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Background: Hypertension is increasingly prevalent globally. Pre-hypertension is associated with cardiovascular mortality but often overlooked, particularly in sub-Saharan Africa, where healthcare resources are limited. The Dietary Inflammatory Index (DII) evaluates the inflammatory potential of dietary patterns, which may influence pre-hypertension risk. This study aims to investigate the relationship between DII and pre-hypertension among adults, highlighting the need for effective dietary interventions. Methods: A muti-center cross sectional study involving 284 adult non-hypertensive patients was conducted in Nigeria and the Democratic Republic of Congo (DRC). Dietary habits were assessed using the Dietary Inflammatory Index (DII), while pre-hypertension was assessed using auscultatory method with a sphygmomanometer and stethoscope, following recommended guidelines. Data analysis included descriptive statistics, chi-square tests, and logistic regression. Results: Of 279 respondents who completed the study, 56.3% had pre-hypertension while 48.4% had high DII (pro-inflammatory). Prevalence varied across age groups, ethnicities, and study sites. Although, DII did not significantly predict pre-hypertension in this study, underweight (aOR = 0.26, CI = 0.07–0.98, p = 0.047), and younger age (aOR = 0.25, CI = 0.08–0.74, p = 0.013), were independently associated with reduced pre-hypertension risk. Conclusion: Pre-hypertension is common among adults in Nigeria and DRC. Dietary inflammatory index did not influence pre-hypertension; however, age and BMI are critical factors that influence the risk of pre-hypertension. [ABSTRACT FROM AUTHOR]

Background: The worldwide incidence of non-alcoholic fatty liver disease (NAFLD) is a pressing health issue, with chronic inflammation critically influencing its development. The Dietary Inflammatory Index (DII) measures the inflammatory potential of one's diet. Our study aimed to investigate the association between DII and fatty liver disease in obese and non-obese individuals. Methods: Data from the 1999–-2001 National Health and Nutrition Examination Survey (NHANES), encompassing 3456 adults aged 20 years and above, were utilized for the analysis. The multivariable analysis assessed the correlation between DII, NAFLD, and obesity while adjusting for demographic variables. The restricted cubic spline (RCS) method was also applied with restricted degrees of freedom to establish a non-linear relationship model between DII and NAFLD. Results: Our study demonstrated significant differences across DII tertiles in various demographic and clinical characteristics. An increase in t DII score by one standard deviation resulted in a 21% increase in the fatty liver risk. This association persisted after adjusting for age, sex, and other covariates. The risk of fatty liver disease increased significantly by 39% in the highest DII tertile. Regression analysis revealed a non-linear correlation between DII and the risk of fatty liver in obese adults. The subgroup analysis showed consistent findings across all subgroups, with particularly strong associations in specific demographic categories. Conclusions: Our findings suggest a significant association between the DII score and risk of fatty liver disease, particularly in obese individuals. These results underscore the potential role of diet-induced inflammation in pathogenesis of NAFLD. [ABSTRACT FROM AUTHOR]

Background and aims: The pathogenic mechanism of sedentary behavior involves chronic inflammation, which can be affected by dietary inflammation. This study aimed to determine the association between dietary inflammation, sedentary behavior, and risk of death. Methods: Data from the National Health and Nutrition Examination Survey (2007–2018) were analyzed. Sedentary behavior was evaluated using self-reported sitting hours in a day, and dietary inflammation was assessed using dietary inflammatory index (DII). Deaths were ascertained through the National Death Index until December 31, 2019. The interaction between dietary inflammation and sedentary behavior was evaluated through multivariable Cox regression analysis. Results: 18,425 participants (mean age: 48.2 years; female proportion, 51.7%) were involved for analysis. During a median follow-up of 7.7 years, we confirmed 1,960 all-cause and 488 cardiovascular deaths. After adjustment for confounders, both pro-inflammatory diets and sitting for 6 h/d or more were risk factors for all-cause and cardiovascular deaths (P < 0.05). Of note, we found that dietary inflammation modified the association between sitting time and the risk of all-cause deaths (P for interaction = 0.03). Compared with shorter sitting time (< 6 h/d), prolonged sitting time (≥ 6 h/d) was correlated with an elevated risk of all-cause deaths among participants with pro-inflammatory diets (DII ≥ 0) (HR: 1.50, 95%CI: 1.35–1.66, P < 0.001), but not among participants with anti-inflammatory diets (DII < 0) (HR: 1.20, 95%CI: 0.98–1.46, P = 0.08). Conclusions: Dietary inflammation modified the association between sedentary behavior and the risk of all-cause deaths. Anti-inflammatory diets might mitigate the detrimental effects of sedentary behavior on survival in US adults. [ABSTRACT FROM AUTHOR]

Chronic inflammation is known to play a critical role in the development of various diseases, such as osteoporosis. The inflammatory potential of a diet can be evaluated using a well-established scale known as the Dietary Inflammatory Index (DII). This study aimed to investigate the relationship between the DII score and the odds of osteoporosis in Iranian women. The study conducted was a case-control study involving 131 postmenopausal healthy women, as well as 131 women with osteoporosis and osteopenia aged 45–65. Osteoporosis was diagnosed through dual-energy X-ray absorptiometry, which measures bone mineral density (BMD) in the femoral neck bone and lumbar spine. To assess the DII score, a validated semi-quantitative food frequency questionnaire was applied. In comparison to the first tertile of DII score, higher and significant odds of osteoporosis/osteopenia were seen in the last tertile (fully adjusted model (body mass index, age, income, education, physical activity, calcium and vitamin D supplements): odds ratio (OR) = 2.43, 95% confidence interval (CI): 1.19–4.95, Ptrend = 0.023). Also, individuals in the highest DII tertile had higher odds of abnormalities in femoral neck and lumbar spine BMD (fully adjusted model: OR = 2.85, 95% CI: 1.37–5.89, Ptrend = 0.007 and OR = 2.59, 95% CI: 1.29–5.19, Ptrend = 0.009, respectively). Based on our findings, it appears that there may be a connection between following pro-inflammatory diets and the odds of osteoporosis in postmenopausal women. [ABSTRACT FROM AUTHOR]

Introduction: To examine the association between dietary inflammatory index (DII) and risk of gestational diabetes mellitus (GDM). Methods: A prospective birth cohort study was conducted in Iran. During the first trimester of pregnancy, food intake was measured using a food frequency questionnaire. Each participant's DII score was calculated, and then, the Cox proportional hazard model was used to calculate the hazard ratio (HR) and 95% CI of GDM across the quartiles of DII. We systematically searched the literature to conduct a meta-analysis of observational studies (PROSPERO: CRD42022331703). To estimate the summary relative risk for the highest versus lowest category of DII, a random-effects meta-analysis was performed. The certainty of evidence was assessed using the GRADE approach. Results: In the prospective cohort study (n = 635 pregnant mothers), the multivariable HRs of GDM for the third and fourth quartiles of DII were 2.98 (95%CI: 1.98, 6.46) and 2.72 (95%CI: 1.11, 6.63), respectively. Based on a meta-analysis of six prospective cohorts and a case-control study (1014 cases of GDM in 7027 pregnant mothers), being in the highest category of the DII was associated with a 27% higher risk of GDM (relative risk: 1.27, 95%CI: 1.01, 1.59; I2 = 50%; low certainty of evidence). A dose-response meta-analysis suggested a positive monotonic association between DII and GDM risk. Conclusions: Our prospective cohort demonstrated a positive correlation between GDM risk and the inflammatory potential of diet in the first trimester of pregnancy. The results need to be confirmed by larger cohort studies. Clinical trial number: Not applicable. [ABSTRACT FROM AUTHOR]

