Search

Your search keyword '"Dietel, Manfred"' showing total 1,408 results
Start Over Author "Dietel, Manfred"
1,408 results on '"Dietel, Manfred"'

2. Testing for deficient mismatch repair and microsatellite instability: A focused update

Author

Rüschoff, Josef, Schildhaus, Hans-Ulrich, Rüschoff, Jan Hendrik, Jöhrens, Korinna, Bocker Edmonston, Tina, Dietmaier, Wolfgang, Bläker, Hendrik, Baretton, Gustavo, Horst, David, Dietel, Manfred, Hartmann, Arndt, Klauschen, Frederick, Merkelbach-Bruse, Sabine, Stenzinger, Albrecht, Schöniger, Sandra, Tiemann, Markus, Weichert, Wilko, and Büttner, Reinhard

Published
2023
Full Text
View/download PDF

3. Testung auf Mismatch-Reparatur-Defizienz und Mikrosatelliteninstabilität: Eine fokussierte Aktualisierung

Author

Rüschoff, Josef, Schildhaus, Hans-Ulrich, Rüschoff, Jan Hendrik, Jöhrens, Korinna, Bocker-Edmonston, Tina, Dietmaier, Wolfgang, Bläker, Hendrik, Baretton, Gustavo, Horst, David, Dietel, Manfred, Hartmann, Arndt, Klauschen, Frederick, Merkelbach-Bruse, Sabine, Stenzinger, Albrecht, Schöniger, Sandra, Tiemann, Markus, Weichert, Wilko, and Büttner, Reinhard

Published
2023
Full Text
View/download PDF

6. Erratum zu: Testung auf Mismatch-Reparatur-Defizienz und Mikrosatelliteninstabilität

Author

Rüschoff, Josef, Schildhaus, Hans-Ulrich, Rüschoff, Jan Hendrik, Jöhrens, Korinna, Bocker-Edmonston, Tina, Dietmaier, Wolfgang, Bläker, Hendrik, Baretton, Gustavo, Horst, David, Dietel, Manfred, Hartmann, Arndt, Klauschen, Frederick, Merkelbach-Bruse, Sabine, Stenzinger, Albrecht, Schöniger, Sandra, Tiemann, Markus, Weichert, Wilko, and Büttner, Reinhard

Published
2023
Full Text
View/download PDF

8. Towards computational fluorescence microscopy: Machine learning-based integrated prediction of morphological and molecular tumor profiles

Author

Binder, Alexander, Bockmayr, Michael, Hägele, Miriam, Wienert, Stephan, Heim, Daniel, Hellweg, Katharina, Stenzinger, Albrecht, Parlow, Laura, Budczies, Jan, Goeppert, Benjamin, Treue, Denise, Kotani, Manato, Ishii, Masaru, Dietel, Manfred, Hocke, Andreas, Denkert, Carsten, Müller, Klaus-Robert, and Klauschen, Frederick

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Recent advances in cancer research largely rely on new developments in microscopic or molecular profiling techniques offering high level of detail with respect to either spatial or molecular features, but usually not both. Here, we present a novel machine learning-based computational approach that allows for the identification of morphological tissue features and the prediction of molecular properties from breast cancer imaging data. This integration of microanatomic information of tumors with complex molecular profiling data, including protein or gene expression, copy number variation, gene methylation and somatic mutations, provides a novel means to computationally score molecular markers with respect to their relevance to cancer and their spatial associations within the tumor microenvironment.

Published
2018

9. MSI testing: What’s new? What should be considered?

Author

Rüschoff, Josef, Baretton, Gustavo, Bläker, Hendrik, Dietmaier, Wolfgang, Dietel, Manfred, Hartmann, Arndt, Horn, Lars-Christian, Jöhrens, Korinna, Kirchner, Thomas, Knüchel, Ruth, Mayr, Doris, Merkelbach-Bruse, Sabine, Schildhaus, Hans-Ulrich, Schirmacher, Peter, Tiemann, Markus, Tiemann, Katharina, Weichert, Wilko, and Büttner, Reinhard

Published
2021
Full Text
View/download PDF

10. Status quo of ALK testing in lung cancer: results of an EQA scheme based on in-situ hybridization, immunohistochemistry, and RNA/DNA sequencing

Author

Jurmeister, Philipp, Vollbrecht, Claudia, Jöhrens, Korinna, Aust, Daniela, Behnke, Anke, Stenzinger, Albrecht, Penzel, Roland, Endris, Volker, Schirmacher, Peter, Fisseler-Eckhoff, Annette, Neumann, Jens, Kirchner, Thomas, Büttner, Reinhard, Merkelbach-Bruse, Sabine, Kreipe, Hans, Jonigk, Danny, Jochum, Wolfram, Rodriguez, Regulo, Dietel, Manfred, Horst, David, Hummel, Michael, and von Laffert, Maximilian

