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5. Concepts and methods for the dosimetry of radioembolisation of the liver with Y-90-loaded microspheres.

Author

Dieudonné, Arnaud, Sanchez-Garcia, Manuel, Bando-Delaunay, Aurélie, and Lebtahi, Rachida

Subjects
LIVER tumors, STATISTICAL models, COMPUTER simulation, HEPATOTOXICOLOGY, RADIOTHERAPY, RECEIVER operating characteristic curves, LOGISTIC regression analysis, RADIOISOTOPES, RADIATION dosimetry, REFLECTION (Philosophy), DESCRIPTIVE statistics, DIAGNOSTIC errors, RADIOBIOLOGY, KAPLAN-Meier estimator, COMPUTERS in medicine, RADIOEMBOLIZATION, RADIATION doses, MICROSCOPY, CONFIDENCE intervals, SENSITIVITY & specificity (Statistics), ALGORITHMS
Abstract

This article aims at presenting in a didactic way, dosimetry concepts and methods that are relevant for radio-embolization of the liver with 90Y-microspheres. The application of the medical internal radiation dose formalism to radio-embolization is introduced. This formalism enables a simplified dosimetry, where the absorbed dose in a given tissue depends on only its mass and initial activity. This is applied in the single-compartment method, partition model, for the liver, tumour and lung dosimetry, and multi-compartment method, allowing identification of multiple tumours. Voxel-based dosimetry approaches are also discussed. This allows taking into account the non-uniform uptake within a compartment, which translates into a non-uniform dose distribution, represented as a dose--volume histogram. For this purpose, dose--kernel convolution allows propagating the energy deposition around voxel-sources in a computationally efficient manner. Alternatively, local-energy deposition is preferable when the spatial resolution is comparable or larger than the beta-particle path. Statistical tools may be relevant in establishing dose--effect relationships in a given population. These include tools such as the logistic regression or receiver operator characteristic analysis. Examples are given for illustration purpose. Moreover, tumour control probability modelling can be assessed through the linear-quadratic model of Lea and Catcheside and its counterpart, the normal-tissue complication probability model of Lyman, which is suitable to the parallel structure of the liver. The selectivity of microsphere administration allows tissue sparing, which can be considered with the concept of equivalent uniform dose, for which examples are also given. The implication of microscopic deposition of microspheres is also illustrated through a liver toxicity model, even though it is not clinically validated. Finally, we propose a reflection around the concept of therapeutic index (TI), which could help tailor treatment planning by determining the treatment safety through the evaluation of TI based on treatment-specific parameters. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Cost-Utility Analysis of Transarterial Radioembolization With Yttrium-90 Resin Microspheres Compared With Sorafenib in Locally Advanced and Inoperable Hepatocellular Carcinoma

Author

Assenat, Eric, Delhom-Christol, Elisabeth, Guiu, Boris, Ilonca, Alina D., Lonjon, Julie, Pageaux, Georges-Philippe, Abdel-Rehim, Mohamed, Al-laham, Wassim, Bouattour, Mohamed, Castera, Laurent, Dieudonné, Arnaud, Lebtahi, Rachida, Ronot, Maxime, Sibert, Annie, Vilgrain, Valérie, Barraud, Hélène, Bazin, Christophe, Bronowicki, Jean-Pierre, Laurent, Valérie, Mathias, Elodie, Chagneau-Derrode, Carine, Perdrisot, Rémy, Silvain, Christine, Tasu, Jean-Pierre, RenéGerolami, Patrick Borentain, Mundler, Olivier, Seitz, Jean-Francois, Vidal, Vincent, Aubé, Christophe, Bouvier, Antoine, Couturier, Olivier, Oberti, Frédéric, Vervueren, Laurent, Brenot-Rossi, Isabelle, Raoul, Jean-Luc, Sar-ran, Anthony, Chalaye, Julia, Costentin, Charlotte, Itti, Emmanuel, Kobeiter, Hicham, Luciani, Alain, Adam, René, Lewin, Maïté, Samuel, Didier, Edeline, Julien, Garin, Etienne, Rolland, Yan, Archambeaud, Isabelle, Eugene, Thomas, Frampas, Eric, Cassinotto, Christophe, Guyot, Martine, Hiriart, Jean-Baptiste, Lapuyade, Bruno, Vergniol, Julien, Bachellier, Philippe, Detour, Julien, Duclos, Bernard, Greget, Michel, Habersetzer, Francois, Imperiale, Alessio, Merle, Philippe, Rode, Agnès, Morvan, Julie, Nguyen-Khac, Eric, Yzet, Thierry, Baudin, Guillaume, Chevallier, Patrick, Mahamat, Abakar, Piche, Thierry, Razzouk, Micheline, Hillon, Patrick, Loffroy, Romaric, Toubeau, Michel, Vincent, Julie, Barabino, Gabriele, Bouarioua, Nadia, Cuilleron, Muriel, Ecochard, Marie, Prevot-Bitot, Nathalie, Leroy, Vincent, Roux, Julie, Sengel, Christian, Bourcier, Valérie, Carrie, Nathalie Ganne, Seror, Olivier, Costo, Sylvie, Dao, Thông, Pelage, Jean-Pierre, Dumortier, Jérôme, Giammarile, Francesco, Valette, Pierre-Jean, Ghazzar, Nadia, Pellerin, Olivier, Taieb, Julien, Weinmann, Pierre, Berlot, Alexandra Heurgue, Marcus, Claude, Sommacale, Daniele, Castilla-Lièvre, Maria-Angéla, Maitre, Sophie, Marthey, Lysiane, Zarca, Kevin, Mimouni, Maroua, Pereira, Helena, Chatellier, Gilles, and Durand-Zaleski, Isabelle