Context Dietary components or its overall properties can influence an individual's sleep status. Objective The aim for this study was to critically search, appraise, and synthesize research evidence on the association between dietary inflammatory index (DII) and sleep quality and its parameters. Data Sources Original published studies on adults were obtained from the PubMed, SCOPUS, ScienceDirect, Cochrane Library, and Google Scholar databases. Data Extraction The search was conducted without date limitation until April 2023. Duplicated and irrelevant investigations were screened out, and the results of the remaining articles were descriptively summarized, then critically appraised and analyzed. Possible mechanistic pathways regarding diet, systemic inflammation, and sleep status were discussed. Data Analysis Of the 102 studies searched, 23 articles (n = 4 cohort studies, 18 cross-sectional studies, and 1 intervention study) were included in the final review. The association between DII and sleep status was investigated subjectively in 21 studies and objectively in 6 studies. The main studied sleep outcomes were sleep quality, duration, latency, efficiency, apnea, disturbances, the use of sleeping medications, daytime dysfunctions, wakefulness after sleep onset, and rapid eye movement. Conclusions According to most of the evidence, DII may not be related to overall sleep quality, sleep duration, latency, efficiency, and the use of sleeping medications. The evidence of positive association was greater between a high DII score (pro-inflammatory diet) with daytime dysfunctions, wakefulness after sleep onset, and sleep apnea. There is insufficient evidence to make any conclusion regarding sleep disturbances and rapid eye movement. [ABSTRACT FROM AUTHOR]

Background: Sarcopenia associated with aging severely affects the quality of life of the elderly; diets have been shown to elicit an inflammatory response in the body, and diets that promote inflammation may lead to damage to muscles. The Dietary Inflammatory Index (DII) has been developed to quantify the inflammatory potential of individual diets. Therefore, this study aimed to investigate the association between the DII, sarcopenia and its components in elderly Chinese people. Methods: In this study, data were obtained from the China Nutrition Improvement Strategies and Applications for the Elderly Research Programme. An assessment of sarcopenia was carried out according to the Asian Working Group on Sarcopenia's (AWGS2019) criteria. The DII was calculated using food intake data obtained using the FFQ method, and then the quartile method was used to categorize the subjects into four groups. Multifactor logistic regression was conducted to examine the associations between DII, sarcopenia and its components. Results: This study included 993 subjects over the age of 65, and the prevalence of sarcopenia was 20.2%. The mean DII score of the study population was 0.99 ± 0.1. After adjusting for the confounders age, gender, marital status, and educational level, the risk of sarcopenia was 1.66 times higher in group Q4 than in group Q1 (p-trend < 0.05). However, this relationship is not statistically significant when other more confounding factors are added. Nevertheless, when further analyzing the relationship between DII and sarcopenia components, it was found that after adjusting the model, a higher DII was associated with a risk of muscle strength loss (OR = 1.65, p-trend < 0.05). Conclusions: Higher DII scores increase the risk of muscle strength loss in older adults. By guiding older adults to adopt a more anti-inflammatory diet, muscle health can be improved in terms of increased muscle strength. Further cohort or interventional studies are necessary to validate our findings. [ABSTRACT FROM AUTHOR]

Background: Given global changes in the environment and dietary habits, it is critical to understand the potential impact of dietary factors and dietary inflammation on respiratory diseases, including COPD. Studying these relationships can help develop more effective prevention strategies. PHDI is a dietary scoring system designed to balance human health and environmental sustainability by promoting increased consumption of plant-based foods and reduced intake of red meat, sugar, and highly processed foods. In contrast, DII quantifies the inflammatory potential of a diet. This study examines the association between PHDI and COPD and assesses whether DII mediates this relationship. Methods: We used subgroup analysis, smooth curve fitting, and multivariable logistic regression to investigate the connection between PHDI and the occurrence of COPD. Furthermore, a mediation analysis was carried out to investigate any possible correlation between DII and the link between PHDI and COPD. Results: 30,304 participants were included in this investigation, and 1,498 of them reported COPD events. For every 10-point increase in PHDI and each unit increase in DII was associated with a 9% reduction (OR = 0.91, 95% CI: 0.86, 0.97) and an 8% increase (OR = 1.08, 95% CI: 1.02, 1.13) in the prevalence of COPD, respectively, when all variables were adjusted for using multivariable logistic regression. Additionally, the results remain robust when PHDI and DII are converted to tertile. An investigation of smooth curve fitting showed a linear correlation between the risk of COPD and PHDI. The results of the mediation analysis showed that 17.95% of the relationship between PHDI and COPD was mediated by DII (p = 0.034). Conclusions: Higher PHDI levels are associated with a lower prevalence of COPD. Additionally, DII appears to mediate this relationship, suggesting that an anti-inflammatory diet may provide benefits. [ABSTRACT FROM AUTHOR]

The dietary inflammatory index (DII) is a common grading system for diet inflammatory potential. Recent investigations link DII to hematopoietic malignancies. However, the relationship between DII and Multiple myeloma (MM) is unknown. DII and MM were examined in a present case–control study of Iranian adults. This case–controlstudy was conducted on adults aged 20 to 75 years, selecting 149 cases with newly diagnosed multiple myeloma and 359 healthy individuals. Dietary assessment was conducted using a validated semi-quantitative food frequency questionnaire (FFQ) including 154 items, and energy-adjusted DII scores were calculated to determine the level of inflammatory properties in each individual's diet using 29 dietary parameters. Conditional logistic regression models were used to investigate the relationship between DII and MM. The case group participating in the study was on average 54 years old and mostly male (52.3%). After adjusting for age, sex, and energy intake, we found that individuals with the highest DII scores were significantly less likely to have MM compared to those with the lowest scores (OR: 0.02; 95% CI 0.01, 0.08). Additional adjustment with other confounders confirmed this association (OR: 0.03; 95% CI 0.01, 0.13). This association did not change significantly with further adjustment for BMI (OR: 0.04; 95% CI 0.01, 0.14). In conclusion, our research showed that a pro-inflammatory diet was associated with a significantly higher risk of MM. If our findings are confirmed in other large studies, these data will provide personalized approaches for MM patients, particularly for physicians and registered cancer dietitians. [ABSTRACT FROM AUTHOR]

Background: Persistent inflammation plays a crucial role in the pathogenesis of metabolic dysfunction–associated steatotic liver disease (MASLD). We aimed to scrutinize the associations of diet-induced inflammation with the improvement or worsening of hepatic steatosis and fibrosis in MASLD. Methods: This longitudinal study involved 2,537 participants from the Ravanser Non-Communicable Disease (RaNCD) cohort (2015–2023). Dietary intake was assessed using the 118-item food frequency questionnaire (FFQ), and diet-induced inflammation was determined using the dietary inflammatory index (DII). The AST to platelet ratio index (APRI) and Fibrosis-4 (FIB-4) were used as confirmed predictive indicators for hepatic fibrosis and the hepatic steatosis index (HSI) was used for hepatic steatosis. Results: Adherence to an inflammatory diet independently increases the risk of worsening hepatic steatosis (RR:1.39; 95%CI: 1.02–1.93; P-value: 0.04) and reduces the risk of improving hepatic steatosis (RR: 66; 95% CI: 0.48–0.98; P-value: 0.01) compared to an anti-inflammatory diet. The DII scores did not show any connection to hepatic fibrosis, as determined by FIB-4 (β: − 1.08; 95%CI: − 2.43 to 0.27; P-value: 0.12) and APRI (β: 0.22; 95%CI: − 1.51 to 1.95; P-value: 0.80). Conclusions: These results underscore the importance of dietary composition in managing hepatic steatosis and highlight the need for further research to explore the mechanisms underlying these associations. [ABSTRACT FROM AUTHOR]

