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155 results on '"Ding, Degang"'

10. Comparison of DNA methylation and cytology tests in urine to detect upper tract urothelial carcinoma: A paired-design diagnostic study.

Author

Wei, Wei, Wu, Danting, Zhang, Zhishu, Liu, Junfeng, Deng, Jun, Zhang, Xiaoli, and Ding, Degang

Subjects
DNA methylation, CIRCULATING tumor DNA, TRANSITIONAL cell carcinoma, CYTOLOGY, RECEIVER operating characteristic curves, URINALYSIS, DNA
Abstract

Objectives To evaluate the diagnostic efficacy of a DNA methylation test, compare that test with cytology alone, fluorescence in situ hybridization (FISH) alone, and cytology plus FISH, and explore reasons that may influence the accuracy of liquid biopsy. Methods We included 37 patients and 12 negative control individuals between April 2019 and May 2022. All patients had undergone radical nephroureterectomy, nephrectomy, diagnostic ureteroscopy, or tissue biopsy. Urine samples were collected for DNA methylation testing, cytology, and FISH. Test performance was calculated, and receiver operating characteristic curves were drawn for comparison. Results Median patient age was 66 years, and κ = 0.576 (P <.001) for the DNA methylation test and tissue pathology. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the DNA methylation test were 76%, 100%, 100%, and 74%, respectively, compared with 31%, 100%, 100%, and 50%, respectively, for cytology. The sensitivity, specificity, PPV, and NPV of cytology plus FISH were 66%, 100%, 100%, and 67%, respectively. The area under the curve (AUC) of the DNA methylation test was 0.879 (P <.001), and the AUC of cytology plus FISH was 0.828 (P <.001). Conclusions The test performance of DNA methylation was satisfactory. The DNA methylation test for the detection of upper tract urothelial carcinoma demonstrated better sensitivity than did cytology alone or cytology with FISH, but the accuracy of the combined tests was still acceptable. Further prospective studies with larger samples are needed to confirm the clinical value of this promising method. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Crystal structure of 3-(methoxycarbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid, C9H12O5

Author

Hou Xuehui, Wang Qinglong, Wang Jianling, Li Aiqin, Ding Degang, and Lv Quanjian

Subjects
2054188, Physics, QC1-999, Crystallography, QD901-999
Abstract

C9H12O5, triclinic, P1‾$P‾{1}$ (no. 2), a = 5.6537(6) Å, b = 7.7954(8) Å, c = 10.6841(9) Å, α = 102.238(8)°, β = 95.381(8)°, γ = 90.940(9)°, V = 457.83(8) Å3, Z = 2, Rgt(F) = 0.0673, wRref(F2) = 0.2279, T = 293(2) K.

Published
2021
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13. Efficacy and safety of LY01005 versus goserelin implant in Chinese patients with prostate cancer: A multicenter, randomized, open-label, phase III, non-inferiority trial

Author

Gu, Chengyuan, primary, Wang, Zengjun, additional, Lin, Tianxin, additional, Liu, Zhiyu, additional, Han, Weiqing, additional, Zhang, Xuhui, additional, Liang, Chao, additional, Liu, Hao, additional, Yu, Yang, additional, Xu, Zhenzhou, additional, Liu, Shuang, additional, Wang, Jingen, additional, Jia, Linghua, additional, Yao, Xin, additional, Liao, Wenfeng, additional, Fu, Cheng, additional, Tan, Zhaohui, additional, He, Guohua, additional, Zhu, Guoxi, additional, Fan, Rui, additional, Yang, Wenzeng, additional, Chen, Xin, additional, Liu, Zhizhong, additional, Zhong, Liqiang, additional, Shi, Benkang, additional, Ding, Degang, additional, Chen, Shubo, additional, Wei, Junli, additional, Yao, Xudong, additional, Chen, Ming, additional, Lu, Zhanpeng, additional, Xie, Qun, additional, Hu, Zhiquan, additional, Wang, Yinhuai, additional, Guo, Hongqian, additional, Fan, Tiwu, additional, Liang, Zhaozhao, additional, Chen, Peng, additional, Wang, Wei, additional, Xu, Tao, additional, Li, Chunsheng, additional, Xing, Jinchun, additional, Liao, Hong, additional, He, Dalin, additional, Wu, Zhibin, additional, Yu, Jiandi, additional, Feng, Zhongwen, additional, Yang, Mengxiang, additional, Dou, Qifeng, additional, Zeng, Quan, additional, Li, Yuanwei, additional, Gou, Xin, additional, Zhou, Guangchen, additional, Wang, Xiaofeng, additional, Zhu, Rujian, additional, Zhang, Zhonghua, additional, Zhang, Bo, additional, Tan, Wanlong, additional, Qu, Xueling, additional, Sun, Hongliang, additional, Gan, Tianyi, additional, and Ye, Dingwei, additional

