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5. SARS-CoV-2 vaccine booster in solid organ transplant recipients previously immunised with inactivated versus mRNA vaccines: A prospective cohort study

Author

Dib, Martín, Le Corre, Nicole, Ortiz, Catalina, García, Daniel, Ferrés, Marcela, Martinez-Valdebenito, Constanza, Ruiz-Tagle, Cinthya, Ojeda, María José, Espinoza, Manuel A., Jara, Aquiles, Arab, Juan Pablo, Rabagliati, Ricardo, Vizcaya, Cecilia, Ceballos, María Elena, Sarmiento, Mauricio, Mondaca, Sebastián, Viñuela, Macarena, Pastore, Antonia, Szwarcfiter, Vania, Galdames, Elizabeth, Barrera, Aldo, Castro, Pablo, Gálvez, Nicolás MS, Soto, Jorge A., Bueno, Susan M., Kalergis, Alexis M., Nervi, Bruno, and Balcells, M. Elvira

Published
2022
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16. INDICACIONES INHABITUALES DE TRASPLANTE HEPÁTICO. RESULTADOS

Author

Troncoso, Andres, primary, Briceño, Eduardo, additional, Cancino, Alejandra, additional, Dellepiane, Paulina, additional, Soriano, Humberto, additional, Gana, Juan Cristóbal, additional, Benítez, Carlos, additional, Wolff, Rodrigo, additional, Barrera, Francisco, additional, Montaña, Rodrigo, additional, Concha, Mario, additional, Pattilo, Juan Carlos, additional, Jarufe, Nicolás, additional, Guerra, Juan Francisco, additional, Dib, Martin, additional, and Martínez, Jorge, additional

Published
2020
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17. Current status of liver transplantation in Latin America

Author

Contreras, Alan G., primary, McCormack, Lucas, additional, Andraus, Wellington, additional, de Souza M Fernandes, Eduardo, additional, Contreras, Alan G., additional, Fernandes, Eduardo de Souza M., additional, Requejo, Alejandro Serrablo, additional, Jarufe, Nicolás, additional, Dib, Martin, additional, Carrasco, Felix, additional, Harguindeguy, Martin, additional, Garbanzo, Jose Pablo, additional, Serpa, Frans, additional, Gimenez, Alejandro, additional, Villaroel, Ricardo, additional, and Vera, Alonso, additional

Published
2020
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18. Reply

Author

Benítez, Carlos, primary, Inzunza, Martin, additional, Dib, Martin, additional, Garrido, Marcelo, additional, and Martínez, Jorge A., additional

Published
2020
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19. Living Donor Liver Transplantation for Imatinib‐Resistant Gastrointestinal Stromal Tumor Liver Metastases: A New Therapeutic Option in Transplant Oncology

Author

Benítez, Carlos, primary, Inzunza, Martin, additional, Riveros, Sergio, additional, Rivas, Violeta, additional, Garrido, Marcelo, additional, Dib, Martin, additional, Barrera, Francisco, additional, Arab, Juan P., additional, Torres, Javiera, additional, Cortinez, Luis I., additional, Briceño, Eduardo, additional, Guerra, Juan F., additional, Fernandes, Eduardo, additional, and Martínez, Jorge A., additional

Published
2020
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24. Liver Transplantation Without Venovenous Bypass: Does Surgical Approach Matter?

Author

Barbas, Andrew S., primary, Levy, Jordan, additional, Mulvihill, Michael S., additional, Goldaracena, Nicolas, additional, Dib, Martin J., additional, Al-Adra, David P., additional, Cattral, Mark S., additional, Ghanekar, Anand, additional, Greig, Paul D., additional, Grant, David R., additional, Sapisochin, Gonzalo, additional, Selzner, Markus, additional, McCluskey, Stuart A., additional, and McGilvray, Ian D., additional

Published
2018
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25. Early Intervention With Live Donor Liver Transplantation Reduces Resource Utilization in NASH: The Toronto Experience

Author

Barbas, Andrew S., primary, Goldaracena, Nicolas, additional, Dib, Martin J., additional, Al-Adra, David P., additional, Aravinthan, Aloysious D., additional, Lilly, Leslie B., additional, Renner, Eberhard L., additional, Selzner, Nazia, additional, Bhat, Mamatha, additional, Cattral, Mark S., additional, Ghanekar, Anand, additional, McGilvray, Ian D., additional, Sapisochin, Gonzalo, additional, Selzner, Markus, additional, Greig, Paul D., additional, and Grant, David R., additional