Objectives: To investigate the association between the Dietary Inflammatory Index (DII) and osteosarcopenia using nationally representative data. Methods: We utilized data from 1,418 men and women aged ≥ 50 years old participating in Iranian Multicenter Osteoporosis Study (IMOS), a nation-wide, cross-sectional study conducted in 2021. Osteosarcopenia was defined based on standard criteria, considering the presence of both osteopenia/osteoporosis and sarcopenia. We assessed dietary patterns using a semi-quantitative 168-item Food Frequency Questionnaire (FFQ) and calculated energy-adjusted DII (E-DII) scores based on 31 specific food items. Multivariable logistic regression models were used to examine the association between osteosarcopenia and E-DII, adjusting for potential confounders. Nutrient intake calculations were performed using Nutritionist IV software. Results: The mean age of participants was 60.1 (SD = 7.9) years, with 770 (54.3%) being women. The prevalence of osteosarcopenia was 8.8% (95% CI: 7.3-10.6%). Osteosarcopenia was more prevalent among women, older participants, and rural inhabitants. However, the difference was not statistically significant for sex and area of residence. After adjusting for confounders, the odds ratios for osteosarcopenia in the second and third tertiles of E-DII score were 2.23 (95% CI: 1.23–4.05) and 2.47 (95% CI: 1.40–4.37), respectively. Conclusions: Our findings suggest an association between osteosarcopenia and the DII. A healthy low-inflammatory diet may play a crucial role in maintaining musculoskeletal health among the elderly. [ABSTRACT FROM AUTHOR]

Background: Since diet is a known modulator of inflammation, the Dietary Inflammatory Index (DII), which quantifies the inflammatory potential of an individual's diet, becomes a significant parameter to consider. Chronic diarrhea is commonly linked to inflammatory processes within the gut. Thus, this study aimed to explore the potential link between DII and chronic diarrhea. Methods: This research utilized data from the National Health and Nutrition Examination Survey (NHANES) 2005–2010. The DII was calculated according to the average intake of 28 nutrients using information gathered from two 24-hour recall interviews. The Bristol Stool Form Scale (BSFS) was adopted to describe chronic diarrhea, identifying stool Type 6 and Type 7. Multivariate logistic regression models examined the causal connection between DII and chronic diarrhea. Additionally, subgroup analyses and interaction tests were conducted. Results: The study encompassed 11,219 adults, among whom 7.45% reported chronic diarrhea. Initially, multivariate logistic regression analysis revealed a positive association between DII and chronic diarrhea. Nevertheless, this connection lost statistical significance (OR = 1.00; 95% CI, 0.96–1.05; P = 0.8501) after adjusting for all confounding variables. Stratified by sex, the analysis revealed a notable rise in the risk of chronic diarrhea with increasing DII among female participants (all P for trend < 0.05). This tendency remained constant even after full adjustment (P for trend = 0.0192), whereas no significant association was noted in males (all P for trend > 0.05). Furthermore, an L-shaped association emerged between DII and chronic diarrhea, with an inflection point of -1.34. In the population with DII scores below -1.34, each unit increase in DII correlated with a 27% reduction in the probability of chronic diarrhea (OR = 0.73; 95% CI, 0.57–0.93), whereas in the population with DII scores above -1.34, the risk increased by 4% (OR = 1.04; 95% CI, 0.98–1.10). Merely, the gender interaction was shown to be statistically significant based on subgroup analyses and interaction tests. Conclusions: A favorable association between DII and chronic diarrhea exists in adults in the United States. Nevertheless, additional long-term prospective studies are required to confirm and solidify those findings. [ABSTRACT FROM AUTHOR]

Background: Increased levels of inflammation in cancer patients and survivors can make them more prone to muscle wasting and sarcopenia. Diet can be an appropriate treatment for alleviating patient complications. Therefore, this study was performed to determine the association between sarcopenia and its components with the dietary inflammatory index (DII) among breast cancer survivors. Methods: A total of 223 female breast cancer survivors were included in this research at the Cancer Prevention Research Center of Seyyed Al-Shohada Hospital and the Iranian Cancer Control Charity Institute (MACSA). Forty-three items of dietary inflammatory index (DII) were extracted from the Food Frequency Questionnaire. Sarcopenia detection was performed according to the Asian criteria. The linear and binary logistic regression was used to assess the association between sarcopenia and its components with DII. Results: Participants in the highest DII quartile had significantly elevated risk of impaired hand grip strength and calf circumference in both crude and adjusted models. Moreover, individuals consuming a more pro-inflammatory diet displayed a greater risk of abnormal appendicular skeletal muscle index in the crude model. After controlling for potential confounders, participants in the top quartile of DII had a 2.992-fold greater risk of possible sarcopenia than those in the bottom quartile (P value = 0.035). In addition, a decreasing linear trend was observed between higher DII score and 0.059 and 0.349- units lower in appendicular skeletal muscle mass index and hand grip strength variables in the crude Model (P-value < 0.05). Conclusion: Diets with more pro-inflammatory features might be associated with increased risk of possible sarcopenia, as well as its components especially muscle mass and strength in women recovering from breast cancer. [ABSTRACT FROM AUTHOR]

Objective: The pathogenesis of periodontal diseases is partially driven by oxidative stress. However, studies on the relationship between periodontitis and the inflammatory load of diet are still insufficient. Therefore, this study aimed to examine the relationship between the diet's inflammatory load and periodontitis and clinical attachment loss (CAL). Methods: This cross-sectional study included 119 participants diagnosed with periodontitis according to the 1999 classification. The dietary inflammatory index (DII) was calculated using three-day food consumption records and divided into quartiles (Q1, Q2, and Q3). Body mass index (BMI) was calculated as weight and height (kg/m2). Clinical attachment loss (CAL) score was determined, and the patients were grouped with those CAL scores as 7 < CAL and ≥7 CAL. Results: Of the 119 patients with periodontitis, aged 46.24 ± 12.84 years, 45.3% were found to have an anti-inflammatory diet profile (n = 54). When the daily energy and nutrient intake of individuals were examined, it was found that the intake of omega-3 fatty acids (p = 0.004), black tea (p = 0.021), and green pepper (p = 0.029) was higher in those with CAL < 7 compared to those with CAL ≥ 7. There was no relationship between the patients' DII and CAL values. Daily energy, protein, fiber, vitamin A, vitamin E, folic acid, Fe, Zn, and Mg intake in patients with an anti-inflammatory diet in Q1 were higher than in Q2 and Q3 (p < 0.001). Conclusion: This study found no relationship between DII levels and CAL scores. However, it was observed that periodontitis patients following an anti-inflammatory diet had higher intakes of omega-3 fatty acids, vitamins A, E, and C, as well as zinc and magnesium which are nutrients known to be effective against inflammation. These patients also had CAL scores below 7. Therefore, reducing the inflammatory load of the diet may prevent the development of periodontitis, and further research in this regard would be beneficial. [ABSTRACT FROM AUTHOR]

