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3. Low polymorphisms in pfact, pfugt and pfcarl genes in African Plasmodium falciparum isolates and absence of association with susceptibility to common anti-malarial drugs

Author

Foguim, Francis Tsombeng, Robert, Marie Gladys, Gueye, Mamadou Wagué, Gendrot, Mathieu, Diawara, Silman, Mosnier, Joel, Amalvict, Rémy, Benoit, Nicolas, Bercion, Raymond, Fall, Bécaye, Madamet, Marylin, Pradines, Bruno, and The French National Reference Centre for Imported Malaria Study Group

Published
2019
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4. Absence of association between polymorphisms in the pfcoronin and pfk13 genes and the presence of Plasmodium falciparum parasites after treatment with artemisinin derivatives in Senegal

Author

Delandre, Océane, primary, Daffe, Sokhna M., additional, Gendrot, Mathieu, additional, Diallo, Maguette N., additional, Madamet, Marylin, additional, Kounta, Mame B., additional, Diop, Moustapha N., additional, Bercion, Raymond, additional, Sow, Abdou, additional, Ngom, Papa M., additional, Lo, Gora, additional, Benoit, Nicolas, additional, Amalvict, Rémy, additional, Fonta, Isabelle, additional, Mosnier, Joel, additional, Diawara, Silman, additional, Wade, Khalifa A., additional, Fall, Mansour, additional, Fall, Khadidiatou B., additional, Fall, Bécaye, additional, and Pradines, Bruno, additional

Published
2020
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5. Modulation of in vitro antimalarial responses by polymorphisms in Plasmodium falciparum ABC transporters (pfmdr1 and pfmdr5)

Author

Gendrot, Mathieu, primary, Wague Gueye, Mamadou, additional, Tsombeng Foguim, Francis, additional, Madamet, Marylin, additional, Wade, Khalifa Ababacar, additional, Bou Kounta, Mame, additional, Fall, Mansour, additional, Diawara, Silman, additional, Benoit, Nicolas, additional, Lo, Gora, additional, Bercion, Raymond, additional, Amalvict, Rémy, additional, Mosnier, Joel, additional, Fall, Bécaye, additional, Briolant, Sébastien, additional, Diatta, Bakary, additional, and Pradines, Bruno, additional

Published
2019
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6. Baseline Ex Vivo and Molecular Responses of Plasmodium falciparum Isolates to Piperaquine before Implementation of Dihydroartemisinin-Piperaquine in Senegal

Author

Robert, Marie Gladys, primary, Foguim Tsombeng, Francis, additional, Gendrot, Mathieu, additional, Diawara, Silman, additional, Madamet, Marylin, additional, Kounta, Mame Bou, additional, Wade, Khalifa Ababacar, additional, Fall, Mansour, additional, Gueye, Mamadou Wague, additional, Benoit, Nicolas, additional, Nakoulima, Aminata, additional, Bercion, Raymond, additional, Amalvict, Rémy, additional, Fall, Bécaye, additional, Wade, Boubacar, additional, Diatta, Bakary, additional, and Pradines, Bruno, additional

Published
2019
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7. Confirmation of Plasmodium falciparum in vitro resistance to monodesethylamodiaquine and chloroquine in Dakar, Senegal, in 2015

Author

Diawara, Silman, primary, Madamet, Marylin, additional, Kounta, Mame Bou, additional, Lo, Gora, additional, Wade, Khalifa Ababacar, additional, Nakoulima, Aminata, additional, Bercion, Raymond, additional, Amalvict, Rémy, additional, Gueye, Mamadou Wague, additional, Fall, Bécaye, additional, Diatta, Bakary, additional, and Pradines, Bruno, additional

Published
2017
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8. Association between Polymorphisms in the Pf mdr6 Gene and Ex Vivo Susceptibility to Quinine in Plasmodium falciparum Parasites from Dakar, Senegal

Author

Gendrot, Mathieu, primary, Diawara, Silman, additional, Madamet, Marylin, additional, Kounta, Mame Bou, additional, Briolant, Sébastien, additional, Wade, Khalifa Ababacar, additional, Fall, Mansour, additional, Benoit, Nicolas, additional, Nakoulima, Aminata, additional, Amalvict, Rémy, additional, Diémé, Yaya, additional, Fall, Bécaye, additional, Wade, Boubacar, additional, Diatta, Bakary, additional, and Pradines, Bruno, additional

Published
2017
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9. Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal

Author

Gendrot, Mathieu, primary, Fall, Bécaye, additional, Madamet, Marylin, additional, Fall, Mansour, additional, Wade, Khalifa Ababacar, additional, Amalvict, Rémy, additional, Nakoulima, Aminata, additional, Benoit, Nicolas, additional, Diawara, Silman, additional, Diémé, Yaya, additional, Diatta, Bakary, additional, Wade, Boubacar, additional, and Pradines, Bruno, additional

Published
2016
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10. High-quality draft genome sequence and description of Haemophilus massiliensis sp. nov.

