğlu, Elif Özsu, Zehra Aycan, Rukiye Uyanık, Esra Bilici, Ayşegül Ceran, and Zeynep Şiklar
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Brain Neoplasms ,Endocrinology, Diabetes and Metabolism ,Magnetic Resonance Imaging ,Hypopituitarism ,Diabetes Insipidus, Neurogenic ,Histiocytosis, Langerhans-Cell ,Pituitary Hormones ,Endocrinology ,Pediatrics, Perinatology and Child Health ,Diabetes Mellitus ,Humans ,Germinoma ,Child ,Diabetes Insipidus - Abstract
Objectives Central diabetes insipidus (CDI) is a rare but important disease of varying etiology that poses challenges in diagnosis and follow-up. Identifying diagnostic difficulties in patients with CDI will help ensure an optimal approach to their management and follow-up. This study aimed to characterize the clinical and etiological characteristics of CDI in pediatric patients. Methods We analyzed the admission and follow-up data of CDI patients aged 0–18 years who were followed in our center between 2010 and 2019. Results The study included 56 patients with a mean age at diagnosis of 7.92 ± 5.11 years and symptom duration of 8.65 ± 21.3 months. The patients were grouped by etiology into those with organic causes, such as structural anomalies, tumors, and trauma (group 1, n=41) and other causes (group 2, n=15). The prevalence of idiopathic CDI was 16%. At least one pituitary hormone deficiency was detected in 60.7%, the most common being thyroid stimulating hormone deficiency. Patients in group 1 had a higher mean age at diagnosis, shorter symptom duration, and higher frequency of other pituitary hormone deficiencies compared to group 2. Additionally, germinoma was detected 1 year subsequent to normal MRI findings at diagnosis and another patient was diagnosed with Langerhans cell histiocytosis (LCH) 5 years after diagnosis. All patients responded well to replacement therapies, but two patients with germinoma died during follow-up. Conclusions In the pediatric age group, intracranial organic pathologies are an important etiology of CDI, and despite a short symptomatic period, determining the cause may be challenging and prolonged. Patients presenting at a young age with a long history of symptoms and no other pituitary hormone deficiency are unlikely to have organic CDI. However, organic causes such as LCH should be evaluated at all ages. Patients with idiopathic disease are candidates for further etiological studies, and repeated cranial imaging is important during follow-up.
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- 2022
21. Diagnosis and Management of Central Diabetes Insipidus in Adults
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Maria Tomkins, Sarah Lawless, Julie Martin-Grace, Mark Sherlock, and Chris J Thompson
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Adult ,Polyuria ,Endocrinology, Diabetes and Metabolism ,Biochemistry (medical) ,Clinical Biochemistry ,Syndrome ,Mini-Review ,Biochemistry ,Arginine Vasopressin ,Diabetes Insipidus, Neurogenic ,Endocrinology ,Diabetes Mellitus ,Humans ,Diabetes Insipidus - Abstract
Central diabetes insipidus (CDI) is a clinical syndrome which results from loss or impaired function of vasopressinergic neurons in the hypothalamus/posterior pituitary, resulting in impaired synthesis and/or secretion of arginine vasopressin (AVP). AVP deficiency leads to the inability to concentrate urine and excessive renal water losses, resulting in a clinical syndrome of hypotonic polyuria with compensatory thirst. CDI is caused by diverse etiologies, although it typically develops due to neoplastic, traumatic, or autoimmune destruction of AVP-synthesizing/secreting neurons. This review focuses on the diagnosis and management of CDI, providing insights into the physiological disturbances underpinning the syndrome. Recent developments in diagnostic techniques, particularly the development of the copeptin assay, have improved accuracy and acceptability of the diagnostic approach to the hypotonic polyuria syndrome. We discuss the management of CDI with particular emphasis on management of fluid intake and pharmacological replacement of AVP. Specific clinical syndromes such as adipsic diabetes insipidus and diabetes insipidus in pregnancy as well as management of the perioperative patient with diabetes insipidus are also discussed.
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- 2022
22. A Study of Minirin Melt in Japanese Patients With Central Diabetes Insipidus (CDI).
- Published
- 2012
23. Ibuprofen use for the treatment of pediatric patients with polyuria and dysnatremia. A case series report.
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Liern M, Clement F, Niell C, Castro S, Sánchez Cestona S, Lis D, and Bergadá I
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- Humans, Child, Polyuria etiology, Polyuria complications, Ibuprofen therapeutic use, Research, Hyponatremia drug therapy, Hyponatremia etiology, Diabetes Insipidus, Neurogenic
- Abstract
Children with sellar and/or suprasellar lesions may develop central diabetes insipidus with subsequent inappropriate antidiuretic hormone secretion. An increased incidence of polyuria, natriuresis, and hyponatremia has been reported in some cases, which make up the diagnostic triad of cerebral salt wasting syndrome. Here we report the clinical course of 7 patients with a history of acute central nervous system injury and central diabetes insipidus followed by cerebral salt wasting syndrome. Treatment included the sequential use of parenteral saline solution, oral sodium chloride, desmopressin, mineralocorticoids, and even thiazides. Due to persistent polyuria and hyponatremia, ibuprofen was added. As a result of this sequential therapeutic regimen, daily urine output reduced significantly from 10 mL/kg/h to 2 mL/kg/h over an average period of 5 days, together with a normalization of natremia (from 161 mEq/L to 143 mEq/L) over an average period of 9 days. No treatment-related adverse effects were observed in any case., (Sociedad Argentina de Pediatría.)
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- 2023
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24. Assessment of quality of life in patients with craniopharyngioma and identification of risk factors for compromised overall wellness.
- Author
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Lin B, Xiang S, Chen J, Jing Y, Ye Z, Zhang Y, Cao X, Yin Z, Qiao N, and Zhou X
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- Humans, Quality of Life, Risk Factors, Surveys and Questionnaires, Craniopharyngioma complications, Craniopharyngioma surgery, Diabetes Insipidus, Neurogenic, Pituitary Neoplasms complications
- Abstract
Objective: Quality of Life (QoL) has been a multifactorial concerning issue in oncology. We aimed to inspect the pre-operative QoL among patients with craniopharyngioma and to explore the potential correlations between parameters of QoL and clinical indices., Subjects and Methods: We enrolled a total of 109 patients with craniopharyngioma. We utilized Short Form 36 (SF-36), Symptom Check List-90, Generalized Anxiety Disorder Questionnaire scale (GAD7), Patient Health Questionnaire Depression (PHQ9) and Pittsburgh Sleep Quality Index to prospectively evaluated their QoL. Parameters of QoL along with clinical indices were compared among sub-groups divided according to Puget classification. Correlation analyses and regression analyses were performed to detect influential determinants to self-reported wellness., Results: Patients presented impaired QoL compared with general population (p < 0.001), as assessed by SF-36. Correlation analyses indicated the detrimental influence resulting from central diabetes insipidus (CDI). Multivariate linear regression unveiled the adverse effect of CDI on Mental Component Summary (coefficient = -13.869, p= 0.007), GAD7 total score (coefficient = 2.072, p = 0.049) as well as PHQ9 total score (coefficient = 3.721, p = 0.001). Multivariate logistic regression verified CDI as a risk factor of developing depressive symptoms (OR = 6.160, p = 0.001)., Conclusion: QoL of patients with craniopharyngioma was remarkably compromised before operation. CDI exerted detrimental influences on patients' QoL and it might serve as a marker for early identification of patients at risk of depression.