Background: The prevalence of chronic kidney disease (CKD) is estimated to be about 13.4% worldwide. Studies have shown that CKD accounts for up to 2% of the health cost burden. Various factors, such as genetic polymorphisms, metabolic disorders, and unhealthy lifestyles, can contribute to the occurrence of CKD. Therefore, the present study aimed to investigate the relationship between renal function and cardiometabolic risk factors, anthropometric characteristics, and the dietary inflammatory index (DII) in an Iranian population. Methods: This study was conducted on 2472 male and female employees of Shiraz University of Medical Sciences (SUMS), selected through census between 2018 and 2019. In this cross-sectional study, renal function was evaluated using serum creatinine (sCr), blood urea nitrogen (BUN), and estimated glomerular filtration rate (eGFR). Biochemical indices including sCr, BUN, fasting blood sugar (FBS), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) were measured using standard laboratory methods. eGFR was calculated using the Modification of Diet in Renal Disease formula. Systolic (SBP) and diastolic (DBP) blood pressure as well as anthropometric indices such as height (Ht), weight (Wt), hip circumference (HC), waist circumference (WC), body mass index (BMI), conicity index (C-Index), visceral adiposity index (VAI), abdominal volume index (AVI), body adiposity index (BAI), and body shape index (ABSI) were measured and calculated using standard methods and formulas. Diet was evaluated through a 113-item food frequency questionnaire, and the DII was calculated according to its specific instructions. To predict the factors influencing renal function and to remove the impact of confounders, multivariable linear regression was employed using the backward elimination method. Results: There was a significant direct relationship between sCr and FBS, TG, HDL, DBP, Wt, and BAI as well as between BUN and age, TG, HDL, and BAI. In addition, there was a significant inverse relationship between eGFR and SBP, Wt, BAI, and VAI. In women compared to men, sCr and BUN values were significantly lower, while eGFR levels were significantly higher. Conclusions: It seems that age, gender, lipid profile, glycemic status, BP, BAI, VAI, and Wt can be considered factors associated with renal function. [ABSTRACT FROM AUTHOR]

Background: Diet and inflammation are both associated with hypertension. We aimed to investigate the relationship between the dietary inflammation index (DII), dietary patterns, and the risk of hypertension among Xinjiang residents. Methods: A total of 930 residents aged 20–80 from Shihezi and Tumushuk were selected as participants using a stratified whole cluster random sampling method. General demographic information, dietary data, and physical examination results were collected from the participants and DII scores were calculated. Restricted cubic spline was used to analyze the dose–response relationship between the DII and the risk of hypertension. LASSO regression was used to screen dietary factors associated with hypertension. Factor analysis was used to extract dietary patterns. Finally, logistic regression modeling was used to analyze the association between the DII, dietary patterns, and the risk of hypertension. Results: The DII was linearly and positively associated with the risk of developing hypertension. Logistic regression analysis showed that the prevalence of hypertension was 2.23 (95% CI: 1.53, 3.23) and 3.29 (95% CI: 2.26, 4.79) in the T2 and T3 groups, respectively, compared with the T1 group. Riboflavin and folate were associated with the risk of hypertension. In the vegetable–egg dietary pattern, the risk of hypertension was reduced by 33%, 39%, and 37% in groups Q2, Q3, and Q4, respectively, compared with group Q1 (Q2: OR = 0.67, 95% CI: 0.45, 0.99; Q3: OR = 0.61, 95% CI: 0.41, 0.92; Q4: OR = 0.63, 95% CI: 0.42, 0.96). Conclusions: The higher the DII score, the higher the risk of hypertension among residents of Xinjiang. In addition, vegetable–egg dietary patterns can reduce the risk of hypertension. Therefore, local residents should be scientifically instructed to increase their intake of vegetables and eggs. [ABSTRACT FROM AUTHOR]

Background: Type 2 diabetes mellitus (T2DM) is a chronic disorder diagnosed by elevated blood sugar. Key risk factors for T2DM include obesity, a sedentary lifestyle, and poor dietary habits. The proportion of macronutrients and the dietary inflammatory index (DII) seem to be associated with the risk of T2DM. This study aimed to assess and compare the macronutrient intake, DII, and BMI of newly diagnosed T2DM patients with healthy individuals in Kermanshah, Iran. Study design: This study employed a case-control design. Methods: A total of 105 newly diagnosed T2DM patients were selected as the case group, while an equal number of control participants were selected from their non-diabetic friends or neighbors. Dietary intake was assessed using a validated food frequency questionnaire. Energy, macronutrients, fatty acids intake, and DII were estimated using ShaFA software. Statistical significance was set at P values below 0.05. Results: The study included 105 newly diagnosed T2DM and 105 healthy individuals. Diabetic patients had significantly lower intake of protein, total fat, polyunsaturated fatty acids (PUFA), and monounsaturated fatty acids (MUFA), while their body mass index (BMI) and DII were higher. Multiple logistic regression indicated that protein, PUFA, and MUFA are protective factors for T2DM, while BMI, carbohydrates, and saturated fat intake are risk factors. A higher DII was correlated with an increased risk of T2DM risk, even after adjusting for BMI. Conclusion: Lower BMI and DII, balanced macronutrient intake, and consumption of MUFA and omega-3 fatty acids may be beneficial in preventing or delaying the onset of T2DM. Further research is needed to explore these associations in greater depth. [ABSTRACT FROM AUTHOR]

Abstract Dietary inflammatory index (DII) was demonstrated to be correlated to quality of life (QoL) in people with osteoarthritis (OA), but there is lack of an exploration of the relationship between the longitudinal trajectories of QoL and DII in OA people. This study aims to investigate the relationship between DII and longitudinal trajectories of QoL, and the moderating effect of physical activity on this relationship in OA people. Data from the Osteoarthritis Initiative database includes baseline measurements and follow-up data at 1, 2, 3, 4, 5, 6, and 8-year intervals for the 12-item Short-Form Health Outcome Survey questionnaire (physical and mental dimensions) and baseline sociodemographic characteristics utilized in this study. Dual Group-Based Trajectory Modeling analysis was employed to identify the profiles of physical and mental QoL trajectories. Multiple logistic regression analysis was used to determine the relationship between DII and QoL profiles. A structural equation model was conducted to assess the moderating effect of physical activity on the relationship between DII and QoL in OA people. A total of 1127 OA people were categorized into three profiles based on their physical and mental QoL: low physical-low mental QoL (14.5%), low physical-high mental QoL (27.1%), and high physical-high mental QoL (58.4%). People with higher DII were more likely to be in the low physical-low mental QoL profile (OR = 1.163, P = 0.014) and low physical-high mental QoL (OR = 1.131, P = 0.013) compared to the high physical-high mental QoL profile. Additionally, a higher level of physical activity could mitigate the relationship between a higher DII and lower QoL (β = 0.064, P = 0.029). A higher DII was associated with a greater likelihood of impaired QoL. Increasing physical activity levels can help mitigate the negative impact.

Jia Ding,1,&ast; Zhehao Xu,2,&ast; Ruiyun Liang,3 Shuangfeng Xie1 1Department of Hematopathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Department of General Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 3Department of Respiratory Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Shuangfeng Xie, Email xiesf@163.comBackground & Aims: There is a growing focus on the role of dietary factors and metabolic conditions in the evolution and progression of iron deficiency (ID), yet few studies have examined the underlying mechanisms. Dietary Inflammatory Index (DII) is a metric that gauges the inflammatory potential of an overall diet. This study explores the association between DII and triglyceride glucose-body mass index (TyG-BMI) with ID in reproductive-age women.Methods: This analysis utilized data from 2311 reproductive-age women in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. ID was identified using serum ferritin and transferrin receptor (TfR). The association between DII, TyG-BMI and ID was assessed using weighted logistic regression, linear regression and restricted cubic spline (RCS) models, with receiver operating characteristic (ROC) curve analysis for diagnostic power. Mediation effects of TyG-BMI were further explored by causal mediation analysis.Results: Among reproductive-age women, both DII and TyG-BMI were significantly positively associated with ID (DII: OR = 1.32, 95% CI 1.19, 1.48; TyG-BMI: OR = 1.13, 95% CI 1.02, 1.35). There is a close relationship between the DII index and TfR (β= 1.17, 95% CI 1.03, 1.13). RCS analysis indicated that the relationships were mostly linear (P-overall < 0.05, P-nonlinear > 0.05). Furthermore, TyG-BMI mediated 5.19%, 12.83%, and 5.63% of the associations between DII and ID, Ferritin, and transferrin receptor (TfR), respectively.Conclusion: The findings suggest that targeted interventions to enhance dietary practices, nutritional intake, and overall metabolic well-being may result in substantial amelioration of ID among reproductive women.Keywords: iron deficiency, reproductive women, dietary inflammatory index, triglyceride glucose-body mass index, insulin resistance

