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Introduction: Understanding the genuine experiences and requirements of caregivers and implementing targeted interventions can have a positive impact on the physical and mental well-being of caregivers with children diagnosed with rheumatic diseases, ultimately reducing their burden and enhancing their quality of life. While there has been a gradual increase in research in this area in recent years, there remains a gap in the evidence that comprehensively and systematically reflects the actual experiences and needs of caregivers. We will employ a mixed-methods approach to evaluate the real-life experiences and requirements of caregivers for children diagnosed with rheumatic diseases to provide insights for both research and clinical interventions. Methods and analysis: All types of studies (quantitative, qualitative, and mixed-methods) involving caregivers of children aged 0 to 18 with rheumatic diseases will be included. We will conduct a comprehensive search across multiple databases, including MEDLINE (PubMed), Embase (Ovid), PsycINFO (Ovid), CINAHL (EBSCO), Cochrane Central Register of Controlled Trials (CENTRAL), CNKI, WanFang, and VIP, as well as the grey literature, to identify primary studies published in either English or Chinese since 2000. Two independent reviewers will conduct the selection process and cross-check the data extraction. The focus of interest will be on understanding the experiences and needs of caregivers for pediatric rheumatic disease patients. In our systematic review, we will employ the 2018 version of the Mixed Methods Assessment Tool (MMAT) to evaluate study quality, and we will apply a convergent integration approach to synthesize the data. Ethics and dissemination: Ethical approval is not needed, as no primary data will be collected. The results will be made available through a peer-reviewed publication. Systematic review registration: PROSPERO 42023465302 [ABSTRACT FROM AUTHOR]

Background: The ability to thrive at work has been demonstrated to be closely linked to the development of nurses.Effective utilization of strengths and maintaining hope are essential elements for clinical nurses’ ability to flourish in their roles. Nevertheless, the relationship between strengths use, hope, and thriving at work remains underexplored. This study aimed to identify distinct subgroups of clinical nurses based on their strengths use and to examine the mediating effect of hope between strengths use and thriving at work. The findings are intended to inform clinical managers on strategies to enhance nurses’ work performance and care quality. Methods: A convenience sample of 568 clinical nurses from two tertiary hospitals in Guangzhou City, Guangdong Province, China, was recruited between January and March 2024. The survey collected sociodemographic data and included the Adult Dispositional Hope Scale, Strengths Use Scale, and Thriving at Work Scale. Potential categories of nurse strengths use characteristics were identified using potential profile analysis, and potential relationships between variables were determined using Pearson correlation analysis, Bayesian factor robustness analyses, and Mediation analysis. Results: LPA identified three distinct groups based on strengths use: low (30.8%), moderate (64.9%), and high (13.2%).The significant mediating effect of hope in the relationship between strengths use based on latent profile analysis and thriving at work was observed (SE = 0.61,95%CI = -10.01, -7.62; SE = 0.76,95%CI = -18.91, -15.91, respectively). Conclusions: There exists heterogeneity in nurses’ strengths use. Hope plays a significant role in mediating the relationship between strengths use and thriving at work. It is recommended that nursing administrators or leaders pay attention to differences in individual levels of strengths use, encourage strengths-based practices and design interventions that foster hope, thereby promoting greater thriving in their professional roles. [ABSTRACT FROM AUTHOR]

Background: Alarmins mediate type 2 T helper cell (Th2) inflammation and serve as upstream signaling elements in allergic inflammation and autoimmune responses. The alarmin interleukin (IL)-25 binds to a multi-domain receptor consisting of IL-17RA and IL-17RB subunits, resulting in the release of Th2 cytokines IL-4, IL-5, IL-9 and IL-13 to drive an inflammatory response. Therefore, the blockage of IL-17RB via SM17, a novel humanized monoclonal antibody, offers an attractive therapeutic target for Th2-mediated diseases, such as asthma. Methods: Wild-type mice were stimulated with house dust mite (HDM) extracts for evaluation of SM17's pre-clinical efficacy in allergic asthma. The safety, pharmacokinectics (PK), pharmacodynamics (PD), and immunogenicity of intravenous (IV) doses of SM17 were assessed in a 2-part clinical study in healthy adult subjects. In Part A, 53 healthy participants were enrolled to receive a single IV dose of SM17 (2, 20, 70, 200, 400, 600, 1200 mg) or placebo. In Part B, 24 healthy subjects were enrolled to receive a single IV dose of SM17 every two weeks (Q2W; 200, 400, 600 mg) or placebo for a total of 3 doses. Results: Animal studies demonstrated that SM17 significantly suppressed Th2 inflammation in the bronchoalveolar lavage fluid and infiltration of immune cells into the lungs. In the Phase I clinical study, no drug-related serious adverse events were observed. Total SM17 exposure increased by approximately 60- to 188-fold with a 60-fold increase in dose from 20 to 1200 mg SM17. Upon administration of the third dose, mean accumulation ratios over 200-600 mg was 1.5 to 2.1, which confirms moderate accumulation of SM17. After Q2W dosing of SM17 over 4 weeks, total exposure increased in a dose-proportional manner from 200 mg to 600 mg SM17. Conclusion: In the pre-clinical studies, we demonstrated that SM17 is a potential therapeutic agent to treat allergic asthma. In the Phase 1 clinical trial, a single IV dose of SM17 up to 1200 mg and three Q2W doses up to 600 mg were well tolerated in healthy participants and demonstrated a favorable safety profile. The pre-clinical efficacy and clinical PK and immunogenicity results of SM17 support further clinical development. Clinical trial registration: https://clinicaltrials.gov/ , identifier NCT05332834. [ABSTRACT FROM AUTHOR]