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- 2023
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25. Copeptin analysis in endocrine disorders.
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Moodley N
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- Child, Adult, Humans, Glycopeptides, Arginine Vasopressin, Arginine, Diabetes Insipidus, Neurogenic
- Abstract
Copeptin is cleaved from the same precursor as arginine vasopressin and is released in equimolar amounts with arginine vasopressin from the posterior pituitary in response to the same stimuli. Its level of stability in the blood, quick and simple analysis, and ease of automation make it much easier to analyze than arginine vasopressin, thereby offering a suitable alternative to measuring arginine vasopressin in endocrine disorders. Research has demonstrated the suitability of copeptin in adults for the differentiation of arginine vasopressin resistance and arginine vasopressin deficiency from primary polydipsia, in addition to the early identification of arginine vasopressin deficiency following pituitary surgery; however, further research is still required in the Syndrome of Inappropriate Antidiuretic Hormone (SIADH) and the pediatric population., Competing Interests: The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Moodley.)
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- 2023
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26. Differenzialdiagnostik und Therapie der Hypophysenadenome.
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Hlaváč, M., Sommer, F., Karpel-Massler, G., Wirtz, R., Hoffmann, T., and Paľa, A.
- Abstract
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- 2019
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27. Ketoacidosis, Hypertriglyceridemia and Acute Pancreatitis Induced by Soft Drink Polydipsia in a Patient with Occult Central Diabetes Insipidus
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Atsushi Suzuki, Jun Onishi, Naoko Iwata, Haruki Fujisawa, Tomoaki Nakamura, Naoto Ishimaru, Yasutaka Tsujimoto, Kazuo Chihara, and Yoshihisa Sugimura
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Adult ,Male ,medicine.medical_specialty ,Carbonated Beverages ,Gastroenterology ,Thirst ,Young Adult ,Polyuria ,Internal medicine ,Diabetes mellitus ,Diabetes Mellitus ,Internal Medicine ,medicine ,Humans ,Polydipsia ,Hypertriglyceridemia ,business.industry ,nutritional and metabolic diseases ,Ketosis ,General Medicine ,medicine.disease ,Ketoacidosis ,Diabetes Insipidus, Neurogenic ,Pancreatitis ,Acute Disease ,Diabetes insipidus ,Acute pancreatitis ,medicine.symptom ,business ,Diabetes Insipidus - Abstract
A 21-year-old Japanese man without known diabetes mellitus had abdominal pain. The diagnosis was ketoacidosis and hypertriglyceridemia-induced acute pancreatitis. He had polydipsia and polyuria and had habitually drunk several soft drinks every day for two years. After hospitalization, despite adequate liquid intake, dehydration remained with hypotonic polyuria. Further examinations revealed the coexistence of central diabetes insipidus (CDI), possibly caused by lymphocytic infundibulo-neurohypophysitis, based on anti-rabphilin-3A antibody positivity. Although CDI had been undiagnosed for two years, over-consumption of sugar-rich soft drinks to ease thirst caused ketoacidosis, hypertriglyceridemia, and acute pancreatitis. There are no previous reports of this three-part combination of symptoms caused by CDI.
- Published
- 2022
28. A case of central diabetes insipidus due to neurophysin II gene abnormality diagnosed based on a family history of nocturnal enuresis
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Hiroshi Maegawa, Takaaki Nakamura, Lucia Sugawara, and Yoshitaka Ishizuka
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Gene mutation ,Endocrinology ,Polyuria ,Neurophysin II ,Diabetes Mellitus ,medicine ,Humans ,Nocturia ,Child ,Neurophysins ,business.industry ,Gene Abnormality ,medicine.disease ,Pedigree ,Hypertonic saline ,Arginine Vasopressin ,Diabetes Insipidus, Neurogenic ,Mutation ,Diabetes insipidus ,Female ,medicine.symptom ,business ,Polydipsia ,hormones, hormone substitutes, and hormone antagonists ,Nocturnal Enuresis - Abstract
The etiology of central diabetes insipidus (DI) is classified into (1) idiopathic, (2) familial, and (3) secondary. Of these, familial central diabetes insipidus shows an autosomal dominant inheritance. We herein report a case in which this disease was diagnosed based on a family history of nocturnal enuresis. A 40-year-old man had had symptoms of polydipsia, polyuria and nocturia since childhood and found that his daughter had the same symptoms. Despite reaching nine years old, his daughter's nocturnal enuresis still had not improved, resulting in her consulting a pediatrician. She was suspected of having familial neurohypophyseal diabetes insipidus (FNDI) based on her family history and was referred along with her father for a detailed examination and treatment. A hypertonic saline load test (HSLT) to evaluate the arginine vasopressin (AVP) reaction was performed in both the proband and his daughter. The results showed no increase in AVP levels in response to high plasma osmolality. The water deprivation test (WDT) revealed he was suffering from partial DI. Based on the above findings and considering the possibility of familial central diabetes insipidus, we performed a gene mutation analysis of AVP-neurophysin II (NPII). Both the father and daughter had an exon 2 abnormality in this gene (c232_234delGAG; pGlu78del), and this gene mutation is known to cause NPII protein abnormality, abolishing the function of AVP as a carrier protein. This case was considered to have provided an opportunity to understand the role of an NPII gene abnormality in familial central diabetes insipidus.