ObjectiveTo identify the correlation of dietary inflammatory index （DII） with sarcopenia in patients with chronic kidney disease （CKD） based on the National Health and Nutrition Examination Survey （NHANES） database.MethodsData from 1999-2006 and 2012-2018 in the NHANES database were analyzed. DII was calculated from dietary data， and patients were divided into DII Q1， DII Q2， DII Q3， and DII Q4 groups based on DII quartiles. Age， gender and the prevalence of sarcopenia were compared between the groups. Logistic regression model was used to analyze the relationship between DII and sarcopenia in patients with trend and stratification analysis. Restricted cubic spline plots （RCS） were used to analyze a nonlinear relationship between DII and sarcopenia.ResultsA total of 1，660 CKD patients were included in this study. There was a significant difference in the prevalence of sarcopenia in CKD patients among the DII Q1 （42.17%）， DII Q2 （46.99%）， DII Q3 （52.05%）， and DII Q4 （58.80%） groups （χ2=25.224， P

Abstract Background The prevalence of chronic kidney disease (CKD) is estimated to be about 13.4% worldwide. Studies have shown that CKD accounts for up to 2% of the health cost burden. Various factors, such as genetic polymorphisms, metabolic disorders, and unhealthy lifestyles, can contribute to the occurrence of CKD. Therefore, the present study aimed to investigate the relationship between renal function and cardiometabolic risk factors, anthropometric characteristics, and the dietary inflammatory index (DII) in an Iranian population. Methods This study was conducted on 2472 male and female employees of Shiraz University of Medical Sciences (SUMS), selected through census between 2018 and 2019. In this cross-sectional study, renal function was evaluated using serum creatinine (sCr), blood urea nitrogen (BUN), and estimated glomerular filtration rate (eGFR). Biochemical indices including sCr, BUN, fasting blood sugar (FBS), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) were measured using standard laboratory methods. eGFR was calculated using the Modification of Diet in Renal Disease formula. Systolic (SBP) and diastolic (DBP) blood pressure as well as anthropometric indices such as height (Ht), weight (Wt), hip circumference (HC), waist circumference (WC), body mass index (BMI), conicity index (C-Index), visceral adiposity index (VAI), abdominal volume index (AVI), body adiposity index (BAI), and body shape index (ABSI) were measured and calculated using standard methods and formulas. Diet was evaluated through a 113-item food frequency questionnaire, and the DII was calculated according to its specific instructions. To predict the factors influencing renal function and to remove the impact of confounders, multivariable linear regression was employed using the backward elimination method. Results There was a significant direct relationship between sCr and FBS, TG, HDL, DBP, Wt, and BAI as well as between BUN and age, TG, HDL, and BAI. In addition, there was a significant inverse relationship between eGFR and SBP, Wt, BAI, and VAI. In women compared to men, sCr and BUN values were significantly lower, while eGFR levels were significantly higher. Conclusions It seems that age, gender, lipid profile, glycemic status, BP, BAI, VAI, and Wt can be considered factors associated with renal function.

Abstract Background Increased levels of inflammation in cancer patients and survivors can make them more prone to muscle wasting and sarcopenia. Diet can be an appropriate treatment for alleviating patient complications. Therefore, this study was performed to determine the association between sarcopenia and its components with the dietary inflammatory index (DII) among breast cancer survivors. Methods A total of 223 female breast cancer survivors were included in this research at the Cancer Prevention Research Center of Seyyed Al-Shohada Hospital and the Iranian Cancer Control Charity Institute (MACSA). Forty-three items of dietary inflammatory index (DII) were extracted from the Food Frequency Questionnaire. Sarcopenia detection was performed according to the Asian criteria. The linear and binary logistic regression was used to assess the association between sarcopenia and its components with DII. Results Participants in the highest DII quartile had significantly elevated risk of impaired hand grip strength and calf circumference in both crude and adjusted models. Moreover, individuals consuming a more pro-inflammatory diet displayed a greater risk of abnormal appendicular skeletal muscle index in the crude model. After controlling for potential confounders, participants in the top quartile of DII had a 2.992-fold greater risk of possible sarcopenia than those in the bottom quartile (P value = 0.035). In addition, a decreasing linear trend was observed between higher DII score and 0.059 and 0.349- units lower in appendicular skeletal muscle mass index and hand grip strength variables in the crude Model (P-value

AIM: To assess the relationship between dietary inflammatory index (DII) and prevalence of glaucoma among individuals aged 40y and above in the United States. METHODS: Participants were drawn from 2 cycles of the National Health and Nutrition Examination Survey (NHANES, 2005-2008) for a cross-sectional study. DII was calculated from 24-hour dietary recall questionnaire conducted by experienced researchers and data analyzed in R according to the NHANES user guide, “Stratified Multi-stage Probability Sampling”. The relationship between DII and glaucoma was evaluated by multi-factor logistic regression analysis and the existence of a non-linear association examined by restricted cubic spline (RCS) analysis. RESULTS: A total of 5359 subjects were included and the cross-sectional analysis weighted to represent the US population of 109 million. DII was elevated in glaucoma patients (P

Pregnancy alters many physiological systems, including the maternal gut microbiota. Diet is a key regulator of this system and can alter the host immune system to promote inflammation. Multiple perinatal disorders have been associated with inflammation, maternal metabolic alterations, and gut microbial dysbiosis, including gestational diabetes mellitus, pre-eclampsia, preterm birth, and mood disorders. However, the effects of high-inflammatory diets on the gut microbiota during pregnancy have yet to be fully explored. We aimed to address this gap using a system-based approach to characterize associations among dietary inflammatory potential, a measure of diet quality, and the gut microbiome during pregnancy. Forty-seven pregnant persons were recruited prior to 16 weeks of gestation. Participants completed a food frequency questionnaire (FFQ) and provided fecal samples. Dietary inflammatory potential was assessed using the Dietary Inflammatory Index (DII) from the FFQ data. Fecal samples were analyzed using 16S rRNA amplicon sequencing. Differential taxon abundances with respect to the DII score were identified, and the microbial metabolic potential was predicted using PICRUSt2. Inflammatory diets were associated with decreased vitamin and mineral intake and a dysbiotic gut microbiota structure and predicted metabolism. Gut microbial compositional differences revealed a decrease in short-chain fatty acid producers such as Faecalibacterium, and an increase in predicted vitamin B12 synthesis, methylglyoxal detoxification, galactose metabolism, and multidrug efflux systems in pregnant individuals with increased DII scores. Dietary inflammatory potential was associated with a reduction in the consumption of vitamins and minerals and predicted gut microbiota metabolic dysregulation.