Published
2021
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8. International recommendations for personalised selective internal radiation therapy of primary and metastatic liver diseases with yttrium-90 resin microspheres

Author

Levillain, Hugo, Bagni, Oreste, Deroose, Christophe M., Dieudonné, Arnaud, Gnesin, Silvano, Grosser, Oliver S., Kappadath, S. Cheenu, Kennedy, Andrew, Kokabi, Nima, Liu, David M., Madoff, David C., Mahvash, Armeen, Martinez de la Cuesta, Antonio, Ng, David C. E., Paprottka, Philipp M., Pettinato, Cinzia, Rodríguez-Fraile, Macarena, Salem, Riad, Sangro, Bruno, Strigari, Lidia, Sze, Daniel Y., de Wit van der veen, Berlinda J., and Flamen, Patrick

Published
2021
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9. Dosimetry for targeted radionuclide therapy in routine clinical practice: experts advice vs. clinical evidence

Author

Dieudonné, Arnaud, primary, Bailly, Clément, additional, Cachin, Florent, additional, Edet-Sanson, Agathe, additional, Kraeber-Bodéré, Françoise, additional, Hapdey, Sébastien, additional, Merlin, Charles, additional, Robin, Philippe, additional, Salaun, Pierre-Yves, additional, Schwartz, Paul, additional, Tonnelet, David, additional, Vera, Pierre, additional, Courbon, Frédéric, additional, and Carlier, Thomas, additional

Published
2023
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12. Performance study of a 360° CZT camera for monitoring 177Lu-PSMA treatment.

Author

Vergnaud, Laure, Badel, Jean-Noël, Giraudet, Anne-Laure, Kryza, David, Mognetti, Thomas, Baudier, Thomas, Rida, Hanan, Dieudonné, Arnaud, and Sarrut, David

Subjects
SCINTILLATION cameras, THREE-dimensional imaging, ROOT-mean-squares, PERFORMANCE theory, SINGLE-photon emission computed tomography
Abstract

Background: The aim of this study was to investigate the quantification performance of a 360° CZT camera for 177Lu-based treatment monitoring. Methods: Three phantoms with known 177Lu activity concentrations were acquired: (1) a uniform cylindrical phantom for calibration, (2) a NEMA IEC body phantom for analysis of different-sized spheres to optimise quantification parameters and (3) a phantom containing two large vials simulating organs at risk for tests. Four sets of reconstruction parameters were tested: (1) Scatter, (2) Scatter and Point Spread Function Recovery (PSFR), (3) PSFR only and (4) Penalised likelihood option and Scatter, varying the number of updates (iterations × subsets) with CT-based attenuation correction only. For each, activity concentration (ARC) and contrast recovery coefficients (CRC) were estimated as well as root mean square. Visualisation and quantification parameters were applied to reconstructed patient image data. Results: Optimised quantification parameters were determined to be: CT-based attenuation correction, scatter correction, 12 iterations, 8 subsets and no filter. ARC, CRC and RMS results were dependant on the methodology used for calculations. Two different reconstruction parameters were recommended for visualisation and for quantification. 3D whole-body SPECT images were acquired and reconstructed for 177Lu-PSMA patients in 2–3 times faster than the time taken for a conventional gamma camera. Conclusion: Quantification of whole-body 3D images of patients treated with 177Lu-PSMA is feasible and an optimised set of parameters has been determined. This camera greatly reduces procedure time for whole-body SPECT. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Health-related quality of life in locally advanced hepatocellular carcinoma treated by either radioembolisation or sorafenib (SARAH trial)