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- 2022
29. Study of the Pathogenesis and Pathophysiology of Familial Neurohypophyseal Diabetes Insipidus
- Author
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Northwestern University
- Published
- 2005
30. [Permanent central diabetes insipidus after traumatic brain injury. Case report and literature review]
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L.I. Astafyeva, Yu.G. Sidneva, I.N. Badmaeva, P.L. Kalinin, Ya.A. Latyshev, A.V. Marshintsev, and S.A. Valiullina
- Subjects
Diabetes Insipidus, Neurogenic ,Male ,Hypernatremia ,Adolescent ,Polyuria ,Brain Injuries, Traumatic ,Diabetes Mellitus ,Humans ,Deamino Arginine Vasopressin ,Neurology (clinical) ,Coma - Abstract
The authors report permanent central diabetes insipidus (CDI) in a patient after severe traumatic brain injury (TBI) in traffic accident. A 16-year-old boy entered to a medical facility in coma (GCS score 6) with the following diagnosis: acute TBI, severe cerebral contusion, subarachnoid hemorrhage, depressed comminuted cranial vault fracture, basilar skull fracture, visceral contusion. CDI was diagnosed in 3 days after injury considering polyuria and hypernatremia (155 mmol/l). Desmopressin therapy was initiated through a feeding tube. Thirst appeared when a patient came out of the coma after 21 days despite ongoing desmopressin therapy. Considering persistent thirst and polyuria, we continued desmopressin therapy in a spray form. Under this therapy, polyuria reduced to 3-3.5 liters per a day. Symptoms of CDI persisted in long-term period (2 years after TBI) while function of adenohypophysis was intact. This case demonstrates a rare development of permanent diabetes insipidus after TBI. CDI manifested only as polyuria and hypernatremia in coma. Thirst joined after recovery of consciousness. Probable causes of CDI were damage to neurohypophysis and partially injury of pituitary stalk because of extended basilar skull fracture and/or irreversible secondary lesion of hypothalamus following diffuse axonal damage after TBI.В статье представлен клинический случай развития постоянной формы центрального несахарного диабета (ЦНД) у пациента после тяжелой черепно-мозговой травмы (ТЧМТ) в результате дорожно-транспортного происшествия. Подросток 16 лет поступил в лечебное учреждение в состоянии комы (6 баллов по шкале комы Глазго) с диагнозом: сочетанная травма; острая ТЧМТ; ушиб головного мозга тяжелой степени; субарахноидальное кровоизлияние; вдавленный многооскольчатый перелом свода черепа справа; протяженный перелом основания черепа; ушиб внутренних органов. На 3-и сутки развились полиурия и гипернатриемия (155 ммоль/л); диагностирован ЦНД и начата терапия десмопрессином в таблетированной форме через зонд. При выходе из комы (21-е сутки) отмечено появление жажды на фоне продолжения терапии. В связи с сохраняющейся жаждой и полиурией произведен перевод на терапию десмопрессином в виде спрея, на этом фоне отмечено уменьшение выделения мочи до 3—3,5 л в сутки. Симптоматика ЦНД наблюдалась и через 2 года после ТЧМТ, при этом функция аденогипофиза оставалась сохранной. Представленный случай является примером развития постоянного несахарного диабета у подростка с ТЧМТ, находившегося под длительным наблюдением. Клиническая картина ЦНД в состоянии комы проявлялась только полиурией и гипернатриемией, а по мере повышения уровня сознания присоединилась жажда. Вероятными причинами развития ЦНД явились повреждение нейрогипофиза и частичное повреждение стебля гипофиза в результате протяженного перелома основания черепа и/или необратимого вторичного повреждения гипоталамуса вследствие диффузного аксонального повреждения головного мозга после ТЧМТ.
- Published
- 2022
31. Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state
- Author
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Hajime Ozaki, Hidetaka Suga, Mayu Sakakibara, Mika Soen, Natsuki Miyake, Tsutomu Miwata, Shiori Taga, Takashi Nagai, Mayuko Kano, Kazuki Mitsumoto, Takashi Miyata, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Shintaro Iwama, Ryoichi Banno, Genzo Iguchi, Yutaka Takahashi, Keiko Muguruma, Haruhisa Inoue, and Hiroshi Arima
- Subjects
Diabetes Insipidus, Neurogenic ,Neurons ,Mice ,Multidisciplinary ,Vasopressins ,Induced Pluripotent Stem Cells ,Hypothalamus ,Animals ,Humans ,Cell Differentiation - Abstract
Familial neurohypophyseal diabetes insipidus (FNDI) is a degenerative disease of vasopressin (AVP) neurons. Studies in mouse in vivo models indicate that accumulation of mutant AVP prehormone is associated with FNDI pathology. However, studying human FNDI pathology in vivo is technically challenging. Therefore, an in vitro human model needs to be developed. When exogenous signals are minimized in the early phase of differentiation in vitro, mouse embryonic stem cells (ESCs)/induced pluripotent stem cells (iPSCs) differentiate into AVP neurons, whereas human ESCs/iPSCs die. Human ESCs/iPSCs are generally more similar to mouse epiblast stem cells (mEpiSCs) compared to mouse ESCs. In this study, we converted human FNDI-specific iPSCs by the naive conversion kit. Although the conversion was partial, we found improved cell survival under minimal exogenous signals and differentiation into rostral hypothalamic organoids. Overall, this method provides a simple and straightforward differentiation direction, which may improve the efficiency of hypothalamic differentiation.
- Published
- 2022
32. Management of children and young people with idiopathic pituitary stalk thickening, central diabetes insipidus, or both: a national clinical practice consensus guideline
- Author
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Ian Kamaly-Asl, Stephen Ball, Helena Gleeson, Kirtana Vallabhaneni, Manuela Cerbone, Thomas S. Jacques, Ashraf Ederies, Ashley B. Grossman, Vaya Tziaferi, Chloe Bulwer, Helen Spoudeas, Vasanta Nanduri, Johannes Visser, and Márta Korbonits
- Subjects
Pediatrics ,medicine.medical_specialty ,Consensus ,Adolescent ,Skeletal survey ,Optic chiasm ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Biopsy ,Developmental and Educational Psychology ,medicine ,Humans ,030212 general & internal medicine ,Child ,Pituitary stalk ,medicine.diagnostic_test ,business.industry ,Organ Size ,Guideline ,medicine.disease ,Occult ,Patient Care Management ,Diabetes Insipidus, Neurogenic ,medicine.anatomical_structure ,Pituitary Gland ,Abdominal ultrasonography ,Practice Guidelines as Topic ,Pediatrics, Perinatology and Child Health ,Diabetes insipidus ,business - Abstract
Unexplained or idiopathic pituitary stalk thickening or central diabetes insipidus not only harbours rare occult malignancies in 40% of cases but can also reflect benign congenital defects. Between 2014 and 2019, a multidisciplinary, expert national guideline development group in the UK systematically developed a management flowchart and clinical practice guideline to inform specialist care and improve outcomes in children and young people (aged
- Published
- 2021
33. Management of Diabetes Insipidus following Surgery for Pituitary and Suprasellar Tumors
- Author
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Khaled M. Aldahmani, Maswood M Ahmad, Mussa H. Almalki, Salem A Beshyah, Imad Brema, Mohammed Almehthel, and Moeber M Mahzari
- Subjects
medicine.medical_specialty ,genetic structures ,Pituitary Adenoma ,Preoperative Risk Factor ,Review ,Central Diabetes Insipidus ,Polyuria ,Pituitary adenoma ,Desmopressin ,Neoplasms ,Diabetes Mellitus ,medicine ,Humans ,Polydipsia ,Cerebrospinal fluid leak ,business.industry ,General Medicine ,medicine.disease ,Craniopharyngioma ,Surgery ,Arginine Vasopressin ,Treatment ,Diabetes Insipidus, Neurogenic ,Pituitary Surgery ,Diabetes insipidus ,medicine.symptom ,Hyponatremia ,business ,Diabetes Insipidus ,medicine.drug - Abstract
Central diabetes insipidus (CDI) is a common complication of pituitary surgery. However, it is most frequently transient. It is defined by the excretion of an abnormally large volume of dilute urine with increasing serum osmolality. The reported incidence of CDI after pituitary surgery is variable; ranging from 0-90 %. Large tumor size, gross total resection, and intraoperative cerebrospinal fluid (CSF) leak usually have an increased risk of CDI as also seen with craniopharyngioma and Rathke’s cleft cysts. It can be associated with high morbidities and mortality if not promptly recognized and treated on time. It is essential to rule out other causes of postoperative polyuria to avoid unnecessary pharmacotherapy and iatrogenic hyponatremia. Once the diagnosis of CDI is established, close monitoring is required to evaluate the response to treatment and to determine whether the CDI is transient or permanent. This review outlines the evaluation and management of patients with CDI after pituitary and suprasellar tumors surgery to help recognize the diagnosis, consider the differential diagnosis, initiate therapeutic interventions, guide monitoring, and long-term management. Keywords: Central diabetes insipidus (CDI), polydipsia, polyuria, pituitary adenoma, preoperative risk factor, and pituitary surgery, arginine vasopressin, desmopressin, and treatment.