Abstract Nonalcoholic fatty liver disease (NAFLD) or metabolic dysfunction–associated steatotic liver disease (MASLD) is a significant global public health dilemma with wide-ranging social and economic implications. Diet and lifestyle modifications remain essential components of NAFLD management. The current study investigated the association between diet-related inflammation and NAFLD among 3110 Iranian adults participating in the Amol Cohort Study (AmolCS), employing the Structural Equation Modeling (SEM) approach.The inflammatory potential of the diet was quantified using an energy-adjusted dietary index (E-DII) score. Findings showed that in the total sample and separately in males, the E-DII score had a significant effect on NAFLD, with mediation through hypertension (βstandardized = 0.16, and 0.13, p

Abstract Background Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disorder. Diet is recognized as a modifiable factor that may influence inflammation and potentially accelerate RA progression. Nevertheless, the effects of diverse dietary patterns and their combined impact on RA progression and long-term mortality remain inadequately understood. This study examined the association between dietary patterns and mortality in patients with RA, focusing on the Healthy Eating Index (HEI-2015) and Dietary Inflammatory Index (DII) and evaluating their combined effects. Methods The analysis included 2,069 patients with RA from the National Health and Nutrition Examination Survey (NHANES) spanning 2003–2018. Weighted multi-variable Cox regression models estimated the relationship between the DII, HEI-2015, combined dietary patterns, and all-cause mortality in patients with RA. Linear associations between the DII, HEI-2015, and all-cause mortality were analyzed using restricted cubic splines (RCS). Dietary factors associated with mortality were identified through the Least Absolute Shrinkage and Selection Operator (LASSO) method, and subgroup and sensitivity analyses were conducted to strengthen the findings. Results Participants had a median age of 59 years (IQR: 48–69), with 42.1% male. Adjusting for potential confounders, the hazard ratio (HR) for individuals adhering to healthy and anti-inflammatory dietary patterns, as opposed to unhealthy and pro-inflammatory patterns, was 0.70 (95% CI: 0.53–0.92; adjusted P = 0.01; trend P = 0.02). In weighted Cox analyses of the DII and HEI-2015, higher quartiles showed no significant mortality risk difference from the lowest quartiles. The LASSO-Cox model identified 12 dietary components predictive of all-cause mortality in patients with RA, with an AUC of 0.749 (0.682–0.815) at 1 year, 0.763 (0.724–0.802) at 3 years, 0.783 (0.749–0.802) at 5 years, and 0.868 (0.712–0.938) for all death events. Kaplan-Meier analysis revealed that the low-risk dietary group exhibited significantly lower mortality compared to the high-risk group (P

Abstract Studies on the association between dietary inflammatory index (DII) and chronic kidney disease (CKD) are limited. We aimed to examine the association between DII and CKD among U.S. adults with particular attention paid to sex differences. A total of 19317participants were included in this study. The exposure variable was DII, which was calculated based on overall inflammatory effect scores. The outcome was CKD, defined as estimated glomerular filtration rate (eGFR)

Xuerong Jia,1,&ast; Min Peng,2,&ast; Zewen Wang,3,&ast; Xiang Li,4,5 Tao Mou,1 Xiaoke Wang,1 Yaqian Xia,6 Jizi Ma,1 Qing Wang,1 Zefang Li,4 Longjiang Zhang,3 Wusheng Zhu,1 Gelin Xu1,2,4 1Department of Neurology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 210002, People’s Republic of China; 2Department of Neurology, Inst Translat Med, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen, Guangdong, 518000, People’s Republic of China; 3Department of Radiology, Jinling Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210002, People’s Republic of China; 4Department of Neurology, Jinling Hospital, Nanjing Medical University, Nanjing, 210002, People’s Republic of China; 5Department of Neurology, The Ninth People’s Hospital of Chongqing, Chongqing, 400700, People’s Republic of China; 6Department of Neurology, The People’s Hospital of Rugao, Rugao, Jiangsu, 226500, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Gelin Xu; Wusheng Zhu, Department of Neurology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, 305&num; East Zhongshan Road, Nanjing, Jiangsu, 210002, People’s Republic of China, Tel + 86-18951919349, Fax + 86-25-84801861, Email gelinxu@nju.edu.cn; zwsemail@sina.comBackground and Purpose: Diet may influence systemic inflammatory status, vascular calcification, and, therefore, the development of atherosclerosis. The Dietary Inflammatory Index (DII) is a measure of the inflammatory potential of diet. Although previous studies have examined the relationship between DII and cardiovascular diseases, its specific association with carotid artery calcification in ischemic stroke patients remains insufficiently explored. This study aimed to evaluate the relationship between Dietary Inflammatory Index (DII) and carotid artery calcification in patients with ischemic stroke.Methods: This is a retrospective cross-sectional analysis based on a prospective registry database. Patients with ischemic stroke were enrolled via Nanjing Stroke Registry Program. DII was calculated based on 39 food components with the help of a food frequency questionnaire. Carotid artery calcification was quantified as calcification score using the Agatston method based on computed tomography angiography. The data were compared among patients stratified by tertiles of DII. Multiple logistic regression models were used to evaluate the influence of DII on carotid artery calcification. Spearman analysis was used to evaluate the relationship between DII and ln-transformed carotid artery calcification score.Results: Of the 601 enrolled, carotid artery calcification was detected in 368 (61.23%) patients. Compared with patients with the lowest DII, those with higher DII had a higher ratio of stroke subtypes of large artery atherosclerosis (p =0.050), a higher calcification score (p < 0.001), and a higher ratio of calcification (p < 0.001). Other baseline characteristics, including sex and age, showed no significant differences across the DII tertiles. Patients with carotid artery calcification had significantly higher DII scores compared to those without calcification (p = 0.018). Logistic regression analysis showed that patients with the highest DII tertile had a higher risk of carotid artery calcification after adjusting for significant cofounders (OR =1.880, 95% CI, 1.205− 2.932; p =0.005). Spearman correlation analysis indicated that DII was associated with ln-transformed carotid artery calcification score in patients with carotid artery calcification (R =0.110, p =0.035).Conclusion: DII was associated with carotid artery calcification in patients with ischemic stroke. Considering a possible causal relationship, the mechanism of this relationship warrants further investigation.Keywords: dietary inflammatory index, artery calcification, carotid, ischemic stroke

Abstract Background Diet may influence susceptibility of human papillomavirus (HPV) infection by affecting inflammation and immunity. However, the association between HPV infection and the inflammatory potential of diet has not been investigated. The research aimed to examine the correlation between HPV status and the dietary inflammatory index (DII®). Methods We utilized data from the National Health and Nutrition Examination Survey (NHANES) 2003–2016 to investigate the correlation between DII and HPV status among 9,256 women aged 18–59 years. DII scores were calculated based on 24-hour dietary recall interviews. The association between HPV status and DII was analyzed using weighted logistic regression and restricted cubic spline (RCS). Results Women with HPV infection exhibited higher DII scores than those without HPV infection. An increased likelihood of HPV infection was found to be significantly associated with higher DII scores (OR = 1.05, 95% CI: 1.01–1.09, P = 0.021), after full multivariate adjustment. Compared with the lowest tertile of DII scores, the ORs (95% CIs) for HPV infection were 1.20 (1.01, 1.42) and 1.27 (1.07, 1.51) for the second and third tertiles, respectively (P for trend = 0.006). RCS analysis showed a U-shaped relationship between DII and HPV infection, with a breakpoint identified at 0.13. Conclusions Our findings suggest that a pro-inflammatory diet is associated with an increased likelihood of HPV infection among women in the United States. Dietary interventions to reduce inflammation may help prevent HPV infection and related diseases.

