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Objective of this study was to evaluate the efficacy and adverse drug reactions (ADR) of palipeddone sustained release tablet in the treatment of schizophrenia in outpatients. Outpatients with schizophrenia treated with palipeddone sustained release tablet (observation group)in our hospital from Apr. to Sep. in 2009 were followed up and compared with those treated with risperidone (control group) during the same period. PANSS and TESS were applied to evaluate efficacy and ADR. Results suggest that the cure rates were 42.4% for control group and 49.6% for observation group. The effective rates were 74.8% for control group and 80.3% for observation group (P

To observe the effect of electroacupuncture (EA) in combination with small dose of clozapine on clinical symptoms of refractory schizophrenia patients so as to evaluate its validity and security.Eighty schizophrenia patients were randomized into medication group and EA + medication group (n=40/group). Patients of medication group were treated with conventional oral administration of clozapine (50-100 mg/d to 200-500 mg/d, for 8 weeks) and those of EA + medication group treated by EA of Baihui(GV 20) and bilateral Taiyang (EX-HN 5) and oral administration of clozapine (50 mg/d to 100-150 mg/d). EA was given to the patients, 3 times a week for 8 weeks. Scores of the Positive and Negative Symptom Scale (PANSS) and the Untoward Effect Symptom Scale (TESS) were used to assess the therapeutic effect.Following treatment, PANSS scores for positive symptoms and the common psychiatric symptoms of the medication and EA + medication groups all decreased evidently from the 2rd week on (P0.05, P0.01), and those of the negative symptoms reduced obviously from the 4th week on (P0.05). Comparison between two groups showed no significant differences in PANSS scores for positive and negative symptoms and the common psychiatric symptoms after the treatment (P0.05). But TESS score of EA+ medication group was evidently lower than that of medication group (P0.01), suggesting an apparently fewer untoward effects in EA + medication group. Of the two 40 cases in medication and EA+ medication groups, 6 (15%) and 5 (12.5%) were cured, 8 and 8 (20%) experienced marked improvement in their symptoms, 17 (42.5%) and 16 (40%) had an improvement, 9 (22.5%) and 11 (27.5%) failed, with the effective rates being 77.5% and 72.5% separately.Both medication and EA+ medication can improve refractory schizophrenia patients'clinical symptoms, but the later has fewer untoward effects.

To evaluate the clinical therapeutic effect of electroacupuncture for treatment of catatonic schizophrenia.Eighty cases were randomly divided into an observation group and a control group, 40 cases in each group. The observation group was treated with electroacupuncture, Baihui (GV 20) and Taiyang (EXHN 5) were selected, once daily; the control group was treated with modified electric convulsive therapy (MECT), the treatment was given once every 2 days or 3 days, 14 to 21 days constituted one course in the two groups.The markedly effective rate and total effective rate were 72.5% and 92.5% in the observation group, 77.5% and 97.5% in the control group, respectively, there was no significant difference between the two groups (both P0.05).The therapeutic effect of electroacupuncture is similar to that of MECT.