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Abstract: Ammonium perchlorate(AP) and LiBH4 can form an oxidation‐fuel energetic system, which provides a new development direction in designing novel mixed explosive formula. The microcalorimetry and self‐designed slow cook‐off setup were used to study thermal performance of AP/LiBH4 energetic powders and grains respectively. Experimental results show that heat release in microcalorimetry method for the mixed system at low temperature was due to the reaction between LiBH4 and residual water vapour. The oxidant gases from AP decomposition participate in the oxidation of LiBH4 at high temperature. The ignition temperature for the AP/LiBH4 grain was 270 °C and the explosion reactions were violent in slow cook‐off test. [ABSTRACT FROM AUTHOR]

Diosgenin can inhibit the growth of A375 and K562 cell lines and induce their apoptosis with an effect on pro-apoptotic members of Bcl-2 family. To study the SAR of diosgenin derivatives, and to improve the anti-tumor activity of diosgenin, a series of novel diosgenin derivatives were designed and synthesized. Their anti-tumor activities in vitro were evaluated. The results revealed that most of the new derivatives had potent effects against K562, A375 and A549 (three tumor cell lines) in vitro, and had no or less effect against H293 and L02 (two normal cell lines). Particularly, some compounds (e.g. 1, 6-8) showed excellent activities on K562 with IC50 values ranging from 1.96 to 4.35 micromol x L(-1).