Abstract Background We aimed to examine the relationship of 2 dietary scores [dietary inflammatory index (DII) and composite dietary antioxidant index (CDAI)] with frailty in elderly adults with diabetes. Methods Data were gathered from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018. The frailty index was calculated using 49 deficits across various systems to define frailty. To examine the relationship of 2 dietary scores (DII and CDAI) with frailty in elderly adults with diabetes, multiple logistic regression analyses were performed. In logistic regression model, DII and CDAI were calculated as both continuous and tertiles. Subgroup analyses were performed to demonstrate stability of results. Restricted cubic splines were utilized to examine the non-linear correlations. Results A total of 2,795 elderly adults with diabetes were included in this study. In the multivariate logistic regression model, the odds ratio (OR) of DII for risk of frailty was 1.08 (95% CI 1.02–1.15) and the OR of CDAI for risk of frailty was 0.96 (95% CI 0.93–0.99). The ORs of DII for risk of frailty were 1.36 (95% CI 1.09–1.70) and 1.33 (95% CI 1.04–1.70) for tertiles 2 and 3, respectively (p for trend 0.027). The ORs of CDAI for risk of frailty were 0.94 (95% CI 0.75–1.17) and 0.75 (95% CI 0.58–0.98) for tertiles 2 and 3, respectively (p for trend 0.036). The subgroup analysis demonstrated reliable and enduring connections between 2 dietary scores and frailty (all p for interaction > 0.05). In the restricted cubic spline analyses, we discovered the non-linear relationship between DII and frailty (P for nonlinearity = 0.045) and linear relationship between CDAI and frailty (P for nonlinearity = 0.769). Conclusion The research showed connections between 2 dietary scores (DII and CDAI) and frailty as measured by frailty index in elderly adults with diabetes.

Lili Wang,1 Le Cheng,1 Chenhui Lv,1 Jie Kou,1 Wenjuan Feng,1 Haoran Xie,1 Ruolin Yan,1 Xi Wang,1 Shuangzhi Chen,1 Xin Song,1 Lushan Xue,1 Cheng Zhang,1 Xuemin Li,2 Haifeng Zhao1,3 1Department of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, Taiyuan, People’s Republic of China; 2Center for Disease Control and Prevention in Shanxi Province, Taiyuan, People’s Republic of China; 3MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, Taiyuan, People’s Republic of ChinaCorrespondence: Haifeng Zhao, Department of Nutrition & Food Hygiene, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, 030001, People’s Republic of China, Tel/Fax +86-351-4135046, Email haifengzao75@163.comBackground: The present study aimed to explore the association between the inflammatory potential of diet, assessed by energy-adjusted dietary inflammatory index (E-DII) and reduced rank regression (RRR)-derived inflammatory dietary pattern, and the risk for cognitive impairment (CI) in community-dwelling older adults, especially in older adults with chronic diseases and multimorbidity.Methods: A total of 549 older adults from Taiyuan city were included in the present cross-sectional study. The Chinese Version of the Mini-Mental State Examination (CMMSE) was used for the evaluation of cognitive function. E-DII score was calculated based on semi-quantitative food frequency questionnaire (FFQ). Blood samples, including interleukin (IL)-1β, interleukin (IL)-18, tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP), were tested for calculating RRR-derived inflammatory dietary pattern. Logistic regression was used to assess the association between inflammatory dietary pattern and risk of CI. In addition, patients with diabetes, hypertension, hyperlipidemia and multimorbidity were screened for further analysis among 549 older adults.Results: In those 549 older adults, adjusting for demographic characteristics and chronic disease status, there was no association between E-DII score tertile (ORT3VST1: 1.357, 95%CI:0.813~2.265, Ptrend = 0.267), RRR-derived inflammatory dietary pattern score tertile (ORT3VST1: 1.092, 95%CI:0.679~ 1.758, Ptrend = 0.737) and risk of CI. However, in older adults with diabetes and multimorbidity, the score tertile of E-DII and RRR-derived inflammatory dietary pattern were positively correlated with risk of CI in a dose-responsive manner (All Ptrend < 0.05). There is insufficient evidence to reach similar conclusion in patients with hypertension and hyperlipidemia (All Ptrend > 0.05).Conclusion: In the present study, pro-inflammatory diet contributed to the increased risk of CI in older adults with diabetes and multimorbidity. These results supplemented vital evidence for the prevention and treatment of CI in older adults with chronic diseases.Keywords: chronic diseases, multimorbidity, cognitive impairment, inflammatory dietary pattern, dietary inflammatory index, reduced rank regression

Abstract Diet and inflammation are crucial in the incidence and progression of coronary heart disease (CHD). This study aimed to investigate the correlation between the Dietary inflammatory index (DII) and all-cause mortality in CHD patients. A total of 1,303 CHD patients from the National Health and Nutrition Examination Survey (NHANES) between 2003 and 2018 were included. Multivariate Cox regression was used to explore the correlation between the DII and the risk of all-cause mortality in these patients. Restricted cubic spline (RCS) analysis was also utilized to examine the relationship between the DII and all-cause mortality risk in CHD patients. Additionally, subgroup analyses were conducted to determine how the correlation between the DII and all-cause mortality varied across different demographics. During a median follow-up period of 77 months among 1,303 CHD patients, 536 died from all causes. The DII scores were significantly higher in deceased patients compared to survivors. After adjusting for confounding factors, the multivariate Cox regression analysis indicated a strong positive correlation between the DII and all-cause mortality in CHD patients. RCS analysis suggested a non-linear relationship between the DII and all-cause mortality among CHD patients. Additionally, an increase in DII was more pronounced in its impact on female patients. The DII is strongly correlated with the risk of all-cause mortality among CHD patients, particularly among females. Thus, managing dietary inflammation is vital for the prevention and treatment of CHD, especially in female patients.

Abstract Type 2 diabetes (T2DM) patients are at high risk for non-alcoholic fatty liver disease (NAFLD). Studies show SVD3 and dietary inflammatory index (DII) are associated with NAFLD. It’s unknown if they interact in T2DM patients with NAFLD. We collected data from 110 hospitalized T2DM patients, measured physiological and biochemical indicators, conducted dietary surveys, and converted data into DII and NFS, FIB-4, and BARD indices. We used logistic regression, mediation effect analysis, and moderation effect analysis to explore the relationship between DII and SVD3 with NAFLD and liver fibrosis in T2DM patients. DII was not significant in either NAFLD incidence in T2DM patients or liver fibrosis in NAFLD patients. SVD3 was positively correlated with NAFLD incidence in T2DM patients, but this correlation became insignificant as DII increased towards pro-inflammation. SVD3 is positively correlated with NAFLD incidence in T2DM patients, but this correlation becomes less significant as DII increases towards pro-inflammation.

Background and aim: Neuromyelitis optica spectrum disorder (NMOSD) is a severe and rare inflammatory disease affecting the central nervous system through optic neuritis and transverse myelitis. Present study aimed to investigate the association between dietary inflammatory index (DII) and risk of NMOSD. Methods: In this case–control study, 30 NMOSD cases and 90 aged matched healthy individuals were recruited. Habitual dietary intakes were assessed by a validated 168-item food frequency questionnaire to calculate the DII score. A multiple adjusted regression was used to determine the odd ratio (OR) of NMOSD across DII tertiles. The Residual method was applied to adjust the energy intake. Results: Participants in the top of DII tertile were more likely to have NMOSD in the crude model compared to those with the lowest one (OR: 4.18; 95%CI: 1.43-12.21). It was the case when multivariable confounders were considered in adjustment model I (OR: 3.98; 95%CI: 1.34-11.82) and II (OR: 4.43; 95%CI: 1.36-14.38), such that, individuals with a greater DII score had 3.98 and 4.43-time higher risk of NMOSD in model I and II, respectively. Conclusion: The Present study suggests that greater adherence to a pro-inflammatory diet may be associated with an increased risk of NMOSD. [ABSTRACT FROM AUTHOR]