Published
2021
Full Text
View/download PDF

11. MSI-Testung: Was ist neu? Was ist zu beachten?

Author

Rüschoff, Josef, Baretton, Gustavo, Bläker, Hendrik, Dietmaier, Wolfgang, Dietel, Manfred, Hartmann, Arndt, Horn, Lars-Christian, Jöhrens, Korinna, Kirchner, Thomas, Knüchel, Ruth, Mayr, Doris, Merkelbach-Bruse, Sabine, Schildhaus, Hans-Ulrich, Schirmacher, Peter, Tiemann, Markus, Tiemann, Katharina, Weichert, Wilko, and Büttner, Reinhard

Published
2021
Full Text
View/download PDF

13. Obduktionen

Author

Madea, Burkhard, Tag, Brigitte, Stenzinger, Albrecht, Gutjahr, Ewgenija, Dietel, Manfred, Pollak, Stefan, Jackowski, Christian, Zollinger, Ulrich, Grellner, Wolfgang, and Madea, Burkhard, editor

Published
2019
Full Text
View/download PDF

15. Harmonization and Standardization of Panel-Based Tumor Mutational Burden Measurement: Real-World Results and Recommendations of the Quality in Pathology Study

Author

Stenzinger, Albrecht, Endris, Volker, Budczies, Jan, Merkelbach-Bruse, Sabine, Kazdal, Daniel, Dietmaier, Wolfgang, Pfarr, Nicole, Siebolts, Udo, Hummel, Michael, Herold, Sylvia, Andreas, Johanna, Zoche, Martin, Tögel, Lars, Rempel, Eugen, Maas, Jörg, Merino, Diana, Stewart, Mark, Zaoui, Karim, Schlesner, Matthias, Glimm, Hanno, Fröhling, Stefan, Allen, Jeff, Horst, David, Baretton, Gustavo, Wickenhauser, Claudia, Tiemann, Markus, Evert, Matthias, Moch, Holger, Kirchner, Thomas, Büttner, Reinhard, Schirmacher, Peter, Jung, Andreas, Haller, Florian, Weichert, Wilko, and Dietel, Manfred

Published
2020
Full Text
View/download PDF

17. A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal

Author

Rindi, Guido, Klimstra, David S., Abedi-Ardekani, Behnoush, Asa, Sylvia L., Bosman, Frederik T., Brambilla, Elisabeth, Busam, Klaus J., de Krijger, Ronald R., Dietel, Manfred, El-Naggar, Adel K., Fernandez-Cuesta, Lynnette, Klöppel, Günter, McCluggage, W.Glenn, Moch, Holger, Ohgaki, Hiroko, Rakha, Emad A., Reed, Nicholas S., Rous, Brian A., Sasano, Hironobu, Scarpa, Aldo, Scoazec, Jean-Yves, Travis, William D., Tallini, Giovanni, Trouillas, Jacqueline, van Krieken, J.Han, and Cree, Ian A.

Published
2018
Full Text
View/download PDF

18. Testing deficient mismatch repair and microsatellite instability

Author

Rüschoff, Josef, primary, Schildhaus, Hans-Ulrich, additional, Rüschoff, Jan Hendrik, additional, Jöhrens, Korinna, additional, Bocker-Edmonston, Tina, additional, Dietmaier, Wolfgang, additional, Bläker, Hendrik, additional, Baretton, Gustavo, additional, Horst, David, additional, Dietel, Manfred, additional, Hartmann, Arndt, additional, Klauschen, Frederick, additional, Merkelbach-Bruse, Sabine, additional, Stenzinger, Albrecht, additional, Schöniger, Sandra, additional, Tiemann, Markus, additional, Weichert, Wilko, additional, and Büttner, Reinhard, additional

Published
2023
Full Text
View/download PDF

20. Bone Marrow Work-up: Report of a Pilot Study

Author

Anagnostopoulos, Ioannis, Lenze, Dido, Hummel, Michael, Dietel, Manfred, Jöhrens, Korinna, Schlag, Peter M., Series editor, Senn, Hans-Jörg, Series editor, Dietel, Manfred, editor, Wittekind, Christian, editor, Bussolati, Gianni, editor, and von Winterfeld, Moritz, editor

Published
2015
Full Text
View/download PDF

21. Clinical and analytical validation of Ki-67 in 9069 patients from IBCSG VIII + IX, BIG1-98 and GeparTrio trial: systematic modulation of interobserver variance in a comprehensive in silico ring trial