- Published
- 2021
34. Changes in copeptin levels before and 3 months after transsphenoidal surgery according to the presence of postoperative central diabetes insipidus
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Kyoung Ryul Lee, Yoo Hyung Kim, Young Soo Je, Jung Hee Kim, Yong Hwy Kim, and Hwan Sub Lim
- Subjects
Adult ,Male ,Neuroendocrine diseases ,Vasopressin ,medicine.medical_specialty ,Time Factors ,Optimal cutoff ,Pituitary diseases ,Sphenoid Sinus ,genetic structures ,medicine.medical_treatment ,Science ,Endocrine cancer ,Normal serum ,Gastroenterology ,Article ,Neurosurgical Procedures ,Postoperative Complications ,Copeptin ,Internal medicine ,medicine ,Humans ,Postoperative Period ,Aged ,Retrospective Studies ,Transsphenoidal surgery ,Multidisciplinary ,business.industry ,Glycopeptides ,Middle Aged ,medicine.disease ,Predictive value ,Diabetes Insipidus, Neurogenic ,ROC Curve ,Neuroendoscopy ,Preoperative Period ,Diabetes insipidus ,Medicine ,Female ,Pituitary surgery ,business - Abstract
Copeptin levels reflect arginine vasopressin (AVP) release from the hypothalamus. Pituitary surgery often impairs AVP release and results in central diabetes insipidus (CDI). Here, we aimed to investigate how serum copeptin level changes 3 months after pituitary surgery and whether it has a diagnostic value for postoperative permanent CDI. Consecutive patients who underwent endoscopic transsphenoidal surgery at a single tertiary hospital were recruited. Serum copeptin levels were measured preoperatively and 3 months postoperatively. Among 88 patients, transient and permanent CDI occurred in 17 (19.3%) and 23 (26.1%), respectively. Three-month postoperative copeptin levels significantly declined from preoperative levels in permanent CDI group (P P = 0.002, − 27.2%). Three months postoperative copeptin level
- Published
- 2021
35. Functional analyses of three different mutations in the AVP-NPII gene causing familial neurohypophyseal diabetes insipidus
- Author
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Hatice Mergen, Mehmet Ünal, Tugce Karaduman, Beril Erdem Tuncdemir, Merve Özcan Türkmen, and Sabire Yazıcı Fen Edebiyat Fakültesi
- Subjects
Neurophysins ,Mutation ,Chemistry ,RIA ,Endocrinology, Diabetes and Metabolism ,Endoplasmic reticulum ,Mutant ,Mutagenesis (molecular biology technique) ,AVP-NPII ,Transfection ,medicine.disease_cause ,Molecular biology ,Pedigree ,Diabetes Insipidus, Neurogenic ,Endocrinology ,Cell culture ,Diabetes Mellitus ,medicine ,Humans ,Functional Analysis ,Gene ,Diabetes Insipidus ,hormones, hormone substitutes, and hormone antagonists ,Intracellular - Abstract
Purpose Familial neurohypophyseal diabetes insipidus (FNDI), a rare disorder, which is clinically characterized by polyuria and polydipsia, results from mutations in the arginine vasopressin-neurophysin II (AVP-NPII) gene. The aim of this study was to perform functional analyses of three different mutations (p.G45C, 207_209delGGC, and p.G88V) defined in the AVP-NPII gene of patients diagnosed with FNDI, which are not included in the literature. Methods For functional analysis studies, the relevant mutations were created using PCR-based site-directed mutagenesis and restriction fragment replacement strategy and expressed in Neuro2A cells. AVP secretion into the cell culture medium was determined by radioimmunoassay (RIA) analysis. Fluorescence imaging studies were conducted to determine the differences in the intracellular trafficking of wild-type (WT) and mutant AVP-NPII precursors. Molecular dynamics (MD) simulations were performed to determine the changing of the conformational properties of domains for both WT and 207-209delGGC mutant structures and dynamics behavior of residues. Results Reduced levels of AVP in the supernatant culture medium of p.G45C and p.G88V transfected cells compared to 207_209delGGC and WT cells were found. Fluorescence imaging studies showed that a substantial portion of the mutant p.G45C and p.G88V AVP-NPII precursors appeared to be located in the endoplasmic reticulum (ER), whereas 207_209delGGC and WT AVP-NPII precursors were distributed throughout the cytoplasm. Conclusions The mutations p.G45C and p.G88V cause a failure in the intracellular trafficking of mutant AVP-NPII precursors. However, 207_209delGGC mutation does not result in impaired cellular trafficking, probably due to not having any significant effect in processes such as the proper folding, gain of three-dimensional structure, or processing. These results will provide valuable information for understanding the influence of mutations on the function of the AVP precursor hormone and cellular trafficking. Therefore, this study will contribute to elucidate the mechanisms of the molecular pathology of AVP-NPII mutations.
- Published
- 2021
36. Polydipsia and polyuria for nine years, unsteady gait and slurred speech for one year
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Fei-fei ZHAI, Lei QIAO, Min QIAN, Shan GAO, and Li-ying CUI
- Subjects
Diabetes insipidus, neurogenic ,Erdheim-Chester disease ,Case reports ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
DOI: 10.3969/j.issn.1672-6731.2015.08.016
- Published
- 2015
37. Neurogenic diabetes insipidus in a critical patient with COVID-19 pneumonia in treatment with extracorporeal membrane oxygenation: a case report.
