1. Randomized parcellation based inference
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Vincent Frouin, Tomáš Paus, Jean-Luc Martinot, Gareth J. Barker, Marcella Rietschel, Gaël Varoquaux, Patricia J. Conrod, Jean-Baptiste Poline, Uli Bromberg, Arun L.W. Bokde, Frauke Nees, Jürgen Gallinat, Bertrand Thirion, Virgile Fritsch, Tobias Banaschewski, Andreas Ströhle, Michael N. Smolka, Zdenka Pausova, Hugh Garavan, Benoit Da Mota, Modelling brain structure, function and variability based on high-field MRI data (PARIETAL), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire de Neuroimagerie Assistée par Ordinateur (LNAO), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Department of Child and Adolescent Psychiatry and Psychotherapy [Mannheim], Universität Heidelberg [Heidelberg] = Heidelberg University, Institute of Psychiatry, King‘s College London, Institute of Neuroscience, Trinity College Dublin-Trinity College Dublin-Discipline of Psychiatry [Dublin], School of Medicine [Dublin], Trinity College Dublin-Trinity College Dublin-School of Medicine [Dublin], Trinity College Dublin, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Institute of Psychiatry, Psychology & Neuroscience, King's College London, Department of Psychiatry and Psychotherapy, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University of Vermont [Burlington], Neuroimagerie en psychiatrie (U1000), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Rotman Research Institute at the Baycrest Centre (RRI), McConnell Brain Imaging Centre (MNI), Montreal Neurological Institute and Hospital, McGill University = Université McGill [Montréal, Canada]-McGill University = Université McGill [Montréal, Canada], School of Psychology [Nottingham], University of Nottingham, UK (UON), SickKids - The Hospital for sick children, The Hospital for sick children [Toronto] (SickKids), Department of Genetic Epidemiology in Psychiatry [Mannhein], Universität Heidelberg [Heidelberg] = Heidelberg University-Central Institute of Mental Health Mannheim, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Digitéo (HiDiNim project and ICoGeN project), Imagen Consortium, European Project: 39513,IMAGEN, Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Service NEUROSPIN (NEUROSPIN), Universität Heidelberg [Heidelberg], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Sud - Paris 11 (UP11), Universität Heidelberg [Heidelberg]-Central Institute of Mental Health Mannheim, Fritsch, Virgile, and Reinforcement-related behaviour in normal brain function and psychopathology - IMAGEN - 39513 - OLD
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[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,permutations ,Cognitive Neuroscience ,[INFO.INFO-IM] Computer Science [cs]/Medical Imaging ,Inference ,Neuroimaging ,Stop signal ,Catechol O-Methyltransferase ,computer.software_genre ,Polymorphism, Single Nucleotide ,[STAT.AP] Statistics [stat]/Applications [stat.AP] ,Voxel ,Resampling ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,medicine ,Cluster Analysis ,Humans ,Computer Simulation ,reproducibility ,Genetic Association Studies ,multiple comparisons ,[STAT.AP]Statistics [stat]/Applications [stat.AP] ,medicine.diagnostic_test ,business.industry ,Brain ,Contrast (statistics) ,Pattern recognition ,Magnetic Resonance Imaging ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,Neurology ,group analysis ,parcellation ,Multiple comparisons problem ,Data mining ,Artificial intelligence ,Functional magnetic resonance imaging ,Psychology ,business ,computer - Abstract
International audience; Neuroimaging group analyses are used to relate inter-subject signal differences observed in brain imaging with behavioral or genetic variables and to assess risks factors of brain diseases. The lack of stability and of sensitivity of current voxel-based analysis schemes may however lead to non-reproducible results. We introduce a new approach to overcome the limitations of standard methods, in which active voxels are detected according to a consensus on several random parcellations of the brain images, while a permutation test controls the false positive risk. Both on synthetic and real data, this approach shows higher sensitivity, better accuracy and higher reproducibility than state-of-the-art methods. In a neuroimaging-genetic application, we find that it succeeds in detecting a significant association between a genetic variant next to the COMT gene and the BOLD signal in the left thalamus for a functional Magnetic Resonance Imaging contrast associated with incorrect responses of the subjects from a Stop Signal Task protocol.
- Published
- 2014
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