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697 results on '"Diao, Yong"'

2. Prognostic Value of Serum α‐Fetoprotein Level as an Important Characteristic of Tumor Biology for Patients Undergoing Liver Resection of Early-Stage Hepatocellular Carcinoma (BCLC Stage 0/A): A Large Multicenter Analysis

Author

Yao, Lan-Qing, Fan, Zhong-Qi, Wang, Ming-Da, Diao, Yong-Kang, Chen, Ting-Hao, Zeng, Yong-Yi, Chen, Zhong, Wang, Xian-Ming, Zhou, Ya-Hao, Li, Jie, Fan, Xin-Ping, Liang, Ying-Jian, Li, Chao, Shen, Feng, Lv, Guo-Yue, and Yang, Tian

Published
2024
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8. ASO Visual Abstract: Prognostic Value of Serum α‐Fetoprotein Level as an Important Characteristic of Tumor Biology for Patients Undergoing Liver Resection of Early-Stage Hepatocellular Carcinoma (BCLC Stage 0/A): A Large Multicenter Analysis

Author

Yao, Lan-Qing, Fan, Zhong-Qi, Wang, Ming-Da, Diao, Yong-Kang, Chen, Ting-Hao, Zeng, Yong-Yi, Chen, Zhong, Wang, Xian-Ming, Zhou, Ya-Hao, Li, Jie, Fan, Xin-Ping, Liang, Ying-Jian, Li, Chao, Shen, Feng, Lv, Guo-Yue, and Yang, Tian

Published
2024
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9. Stratifying risk of failure to achieve textbook outcomes among patients undergoing hepatectomy for hepatocellular carcinoma: A multicenter score validation study

Author

Liu, Han, Diao, Yong-Kang, Wei, Feng, Wang, Si-Yuan, Liang, Ying-Jian, Wu, Yi-Fan, Zheng, Qi-Xuan, Wang, Xian-Ming, Wang, Hong, Li, Jie, Chen, Ting-Hao, Wu, Xiao-Chang, Gu, Wei-Min, Zhou, Ya-Hao, Guo, Hong-Wei, Shao, Guang-Zhao, Xu, Jia-Hao, Yao, Lan-Qing, Wang, Ming-Da, Shen, Feng, Pawlik, Timothy M., Lau, Wan Yee, Lv, Guo-Yue, and Yang, Tian

Published
2024
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16. Association of Concurrent Metabolic Syndrome with Long-term Oncological Prognosis Following Liver Resection for Hepatocellular Carcinoma Among Patients with Chronic Hepatitis B Virus Infection: A Multicenter Study of 1753 Patients

Author

Wang, Ming-Da, Tang, Shi-Chuan, Li, Chao, Sun, Li-Yang, Xu, Xiao, Liang, Ying-Jian, Liu, Fu-Bao, Gu, Wei-Min, Wang, Xian-Ming, Zhou, Ya-Hao, Lau, Wan Yee, Zhang, Cheng-Wu, Yao, Lan-Qing, Diao, Yong-Kang, Gu, Li-Hui, Shen, Feng, Zeng, Yong-Yi, and Yang, Tian

Published
2023
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19. Failure to Achieve Textbook Outcomes: Stratifying Risk Among Patients Undergoing Hepatectomy for Hepatocellular Carcinoma A Multicenter Score Validation Study

Author

Liu, Han, primary, Diao, Yong-Kang, additional, Wei, Feng, additional, Wang, Si-Yuan, additional, Liang, Ying-Jian, additional, Wu, Yi-Fan, additional, Zheng, Qi-Xuan, additional, Wang, Xian-Ming, additional, Wang, Hong, additional, Li, Jie, additional, Chen, Ting-Hao, additional, Wu, Xiao-Chang, additional, Gu, Wei-Min, additional, Zhou, Ya-Hao, additional, Guo, Hong-Wei, additional, Shao, Guang-Zhao, additional, Xu, Jia-Hao, additional, Yao, Lan-Qing, additional, Wang, Ming-Da, additional, Shen, Feng, additional, Pawlik, Timothy M., additional, Lau, Wan Yee, additional, Lv, Guo-Yue, additional, and Yang, Tian, additional