Author

Pereira, Helena, primary, Bouattour, Mohamed, additional, Burgio, Marco D., additional, Assenat, Eric, additional, Grégory, Jules, additional, Bronowicki, Jean-Pierre, additional, Chatellier, Gilles, additional, Vilgrain, Valérie, additional, Delhom-Christol, Elisabeth, additional, Fourcade, Marjolène, additional, Guiu, Boris, additional, Ilonca, Alina Diana, additional, Lonjon, Julie, additional, Pageaux, Georges-Philippe, additional, Abdel-Rehim, Mohamed, additional, Allaham, Wassim, additional, Castera, Laurent, additional, Dieudonné, Arnaud, additional, Lebtahi, Rachida, additional, Ronot, Maxime, additional, Sibert, Annie, additional, Chor, Hélène, additional, Devictor, Julie, additional, Barraud, Hélène, additional, Bazin, Christophe, additional, Imbert, Laetitia, additional, Laurent, Valérie, additional, Mathias, Elodie, additional, Chagneau-Derrode, Carine, additional, Gallais, Christelle, additional, Perdrisot, Rémy, additional, Silvain, Christine, additional, Tasu, Jean Pierre, additional, Borentain, Patrick, additional, Farman, Bardia, additional, Gerolami, René, additional, Mundler, Olivier, additional, Seitz, Jean-Francois, additional, Vidal, Vincent, additional, Aubé, Christophe, additional, Bouchet, Francis, additional, Bouvier, Antoine, additional, Couturier, Olivier, additional, Oberti, Frédéric, additional, Vervueren, Laurent, additional, Brenot-Rossi, Isabelle, additional, Darreon, Julien, additional, Raoul, Jean Luc, additional, Sarran, Anthony, additional, Chalaye, Julia, additional, Costentin, Charlotte, additional, Itti, Emmanuel, additional, Kobeiter, Hicham, additional, Luciani, Alain, additional, Masset, Hélène, additional, Adam, René, additional, Lewin, Maïté, additional, Samuel, Didier, additional, Edeline, Julien, additional, Garin, Etienne, additional, Laffont, Sophie, additional, Rolland, Yan, additional, Archambeaud, Isabelle, additional, Carlier, Thomas, additional, Eugene, Thomas, additional, Frampas, Eric, additional, Cassinotto, Christophe, additional, Guyot, Martine, additional, Hiriart, Jean-Baptiste, additional, Lapuyade, Bruno, additional, Tendero, Karine, additional, Vergniol, Julien, additional, Bachellier, Philippe, additional, Détour, Julien, additional, Duclos, Bernard, additional, Greget, Michel, additional, Habersetzer, Francois, additional, Imperiale, Alessio, additional, Enderlin, Elise, additional, Merle, Philippe, additional, Rode, Agnès, additional, Morvan, Julie, additional, Nguyen-Khac, Eric, additional, Talbot, Antoine, additional, Yzet, Thierry, additional, Baudin, Guillaume, additional, Chevallier, Patrick, additional, Mahamat, Abakar, additional, Maurel, Fabien, additional, Piche, Thierry, additional, Razzouk, Micheline, additional, Hillon, Patrick, additional, Loffroy, Romaric, additional, Toubeau, Michel, additional, Vincent, Julie, additional, Vrigneaud, Jean-Marc, additional, Barabino, Gabriele, additional, Bouarioua, Nadia, additional, Cuilleron, Muriel, additional, Ecochard, Marie, additional, Prevot-Bitot, Nathalie, additional, Rousset, Evelyne, additional, Leroy, Vincent, additional, Reboulet, Ghislaine, additional, Roux, Julie, additional, Sengel, Christian, additional, Bourcier, Valérie, additional, Ganne-Carrie, Nathalie, additional, Seror, Olivier, additional, Costo, Sylvie, additional, Dao, Thông, additional, Desmonts, Cédric, additional, Pelage, Jean-Pierre, additional, Defez, Didier, additional, Dumortier, Jérôme, additional, Giammarile, Francesco, additional, Valette, Pierre-Jean, additional, Bernardini, Michela, additional, Ghazar, Nadia, additional, Pellerin, Olivier, additional, Taieb, Julien, additional, Weinmann, Pierre, additional, Heurgue-Berlot, Alexandra, additional, Marcus, Claude, additional, Sommacale, Daniele, additional, Castilla-Lièvre, Maria-Angéla, additional, Forbes, Aurélie, additional, Maitre, Sophie, additional, and Marthey, Lysiane, additional

Published
2021
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16. Cost-Utility Analysis of Transarterial Radioembolization With Yttrium-90 Resin Microspheres Compared With Sorafenib in Locally Advanced and Inoperable Hepatocellular Carcinoma

Author

Zarca, Kevin, primary, Mimouni, Maroua, additional, Pereira, Helena, additional, Chatellier, Gilles, additional, Vilgrain, Valérie, additional, Durand-Zaleski, Isabelle, additional, Assenat, Eric, additional, Delhom-Christol, Elisabeth, additional, Guiu, Boris, additional, Ilonca, Alina D., additional, Lonjon, Julie, additional, Pageaux, Georges-Philippe, additional, Abdel-Rehim, Mohamed, additional, Al-laham, Wassim, additional, Bouattour, Mohamed, additional, Castera, Laurent, additional, Dieudonné, Arnaud, additional, Lebtahi, Rachida, additional, Ronot, Maxime, additional, Sibert, Annie, additional, Barraud, Hélène, additional, Bazin, Christophe, additional, Bronowicki, Jean-Pierre, additional, Laurent, Valérie, additional, Mathias, Elodie, additional, Chagneau-Derrode, Carine, additional, Perdrisot, Rémy, additional, Silvain, Christine, additional, Tasu, Jean-Pierre, additional, RenéGerolami, Patrick Borentain, additional, Mundler, Olivier, additional, Seitz, Jean-Francois, additional, Vidal, Vincent, additional, Aubé, Christophe, additional, Bouvier, Antoine, additional, Couturier, Olivier, additional, Oberti, Frédéric, additional, Vervueren, Laurent, additional, Brenot-Rossi, Isabelle, additional, Raoul, Jean-Luc, additional, Sar-ran, Anthony, additional, Chalaye, Julia, additional, Costentin, Charlotte, additional, Itti, Emmanuel, additional, Kobeiter, Hicham, additional, Luciani, Alain, additional, Adam, René, additional, Lewin, Maïté, additional, Samuel, Didier, additional, Edeline, Julien, additional, Garin, Etienne, additional, Rolland, Yan, additional, Archambeaud, Isabelle, additional, Eugene, Thomas, additional, Frampas, Eric, additional, Cassinotto, Christophe, additional, Guyot, Martine, additional, Hiriart, Jean-Baptiste, additional, Lapuyade, Bruno, additional, Vergniol, Julien, additional, Bachellier, Philippe, additional, Detour, Julien, additional, Duclos, Bernard, additional, Greget, Michel, additional, Habersetzer, Francois, additional, Imperiale, Alessio, additional, Merle, Philippe, additional, Rode, Agnès, additional, Morvan, Julie, additional, Nguyen-Khac, Eric, additional, Yzet, Thierry, additional, Baudin, Guillaume, additional, Chevallier, Patrick, additional, Mahamat, Abakar, additional, Piche, Thierry, additional, Razzouk, Micheline, additional, Hillon, Patrick, additional, Loffroy, Romaric, additional, Toubeau, Michel, additional, Vincent, Julie, additional, Barabino, Gabriele, additional, Bouarioua, Nadia, additional, Cuilleron, Muriel, additional, Ecochard, Marie, additional, Prevot-Bitot, Nathalie, additional, Leroy, Vincent, additional, Roux, Julie, additional, Sengel, Christian, additional, Bourcier, Valérie, additional, Carrie, Nathalie Ganne-, additional, Seror, Olivier, additional, Costo, Sylvie, additional, Dao, Thông, additional, Pelage, Jean-Pierre, additional, Dumortier, Jérôme, additional, Giammarile, Francesco, additional, Valette, Pierre-Jean, additional, Ghazzar, Nadia, additional, Pellerin, Olivier, additional, Taieb, Julien, additional, Weinmann, Pierre, additional, Berlot, Alexandra Heurgue-, additional, Marcus, Claude, additional, Sommacale, Daniele, additional, Castilla-Lièvre, Maria-Angéla, additional, Maitre, Sophie, additional, and Marthey, Lysiane, additional