Author

Denkert, Carsten, Budczies, Jan, Regan, Meredith M., Loibl, Sibylle, Dell’Orto, Patrizia, von Minckwitz, Gunter, Mastropasqua, Mauro G., Solbach, Christine, Thürlimann, Beat, Mehta, Keyur, Blohmer, Jens-Uwe, Colleoni, Marco, Müller, Volkmar, Klauschen, Frederick, Ataseven, Beyhan, Engels, Knut, Kammler, Roswitha, Pfitzner, Berit M., Dietel, Manfred, Fasching, Peter A., and Viale, Giuseppe

Published
2019
Full Text
View/download PDF

22. Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue - a GC-TOFMS based metabolomics study

Author

Budczies, Jan, Denkert, Carsten, Müller, Berit M, Brockmöller, Scarlet F, Klauschen, Frederick, Györffy, Balazs, Dietel, Manfred, Richter-Ehrenstein, Christiane, Marten, Ulrike, Salek, Reza M, Griffin, Julian L, Hilvo, Mika, Orešič, Matej, Wohlgemuth, Gert, and Fiehn, Oliver

Abstract

AbstractBackgroundChanges in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far.ResultsA cohort of 271 breast cancer and 98 normal tissue samples was investigated using GC-TOFMS-based metabolomics. A total number of 468 metabolite peaks could be detected; out of these 368 (79%) were significantly changed between cancer and normal tissues (p80%. Two-metabolite classifiers, constructed as ratios of the tumor and normal tissues markers, separated cancer from normal tissues with high sensitivity and specificity. Specifically, the cytidine-5-monophosphate / pentadecanoic acid metabolic ratio was the most significant discriminator between cancer and normal tissues and allowed detection of cancer with a sensitivity of 94.8% and a specificity of 93.9%.ConclusionsFor the first time, a comprehensive metabolic map of breast cancer was constructed by GC-TOF analysis of a large cohort of breast cancer and normal tissues. Furthermore, our results demonstrate that spectrometry-based approaches have the potential to contribute to the analysis of biopsies or clinical tissue samples complementary to histopathology.

Published
2012

24. Data from Atypical Protein Kinase C ζ Exhibits a Proapoptotic Function in Ovarian Cancer

Author

Nazarenko, Irina, primary, Jenny, Marcel, primary, Keil, Jana, primary, Gieseler, Cornelia, primary, Weisshaupt, Karen, primary, Sehouli, Jalid, primary, Legewie, Stefan, primary, Herbst, Lena, primary, Weichert, Wilko, primary, Darb-Esfahani, Silvia, primary, Dietel, Manfred, primary, Schäfer, Reinhold, primary, Ueberall, Florian, primary, and Sers, Christine, primary

Published
2023
Full Text
View/download PDF

25. Supplementary Data from Atypical Protein Kinase C ζ Exhibits a Proapoptotic Function in Ovarian Cancer

Author

Nazarenko, Irina, primary, Jenny, Marcel, primary, Keil, Jana, primary, Gieseler, Cornelia, primary, Weisshaupt, Karen, primary, Sehouli, Jalid, primary, Legewie, Stefan, primary, Herbst, Lena, primary, Weichert, Wilko, primary, Darb-Esfahani, Silvia, primary, Dietel, Manfred, primary, Schäfer, Reinhold, primary, Ueberall, Florian, primary, and Sers, Christine, primary

Published
2023
Full Text
View/download PDF

28. Ovar

Author

Dietel, Manfred, Denkert, Carsten, Darb-Esfahani, Silvia, Klöppel, Günter, editor, Kreipe, Hans, editor, Remmele, Wolfgang, editor, and Dietel, Manfred, editor

Published
2013
Full Text
View/download PDF

29. Tube

Author

Dietel, Manfred, Denkert, Carsten, Darb-Esfahani, Silvia, Klöppel, Günter, editor, Kreipe, Hans, editor, Remmele, Wolfgang, editor, and Dietel, Manfred, editor

Published
2013
Full Text
View/download PDF

31. Supplemental Table S2 from EGFR Mutation Status and First-Line Treatment in Patients with Stage III/IV Non–Small Cell Lung Cancer in Germany: An Observational Study

Author

Schuette, Wolfgang, primary, Schirmacher, Peter, primary, Eberhardt, Wilfried Ernst Erich, primary, Fischer, Juergen R., primary, von der Schulenburg, J.-Matthias Graf, primary, Mezger, Joerg, primary, Schumann, Christian, primary, Serke, Monika, primary, Zaun, Silke, primary, Dietel, Manfred, primary, and Thomas, Michael, primary

Published
2023
Full Text
View/download PDF

33. Supplementary Data from Class I Histone Deacetylase Expression Has Independent Prognostic Impact in Human Colorectal Cancer: Specific Role of Class I Histone Deacetylases In vitro and In vivo

Author

Weichert, Wilko, primary, Röske, Annika, primary, Niesporek, Silvia, primary, Noske, Aurelia, primary, Buckendahl, Ann-Christin, primary, Dietel, Manfred, primary, Gekeler, Volker, primary, Boehm, Markus, primary, Beckers, Thomas, primary, and Denkert, Carsten, primary