- Author
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Samaniego-Segovia B, Rizo-Topete L, Garza-Gomez M, Rodriguez-Salinas CA, Martínez-Cadena S, López-Romo A, Gomez-Gutierrez R, Chavarría-Martínez U, and Sánchez-Salazar S
- Subjects
- Female, Humans, Adult, Polyuria, Oxygen, Diabetes Insipidus, Neurogenic, COVID-19 complications, COVID-19 therapy, Extracorporeal Membrane Oxygenation, Respiratory Distress Syndrome etiology, Respiratory Distress Syndrome therapy, Diabetes Mellitus
- Abstract
The following case report analyses a patient with extracorporeal membrane oxygenation (ECMO), who suffered from a severe Acute Respiratory Distress Syndrome (ARDS) due to COVID-19 pneumonia. ARDS is defined as a diffuse and inflammatory injury of the lungs; classifying this as severe when the ratio of arterial oxygen tension to a fraction of inspired oxygen (PaO
2 /FiO2 ) is equal to or lower than 100 mmHg. To decide if the patient was suitable for the use of ECMO therapy, the ELSO criteria were used; and in this case, the patient matched with the criteria of hypoxemic respiratory failure (with a PaO2 /FiO2 < 80 mmHg) after optimal medical management, including, in the absence of contraindications, a trial of prone positioning. During hospitalization, the patient presented a Central Diabetes Insipidus (CDI), probably explained by the damage hypoxia generated on the central nervous system. There are few reports of this complication produced by COVID-19. The case is about a 39-year-old woman, who started with ECMO 6 days after the beginning of Invasive Mechanical Ventilation (IMV), because of a severe ARDS. On the fifth day of ECMO, the patient started with a polyuria of 7 L in 24 h. A series of paraclinical studies were made, but no evidence of central nervous system lesions was found. After treatment with desmopressin was initiated and the ARDS was solved, polyuria stopped; with this, CDI was diagnosed. There are many complications secondary to the evolution of COVID-19 infection, and some of them are not yet well explained., (© The Author(s), published by EDP Sciences, 2023.)- Published
- 2023
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38. Arginine vasopressin deficiency and conivaptan (a V1a-V2 receptor antagonist) treatment reverses liver damage and fibrosis in rats with chronic portocaval anastomosis.
- Author
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Navarro-Gonzalez YD, Ventura-Juarez J, Muñoz-Ortega MH, González-Blas D, Calvillo-Robedo A, Avila-Blanco ME, Valdez-Urias F, and Quintanar-Stephano A
- Subjects
- Cricetinae, Rats, Animals, Antidiuretic Hormone Receptor Antagonists pharmacology, Arginine Vasopressin pharmacology, Liver Cirrhosis drug therapy, Anastomosis, Surgical, Arginine, Receptors, Vasopressin genetics, Diabetes Insipidus, Neurogenic
- Abstract
Arginine vasopressin (AVP) is a naturally occurring hormone synthesized in the hypothalamus. AVP demonstrates pro-fibrotic effects as it stimulates hepatic stellate cells to secrete transforming growth factor-β (TGF-β) and collagen. Previous work in liver cirrhotic (CCL
4 -induced) hamsters demonstrated that AVP deficiency induced by neurointermediate pituitary lobectomy (NIL) can restore liver function. Therefore, we hypothesized that liver fibrosis would decrease in portocaval anastomosis (PCA) rats, which model chronic liver diseases, when they are treated with the V1a-V2 AVP receptor antagonist conivaptan (CV). In this study, changes in liver histology and gene expression were analysed in five experimental groups: control, PCA, NIL, PCA + NIL and PCA + CV, with NIL surgery or CV treatment administered 8 weeks after PCA surgery. Body weight gain was assessed on a weekly basis, and serum liver function, liver weight and liver glycogen content were assessed following euthanasia. Most PCA-induced phenotypes were reverted to normal levels following AVP-modelled deficiency, though hypoglycemia and ammonium levels remained elevated in the PCA + CV group. Liver histopathological findings showed a significant reversal in collagen content, less fibrosis in the triad and liver septa and increased regenerative nodules. Molecular analyses showed that the expression of fibrogenic genes (TGF-β and collagen type I) decreased in the PCA + CV group. Our findings strongly suggest that chronic NIL or CV treatment can induce a favourable microenvironment to decrease liver fibrosis and support CV as an alternative treatment for liver fibrosis., (© 2023 Company of the International Journal of Experimental Pathology (CIJEP).)- Published
- 2023
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39. Oxytocin in response to MDMA provocation test in patients with arginine vasopressin deficiency (central diabetes insipidus): a single-centre, case-control study with nested, randomised, double-blind, placebo-controlled crossover trial.
- Author
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Atila C, Holze F, Murugesu R, Rommers N, Hutter N, Varghese N, Sailer CO, Eckert A, Heinrichs M, Liechti ME, and Christ-Crain M
- Subjects
- Humans, Oxytocin, Cross-Over Studies, Case-Control Studies, Double-Blind Method, Arginine, N-Methyl-3,4-methylenedioxyamphetamine adverse effects, Diabetes Insipidus, Neurogenic, Diabetes Mellitus
- Abstract
Background: Disruptions of the hypothalamic-pituitary axis can cause an arginine vasopressin deficiency, also known as central diabetes insipidus. Patients with this condition are at high risk of additional oxytocin deficiency owing to the close anatomical proximity of oxytocin-producing neurons; however, no conclusive evidence for such a deficiency has been reported. We aimed to use 3,4-methylenedioxymethamphetamine (MDMA, also known as ecstasy), a strong activator of the central oxytocinergic system, as a biochemical and psychoactive provocation test to investigate oxytocin deficiency in patients with arginine vasopressin deficiency (central diabetes insipidus)., Methods: This single-centre, case-control study with nested, randomised, double-blind, placebo-controlled crossover trial included patients with arginine vasopressin deficiency (central diabetes insipidus) and healthy controls (matched 1:1 by age, sex, and BMI) and was conducted at the University Hospital Basel, Basel, Switzerland. We used block randomisation to assign participants to receive either a single oral dose of MDMA (100 mg) or placebo in the first experimental session; patients received the opposite treatment at the next session, with a wash-out period of at least 2 weeks between the two sessions. Participants and investigators assessing the outcomes were masked to assignment. Oxytocin concentrations were measured at 0, 90, 120, 150, 180, and 300 min after MDMA or placebo. The primary outcome was the area under the plasma oxytocin concentration curve (AUC) after drug intake. The AUC was compared between groups and conditions using a linear mixed-effects model. Subjective drug effects were assessed throughout the study using ten-point visual analogue scales. Acute adverse effects were assessed before and 360 min after drug intake using a 66-item list of complaints. This trial is registered with ClinicalTrials.gov, NCT04648137., Findings: Between Feb 1, 2021, and May 1, 2022, we recruited 15 patients with arginine vasopressin deficiency (central diabetes insipidus) and 15 healthy controls. All participants completed the study and were included in the analyses. In healthy controls, median plasma oxytocin concentration was 77 pg/mL (IQR 59-94) at baseline and increased by 659 pg/mL (355-914) in response to MDMA, resulting in an AUC of 102 095 pg/mL (41 782-129 565); in patients, baseline oxytocin concentration was 60 pg/mL (51-74) and only slightly increased by 66 pg/mL (16-94) in response to MDMA, resulting in an AUC of 6446 pg/mL (1291-11 577). The effect of MDMA on oxytocin was significantly different between groups: the AUC for oxytocin was 82% (95% CI 70-186) higher in healthy controls than in patients (difference 85 678 pg/mL [95% CI 63 356-108 000], p<0·0001). The increase in oxytocin in healthy controls was associated with typical strong subjective prosocial, empathic, and anxiolytic effects, whereas only minimal subjective effects were observed in patients, in agreement with the lack of increase in oxytocin concentrations. The most frequently reported adverse effects were fatigue (eight [53%] healthy controls and eight [53%] patients), lack of appetite (ten [67%] healthy controls and eight [53%] patients), lack of concentration (eight [53%] healthy controls and seven [47%] patients), and dry mouth (eight [53%] healthy controls and eight [53%] patients). In addition, two (13%) healthy controls and four (27%) patients developed transient mild hypokalaemia., Interpretation: These findings are highly suggestive of clinically meaningful oxytocin deficiency in patients with arginine vasopressin deficiency (central diabetes insipidus), laying the groundwork for a new hypothalamic-pituitary disease entity., Funding: Swiss National Science Foundation, Swiss Academy of Medical Sciences, and the G&J Bangerter-Rhyner Foundation., Competing Interests: Declaration of interests MEL has received consulting and license fees and funding from MindMed for patents and knowledge related to MDMA; the received fees and funding are not related to the present study. MEL owns stocks of MindMed. All other authors declare no competing interests., (Copyright © 2023 Elsevier Ltd. All rights reserved.)
