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Aim. To estimate the prevalence and trends of the long-term dynamics of morbidity and mortality associated with various manifestations of HPV infection in Russia in recent years. Materials and methods. We analyzed retrospective data with diagnostic codes related to cervical cancer, penile cancer, anal canal cancer, head and neck cancer (including the oral cavity, oropharynx, larynx and larynx), anogenital (venereal) warts from the official statistic of cancer register and STIs using incidence and mortality rates in Russia between January 2007 and December 2016 and retrospective data with diagnostic codes related to cancer of the vulva and cancer of the vagina between January 2011 and December 2016. Based on the available data on the involvement of HPV in the occurrence of pathological changes, the annual generalized indices for HPV-associated neoplasms were calculated. Results. The estimated number of HPV-associated lesions in the Russian Federation for 2007-2016 amounted to 5 761 170 cases, of which 224 630 - among men and 5 536 540 - among women. The estimated number of deaths from HPV-associated cancers was 109 510 cases, of which 32 080 - among men and 77 430 - among women. The estimated incidence of HPV-associated cancers neoplasms during this period increased by 10% among the male population and by 22% among the female population, reaching 8.0 cases per 100 000 male population in 2016 and 25.2 cases per 100 thousand female population. The death rate from HPV-associated cancers did not change significantly, and in 2016 it was 4.9 cases per 100 thousand male population and 10.2 cases per 100 thousand female population. Conclusion. There is an increase in morbidity and stabilization of mortality rates from HPV-associated cancers for both female and male populations, and a decrease in the incidence of anogenital (venereal) warts.