Published
2021
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17. Relationship of Tumor Radiation-absorbed Dose to Survival and Response in Hepatocellular Carcinoma Treated with Transarterial Radioembolization with Y in the SARAH Study

Author

Hermann, Anne-Laure, Dieudonné, Arnaud, Ronot, Maxime, Sanchez, Manuel, Pereira, Helena, Chatellier, Gilles, Garin, Etienne, Castera, Laurent, Lebtahi, Rachida, Vilgrain, Valérie, Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Paris (UP), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), CIC - HEGP (CIC 1418), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), CRLCC Eugène Marquis (CRLCC), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Paris Cité (UPCité), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience; Background Little is known about factors that influence the efficacy of transarterial radioembolization (TARE). Purpose To determine the relationship between tumor radiation-absorbed dose and survival and tumor response in locally advanced inoperable hepatocellular carcinoma treated with TARE. Materials and Methods This was a secondary analysis of prospectively acquired data (between December 2011 and March 2015) from participants who received TARE in the Sorafenib versus Radioembolization in Advanced Hepatocellular Carcinoma (SARAH) trial (ClinicalTrials.gov identifier NCT01482442). Tumor-absorbed dose was computed using technetium 99m (Tc) macroaggregated human albumin (MAA) SPECT/CT. Visual agreement among CT, Tc-MAA SPECT/CT, and yttrium 90 (Y) SPECT/CT or PET/CT was scored as optimal, suboptimal, or not optimal. Overall survival (OS) and tumor response at 6-month follow-up CT (Response Evaluation Criteria in Solid Tumors, version 1.1) were assessed. OS was evaluated using Kaplan-Meier tests. A propensity score comparing participants receiving a tumor dose greater than or equal to 100 Gy (best cut-off according to the receiver operating characteristic curve and median tumor radiation-absorbed dose values in the study groups) with those receiving sorafenib was calculated. Results One hundred twenty-one participants (median age, 67 years; interquartile range [IQR] 61-73 years; 110 men) were evaluated in the dose-survival group, and 109 (median age, 66 years; IQR 61-71 years; 100 men) were evaluated in the dose-tumor response group. In the dose-survival group, median OS was 9.3 months (95% confidence interval [CI] 6.7 months, 10.7 months), and median tumor radiation-absorbed dose was 112 Gy (IQR 68-220 Gy). Participants who received at least 100 Gy (n = 67) had longer survival than those who received less than 100 Gy (median, 14.1 months [95% CI 9.6 months, 18.6 months] vs 6.1 months [95% CI 4.9 months, 6.8 months], respectively; P < .001), and those with optimal agreement (n = 24) had the longest median OS (24.9 months; 95% CI 9.6 months, 33.9 months). In the dose-tumor response group, tumor radiation-absorbed dose was higher in participants with disease control versus those with progressive disease (median, 121 Gy [IQR 86-190 Gy] vs 85 Gy [IQR 58-164 Gy]; P = .02). The highest disease control rate was observed in 31 of 40 participants (78%) with a tumor radiation-absorbed dose greater than or equal to 100 Gy and optimal agreement. Conclusion Higher tumor radiation-absorbed dose computed at technetium 99m macroaggregated human albumin SPECT/CT was associated with better overall survival and disease control in hepatocellular carcinoma treated with transarterial radioembolization with yttrium 90 in the Sorafenib versus Radioembolization in Advanced Hepatocellular Carcinoma trial. © RSNA, 2020 Online supplemental material is available for this article. See also the editorial by Sofocleous and Kamarinos in this issue.

Published
2020

19. Prognostic impact of bone metastases detected by 18F-DOPA PET in patients with metastatic midgut neuroendocrine tumors.