Aims The aim of this study was to simultaneously analyze estrogen quinone-derived adducts, including 17β-estradiol-2,3-quinone (E 2 -2,3-Q) and 17β-estradiol-3,4-quinone (E 2 -3,4-Q), in human albumin (Alb) and hemoglobin (Hb) derived from breast cancer patients with five-year postoperative treatment without recurrence in Taiwan and to evaluate the treatment-related effects on the production of these adducts. Settings and Design Cohort Methods and Material: Blood samples derived from breast cancer 5-year survivors without recurrence were collected. Albumin and hemoglobin adducts of E 2 -3,4-Q and E 2 -2,3-Q were analyzed to evaluate the degree of disposition of estrogen to quinones and to compare these adduct levels with those in patients before treatment. Statistical Analysis All data are expressed as mean ± standard deviation of three determinations. We used Student’s t -test to examine subgroups. Data were transformed to the natural logarithm and tested for normal distribution for parametric analyses. Linear correlations were investigated between individual adduct levels by simple regression. Statistical analysis was performed using the SPSS Statistics 20.0. Results Result confirmed that logged levels of E 2 -2,3-Q-derived adducts correlated significantly with those of E 2 -3,4-Q-derived adducts (correlation coefficient r =.336-.624). Mean levels of E 2 -2,3-Q-4-S-Alb and E 2 -3,4-Q-2-S-Alb in 5-year survivors were reduced by 60-70% when compared to those in the breast cancer patients with less than one year of diagnosis/preoperative treatment (P

As China increasingly focuses on sustainable development, understanding and influencing urban residents’ energy-saving behaviors becomes vital for addressing high energy consumption issues. Thus, this research chooses the residents in China as its object, and studies the factors influencing residents’ habitual energy-saving behaviors. We establish a comprehensive theoretical model suitable for this study based on the Stimulus-Organism-Response (SOR) theory. Utilizing on-the-spot investigations, extensive data collection and model establishment, our research reveals that “altruism” – defined here as actions driven by concern for societal expectations – predominantly motivates daily energy-saving behaviors. In addition, external factors (cost of energy-saving measures) have a significant impact on residents’ energy-saving investment behaviors. Based on our findings, we propose specific policy recommendations focusing on publicity on environmental pollution, the platform for sharing energy conservation experiences and formulation of group-differentiated energy conservation policies. Therefore, this study provides policy implications for motivating residents to take energy-saving actions. [ABSTRACT FROM AUTHOR]

This research tries to establish the emissions diffusion model of high-speed motor vehicles on the Capital Ring Expressway (CRE) around Beijing, China, applying the MOVES and the CALPUFF models. Data required for this study have been collected from different sources. The results show that small buses and large trucks have the highest pollutant emissions on the CRE. The pollutants like CO and HC mainly comes from gasoline vehicles, while NOx, PM10 and PM2.5 comes from diesel vehicles. The average concentrations of the diffusion of CO, NOx, CH4, PM10, and PM2.5 along with the CRE are 6.5 mg/m3, 2.3 mg/m3, 0.27 mg/m3, 0.055 mg/m3 and 0.056 mg/m3 respectively. The results of this study have practical significance and influence on the emission reduction and concentration control strategies under different circumstances, and put forward suggestions on changing transportation modes, strengthening supervision and so on. It has produced a number of recommendations for the policy makers including (1) active promotion of new energy vehicles on expressways, (2) strategic change of the mode of passenger and freight transportation on expressways, (3) strengthen traffic management and supervision of motor vehicles on expressways, and (4) strengthen vegetation protection in rural and ecologically sound areas along the route. [ABSTRACT FROM AUTHOR]

A dual NIR fluorescent probe Cy-ND is developed for viscosity sensing with λex/em = 766/806 nm, making it apt for biological analysis, whose response is validated through DFT and TDDFT computations. Cy-ND successfully detected viscosity changes amidst acute alcohol-induced liver injury and liver ischemia-reperfusion injury. [ABSTRACT FROM AUTHOR]