Published
2023
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17. Correlation between mesenchymal circulating tumor cells and prognosis of urologic malignancies: a single-center retrospective analysis

Author

Wang, Lingdian and Ding, Degang

Subjects
Original Article
Abstract

Objective: To evaluate the correlation of circulating tumor cells (CTCs) and mesenchymal CTCs (M-CTCs) with clinical characteristics and survival of patients with urologic malignancies. Methods: The clinical data of 52 patients with urinary system malignancy in Henan Provincial People’s Hospital were retrospectively analyzed (40 cases of renal malignant tumor, 7 cases of prostate cancer, 3 cases of urothelial carcinoma, 1 case of testis cancer, and 1 case of penile cancer). The CTC counts of patients were collected, and the expression of epithelial-mesenchymal transition phenotype in CTCs was evaluated. The relationship of different types of CTC counts with tumor stage, location, size, metastasis, and differentiation, as well as their effect on progression-free survival (PFS) were analyzed. Results: We detected CTCs in all patients with urinary system malignancy. The positive rates of epithelial CTCs (E-CTC), M-CTCs, and epithelial/mesenchymal CTCs (E/M-CTCs) were 34.62%, 26.92% and 94.23%, respectively. Total CTCs (T-CTCs), M-CTCs and E/M-CTCs were correlated with distant metastasis (Z=-3.052, -3.574, -2.898; all P

Published
2023

18. Segmental ureterectomy for high-risk ureteral carcinoma: a preliminary report.

Author

Wei, Wei, Liu, Junfeng, Wang, Lingdian, Duan, Xiaoyu, and Ding, Degang

Subjects
PROGRESSION-free survival, KIDNEY surgery, CARCINOMA, URETEROSCOPY, SURGICAL complications
Abstract

Background: EAU guidelines strongly recommend kidney sparing surgery (KSS) as the primary treatment option for the low-risk UTUC patients. While there are few reports involving the KSS treated for the high-risk counterparts, especially the ureteral resection. Objective: To evaluate the effectiveness and safety of the segmental ureterectomy (SU) for the patients with high-risk ureteral carcinoma. Materials and methods: We included 20 patients from May 2017 to December 2021 who underwent segmental ureterectomy (SU) in Henan Provincial People's Hospital. The overall survival (OS) and progression free survival (PFS) were evaluated. Besides, the ECOG scores and postoperative complications were also included. Results: As of December 2022, the mean OS was 62.1months (95%CI:55.6-68.6months) and the mean PFS was 45.0months (95%CI:35.9-54.1months). The median OS and median PFS were not reached. The 3-year OS rate was 70% and the 3-year PFS rate was 50%. The percentage of Clavien I and II complications was 15%. Conclusion: For the selected patients with high-risk ureteral carcinoma, the efficacy and safety of segmental ureterectomy were satisfactory. But we still need to conduct prospective or randomized study to validate the value of SU in patients with high-risk ureteral carcinoma. [ABSTRACT FROM AUTHOR]

Published
2023
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25. p53 inhibition attenuates cisplatin-induced acute kidney injury through microRNA-142-5p regulating SIRT7/NF-κB.

Author

Chen, Guoxiao, Xue, Huanzhou, Zhang, Xiangsheng, Ding, Degang, and Zhang, Shilong

Subjects
ACUTE kidney failure, CISPLATIN, NF-kappa B, EPITHELIAL cells
Abstract

Renal tubular epithelial cell apoptosis is the main mechanism of cisplatin-induced acute kidney injury. The role of microRNAs (miRNAs) in the apoptosis of renal tubular epithelial cells has been suggested, but the underlying mechanism has not been fully elucidated. We used microarray analysis to identify miR-142-5p involved in cisplatin-induced acute kidney injury. miR-142-5p was down-regulated in human renal tubular epithelial (HK-2) cells with cisplatin treatment. Notably, the overexpression of miR-142-5p attenuated the cisplatin-induced HK-2 cell apoptosis and inhibition of miR-142-5p aggravated cisplatin-induced HK-2 cell apoptosis. During cisplatin treatment, p53 was activated. The inhibition of p53 by pifithrin-α attenuated the cisplatin-induced kidney injury and up-regulated miR-142-5p expression. We also identified the Sirtuin7 (SIRT7) as a target of miR-142-5p. Furthermore, we demonstrated that the inhibition of SIRT7 prevented cisplatin-induced HK-2 cell apoptosis and decreased the expression of nuclear factor kappa B (NF-κB). Our data revealed that p53 inhibition could attenuate cisplatin-induced acute kidney injury by up-regulating miR-142-5p to repress SIRT7/NF-κB. These findings may provide a novel therapeutic target of cisplatin-induced acute kidney injury. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Additional file 1 of Revealing potential lipid biomarkers in clear cell renal cell carcinoma using targeted quantitative lipidomics

