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399 results on '"Ding, Yan-Qing"'

10. A cohort autopsy study defines COVID-19 systemic pathogenesis

Author

Yao, Xiao-Hong, Luo, Tao, Shi, Yu, He, Zhi-Cheng, Tang, Rui, Zhang, Pei-Pei, Cai, Jun, Zhou, Xiang-Dong, Jiang, Dong-Po, Fei, Xiao-Chun, Huang, Xue-Quan, Zhao, Lei, Zhang, Heng, Wu, Hai-Bo, Ren, Yong, Liu, Zhen-Hua, Zhang, Hua-Rong, Chen, Cong, Fu, Wen-Juan, Li, Heng, Xia, Xin-Yi, Chen, Rong, Wang, Yan, Liu, Xin-Dong, Yin, Chang-Lin, Yan, Ze-Xuan, Wang, Juan, Jing, Rui, Li, Tai-Sheng, Li, Wei-Qin, Wang, Chao-Fu, Ding, Yan-Qing, Mao, Qing, Zhang, Ding-Yu, Zhang, Shu-Yang, Ping, Yi-Fang, and Bian, Xiu-Wu

Published
2021
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14. LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis

Author

Xu, Meng, Xu, Hong-Hai, Lin, Yuan, Sun, Xiangnan, Wang, Li-Jing, Fang, Zhe-Ping, Su, Xue-Han, Liang, Xiang-Jing, Hu, Yang, Liu, Zhi-Min, Cheng, Yuanxiong, Wei, Yuanyuan, Li, Jiabin, Li, Li, Liu, Hong-Juan, Cheng, Zhiqiang, Tang, Na, Peng, Chao, Li, Tingting, Liu, Tengfei, Qiao, Liang, Wu, Dalei, Ding, Yan-Qing, and Zhou, Wei-Jie

Published
2019
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15. Autopsy analysis reveals increased macrophage infiltration and cell apoptosis in COVID-19 patients with severe pulmonary fibrosis

Author

Xiao, Shi-Qi, primary, Wen, Tian-Zi, additional, Chen, Xin-Yu, additional, Chen, He-Yuan, additional, Li, Zhuang, additional, He, Zhi-Cheng, additional, Luo, Tao, additional, Tang, Rui, additional, Fu, Wen-Juan, additional, Cao, Mian-Fu, additional, Chen, Lu, additional, Niu, Qin, additional, Wang, Shuai, additional, Lan, Yang, additional, Ge, Jia, additional, Li, Qing-Rui, additional, Guo, Hai-Tao, additional, Wang, Yan-Xia, additional, Ping, Yi-Fang, additional, Shen, Hong, additional, Wang, Yan, additional, Ding, Yan-Qing, additional, Bian, Xiu-Wu, additional, and Yao, Xiao-Hong, additional

Published
2023
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17. SEMA3B‐AS1 suppresses colorectal carcinoma progression by inhibiting Semaphorin 3B‐dependent VEGF signaling pathway activation

Author

Wang, Yi‐Qing, primary, Chen, Hui, additional, Xu, Shuang, additional, Liao, Cong‐Rui, additional, Xu, Anran, additional, Han, Yue, additional, Yang, Min‐Hui, additional, Zhao, Li, additional, Hu, Sha‐Sha, additional, Wang, Lan, additional, Li, Qing‐Yuan, additional, Zhan, Ling‐Ying, additional, Ding, Yan‐Qing, additional, and Wang, Shuang, additional

Published
2023
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25. Supplementary Figure 1 from CLIC4, ERp29, and Smac/DIABLO Derived from Metastatic Cancer Stem–like Cells Stratify Prognostic Risks of Colorectal Cancer

Author

Deng, Yong-Jian, primary, Tang, Na, primary, Liu, Chao, primary, Zhang, Jiang-Yu, primary, An, Sheng-Li, primary, Peng, Yin-Li, primary, Ma, Li-Li, primary, Li, Guang-Qiu, primary, Jiang, Qiang, primary, Hu, Chun-Ting, primary, Wang, Ya-Nan, primary, Liang, Yao-Ze, primary, Bian, Xiu-Wu, primary, Fang, Wei-Gang, primary, and Ding, Yan-Qing, primary

Published
2023
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26. Supplementary Data from microRNA-224 Promotes Cell Proliferation and Tumor Growth in Human Colorectal Cancer by Repressing PHLPP1 and PHLPP2

Author

Liao, Wen-Ting, primary, Li, Ting-Ting, primary, Wang, Zheng-Gen, primary, Wang, Shu-Yang, primary, He, Mei-Rong, primary, Ye, Ya-Ping, primary, Qi, Lu, primary, Cui, Yan-Mei, primary, Wu, Ping, primary, Jiao, Hong-Li, primary, Zhang, Chi, primary, Xie, Yi-Jun, primary, Wang, Jun-Xian, primary, and Ding, Yan-Qing, primary