Published
2023
Full Text
View/download PDF

34. EPI-14-1149 from EGFR Mutation Status and First-Line Treatment in Patients with Stage III/IV Non–Small Cell Lung Cancer in Germany: An Observational Study

Author

Schuette, Wolfgang, primary, Schirmacher, Peter, primary, Eberhardt, Wilfried Ernst Erich, primary, Fischer, Juergen R., primary, von der Schulenburg, J.-Matthias Graf, primary, Mezger, Joerg, primary, Schumann, Christian, primary, Serke, Monika, primary, Zaun, Silke, primary, Dietel, Manfred, primary, and Thomas, Michael, primary

Published
2023
Full Text
View/download PDF

37. Supplemental Methods, Figures 1-2, Table S1 from Standardized Ki67 Diagnostics Using Automated Scoring—Clinical Validation in the GeparTrio Breast Cancer Study

Author

Klauschen, Frederick, primary, Wienert, Stephan, primary, Schmitt, Wolfgang D., primary, Loibl, Sibylle, primary, Gerber, Bernd, primary, Blohmer, Jens-Uwe, primary, Huober, Jens, primary, Rüdiger, Thomas, primary, Erbstößer, Erhard, primary, Mehta, Keyur, primary, Lederer, Bianca, primary, Dietel, Manfred, primary, Denkert, Carsten, primary, and von Minckwitz, Gunter, primary

Published
2023
Full Text
View/download PDF

38. Supplementary Figures and Tables from Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas

Author

Hilvo, Mika, primary, de Santiago, Ines, primary, Gopalacharyulu, Peddinti, primary, Schmitt, Wolfgang D., primary, Budczies, Jan, primary, Kuhberg, Marc, primary, Dietel, Manfred, primary, Aittokallio, Tero, primary, Markowetz, Florian, primary, Denkert, Carsten, primary, Sehouli, Jalid, primary, Frezza, Christian, primary, Darb-Esfahani, Silvia, primary, and Braicu, Elena Ioana, primary

Published
2023
Full Text
View/download PDF

39. Supplementary Materials and Methods, Tables 1-4, Figures 1-5 from Hyperactivation of the Insulin-like Growth Factor Receptor I Signaling Pathway Is an Essential Event for Cisplatin Resistance of Ovarian Cancer Cells

Author

Eckstein, Niels, primary, Servan, Kati, primary, Hildebrandt, Barbara, primary, Pölitz, Anne, primary, Jonquières, Georg von, primary, Wolf-Kümmeth, Sybille, primary, Napierski, Inge, primary, Hamacher, Alexandra, primary, Kassack, Matthias U., primary, Budczies, Jan, primary, Beier, Manfred, primary, Dietel, Manfred, primary, Royer-Pokora, Brigitte, primary, Denkert, Carsten, primary, and Royer, Hans-Dieter, primary

Published
2023
Full Text
View/download PDF

41. Supplementary Table S2 from Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas

Author

Hilvo, Mika, primary, de Santiago, Ines, primary, Gopalacharyulu, Peddinti, primary, Schmitt, Wolfgang D., primary, Budczies, Jan, primary, Kuhberg, Marc, primary, Dietel, Manfred, primary, Aittokallio, Tero, primary, Markowetz, Florian, primary, Denkert, Carsten, primary, Sehouli, Jalid, primary, Frezza, Christian, primary, Darb-Esfahani, Silvia, primary, and Braicu, Elena Ioana, primary

Published
2023
Full Text
View/download PDF

42. Supplementary Figure Legends from Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas

Author

Hilvo, Mika, primary, de Santiago, Ines, primary, Gopalacharyulu, Peddinti, primary, Schmitt, Wolfgang D., primary, Budczies, Jan, primary, Kuhberg, Marc, primary, Dietel, Manfred, primary, Aittokallio, Tero, primary, Markowetz, Florian, primary, Denkert, Carsten, primary, Sehouli, Jalid, primary, Frezza, Christian, primary, Darb-Esfahani, Silvia, primary, and Braicu, Elena Ioana, primary

Published
2023
Full Text
View/download PDF

44. Supplementary Methods from Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas

Author

Hilvo, Mika, primary, de Santiago, Ines, primary, Gopalacharyulu, Peddinti, primary, Schmitt, Wolfgang D., primary, Budczies, Jan, primary, Kuhberg, Marc, primary, Dietel, Manfred, primary, Aittokallio, Tero, primary, Markowetz, Florian, primary, Denkert, Carsten, primary, Sehouli, Jalid, primary, Frezza, Christian, primary, Darb-Esfahani, Silvia, primary, and Braicu, Elena Ioana, primary

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results