Author

Deleval, Nicolas, Pesque, Louise, Dieudonné, Arnaud, Viry, Flore, Hentic, Olivia, Lebtahi, Rachida, Ruszniewski, Philippe, and de Mestier, Louis

Subjects
BONE metastasis, NEUROENDOCRINE tumors, PROGNOSIS, OVERALL survival, METASTASIS, OSTEOBLASTS, DOPA, MENTAL health surveys, IMPACT of Event Scale
Abstract

Objectives: Bone metastases (BM) may influence negatively the prognosis of midgut neuroendocrine tumors (NET). The diagnostic sensitivity of 18F-DOPA PET for midgut NET and associated metastases is high. This study aimed to assess the prognostic impact of BM detected by 18F-DOPA PET in metastatic midgut NET.Methods: All patients with a metastatic midgut NET, who underwent a 18F-DOPA PET between June 2011 and June 2018, were included. BM were defined following imaging criteria and were classified as poly-BM or oligo-BM, according to their number (< 5 or ≥ 5, respectively). The variables associated with the presence of BM were evaluated by logistic regression. The factors associated with overall survival were explored by Cox regression models.Results: Among 155 patients included, 46 had BM (29.7%). A carcinoid syndrome (OR 2.96, p = 0.009) and ≥ 3 extra-skeletal metastatic organs (OR 4.99, p = 0.002) were independently associated with the presence of BM. BM were mainly osteoblastic (78%), rarely symptomatic (8.9%), and had a short-term therapeutic impact for 3 patients (6.5%). The presence of BM (HR 2.67, p = 0.034), older age (HR 1.07, p = 0.016), and higher Ki67 (HR 1.09, p = 0.025) were independent prognostic factors. Unlike poly-BM (HR 1.92, p = 0.007), oligo-BM was not a poor prognosis factor (HR 0.77, p = 0.699) compared to the group without BM.Conclusion: 18F-DOPA PET frequently detects BM in patients with metastatic midgut NET. BM have a negative prognostic impact, especially poly-BM. Conversely, oligo-BM do not influence the prognosis and may not impact therapeutic decisions.Key Points: • 18F-DOPA PET detected bone metastases in 46 (29.7%) of 155 patients with metastatic midgut neuroendocrine tumors. • Bone metastases have a negative prognostic impact in metastatic midgut neuroendocrine tumors. • Bone oligo-metastases (< 5) do not influence the prognosis and may not impact therapeutic decisions. [ABSTRACT FROM AUTHOR]

Published
2021
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20. Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled phase 3 trial

Author

Vilgrain, Valérie, primary, Pereira, Helena, additional, Assenat, Eric, additional, Guiu, Boris, additional, Ilonca, Alina Diana, additional, Pageaux, Georges-Philippe, additional, Sibert, Annie, additional, Bouattour, Mohamed, additional, Lebtahi, Rachida, additional, Allaham, Wassim, additional, Barraud, Hélène, additional, Laurent, Valérie, additional, Mathias, Elodie, additional, Bronowicki, Jean-Pierre, additional, Tasu, Jean-Pierre, additional, Perdrisot, Rémy, additional, Silvain, Christine, additional, Gerolami, René, additional, Mundler, Olivier, additional, Seitz, Jean-Francois, additional, Vidal, Vincent, additional, Aubé, Christophe, additional, Oberti, Frédéric, additional, Couturier, Olivier, additional, Brenot-Rossi, Isabelle, additional, Raoul, Jean-Luc, additional, Sarran, Anthony, additional, Costentin, Charlotte, additional, Itti, Emmanuel, additional, Luciani, Alain, additional, Adam, René, additional, Lewin, Maïté, additional, Samuel, Didier, additional, Ronot, Maxime, additional, Dinut, Aurelia, additional, Castera, Laurent, additional, Chatellier, Gilles, additional, Delhom - Christol, Elisabeth, additional, Ilonca, Alina D, additional, Lonjon, Julie, additional, Abdel-Rehim, Mohamed, additional, Dieudonné, Arnaud, additional, Vilgrain, Valérie, additional, Bazin, Christophe, additional, Chagneau-Derrode, Carine, additional, Borentain, Patrick, additional, Bouvier, Antoine, additional, Vervueren, Laurent, additional, Chalaye, Julia, additional, Kobeiter, Hicham, additional, Edeline, Julien, additional, Garin, Etienne, additional, Rolland, Yan, additional, Archambeaud, Isabelle, additional, Eugene, Thomas, additional, Frampas, Eric, additional, Cassinotto, Christophe, additional, Guyot, Martine, additional, Hiriart, Jean-Baptiste, additional, Lapuyade, Bruno, additional, Vergniol, Julien, additional, Bachellier, Philippe, additional, Detour, Julien, additional, Duclos, Bernard, additional, Greget, Michel, additional, Habersetzer, Francois, additional, Imperiale, Alessio, additional, Merle, Philippe, additional, Rode, Agnès, additional, Morvan, Julie, additional, Nguyen-Khac, Eric, additional, Yzet, Thierry, additional, Baudin, Guillaume, additional, Chevallier, Patrick, additional, Mahamat, Abakar, additional, Piche, Thierry, additional, Razzouk, Micheline, additional, Hillon, Patrick, additional, Loffroy, Romaric, additional, Toubeau, Michel, additional, Vincent, Julie, additional, Barabino, Gabriele, additional, Bouarioua, Nadia, additional, Cuilleron, Muriel, additional, Ecochard, Marie, additional, Prevot-Bitot, Nathalie, additional, Leroy, Vincent, additional, Roux, Julie, additional, Sengel, Christian, additional, Bourcier, Valérie, additional, Ganne-Carrie, Nathalie, additional, Seror, Olivier, additional, Costo, Sylvie, additional, Dao, Thông, additional, Pelage, Jean-Pierre, additional, Dumortier, Jérôme, additional, Giammarile, Francesco, additional, Valette, Pierre-Jean, additional, Ghazzar, Nadia, additional, Pellerin, Olivier, additional, Taieb, Julien, additional, Weinmann, Pierre, additional, Heurgue-Berlot, Alexandra, additional, Marcus, Claude, additional, Sommacale, Daniele, additional, Castilla-Lièvre, Maria-Angéla, additional, Maitre, Sophie, additional, and Marthey, Lysiane, additional