Published
2024
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20. Association of Pringle maneuver with postoperative recurrence and survival following hepatectomy for hepatocellular carcinoma: a multicenter propensity score and competing-risks regression analysis

Author

Tang, Shi-Chuan, primary, Diao, Yong-Kang, additional, Lin, Kong-Ying, additional, Li, Chao, additional, Xu, Xiao, additional, Liang, Lei, additional, Kong, Jie, additional, Chen, Qing-Jing, additional, Wang, Xian-Ming, additional, Liu, Fu-Bao, additional, Gu, Wei-Min, additional, Zhou, Ya-Hao, additional, Liang, Ying-Jian, additional, Liu, Hong-Zhi, additional, Wang, Ming-Da, additional, Yao, Lan-Qing, additional, Pawlik, Timothy M., additional, Shen, Feng, additional, Lau, Wan Yee, additional, Yang, Tian, additional, and Zeng, Yong-Yi, additional

Published
2024
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24. Prospective validation of the Eastern Staging in predicting survival after surgical resection for patients with hepatocellular carcinoma: a multicenter study from China

Author

Yang, Shun-Chao, Liang, Lei, Wang, Ming-Da, Wang, Xian-Ming, Gu, Li-Hui, Lin, Kong-Ying, Zhou, Ya-Hao, Chen, Ting-Hao, Gu, Wei-Min, Li, Jie, Wang, Hong, Chen, Zhong, Li, Chao, Yao, Lan-Qing, Diao, Yong-Kang, Sun, Li-Yang, Zhang, Cheng-Wu, Zeng, Yong-Yi, Lau, Wan Yee, Huang, Dong-Sheng, Shen, Feng, and Yang, Tian

Published
2023
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25. Association of Preoperative Body Mass Index with Surgical Textbook Outcomes Following Hepatectomy for Hepatocellular Carcinoma: A Multicenter Study of 1206 Patients

Author

Liu, Zhi-Peng, Yao, Lan-Qing, Diao, Yong-Kang, Chen, Zi-Xiang, Feng, Zi-Han, Gu, Wei-Min, Chen, Zheng-Liang, Chen, Ting-Hao, Zhou, Ya-Hao, Wang, Hong, Xu, Xin-Fei, Wang, Ming-Da, Li, Chao, Liang, Lei, Zhang, Cheng-Wu, Pawlik, Timothy M., Lau, Wan Yee, Shen, Feng, Chen, Zhi-Yu, and Yang, Tian

Published
2022
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26. Clinical Features of Recurrence After Hepatic Resection for Early-Stage Hepatocellular Carcinoma and Long-Term Survival Outcomes of Patients with Recurrence: A Multi-institutional Analysis

Author

Yao, Lan-Qing, Chen, Zheng-Liang, Feng, Zi-Han, Diao, Yong-Kang, Li, Chao, Sun, Hai-Ying, Zhong, Jian-Hong, Chen, Ting-Hao, Gu, Wei-Min, Zhou, Ya-Hao, Zhang, Wan-Guang, Wang, Hong, Zeng, Yong-Yi, Wu, Han, Wang, Ming-Da, Xu, Xin-Fei, Pawlik, Timothy M., Lau, Wan Yee, Shen, Feng, and Yang, Tian

Published
2022
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33. Impact of concurrent splenectomy and esophagogastric devascularization on surgical outcomes of partial hepatectomy for hepatocellular carcinoma in patients with clinically significant portal hypertension: A multicenter propensity score matching analysis

Author

Chen, Zheng-Liang, Yao, Lan-Qing, Pu, Jia-Le, Wu, Han, Xu, Xin-Fei, Chen, Ting-Hao, Zhou, Ya-Hao, Wang, Hong, Chen, Zhi-Yu, Sun, Li-Yang, Diao, Yong-Kang, Zhong, Jian-Hong, Lau, Wan Yee, Pawlik, Timothy M., Huang, Dong-Sheng, Shen, Feng, Liang, Ying-Jian, and Yang, Tian