Author

Lo, Cheikh Ibrahima, primary, Sankar, Senthil Alias, additional, Fall, Bécaye, additional, Sambe-Ba, Bissoume, additional, Diawara, Silman, additional, Gueye, Mamadou Wague, additional, Mediannikov, Oleg, additional, Blanc-Tailleur, Caroline, additional, Wade, Boubacar, additional, Raoult, Didier, additional, Fournier, Pierre-Edouard, additional, and Fenollar, Florence, additional

Published
2016
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11. MALDI-TOF Mass Spectrometry: A Powerful Tool for Clinical Microbiology at Hôpital Principal de Dakar, Senegal (West Africa)

Author

Lo, Cheikh I., primary, Fall, Bécaye, additional, Sambe-Ba, Bissoume, additional, Diawara, Silman, additional, Gueye, Mamadou W., additional, Mediannikov, Oleg, additional, Sokhna, Cheikh, additional, Faye, Ngor, additional, Diemé, Yaya, additional, Wade, Boubacar, additional, Raoult, Didier, additional, and Fenollar, Florence, additional

Published
2015
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13. The Ongoing Revolution of MALDI-TOF Mass Spectrometry for Microbiology Reaches Tropical Africa

Author

Fall, Bécaye, primary, Raoult, Didier, additional, Diawara, Silman, additional, Mediannikov, Oleg, additional, Chatellier, Sonia, additional, Samb-Ba, Bissoume, additional, Fenollar, Florence, additional, Gueye, Mamadou Wague, additional, Sow, Kowry, additional, Wade, Boubacar, additional, Sokhna, Cheikh, additional, Perrot, Nadine, additional, Aubadie-Ladrix, Maxence, additional, Diemé, Yaya, additional, and Lo, Cheikh Ibrahima, additional

Published
2015
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15. Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex VivoSusceptibility to Conventional Antimalarial Drugs in Plasmodium falciparumIsolates from Dakar, Senegal

Author

Gendrot, Mathieu, Fall, Bécaye, Madamet, Marylin, Fall, Mansour, Wade, Khalifa Ababacar, Amalvict, Rémy, Nakoulima, Aminata, Benoit, Nicolas, Diawara, Silman, Diémé, Yaya, Diatta, Bakary, Wade, Boubacar, and Pradines, Bruno

Abstract

ABSTRACTThe RING E3 ubiquitin protein ligase is crucial for facilitating the transfer of ubiquitin. The only polymorphism identified in the E3 ubiquitin protein ligase gene was the D113N mutation (62.5%) but was not significantly associated with the 50% inhibitory concentration (IC50) of conventional antimalarial drugs. However, some mutated isolates (D113N) present a trend of reduced susceptibility to piperaquine (P= 0.0938). To evaluate the association of D113N polymorphism with susceptibility to antimalarials, more isolates are necessary.

Published
2016
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16. Baseline Ex Vivoand Molecular Responses of Plasmodium falciparumIsolates to Piperaquine before Implementation of Dihydroartemisinin-Piperaquine in Senegal

Author

Robert, Marie Gladys, Foguim Tsombeng, Francis, Gendrot, Mathieu, Diawara, Silman, Madamet, Marylin, Kounta, Mame Bou, Wade, Khalifa Ababacar, Fall, Mansour, Gueye, Mamadou Wague, Benoit, Nicolas, Nakoulima, Aminata, Bercion, Raymond, Amalvict, Rémy, Fall, Bécaye, Wade, Boubacar, Diatta, Bakary, and Pradines, Bruno

Abstract

Dihydroartemisinin-piperaquine, which was registered in 2017 in Senegal, is not currently used as the first-line treatment against uncomplicated malaria. A total of 6.6% to 17.1% of P. falciparumisolates collected in Dakar in 2013 to 2015 showed ex vivo-reduced susceptibility to piperaquine.

Published
2019
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17. Association between Polymorphisms in the Pfmdr6Gene and Ex VivoSusceptibility to Quinine in Plasmodium falciparumParasites from Dakar, Senegal

Author

Gendrot, Mathieu, Diawara, Silman, Madamet, Marylin, Kounta, Mame Bou, Briolant, Sébastien, Wade, Khalifa Ababacar, Fall, Mansour, Benoit, Nicolas, Nakoulima, Aminata, Amalvict, Rémy, Diémé, Yaya, Fall, Bécaye, Wade, Boubacar, Diatta, Bakary, and Pradines, Bruno

Abstract

ABSTRACTPolymorphisms and the overexpression of transporter genes, especially of the ATP-binding cassette superfamily, have been involved in antimalarial drug resistance. The objective of this study was to use 77 Senegalese Plasmodium falciparumisolates to evaluate the association between the number of Asn residues in the polymorphic microsatellite region of the Plasmodium falciparummultidrug resistance 6 gene (Pfmdr6) and the ex vivosusceptibility to antimalarials. A significant association was observed between the presence of 7 or 9 Asn repeats and reduced susceptibility to quinine.

Published
2017
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