Published
2017
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21. A gate evaluation of the sources of error in quantitative 90Y PET

Author

Strydhorst, Jared, Carlier, Thomas, Dieudonné, Arnaud, Conti, Maurizio, Buvat, Irène, Imagerie Moléculaire in Vivo (IMIV - U1023 - ERL9218), Service Hospitalier Frédéric Joliot (SHFJ), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Siemens Molecular Imaging [Knoxville], This work was funded by the INCa PhysiCancer MILADY Project No. PC201414., Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Bernardo, Elizabeth

Subjects
[SDV.CAN] Life Sciences [q-bio]/Cancer, PET/CT simulation, yttrium-90, GATE, [SDV.CAN]Life Sciences [q-bio]/Cancer, quantification
Abstract

International audience; Purpose: Accurate reconstruction of the dose delivered by 90Y microspheres using a postembolization PET scan would permit the establishment of more accurate dose–response relationships for treatment of hepatocellular carcinoma with 90Y. However, the quality of the PET data obtained is compromised by several factors, including poor count statistics and a very high random fraction. This work uses Monte Carlo simulations to investigate what impact factors other than low count statistics have on the quantification of 90Y PET.Methods: PET acquisitions of two phantoms—a NEMA PET phantom and the NEMA IEC PET body phantom-containing either 90Y or 18F were simulated using GATE. Simulated projections were created with subsets of the simulation data allowing the contributions of random, scatter, and LSO background to be independently evaluated. The simulated projections were reconstructed using the commercial software for the simulated scanner, and the quantitative accuracy of the reconstructionand the contrast recovery of the reconstructed images were evaluated.Results: The quantitative accuracy of the 90Y reconstructions were not strongly influenced by the high random fraction present in the projection data, and the activity concentration was recovered to within 5% of the known value. The contrast recovery measured for simulated 90Y data was slightly poorer than that for simulated 18F data with similar count statistics. However, the degradation was not strongly linked to any particular factor. Using a more restricted energy range to reduce the randomfraction in the projections had no significant effect.Conclusions: Simulations of 90Y PET confirm that quantitative 90Y is achievable with the same approach as that used for 18F, and that there is likely very little margin for improvement by attempting to model aspects unique to 90Y, such as the much higher random fraction or the presence of bremsstrahlung in the singles data.

Published
2016

23. Relationship of Tumor Radiation–absorbed Dose to Survival and Response in Hepatocellular Carcinoma Treated with Transarterial Radioembolization with 90Y in the SARAH Study

Author

Hermann, Anne-Laure, Dieudonné, Arnaud, Ronot, Maxime, Sanchez, Manuel, Pereira, Helena, Chatellier, Gilles, Garin, Etienne, Castera, Laurent, Lebtahi, Rachida, and Vilgrain, Valérie

Abstract

Higher tumor radiation–absorbed dose according to technetium 99m macroaggregated human albumin SPECT/CT was associated with better survival and tumor response in hepatocellular carcinoma treated with transarterial radioembolization with yttrium 90.

Published
2020
Full Text
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24. A new approach for dose calculation in targeted radionuclide therapy (TRT) based on collapsed cone superposition: validation with (90)Y

Author

Sanchez Garcia, Manuel, Gardin, Isabelle, Lebtahi, Rachida, Dieudonné, Arnaud, Hôpital Beaujon, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon, Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Normandie Université (NU), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Breton, Céline

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

25. Implementation and validation a collapsed cone superposition for the dosimetry of yttrium 90 therapy

Author

Sanchez Garcia, Manuel, Gardin, Isabelle, Lebtahi, Rachida, Dieudonné, Arnaud, Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Normandie Université (NU), Service de médecine nucléaire [Rouen], CRLCC Haute Normandie-Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Service de Médecine Nucléaire [Paris 18eme], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Beaujon, Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), CRLCC Haute Normandie-CRLCC Henri Becquerel, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Hôpital Beaujon-Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], and Breton, Céline

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

27. Clinical feasibility of 3D Dosimetry g Voxel S-values or the treament of hepatocellular carcinoma with Yttrium 90 microspheres

Author

Dieudonné, Arnaud, Garin, Etienne, Laffont, Sophie, Rolland, Yan, Lebtahi, Rachida, Gardin, Isabelle, Hôpital Beaujon, Hôpital Beaujon-Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Service de Médecine Nucléaire [Paris 18eme], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), and Breton, Céline

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011

29. A preliminary study of quantitative protocols in indium 111 SPECT using computional simulations and phantoms

Author

Assié, Karine, Dieudonné, Arnaud, Gardin, Isabelle, Vera, Pierre, Buvat, Irène, Service de médecine nucléaire [Rouen], CRLCC Haute Normandie-Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Normandie Université (NU), Imagerie et Modélisation en Neurobiologie et Cancérologie (IMNC (UMR_8165)), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), CRLCC Haute Normandie-CRLCC Henri Becquerel, Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), and Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2010

31. VoxelDose : A software for 3D dosimetry in Targeted radiotherapy using S-values at the voxel level

Author

Dieudonné, Arnaud, Gardin, Isabelle, Zhang, Peng, Bolch, Wesley, Assié, Karine, Buvat, Irène, Service de médecine nucléaire [Rouen], CRLCC Haute Normandie-CRLCC Henri Becquerel, Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Nuclear & Radiological Engineering and Biomedical Engineering, University of Florida [Gainesville], Imagerie et Modélisation en Neurobiologie et Cancérologie (IMNC (UMR_8165)), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), CRLCC Haute Normandie-Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU), and University of Florida [Gainesville] (UF)