Published
2022
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34. ASO Visual Abstract: Association of Concurrent Metabolic Syndrome with Long-term Oncological Prognosis Following Liver Resection for Hepatocellular Carcinoma Among Patients with Chronic Hepatitis B Virus Infection—A Multicenter Study of 1753 Patients

Author

Wang, Ming-Da, Tang, Shi-Chuan, Li, Chao, Sun, Li-Yang, Xu, Xiao, Liang, Ying-Jian, Liu, Fu-Bao, Gu, Wei-Min, Wang, Xian-Ming, Zhou, Ya-Hao, Lau, Wan Yee, Zhang, Cheng-Wu, Yao, Lan-Qing, Diao, Yong-Kang, Gu, Li-Hui, Shen, Feng, Zeng, Yong-Yi, and Yang, Tian

Published
2023
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35. Identification of new AAV vectors with enhanced blood–brain barrier penetration efficiency via organ-on-a-chip.

Author

Li, Mengmeng, Zhong, Yujian, Zhu, Mingyang, Pang, Chunjin, Xiao, Lu, Bu, Ye, Li, Huapeng, Diao, Yong, Yang, Chaoyong, and Liu, Dan

Subjects
BLOOD-brain barrier, MICROPHYSIOLOGICAL systems, HIGH throughput screening (Drug development), PROTEIN receptors, GENE therapy, PERMEABILITY
Abstract

To overcome limitations in the generalizability and efficiency of current AAV vectors, in this current study, we constructed an AAV variant library by the insertion of random heptapeptide sequences in the receptor-binding domain of the AAV9 capsid gene. We then applied a recently developed organ-on-a-chip in vitro model of the human blood–brain barrier (BBB) to iteratively enrich for variants that efficiently cross the BBB and transduce astrocyte cells. Through multiple rounds of screening, we obtained two candidate AAV variants, AAV-M6 and AAV-M8, which showed significantly higher BBB penetration efficiency than AAV9 or AAV-PHP.eB. Quantitative PCR (qPCR) assay showed that AAV-M6 could accumulate to a 5 times higher titer, while AAV-M8 reached a 3 times higher titer, than AAV-PHP.eB in the neural chamber of the model. The transduction assay further verified that the AAV-M6 candidate vector was able to infect HA-1800 cells after crossing the BBB, suggesting it could potentially transduce brain parenchymal cells after crossing the hCMEC/D3 layer at higher efficiency than AAV-PHP.eB. Molecular simulations suggested that the human receptor proteins, LY6D and M6PR, could bind the AAV-M6 heptapeptide insertion with high affinity. This study provides two promising candidate AAV vectors and demonstrates the use of this in vitro BBB model for scalable, high-throughput screening of gene therapies. These tools can drive investigations of the mechanisms underlying BBB permeability and the cell-type specificity of virus vectors. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Numerical study on transport and deposition characteristics of particles associated with heat setting process in opposed jet flow field.

Author

Dai, Jia-ao, Diao, Yong fa, and Zhang, Lei

Subjects
*JETS (Fluid dynamics), *AIR ducts, *STANDARD deviations, *JET impingement, *FIRE prevention, *TURBULENT jets (Fluid dynamics)
Abstract

The transport and deposition of particles accompanying the heat setting process in the opposed jet air supply system have a significant impact on the equipment safety. This paper used the Realizable k–ε model to simulate the flow field distribution of the impinging jet and the Lagrange method to track the trajectory of particles, by considering factors, such as jet velocity (7–13 m/s), oven temperature (413–473 K), and particle size (1–30 μ m) changes, the instantaneous force process of particles was analyzed and their deposition mechanism was revealed. The numerical results have been well validated, with the root mean square error of within 10%. The results indicate that the flow field form of the opposed jet significantly affects particle placement on the surface of the air duct, the maximum turbulent vortex structure appears at the inlet of the air duct on both sides of the protruding nozzle, enhancing the capture of particles. Under the influence of gravity, the lower surface of the air duct becomes the main deposition surface, this phenomenon becomes more pronounced as the particle size increases and the maximum deposition rate difference between the upper and lower layers is 37%. The number of particles deposited on the rear end of the air duct is greater than that on the front end, and the deposition rate decreases with the increase in jet velocity. In the initial stage, a temperature gradient appeared in the machine room, which provided upward lift for the particles, resulting in more small diameter particles ( d p < 10 μ m) depositing on the upper surface of the air duct. The results can provide theoretical support for the fire prevention and pollutant purification of equipment, such as heat setting machines. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Self-Assembly of Rhein and Matrine Nanoparticles for Enhanced Wound Healing.