Published
2017
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26. Treatment with Optifast reduces hepatic steatosis and increases candidacy rates for living donor liver transplantation

Author

Doyle, Adam, primary, Adeyi, Oyedele, additional, Khalili, Korosh, additional, Fischer, Sandra, additional, Dib, Martin, additional, Goldaracena, Nicolas, additional, Dillon, Jayne, additional, Grant, David, additional, Cattral, Mark, additional, McGilvray, Ian, additional, Greig, Paul, additional, Ghanekar, Anand, additional, Lilly, Leslie, additional, Renner, Eberhard, additional, Levy, Gary, additional, and Selzner, Nazia, additional

Published
2016
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28. The extended Toronto criteria for liver transplantation in patients with hepatocellular carcinoma: A prospective validation study

Author

Sapisochin, Gonzalo, primary, Goldaracena, Nicolas, additional, Laurence, Jerome M., additional, Dib, Martin, additional, Barbas, Andrew, additional, Ghanekar, Anand, additional, Cleary, Sean P., additional, Lilly, Les, additional, Cattral, Mark S., additional, Marquez, Max, additional, Selzner, Markus, additional, Renner, Eberhard, additional, Selzner, Nazia, additional, McGilvray, Ian D., additional, Greig, Paul D., additional, and Grant, David R., additional

Published
2016
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30. Specific Activin Receptor–Like Kinase 3 Inhibitors Enhance Liver Regeneration

Author

Tsugawa, Daisuke, primary, Oya, Yuki, additional, Masuzaki, Ryota, additional, Ray, Kevin, additional, Engers, Darren W., additional, Dib, Martin, additional, Do, Nhue, additional, Kuramitsu, Kaori, additional, Ho, Karen, additional, Frist, Audrey, additional, Yu, Paul B., additional, Bloch, Kenneth D., additional, Lindsley, Craig W., additional, Hopkins, Corey R., additional, Hong, Charles C., additional, and Karp, Seth J., additional

Published
2014
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36. BMP4 is a novel paracrine inhibitor of liver regeneration.

Author

Nhue Do, Rong Zhao, Ray, Kevin, Ho, Karen, Dib, Martin, Xianghui Ren, Kuzontkoski, Paula, Terwilliger, Ernest, and Karp, Seth J.

Abstract

Transforming growth factor (TGF)-β family members exert strong effects on restoration of liver mass after injury. Bone morphogenetic proteins (BMPs) are members of the TGF-β family and are found in the liver, suggesting that these proteins may play a role in liver regeneration. We examined BMP signaling in the liver during hepatectomy. We found that BMP4 is constitutively expressed in the peribiliary stroma and endothelial cells of the liver and that expression is decreased after hepatectomy. Mice driven to maintain BMP4 expression in the liver display inhibited hepatocyte proliferation and restoration of liver mass after hepatectomy, suggesting that reduced BMP4 is necessary for normal regeneration. Consistent with this finding, hepatocyte-specific deletion of the BMP receptor activin receptor-like kinase 3 (Alk3) enhances regeneration and reduces phosphorylation of SMAD1/5/8, a transducer of BMP signaling. In contrast to experiments in wild-type mice, maintaining BMP4 levels has no effect on liver regeneration in hepatocyte-specific Alk3 null mice, providing evidence that BMP4 signals through Alk3 to inhibit liver regeneration. Consistent with these findings, the BMP4 antagonist Noggin enhances regeneration. Furthermore, high-dose BMP4 inhibits proliferation of primary hepatocytes and HepG2 cells in culture. These findings elucidate a new, potentially clinically relevant paradigm in which a constitutively expressed paracrine inhibitory factor plays a critical role in liver regeneration. [ABSTRACT FROM AUTHOR]

Published
2012
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37. [Liver transplantation for non-resectable colorectal liver metastases: A review].

Author

García D, Rebolledo P, Achurra P, Briceño E, Viñuela E, Mondaca S, Arab JP, Martínez J, Nervi B, and Dib M

Subjects
Humans, Hepatectomy methods, Liver Transplantation methods, Colorectal Neoplasms diagnosis, Liver Neoplasms surgery, Liver Neoplasms pathology
Abstract

In Chile, colorectal cancer ranks third in incidence and fifth in mortality. Half of these patients have liver metastases at the diagnosis, and only 30% of them are resectable. Despite the development of many complex hepatobiliary procedures to achieve the total resection of metastases, the long-term survival with these techniques is not good. Liver transplantation is an alternative to treat unresectable liver metastasis from colorectal cancer with a good outcome. Several prognostic scores allow the selection of patients with good tumor biology. These patients have better overall and disease-free survival after liver transplantation. The use of immunosuppressive treatment doesn't increase recurrence, and even the pattern of tumor growth is slower in liver transplant recipients. The purpose of this review is to summarize the current evidence in this topic and to highlight the need for a formal protocol for liver transplantation for unresectable colorectal liver metastases, using living donors or marginal grafts to avoid competition with the rest of the national waiting list.