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2008

32. Use of fine resolution Voxel S-Values for absorbed dose calculation from SPECT or PET based cumulated activity distributions

Author

Dieudonné, Arnaud, Bolch, Wesley, Gardin, Isabelle, Service de médecine nucléaire [Rouen], CRLCC Haute Normandie-Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU), Nuclear & Radiological Engineering and Biomedical Engineering, and University of Florida [Gainesville] (UF)

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2008

33. Software development for 3D internal dosimetry in targeted radiotherapy

Author

Dieudonné, Arnaud, Gardin, Isabelle, Bolch, Wesley, Zhang, Peng, Assié, Karine, Hapdey, Sébastien, Buvat, Irène, Service de médecine nucléaire [Rouen], CRLCC Haute Normandie-Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Normandie Université (NU), Nuclear & Radiological Engineering and Biomedical Engineering, University of Florida [Gainesville] (UF), Imagerie et Modélisation en Neurobiologie et Cancérologie (IMNC (UMR_8165)), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), CRLCC Haute Normandie-CRLCC Henri Becquerel, Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), and University of Florida [Gainesville]

Subjects
[SDV]Life Sciences [q-bio]
Published
2007

34. 3D internal dosimetry for radio-immunotherapy using voxel S-Values approach

Author

Dieudonné, Arnaud, Bolch, Wesley, Gardin, Isabelle, Service de médecine nucléaire [Rouen], CRLCC Haute Normandie-Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Nuclear & Radiological Engineering and Biomedical Engineering, and University of Florida [Gainesville] (UF)

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2007

35. [18F]FDG PET/CT predicts progression-free survival in patients with idiopathic pulmonary fibrosis.

Author

Justet, Aurélien, Laurent-Bellue, Astrid, Thabut, Gabriel, Dieudonné, Arnaud, Debray, Marie-Pierre, Borie, Raphael, Aubier, Michel, Lebtahi, Rachida, and Crestani, Bruno

Subjects
PROGRESSION-free survival, IDIOPATHIC pulmonary fibrosis, FLUORODEOXYGLUCOSE F18, GLYCOLYSIS, POSITRON emission tomography, THERAPEUTICS, DEOXY sugars, PROGNOSIS, RADIOPHARMACEUTICALS, RESEARCH evaluation, SMOKING, SURVIVAL, COMORBIDITY, DISEASE incidence
Abstract

Background: Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by an unpredictable course. Prognostic markers and disease activity markers are needed. The purpose of this single-center retrospective study was to evaluate the prognostic value of lung fluorodeoxyglucose ([18F]-FDG) uptake assessed by standardized uptake value (SUV), metabolic lung volume (MLV) and total lesion glycolysis (TLG) in patients with IPF.Methods: We included 27 IPF patients (IPF group) and 15 patients with a gastrointestinal neuroendocrine tumor without thoracic involvement (control group). We quantified lung SUV mean and SUV max, MLV and TLG and assessed clinical data, high-resolution CT (HRCT) fibrosis and ground-glass score; lung function; gender, age, physiology (GAP) stage at inclusion and during follow-up; and survival.Results: Lung SUV mean and SUV max were higher in IPF patients than controls (p <0.00001). For patients with IPF, SUV mean, SUV max, MLV and TLG were correlated with severity of lung involvement as measured by a decline in forced vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide (DLCO) and increased GAP score. In a univariate and in a multivariate Cox proportional-hazards model, risk of death was increased although not significantly with high SUV mean. On univariate analysis, risk of death was significantly associated with high TLG and MLV, which disappeared after adjustment functional variables or GAP index. Increased MLV and TLG were independent predictors of death or disease progression during the 12 months after PET scan completion (for every 100-point increase in TLG, hazard ratio [HR]: 1.11 (95% CI 1.06; 1.36), p = 0.003; for every 100-point increase in MLV, HR: 1.20 (1.04; 1.19), p = 0.002). On multivariable analysis including TLG or MLV with age, FVC, and DLCO or GAP index, TLG and MLV remained associated with progression-free survival (HR: 1.1 [1.03; 1.22], p = 0.01; and 1.13 [1.0; 1.2], p = 0.005).Conclusion: FDG lung uptake may be a marker of IPF severity and predict progression-free survival for patients with IPF. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
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36. Pretreatment Dosimetry in HCC Radioembolization with 90Y Glass Microspheres Cannot Be Invalidated with a Bare Visual Evaluation of 99mTc-MAA Uptake of Colorectal Metastases Treated with Resin Microspheres

Author

Chiesa, Carlo, primary, Lambert, Bieke, additional, Maccauro, Marco, additional, Ezziddin, Samer, additional, Ahmadzadehfar, Hojjat, additional, Dieudonné, Arnaud, additional, Cremonesi, Marta, additional, Konijnenberg, Mark, additional, Lassmann, Michael, additional, Pettinato, Cinzia, additional, Strigari, Lidia, additional, Vanderlinden, Bruno, additional, Crippa, Flavio, additional, Flamen, Patrick, additional, and Garin, Etienne, additional

Published
2014
Full Text
View/download PDF

38. A gate evaluation of the sources of error in quantitative 90Y PET.

Author

Strydhorst, Jared, Carlier, Thomas, Dieudonné, Arnaud, Conti, Maurizio, and Buvat, Irène

Subjects
POSITRON emission tomography, IMAGE reconstruction, LIVER cancer, CANCER radiotherapy, IMAGING phantoms
Abstract