Author

Wu, Xunxun, Zang, Ranqing, Qiu, Yiting, Yang, Ni, Liu, Meiyan, Wei, Site, Xu, Xianxiang, and Diao, Yong

Subjects
CONTROLLED release drugs, MOLECULAR dynamics, MOLECULAR self-assembly, NATURAL products, LIGHT scattering, WOUND healing
Abstract

Carrier-free self-assembly has gradually shifted the focus of research on natural products, which effectively improve the bioavailability and the drug-loading rate. However, in spite of the existing studies, the development of self-assembled natural phytochemicals that possess pharmacological effects still has scope for further exploration and enhancement. Herein, a nano-delivery system was fabricated through the direct self-assembly of Rhein and Matrine and was identified as a self-assembled Rhein-Matrine nanoparticles (RM NPs). The morphology of RM NPs was characterized by TEM. The molecular mechanisms of self-assembly were explored using FT-IR, 1H NMR, and molecular dynamics simulation analysis. Gelatin methacryloyl (GelMA) hydrogel was used as a drug carrier for controlled release and targeted delivery of RM NPs. The potential wound repair properties of RM NPs were evaluated on a skin wound-healing model. TEM and dynamic light scattering study demonstrated that the RM NPs were close to spherical, and the average size was approximately 75 nm. 1H NMR of RM NPs demonstrated strong and weak changes in the interaction energies during self-assembly. Further molecular dynamics simulation analysis predicted the self-assembly behavior. An in vivo skin wound-healing model demonstrated that RM NPs present better protection effect against skin damages. Taken together, RM NPs are a new self-assembly system; this may provide new directions for natural product applications. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Conversion therapy for advanced hepatocellular carcinoma in the era of precision medicine: Current status, challenges and opportunities.

Author

Wang, Ming‐Da, Xu, Xue‐Jun, Wang, Ke‐Chun, Diao, Yong‐Kang, Xu, Jia‐Hao, Gu, Li‐Hui, Yao, Lan‐Qing, Li, Chao, Lv, Guo‐Yue, and Yang, Tian

Abstract

Hepatocellular carcinoma (HCC), the most prevalent malignancy of the digestive tract, is characterized by a high mortality rate and poor prognosis, primarily due to its initial diagnosis at an advanced stage that precludes any surgical intervention. Recent advancements in systemic therapies have significantly improved oncological outcomes for intermediate and advanced‐stage HCC, and the combination of locoregional and systemic therapies further facilitates tumor downstaging and increases the likelihood of surgical resectability for initially unresectable cases following conversion therapies. This shift toward high conversion rates with novel, multimodal treatment approaches has become a principal pathway for prolonged survival in patients with advanced HCC. However, the field of conversion therapy for HCC is marked by controversies, including the selection of potential surgical candidates, formulation of conversion therapy regimens, determination of optimal surgical timing, and application of adjuvant therapy post‐surgery. Addressing these challenges and refining clinical protocols and research in HCC conversion therapy is essential for setting the groundwork for future advancements in treatment strategies and clinical research. This narrative review comprehensively summarizes the current strategies and clinical experiences in conversion therapy for advanced‐stage HCC, emphasizing the unresolved issues and the path forward in the context of precision medicine. This work not only provides a comprehensive overview of the evolving landscape of treatment modalities for conversion therapy but also paves the way for future studies and innovations in this field. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Adjuvant immunotherapy improves recurrence-free and overall survival following surgical resection for intermediate/advanced hepatocellular carcinoma a multicenter propensity matching analysis