Published
2022
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38. BMP4 is a novel paracrine inhibitor of liver regeneration.

Author

Do N, Zhao R, Ray K, Ho K, Dib M, Ren X, Kuzontkoski P, Terwilliger E, and Karp SJ

Subjects
Animals, Bone Morphogenetic Protein 4 biosynthesis, Bone Morphogenetic Protein Receptors, Type I genetics, Dependovirus physiology, Hep G2 Cells, Hepatectomy, Humans, Mice, Smad1 Protein metabolism, Bone Morphogenetic Protein 4 physiology, Liver Regeneration drug effects
Abstract

Transforming growth factor (TGF)-β family members exert strong effects on restoration of liver mass after injury. Bone morphogenetic proteins (BMPs) are members of the TGF-β family and are found in the liver, suggesting that these proteins may play a role in liver regeneration. We examined BMP signaling in the liver during hepatectomy. We found that BMP4 is constitutively expressed in the peribiliary stroma and endothelial cells of the liver and that expression is decreased after hepatectomy. Mice driven to maintain BMP4 expression in the liver display inhibited hepatocyte proliferation and restoration of liver mass after hepatectomy, suggesting that reduced BMP4 is necessary for normal regeneration. Consistent with this finding, hepatocyte-specific deletion of the BMP receptor activin receptor-like kinase 3 (Alk3) enhances regeneration and reduces phosphorylation of SMAD1/5/8, a transducer of BMP signaling. In contrast to experiments in wild-type mice, maintaining BMP4 levels has no effect on liver regeneration in hepatocyte-specific Alk3 null mice, providing evidence that BMP4 signals through Alk3 to inhibit liver regeneration. Consistent with these findings, the BMP4 antagonist Noggin enhances regeneration. Furthermore, high-dose BMP4 inhibits proliferation of primary hepatocytes and HepG2 cells in culture. These findings elucidate a new, potentially clinically relevant paradigm in which a constitutively expressed paracrine inhibitory factor plays a critical role in liver regeneration.

Published
2012
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39. Tob1 is a constitutively expressed repressor of liver regeneration.

Author

Ho KJ, Do NL, Otu HH, Dib MJ, Ren X, Enjyoji K, Robson SC, Terwilliger EF, and Karp SJ

Subjects
Animals, CCAAT-Enhancer-Binding Protein-alpha metabolism, Carrier Proteins genetics, Cell Proliferation, Cyclin-Dependent Kinases metabolism, Cyclins metabolism, Dependovirus genetics, Exoribonucleases, Gene Expression Regulation, Gene Regulatory Networks, Hepatectomy, Hepatocytes metabolism, Hepatocytes pathology, Intracellular Signaling Peptides and Proteins, Liver enzymology, Liver pathology, Mice, Mice, Inbred C57BL, Organ Size, Protein Binding, Proteins metabolism, RNA, Messenger genetics, RNA, Messenger metabolism, Ribonucleases, Signal Transduction genetics, Smad Proteins metabolism, Transcription, Genetic, Carrier Proteins metabolism, Liver Regeneration physiology, Repressor Proteins metabolism
Abstract

How proliferative and inhibitory signals integrate to control liver regeneration remains poorly understood. A screen for antiproliferative factors repressed after liver injury identified transducer of ErbB2.1 (Tob1), a member of the PC3/BTG1 family of mito-inhibitory molecules as a target for further evaluation. Tob1 protein decreases after 2/3 hepatectomy in mice secondary to posttranscriptional mechanisms. Deletion of Tob1 increases hepatocyte proliferation and accelerates restoration of liver mass after hepatectomy. Down-regulation of Tob1 is required for normal liver regeneration, and Tob1 controls hepatocyte proliferation in a dose-dependent fashion. Tob1 associates directly with both Caf1 and cyclin-dependent kinase (Cdk) 1 and modulates Cdk1 kinase activity. In addition, Tob1 has significant effects on the transcription of critical cell cycle components, including E2F target genes and genes involved in p53 signaling. We provide direct evidence that levels of an inhibitory factor control the rate of liver regeneration, and we identify Tob1 as a crucial check point molecule that modulates the expression and activity of cell cycle proteins.

Published
2010
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