Search

Background: Chikungunya is a globally spreading infectious arboviral disease transmitted from a diurnal bite of the Aedes aegypti and Aedes albopictus Mosquitoes. It is a disease with sporadic outbreaks. It is now resurfacing in South East Asia especially in India, where it is found to have high mortality and morbidity and presenting with atypical presentation, especially with the neurotropic presentation., Objective: To review clinical profile of patients who required admission in the Intensive care unit with atypical presentation of Chikungunya and to study their clinical spectrum and outcome over a course of three years in India., Method and Findings: Using Established guidelines, we conducted a prospective study in a Tertiary care center where we identified patients who required intensive care admissions and were admitted with complicated chikungunya infection and then evaluated their clinical progression of the disease., Conclusion: CHIKV infection is rapidly emerging in more than 100 countries and more and more atypical serious neurological manifestations are seen in elderly populations. Many of these patients have high morbidity and mortality., (© Journal of the Association of Physicians of India 2011.)

Introduction: Microbiological surveillance data is of crucial importance in appropriate management of patients with infectious diseases. The current study was conducted to study the microbiological surveillance data along with antibiotic sensitivity patterns for isolates collected at a single tertiary care center from Western India over last four years and to analyze the change in the patterns of nosocomial infections seen over the last four year period., Design: Retrospective study. Culture reports data were retrospectively collected from microbiology department of Sterling hospital Ahmedabad. Isolates from clinical specimen from blood cultures, surgical site swabs, abdominal drain fluid, urine samples and bronchoscopy samples were analysed in present study. Isolates from respiratory secretions includind endotracheal, tracheostomy and sputums were excluded from analysis, Frequency of different organisms which were isolated as well the sensitivity patterns to major antibiotics were recorded., Results: Among the blood isolates there was a clear trend regarding the emergence of gram positive organisms with Staphylococcus being the most common isolate from 149 blood culture specimens in the period 2008-09 (27.4%). Majority (> 85%) of gram negative isolates causing blood stream infections were sensitive to Amikacin, Cefoperazone-Sulbactam, Piperaciln-Tazobactam, Meropenem and Colistin. On the other hand, sensitivity of gram negative isolates from other sites to these antibiotics was much more variable. Incidence of candidemia went down from 20.3% to 13.4% in 2005-6 and in 2008-09 respectively., Conclusion: Staphylococcus aureus has emerged as the dominant pathogen causing the blood stream infections in last two years. Piperacilin-tazobactum, cefaperazone-sulbactum or meropenem may be appropriate as empiric antibiotic choice for gram negative blood stream infections along with Amikacin for patients with serious infections.