Purpose: Accurate reconstruction of the dose delivered by 90Y microspheres using a postembolization PET scan would permit the establishment of more accurate dose-response relationships for treatment of hepatocellular carcinoma with 90Y. However, the quality of the PET data obtained is compromised by several factors, including poor count statistics and a very high random fraction. This work uses Monte Carlo simulations to investigate what impact factors other than low count statistics have on the quantification of 90Y PET. Methods: PET acquisitions of two phantoms--a NEMA PET phantom and the NEMA IEC PET body phantom-containing either 90Y or 18F were simulated using GATE. Simulated projections were created with subsets of the simulation data allowing the contributions of random, scatter, and LSO background to be independently evaluated. The simulated projections were reconstructed using the commercial software for the simulated scanner, and the quantitative accuracy of the reconstruction and the contrast recovery of the reconstructed images were evaluated. Results: The quantitative accuracy of the 90Y reconstructions were not strongly influenced by the high random fraction present in the projection data, and the activity concentration was recovered to within 5% of the known value. The contrast recovery measured for simulated 90Y data was slightly poorer than that for simulated 18F data with similar count statistics. However, the degradation was not strongly linked to any particular factor. Using a more restricted energy range to reduce the random fraction in the projections had no significant effect. Conclusions: Simulations of 90Y PET confirm that quantitative 90Y is achievable with the same approach as that used for 18F, and that there is likely very little margin for improvement by attempting to model aspects unique to 90Y, such as the much higher random fraction or the presence of bremsstrahlung in the singles data. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

40. Study of the Impact of Tissue Density Heterogeneities on 3-Dimensional Abdominal Dosimetry: Comparison Between Dose Kernel Convolution and Direct Monte Carlo Methods

Author

Dieudonné, Arnaud, primary, Hobbs, Robert F., additional, Lebtahi, Rachida, additional, Maurel, Fabien, additional, Baechler, Sébastien, additional, Wahl, Richard L., additional, Boubaker, Ariane, additional, Le Guludec, Dominique, additional, Sgouros, Georges, additional, and Gardin, Isabelle, additional

Published
2012
Full Text
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45. MEDICAL PHYSICS PERSONNEL FOR MEDICAL IMAGING: REQUIREMENTS, CONDITIONS OF INVOLVEMENT AND STAFFING LEVELS--FRENCH RECOMMENDATIONS.

Author

Isambert, Aurélie, Le Du, Dominique, Valéro, Marc, Guilhem, Marie-Thérèse, Rousse, Carole, Dieudonné, Arnaud, Blanchard, Vincent, Pierrat, Noëlle, and Salvat, Cécile

Subjects
MEDICAL physics, DIAGNOSTIC imaging, MEDICAL personnel -- Services for, RADIATION protection
Abstract

The French regulations concerning the involvement of medical physicists in medical imaging procedures are relatively vague. In May 2013, the ASN and the SFPM issued recommendations regarding Medical Physics Personnel for Medical Imaging: Requirements, Conditions of Involvement and Staffing Levels. In these recommendations, the various areas of activity of medical physicists in radiology and nuclear medicine have been identified and described, and the time required to perform each task has been evaluated. Criteria for defining medical physics staffing levels are thus proposed. These criteria are defined according to the technical platform, the procedures and techniques practised on it, the number of patients treated and the number of persons in the medical and paramedical teams requiring periodic training. The result of this work is an aid available to each medical establishment to determine their own needs in terms of medical physics. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

46. MEDICAL PHYSICS PERSONNEL FOR MEDICAL IMAGING: REQUIREMENTS, CONDITIONS OF INVOLVEMENTAND STAFFING LEVELS--FRENCH RECOMMENDATIONS.

Author

Isambert, Aurélie, Le Du, Dominique, Valéro, Marc, Guilhem, Marie-Thérèse, Rousse, Carole, Dieudonné, Arnaud, Blanchard, Vincent, Pierrat, Noëlle, and Salvat, Cécile

Subjects
DIAGNOSTIC imaging, MEDICAL physics, BIOPHYSICISTS, RADIOLOGY, NUCLEAR medicine, ALLIED health personnel, TRAINING
Abstract

The French regulations concerning the involvement of medical physicists in medical imaging procedures are relatively vague. In May 2013, the ASN and the SFPM issued recommendations regarding Medical Physics Personnel for Medical Imaging: Requirements, Conditions of Involvement and Staffing Levels. In these recommendations, the various areas of activity of medical physicists in radiology and nuclear medicine have been identified and described, and the time required to perform each task has been evaluated. Criteria for defining medical physics staffing levels are thus proposed. These criteria are defined according to the technical platform, the procedures and techniques practised on it, the number of patients treated and the number of persons in the medical and paramedical teams requiring periodic training. The result of this work is an aid available to each medical establishment to determine their own needs in terms of medical physics. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

50. Pretreatment Dosimetry in HCC Radioembolization with 90Y Glass Microspheres Cannot Be Invalidated with a Bare Visual Evaluation of 99mTc-MAA Uptake of Colorectal Metastases Treated with Resin Microspheres.

Author

Chiesa, Carlo, Lambert, Bieke, Maccauro, Marco, Ezziddin, Samer, Ahmadzadehfar, Hojjat, Dieudonné, Arnaud, Cremonesi, Marta, Konijnenberg, Mark, Lassmann, Michael, Pettinato, Cinzia, Strigari, Lidia, Vanderlinden, Bruno, Crippa, Flavio, Flamen, Patrick, and Garin, Etienne

Published
2014
Full Text
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