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- 2023
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40. Oxytocin deficiency in patients with arginine vasopressin deficiency (central diabetes insipidus).
- Author
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Ilie MD and Raverot G
- Subjects
- Humans, Oxytocin, Deamino Arginine Vasopressin, Arginine, Diabetes Insipidus, Neurogenic, Diabetes Insipidus complications, Diabetes Mellitus
- Abstract
Competing Interests: We declare no competing interests.
- Published
- 2023
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41. Secondary autoimmune hypothalamitis with severe memory impairment 7 years after the onset of diabetes insipidus due to lymphocytic hypophysitis: a case report
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Takahiro Asada, Shintaro Takenoshita, Mayuko Senda, Koichiro Yamamoto, Ryo Sasaki, Fumio Otsuka, Seishi Terada, and Norihito Yamada
- Subjects
Memory Disorders ,Lymphocytic hypophysitis ,General Medicine ,Memory impairment ,Middle Aged ,Magnetic Resonance Imaging ,Methylprednisolone ,Hypopituitarism ,Diabetes Insipidus, Neurogenic ,Cognitive dysfunction ,Diabetes Mellitus ,Humans ,Autoimmune Hypophysitis ,Female ,Neurology (clinical) ,Autoimmune hypothalamitis ,Diabetes Insipidus - Abstract
Background Autoimmune hypothalamitis is a very rare neuroendocrine disorder that causes central diabetes insipidus, headache, visual impairment, and sometimes cognitive impairment. Autoimmune hypothalamitis may occur in association with autoimmune hypophysitis, including lymphocytic hypophysitis, or in isolation. It is not known whether autoimmune hypothalamitis and autoimmune hypophysitis are consecutive diseases. Case presentation A 52-year-old woman developed autoimmune hypothalamitis 7 years after developing central diabetes insipidus due to lymphocytic hypophysitis, resulting in severe memory impairment. High-dose intravenous methylprednisolone therapy improved her cognitive function and decreased the size of the lesion. Conclusion This case presented a unique clinical course, with a long period of time between the onset of autoimmune hypopituitaritis and the development of autoimmune hypothalamitis.
- Published
- 2022
42. Central Diabetes Insipidus: Another Rare Complication of SARS-CoV-2 Infection in Children?
- Author
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Mauro Lizzi, Maurizio Aricò, Giorgia Carlone, Maria Teresa Anzellotti, Daniela Trotta, and Vincenzo Palatino
- Subjects
Microbiology (medical) ,Diabetes Insipidus, Neurogenic ,Infectious Diseases ,SARS-CoV-2 ,Pediatrics, Perinatology and Child Health ,Diabetes Mellitus ,COVID-19 ,Humans ,Child - Published
- 2022
43. Congenital nephrogenic diabetes insipidus accompanied with central nephrogenic diabetes secondary to pituitary surgery -a case report
- Author
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Yimin Shen, Lijun Wang, Yvbo Xin, Yuezhong Ren, and Wei Zhang
- Subjects
Adenoma ,Adult ,medicine.medical_specialty ,China ,Receptors, Vasopressin ,Endocrinology, Diabetes and Metabolism ,Nephrogenic diabetes insipidus ,Central nephrogenic diabetes ,030232 urology & nephrology ,Urology ,Mutation, Missense ,Diabetes Insipidus, Nephrogenic ,Case Report ,Neurosurgical Procedures ,Diseases of the endocrine glands. Clinical endocrinology ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Polyuria ,Arginine vasopressin receptor 2 ,Diabetes mellitus ,medicine ,Humans ,Pituitary Neoplasms ,030212 general & internal medicine ,Desmopressin ,business.industry ,Pituitary apoplexy ,General Medicine ,medicine.disease ,RC648-665 ,Diabetes Insipidus, Neurogenic ,Diabetes insipidus ,Female ,medicine.symptom ,business ,Polydipsia ,Pituitary Apoplexy ,hormones, hormone substitutes, and hormone antagonists ,AVPR2 mutation ,medicine.drug - Abstract
Background Diabetes insipidus (DI) can be a common cause of polydipsia and polyuria. Here, we present a case of congenital nephrogenic diabetes insipidus (CNDI) accompanied with central diabetes insipidus (CDI) secondary to pituitary surgery. Case presentation A 24-year-old Chinese woman came to our hospital with the complaints of polydipsia and polyuria for 6 months. Six months ago, she was detected with pituitary apoplexy, and thereby getting pituitary surgery. However, the water deprivation test demonstrated no significant changes in urine volume and urine gravity in response to fluid depression or AVP administration. In addition, the genetic results confirmed a heterozygous mutation in arginine vasopressin receptor type 2 (AVPR2) genes. Conclusions She was considered with CNDI as well as acquired CDI secondary to pituitary surgery. She was given with hydrochlorothiazide (HCTZ) 25 mg twice a day as well as desmopressin (DDAVP, Minirin) 0.1 mg three times a day. There is no recurrence of polyuria or polydipsia observed for more than 6 months. It can be hard to consider AVPR2 mutation in female carriers, especially in those with subtle clinical presentation. Hence, direct detection of DNA sequencing with AVPR2 is a convenient and accurate method in CNDI diagnosis.
- Published
- 2021
44. Variability in Oral Desmopressin Dose Requirements in Children with Central Diabetes Insipidus
- Author
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Erica A. Eugster and Nourah Almutlaq
- Subjects
Male ,medicine.medical_specialty ,Vasopressin ,Adolescent ,Administration, Oral ,Drug Administration Schedule ,Thirst ,Polyuria ,Internal medicine ,medicine ,Humans ,Deamino Arginine Vasopressin ,Child ,Desmopressin ,Retrospective Studies ,Dose-Response Relationship, Drug ,business.industry ,Antidiuretic Agents ,digestive, oral, and skin physiology ,Infant ,medicine.disease ,Diabetes Insipidus, Neurogenic ,Treatment Outcome ,Endocrinology ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Diabetes insipidus ,Etiology ,Female ,medicine.symptom ,business ,Hyponatremia ,Body mass index ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
There is inconsistency in the amount of oral desmopressin that children with central diabetes insipidus require. We investigated whether clinical characteristics influenced desmopressin dose requirements in 100 children with central diabetes insipidus. Extremely large doses were associated with acquired etiology (P = .04), greater body mass index z score, intact thirst, and additional pituitary hormone deficiencies (P .001).