Objectives: Dietary inflammatory index (DII) is utilized to determine the inflammatory effects of nutrients and foods on various diseases. Inflammation is a potential risk factor for anemia. We hypothesize that pro-inflammatory diets boost the incidence of anemia, as indicated by high DII. Methods: 41, 360 Americans were included in this study from the U.S. National Health and Nutrition Survey (NHANES) from 2003–2018. Multivariable logistic regression models were employed to examine the association between DII and anemia. Results: After adjustment for all the covariates, the odds ratios (ORs) (95% CI) between the risk of anemia and DII across tertile 3 were 1.2556 (95% CI 1.0621, 1.4843; P = 0.0077), and the trend test was statistically significant (P for trend = 0.009). Furthermore, in the subgroup analysis stratified by gender. The ORs (95% CI) between the risk of anemia and DII across tertile 2 and 3 were 1.8071 (95% CI 1.1754, 2.7783; P = 0.0070) and 2.1591 (95% CI 1.4009, 3.3278; P = 0.0005) in men after multivariable adjustment. However, in women, this association was only significantly different (P < 0.05) across tertile 3 in the crude model. In the subgroup analysis stratified by race, this association was significant (P < 0.05) between the risk of anemia and DII for Non-Hispanic Whites/Blacks after adjustment. Discussion: Together, anemia was significantly associated with DII using logistic regression. In stratified analyses, higher DII scores were linked to an increased incidence of anemia in men, while no association was found in women after adjustment. Additionally, anemia may be associated with greater pro-inflammatory diets in Non-Hispanic Whites/Blacks. Conclusion: In the present study, we evaluate the potential relationship between DII and anemia using data from NHANES. This cross-sectional study confirmed the hypothesis that the higher DII was significantly associated with a higher risk of anemia in the U.S. population. [ABSTRACT FROM AUTHOR]

Chronic kidney disease (CKD) is a global health concern that is frequently associated with hypertension. Inflammation is an important factor in the development of both illnesses. The Dietary Inflammation Index (DII) has evolved as a way to measure how much a diet can cause inflammation, which may impact CKD, especially in hypertensive persons. The study’s goal is to investigate the link between DII and the occurrence of CKD in hypertensive individuals. This study examined data from 22940 hypertensive patients from 1999 to 2018 of the National Health and Nutrition Examination Survey (NHANES). The DII was computed using 28 dietary components. CKD was diagnosed based on the estimated glomerular filtration rate and urine albumin-to-creatinine ratio. The link between DII and CKD was explored using sampling-weighted logistic regression and restricted cubic splines. Higher DII scores were shown to be strongly related with an increased risk of CKD. In the fully adjusted model, this connection remained consistent across demographic and clinical categories. The study found a strong association between a pro-inflammatory diet and an elevated risk of CKD in hypertensive individuals, emphasizing the potential of dietary changes in CKD management. [ABSTRACT FROM AUTHOR]

Inflammation plays a crucial role in occurrence of kidney injury, and specific dietary patterns can influence systemic inflammation levels. However, the relationship between dietary inflammatory potential and early-stage kidney damage remains unclear. 2,108 participants was recruited from 2001–2002 National Health and Nutrition Examination Survey (NHANES). Dietary Inflammatory Index (DII) is utilized to assess dietary inflammatory potential, calculated through a 24-h dietary recall questionnaire. Early renal injury was evaluated using urinary albumin to creatinine (UACR), cystatin C (CysC), β-2 microglobulin (β2M), and estimated glomerular filtration rate (eGFR) based on serum creatinine (eGFRs), cystatin C (eGFRc), and both Scr and CysC (eGFRs&c). Participant characteristics were analyzed, and association between DII, hypertension, and early renal injury markers was explored using multiple linear and logistic regression models. The average age of participants was 53.9 years. DII exhibited a positive correlation with UACR (β = −0.048[0.017,0.078]), β2M (β = 0.019[0.010,0.027]), CysC (β = 0.012 [0.004,0.021]). Conversely, a negative correlation was observed between DII and eGFRc (β = −1.126[−1.554, −0.699]), eGFRs&c (β=-1.101[−1.653, −0.549]). A significant association was observed between hypertension and abnormality of early kidney damage markers. Subgroup analysis reveals that the positive correlation between DII and the occurrence of abnormal markers of early kidney damage is only observed in individuals with hypertension. Furthermore, an interaction between DII and hypertension was detected in eGFRs&c (OR:1.250[1.042, 1.499], p for interaction = 0.03). Higher levels of DII may be associated with occurrence of early kidney damage. For individuals with hypertension, avoiding excessive consumption of pro-inflammatory foods may reduce the risk of renal injury. [ABSTRACT FROM AUTHOR]

Objective To investigate the association between dietary inflammatory index (DII) and osteoporosis in the population with non-alcoholic fatty liver disease (NAFLD). Methods The data from the National Health and Nutrition Examination Survey (NHANES) for the years 2017-2018 were utilized in this study, with a total of 1686 participants included. Participants were divided into two groups based on whether they had osteoporosis, and the general characteristics of the two groups were compared. The participants were stratified into tertiles based on the DII score. Utilizing the recommended NHANES weights, binary logistic regression was employed to analyze the relationship between DII and osteoporosis. Additionally, linear correlation analysis was conducted to examine the correlation between DII and bone mineral density (BMD). Results Compared with the non- osteoporosis group, participants in the osteoporosis group were found to have older age, lower BMI, higher proportion of females, and higher DII scores, with statistically significant differences (all P < 0.05); Binary logistic regression analysis revealed a significant association between DII and the risk of osteoporosis in the NAFLD population (adjusted odds ratio [OR] = 1.34, 95% confidence interval [CI]: 1.07-1.68, P=0.010) after adjusting for all potential confounding factors. Compared to the T1 group, the T3 group had a higher risk of developing osteoporosis (adjusted OR 3. 19, 95% CI: 1.34-7.58, P=0.009) after adjusting for all potential confounding factors. Correlation analysis showed a negative correlation between DII scores and femoral neck BMD, lumbar spine BMD, and total hip BMD (r=0.0661, 0.0649, 0.132 9, P 0.032, 0.049, <0.001, respectively). Conclusion The association between a higher DII score, representing a pro-inflammatory diet, and the risk of osteoporosis in the NAFLD population was observed. Furthermore, there was a negative correlation between DII scores and bone density. Thus, a high DII score serves as a risk factor for osteoporosis in the NAFLD population. [ABSTRACT FROM AUTHOR]

Background: The relationship between diet, inflammation and mental health has been receiving increasing interest. However, limited data are available on the inflammatory role of diet in university students, among whom depression is commonly observed. Aim: The aim of our study is to investigate the relationship between dietary inflammatory index (DII) and depression among female students of nutrition and dietetics department, whom we assume to be conscious about health. Methods: DII scores were determined by averaging the 3-day dietary records. Depression status of the students was determined by using Beck Depression Inventory (BDI). Results: Our study was conducted with 122 female university students. The mean total BDI score of the students in the first tertile (more anti-inflammatory effect) was found significantly lower than those of the students in the second and third tertiles (p = 0.001). In addition, there were no significant difference between the depression scores of the students and their grade level (p = 0.114) and place of residence (p = 0.866). We found a positive association between DII and depressive symptoms (Model 1, B = 0.512, %95 CI: 0.236–0.789, p = 0.000). This relationship was also found when adjusting for age, weight, body mass index, smoking status, and presence of chronic disease (Model 2, B = 0.496, %95 CI: 0.217–0.776, p = 0.006; Model 3, B = 0.493, %95 CI: 0.210–0.777, p = 0.024. Conclusion: Supporting that the inflammatory burden of diet is associated with mental health, our findings are of significance for the development of anti-inflammatory nutritional approaches among students who are prone to depression. [ABSTRACT FROM AUTHOR]