Author

Xu, Xiao, primary, Wang, Ming-Da, additional, Xu, Jia-Hao, additional, Fan, Zhong-Qi, additional, Diao, Yong-Kang, additional, Chen, Zhong, additional, Jia, Hang-Dong, additional, Liu, Fu-Bao, additional, Zeng, Yong-Yi, additional, Wang, Xian-Ming, additional, Wu, Han, additional, Qiu, Wei, additional, Li, Chao, additional, Pawlik, Timothy M., additional, Lau, Wan Yee, additional, Shen, Feng, additional, Lv, Guo-Yue, additional, and Yang, Tian, additional

Published
2024
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44. Postoperative morbidity adversely impacts long-term oncologic prognosis following hepatectomy for hepatocellular carcinoma: A multicenter observational study

Author

Li, Lin-Qiang, Liang, Lei, Sun, Li-Yang, Li, Chao, Wu, Han, Zhang, Yao-Ming, Zhang, Wan-Guang, Wang, Hong, Zhou, Ya-Hao, Gu, Wei-Min, Chen, Ting-Hao, Li, Jie, Liang, Ying-Jian, Xu, Qiu-Ran, Diao, Yong-Kang, Jia, Hang-Dong, Wang, Ming-Da, Zhang, Cheng-Wu, Shen, Feng, Huang, Dong-Sheng, and Yang, Tian

Published
2021
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46. ASO Visual Abstract: Prognostic Value of Serum α‐Fetoprotein Level as an Important Characteristic of Tumor Biology for Patients Undergoing Liver Resection of Early-Stage Hepatocellular Carcinoma (BCLC Stage 0/A): A Large Multicenter Analysis

Author

Yao, Lan-Qing, primary, Fan, Zhong-Qi, additional, Wang, Ming-Da, additional, Diao, Yong-Kang, additional, Chen, Ting-Hao, additional, Zeng, Yong-Yi, additional, Chen, Zhong, additional, Wang, Xian-Ming, additional, Zhou, Ya-Hao, additional, Li, Jie, additional, Fan, Xin-Ping, additional, Liang, Ying-Jian, additional, Li, Chao, additional, Shen, Feng, additional, Lv, Guo-Yue, additional, and Yang, Tian, additional

Published
2023
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49. Development and validation of an individualized prediction calculator of postoperative mortality within 6 months after surgical resection for hepatocellular carcinoma: an international multicenter study

Author

Liang, Lei, Quan, Bing, Wu, Han, Diao, Yong-Kang, Li, Jie, Chen, Ting-Hao, Zhang, Yao-Ming, Zhou, Ya-Hao, Zhang, Wan-Guang, Wang, Hong, Serenari, Matteo, Cescon, Matteo, Schwartz, Myron, Zeng, Yong-Yi, Liang, Ying-Jian, Jia, Hang-Dong, Xing, Hao, Li, Chao, Wang, Ming-Da, Yan, Wen-Tao, Chen, Wan-Yuan, Lau, Wan Yee, Zhang, Cheng-Wu, Pawlik, Timothy M., Huang, Dong-Sheng, Shen, Feng, and Yang, Tian

Published
2021
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50. ASO Visual Abstract: Association of Preoperative Body Mass Index with Surgical Textbook Outcomes following Hepatectomy for Hepatocellular Carcinoma: A Multicenter Study of 1206 Patients

Author

Liu, Zhi-Peng, Yao, Lan-Qing, Diao, Yong-Kang, Chen, Zi-Xiang, Feng, Zi-Han, Gu, Wei-Min, Chen, Zheng-Liang, Chen, Ting-Hao, Zhou, Ya-Hao, Wang, Hong, Xu, Xin-Fei, Wang, Ming-Da, Li, Chao, Liang, Lei, Zhang, Cheng-Wu, Pawlik, Timothy M., Lau, Wan Yee, Shen, Feng, Chen, Zhi-Yu, and Yang, Tian

Published
2022
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