- Published
- 2021
45. [Hypernatremia and polyuria in a female patient with an initial diagnosis of secondary acute myeloid leukemia]
- Author
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E, Aydilek, K, Jäger, K, Xhaxho, R, Akdas, M, Wallbach, G, Wulf, and N, Brökers
- Subjects
Diabetes Insipidus, Neurogenic ,Leukemia, Myeloid, Acute ,Hypernatremia ,Polyuria ,Humans ,Female ,Deamino Arginine Vasopressin ,Neoplasms, Second Primary ,Aged - Abstract
A 66-year-old female patient with the initial diagnosis of acute myeloid leukemia is reported. Paraneoplastic syndrome manifested as hypernatremia due to central diabetes insipidus (CDI), which could be controlled with the administration of desmopressin. After initiation of the induction therapy, the required desmopressin administration could be reduced and terminated. In the further course, the early increasing polyuria and hypernatremia indicated the primary refractory acute myeloid leukemia.Dargestellt wird der Krankheitsverlauf einer 66-jährigen Patientin mit der Erstdiagnose einer akuten myeloischen Leukämie. Als paraneoplastisches Syndrom zeigten sich eine Hypernatriämie sowie Polyurie infolge eines zentralen Diabetes insipidus (CDI), welcher mittels Desmopressingabe kontrolliert werden konnte. Nach Einleitung einer Induktionstherapie kam es im Verlauf nach Beendigung der Desmopressintherapie noch vor Anstieg des Blastenanteils zu einer erneuten Hypernatriämie und Polyurie als Hinweis auf eine primäre Refraktärität.
- Published
- 2022
46. Central diabetes insipidus from a patient's perspective: management, psychological co-morbidities, and renaming of the condition: results from an international web-based survey
- Author
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Cihan Atila, Paul Benjamin Loughrey, Aoife Garrahy, Bettina Winzeler, Julie Refardt, Patricia Gildroy, Malak Hamza, Aparna Pal, Joseph G Verbalis, Christopher J Thompson, Lars G Hemkens, Steven J Hunter, Mark Sherlock, Miles J Levy, Niki Karavitaki, John Newell-Price, John A H Wass, and Mirjam Christ-Crain
- Subjects
Adult ,Male ,Internet ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Middle Aged ,Arginine ,Diabetes Insipidus, Neurogenic ,Endocrinology ,Cross-Sectional Studies ,Internal Medicine ,Diabetes Mellitus ,Quality of Life ,Humans ,Deamino Arginine Vasopressin ,Female ,Morbidity ,Child ,Diabetes Insipidus ,Hyponatremia - Abstract
Background\ud \ud Central diabetes insipidus is a rare neuroendocrine condition. Data on treatment-associated side-effects, psychological comorbidities, and incorrect management are scarce. The aim of this study was to investigate patients’ perspectives on their disease.\ud \ud \ud \ud Methods\ud \ud This study used a cross-sectional, web-based, anonymous survey, developed by endocrinologists and patient representatives, to collect the opinions of patients with central diabetes insipidus on management and complications of their disease, psychological comorbidities, degree of knowledge and awareness of the condition among health-care professionals, and renaming the disease to avoid confusion with diabetes mellitus (diabetes).\ud \ud \ud \ud Findings\ud \ud Between Aug 23, 2021, and Feb 7, 2022, 1034 patients with central diabetes insipidus participated in the survey. 91 (9%) participants were children and adolescents (37 [41%] girls and 54 [59%] boys; median age 10 years [IQR 6–15]) and 943 (91%) were adults (757 [80%] women and 186 [20%] men]; median age 44 years [34–54]). 488 (47%) participants had isolated posterior pituitary dysfunction and 546 (53%) had combined anterior and posterior pituitary dysfunction. Main aetiologies were idiopathic (315 [30%] of 1034 participants) and tumours and cysts (pre-surgical 217 [21%]; post-surgical 254 [25%]). 260 (26%; 95% CI [0·23–0·29]) of 994 patients on desmopressin therapy had hyponatraemia leading to hospitalisation. Patients who routinely omitted or delayed desmopressin to allow intermittent aquaresis had a significantly lower prevalence of hyponatraemia compared with those not aware of this approach (odds ratio 0·55 [95% CI 0·39–0·77]; p=0·0006). Of patients who had to be hospitalised for any medical reason, 71 (13%; 95% CI 0·10–0·16) of 535 patients did not receive desmopressin while in a fasting state (nil by mouth) without intravenous fluid replacement and reported symptoms of dehydration. 660 (64%; 0·61–0·67) participants reported lower quality of life, and 369 (36%; 0·33–0·39) had psychological changes subjectively associated with their central diabetes insipidus. 823 (80%; 0·77–0·82) participants encountered a situation where central diabetes insipidus was confused with diabetes mellitus (diabetes) by health-care professionals. 884 (85%; 0·83–0·88) participants supported renaming the disease; the most favoured alternative names were vasopressin deficiency and arginine vasopressin deficiency.\ud \ud \ud \ud Interpretation\ud \ud This is the largest survey of patients with central diabetes insipidus, reporting a high prevalence of treatment-associated side-effects, mismanagement during hospitalisation, psychological comorbidities, and a clear support for renaming the disease. Our data are the first to indicate the value of routinely omitting or delaying desmopressin.\ud \ud \ud \ud Funding\ud \ud Swiss National Science Foundation, Swiss Academy of Medical Sciences, and G&J Bangerter-Rhyner-Foundation.
- Published
- 2022
47. [Central diabetes insipidus]
- Author
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Judith, Charbit, Narimane, Berkane, Meriem, Sal, and Hélène, Bihan
- Subjects
Diabetes Insipidus, Neurogenic ,Male ,Pregnancy ,Diabetes Mellitus ,Humans ,Female ,Syndrome ,Magnetic Resonance Imaging ,Diabetes Insipidus ,Hospitals - Abstract
"Central diabetes insipidus Diabetes insipidus may remain undetected for a long time, the ionogram remaining normal as long as polydipsia compensates for diuresis. In the first place, and by argument of frequency, polyuria should rule out diabetes. Diabetes insipidus is evoked in the presence of an incapacitating polyuro polydipsic syndrome, especially at night. Pituitary MRI eliminate a tumoral or infiltrative cause and confirm a central cause by the disappearance of the physiological t1 hypersignal in the post-pituitary gland. A water restriction test should only be performed in a hospital setting under close supervision. Lifetime hormone replacement therapy is appropriate in situations of pregnancy, risk of dehydration, and signs of overdose must be known by the patient, who must be educated about his or her disease.""Diabète insipide central Le diabète insipide peut rester longtemps inaperçu, l’ionogramme restant normal tant que la polydipsie compense la diurèse. En premier lieu, et par argument de fréquence, une polyurie doit faire éliminer un diabète. Le diabète insipide est évoqué devant un syndrome polyuro-polydipsique invalidant, notamment nocturne. L’IRM hypophysaire a alors deux objectifs : éliminer une cause tumorale ou infiltrative et affirmer une cause centrale par la disparition de l’hypersignal t1 physiologique au niveau de la post-hypophyse. Un test de restriction hydrique ne doit être réalisé qu’en milieu hospitalier sous surveillance rapprochée. Le traitement hormonal substitutif à vie est adapté dans les situations de grossesse, de risque de déshydratation et les signes de surdosage doivent être connus du patient, éduqué à sa maladie."