Author

Li, Wen, Wang, Xiaobin, Zhang, Xianbin, Gong, Peng, Ding, Degang, Wang, Ning, and Wang, Zhifeng

Abstract

Additional file 1: Fig. S1. The non-significant lipid count between groups. There are no significant differences in all group comparisons. Fig. S2. Chain length of lipid subtypes between groups. Significant differences are marked with an asterisk, and no significant differences are not marked. Fig. S3 Chain unsaturation of lipid subtypes between groups. Significant differences are marked with an asterisk.

Published
2021
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38. Thirty‐six‐month results of laparoscopic‐based renal denervation plus unilateral laparoscopic adrenalectomy for the treatment of patients with resistant hypertension caused by unilateral aldosterone‐producing adenoma

Author

Liu, Yahui, primary, Zhu, Binbin, additional, Zhu, Lijie, additional, Zhao, Linwei, additional, Fan, Zhiqiang, additional, Ding, Degang, additional, Liu, Zhonghua, additional, Zhao, Qiuping, additional, Qi, Datun, additional, Zhang, You, additional, Wang, Ji‐Guang, additional, and Gao, Chuanyu, additional

Published
2021
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41. A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer

Author

Ruan, Qiang, primary, Ding, Degang, additional, Wang, Bin, additional, He, Chaohong, additional, Ren, Xuequn, additional, Feng, Zhenhua, additional, Pang, Zhigang, additional, Wang, Jin, additional, Zhang, Xiangliang, additional, Tang, Hongsheng, additional, Wang, Jiahong, additional, He, Qingjun, additional, Lei, Ziying, additional, Liao, Quanxing, additional, Luo, Jiali, additional, and Cui, Shuzhong, additional

Published
2021
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42. Synthesis of Functionalized 4,1‐Benzothiazepines via a [4+3] Annulation between Aza‐o‐Quinone Methides and Pyridinium 1,4‐Zwitterionic Thiolates.

Author

Wang, Chuan‐Chuan, Liu, Xue‐Hua, Wang, Xin‐Lu, Cui, Hua‐Peng, Ma, Zhi‐Wei, Ding, Degang, Liu, Jun‐Tao, Meng, Lei, and Chen, Ya‐Jing

Subjects
THIOLATES, ANNULATION, SULFONES, ZWITTERIONS, SULFOXIDES, AZA compounds, HETEROCYCLIC compounds
Abstract

The [4+3] annulation of aza‐o‐quinone methides and pyridinium 1,4‐zwitterionic thiolates has been developed for the one‐step synthesis of functionalized 2,3‐unsaturated 4,1‐benzothiazepines under mild and metal‐free conditions. The produced 4,1‐benzothiazepines can easily be converted into biologically interesting sulfoxides and sulfones via selective oxidization with m‐CPBA. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Clinical outcomes of laparoscopic‐based renal denervation plus adrenalectomy vs adrenalectomy alone for treating resistant hypertension caused by unilateral aldosterone‐producing adenoma

Author

Liu, Yahui, primary, Zhu, Binbin, additional, Zhu, Lijie, additional, Zhao, Linwei, additional, Ding, Degang, additional, Liu, Zhonghua, additional, Fan, Zhiqiang, additional, Zhao, Qiuping, additional, Zhang, You, additional, Wang, Jiguang, additional, and Gao, Chuanyu, additional

Published
2020
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44. Enantioselective Synthesis of Coumarins Catalyzed by Chiral Squaramide

Author

Liu, Zhijing, Ma, Zhiwei, Wang, Chuanchuan, Ding, Degang, Liu, Juntao, Chen, Xiaopei, and Geng, Guangwei

Abstract

A newly chiral tertiary amine-squaramide has successfully developed and applied into the asymmetric Michael addition of 4-hydroxycoumarin to β,γγ-unsaturated α-ketoesters. The catalyst system performed well with a low catalyst loading of 1 mol% under mild reaction conditions. A series of coumarin derivatives were obtained with good yields and enantioselectivities.

Published
2022
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