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The article discusses the high risk of lower extremity amputations in patients with lower limb infection or ulceration. Topics discussed include the topical wound healing agents approved by the Food and Drug Administration (FDA) which are Apligraf, Dermagraft, and Becaplermin, common complications including poor healing lower extremity ulcers, bone and soft tissue infections, and diabetes, and peripheral arterial disease (PAD) as a leading cause of lower extremity amputation.

The article discusses the opportunities presented by collaborations between various medical personnel on reducing diabetic morbidity. Topics discussed include the concept behind the increasingly popular limb preservation program practiced by several organizations, the role played by sedentary lifestyle and greater consumption of energy-rich food to the growth of obesity and diabetes and the success seen by Great Britain with multidisciplinary diabetic teams.