- Published
- 2022
48. Central Diabetes Insipidus Due to IgG4-related Hypophysitis That Required over One Year to Reach the Final Diagnosis Due to Symptoms Being Masked by Sialadenitis
- Author
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Yuichiro Iwamoto, Shigehito Mori, Fuminori Tatsumi, Toshitomo Sugisaki, Kazunori Dan, Yukino Katakura, Tomohiko Kimura, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, and Hideaki Kaneto
- Subjects
Male ,Inflammation ,Polyuria ,Pituitary Diseases ,Prednisolone ,General Medicine ,Middle Aged ,Sialadenitis ,Diabetes Insipidus, Neurogenic ,Immunoglobulin G ,Internal Medicine ,Diabetes Mellitus ,Humans ,Autoimmune Hypophysitis ,Immunoglobulin G4-Related Disease ,Diabetes Insipidus - Abstract
Pituitary inflammation due to IgG4-related disease is a rare condition and is sometimes accompanied by central diabetes insipidus. Central diabetes insipidus produces a strong thirst sensation, which may be difficult to distinguish when complicated by salivary insufficiency. A 45-year-old man was admitted to our department for a thorough examination of his thirst and polyuria. He had suddenly developed these symptoms more than one year earlier and visited an oral surgeon. Swelling of the left submandibular gland, right parotid gland, and cervical lymph nodes had been observed. Since his IgG4 level was relatively high at 792 mg/dL and a lip biopsy showed high plasmacytoid infiltration around the gland ducts, he had been diagnosed with IgG4-related disease. He had started taking 0.4 mg/kg/day of prednisolone, and his chief complaint temporarily improved. However, since the symptom recurred, he was referred to our institution. After admission, to examine the cause of his thirst and polyuria, we performed a water restriction test, vasopressin loading test, hypertonic saline loading test and pituitary magnetic resonance imaging. Based on the findings, we diagnosed him with central diabetes insipidus due to IgG4-related hypophysitis. We increased the dose of prednisolone to 0.6 mg/kg/day and started 10 μg/day of intranasal desmopressin. His symptoms were subsequently alleviated, and his serum IgG4 level finally normalized. We should remember that IgG4-related disease can be accompanied by hypophysitis and that central diabetes insipidus is brought about by IgG4-related hypophysitis. This case report should remind physicians of the fact that pituitary inflammation due to IgG4-related disease is very rare and can be masked by symptoms due to salivary gland inflammation, which can lead to pitfalls in the diagnosis in clinical practice.
- Published
- 2022
49. Management of transient central diabetes insipidus with intravenous desmopressin in a premature infant with gastroschisis and septo-optic dysplasia: A case report
- Author
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Helen M Towers and Faith Kim
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,genetic structures ,Laboratory monitoring ,Population ,030209 endocrinology & metabolism ,Infant, Premature, Diseases ,03 medical and health sciences ,Route of administration ,0302 clinical medicine ,Septo-Optic Dysplasia ,030225 pediatrics ,medicine ,Humans ,Deamino Arginine Vasopressin ,Desmopressin ,education ,education.field_of_study ,Gastroschisis ,business.industry ,Septo-optic dysplasia ,medicine.disease ,Diabetes Insipidus, Neurogenic ,Dysplasia ,Pediatrics, Perinatology and Child Health ,Diabetes insipidus ,business ,Infant, Premature ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
Central diabetes insipidus (CDI) may occur in the setting of intracranial abnormalities that affect the hypothalamus-pituitary system. It occurs rarely in neonates, especially in the premature population, and represents a challenging disease process to treat pharmacologically. Little is known regarding the treatment options in premature infants, including dose and route of administration of intravenous desmopressin (DDAVP). We present a case of a late premature male infant with gastroschisis and septo-optic dysplasia who developed transient CDI. He was treated with intravenous DDAVP but required frequent laboratory monitoring and a multidisciplinary approach, and ultimately his CDI resolved. Although there are minimal guidelines regarding the appropriate formulation and dosage of DDAVP for management of CDI in infants, we initiated the lowest dose available and titrated the medication based on close monitoring of urine output and serum sodium levels in order to successfully treat his transient CDI.
- Published
- 2021
50. A case of isolated hypothalamitis with a literature review and a comparison with autoimmune hypophysitis
- Author
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Ichiro Horie, Takao Ando, Naoko Inoshita, Yoshihisa Sugimura, Tetsuro Niri, Haruki Fujisawa, Atsushi Suzuki, Noriaki Fukuhara, Hiroshi Nishioka, Atsushi Kawakami, Hiromi Kawahara, and Norio Abiru
- Subjects
Adult ,Pathology ,medicine.medical_specialty ,Pituitary gland ,Hypophysitis ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Hyperphagia ,Hypopituitarism ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Japan ,Langerhans cell histiocytosis ,Biopsy ,medicine ,Humans ,Autoimmune Hypophysitis ,Amenorrhea ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Magnetic Resonance Imaging ,Diabetes Insipidus, Neurogenic ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Diabetes insipidus ,Autoimmune hypophysitis ,Prednisolone ,Female ,business ,Vasculitis ,Hypothalamic Diseases ,medicine.drug - Abstract
Idiopathic hypothalamitis is a rare condition that can cause anterior pituitary dysfunction and central diabetes insipidus (CDI), occasionally accompanied by a disturbance of autonomic regulation known as hypothalamic syndrome. This condition has been described as a subtype of autoimmune (lymphocytic) hypophysitis; however, some cases of isolated hypothalamic involvement with no inflammatory lesions in either the pituitary gland or infundibulum have been reported. The detailed epidemiology and pathophysiology of isolated hypothalamitis have not been clarified. We herein report a case of a solitary hypothalamic lesion in a young woman who showed spontaneous development of CDI and panhypopituitarism accompanied by hyperphagia. The hypothalamic lesion increased from 11 × 7 to 17 × 7 mm over 16 months based on the sagittal slices of magnetic resonance imaging examinations. The negative results for anti-pituitary antibodies and anti-Rabphilin-3A antibodies suggested that upward extension of lymphocytic adenohypophysitis or infundibulo-neurohypophysitis was unlikely. Infectious disease, granulomatosis, Langerhans cell histiocytosis, vasculitis, and systemic neoplastic diseases were excluded by the findings of a laboratory investigation, cerebrospinal fluid examination, and imaging studies. To make a definitive diagnosis, we performed a ventriculoscopic biopsy of the hypothalamic lesion. Histology revealed an infiltration of nonspecific lymphoplasmacytes with no evidence of neoplasm, which was consistent with a diagnosis of idiopathic hypothalamitis. Subsequently, the patient was treated with methylprednisolone pulse therapy followed by oral prednisolone. The hypothalamic lesion improved and remained undetectable after withdrawal of the prednisolone, suggesting that the glucocorticoid treatment was effective for isolated hypothalamitis while the patient remains dependent on the replacement of multiple hormones.
- Published
- 2021
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