Published
2023
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27. Supplementary Figure 5 from CLIC4, ERp29, and Smac/DIABLO Derived from Metastatic Cancer Stem–like Cells Stratify Prognostic Risks of Colorectal Cancer

Author

Deng, Yong-Jian, primary, Tang, Na, primary, Liu, Chao, primary, Zhang, Jiang-Yu, primary, An, Sheng-Li, primary, Peng, Yin-Li, primary, Ma, Li-Li, primary, Li, Guang-Qiu, primary, Jiang, Qiang, primary, Hu, Chun-Ting, primary, Wang, Ya-Nan, primary, Liang, Yao-Ze, primary, Bian, Xiu-Wu, primary, Fang, Wei-Gang, primary, and Ding, Yan-Qing, primary

Published
2023
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28. Supplementary Figure 6 from CLIC4, ERp29, and Smac/DIABLO Derived from Metastatic Cancer Stem–like Cells Stratify Prognostic Risks of Colorectal Cancer

Author

Deng, Yong-Jian, primary, Tang, Na, primary, Liu, Chao, primary, Zhang, Jiang-Yu, primary, An, Sheng-Li, primary, Peng, Yin-Li, primary, Ma, Li-Li, primary, Li, Guang-Qiu, primary, Jiang, Qiang, primary, Hu, Chun-Ting, primary, Wang, Ya-Nan, primary, Liang, Yao-Ze, primary, Bian, Xiu-Wu, primary, Fang, Wei-Gang, primary, and Ding, Yan-Qing, primary

Published
2023
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29. Supplementary Figure 4 from microRNA-224 Promotes Cell Proliferation and Tumor Growth in Human Colorectal Cancer by Repressing PHLPP1 and PHLPP2

Author

Liao, Wen-Ting, primary, Li, Ting-Ting, primary, Wang, Zheng-Gen, primary, Wang, Shu-Yang, primary, He, Mei-Rong, primary, Ye, Ya-Ping, primary, Qi, Lu, primary, Cui, Yan-Mei, primary, Wu, Ping, primary, Jiao, Hong-Li, primary, Zhang, Chi, primary, Xie, Yi-Jun, primary, Wang, Jun-Xian, primary, and Ding, Yan-Qing, primary

Published
2023
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30. Supplementary Figure 3 from microRNA-224 Promotes Cell Proliferation and Tumor Growth in Human Colorectal Cancer by Repressing PHLPP1 and PHLPP2

Author

Liao, Wen-Ting, primary, Li, Ting-Ting, primary, Wang, Zheng-Gen, primary, Wang, Shu-Yang, primary, He, Mei-Rong, primary, Ye, Ya-Ping, primary, Qi, Lu, primary, Cui, Yan-Mei, primary, Wu, Ping, primary, Jiao, Hong-Li, primary, Zhang, Chi, primary, Xie, Yi-Jun, primary, Wang, Jun-Xian, primary, and Ding, Yan-Qing, primary

Published
2023
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31. Supplementary Figure 1 from microRNA-224 Promotes Cell Proliferation and Tumor Growth in Human Colorectal Cancer by Repressing PHLPP1 and PHLPP2

Author

Liao, Wen-Ting, primary, Li, Ting-Ting, primary, Wang, Zheng-Gen, primary, Wang, Shu-Yang, primary, He, Mei-Rong, primary, Ye, Ya-Ping, primary, Qi, Lu, primary, Cui, Yan-Mei, primary, Wu, Ping, primary, Jiao, Hong-Li, primary, Zhang, Chi, primary, Xie, Yi-Jun, primary, Wang, Jun-Xian, primary, and Ding, Yan-Qing, primary

Published
2023
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34. Supplementary Table 1 from CLIC4, ERp29, and Smac/DIABLO Derived from Metastatic Cancer Stem–like Cells Stratify Prognostic Risks of Colorectal Cancer

Author

Deng, Yong-Jian, primary, Tang, Na, primary, Liu, Chao, primary, Zhang, Jiang-Yu, primary, An, Sheng-Li, primary, Peng, Yin-Li, primary, Ma, Li-Li, primary, Li, Guang-Qiu, primary, Jiang, Qiang, primary, Hu, Chun-Ting, primary, Wang, Ya-Nan, primary, Liang, Yao-Ze, primary, Bian, Xiu-Wu, primary, Fang, Wei-Gang, primary, and Ding, Yan-Qing, primary

Published
2023
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35. Supplementary Methods from CLIC4, ERp29, and Smac/DIABLO Derived from Metastatic Cancer Stem–like Cells Stratify Prognostic Risks of Colorectal Cancer

Author

Deng, Yong-Jian, primary, Tang, Na, primary, Liu, Chao, primary, Zhang, Jiang-Yu, primary, An, Sheng-Li, primary, Peng, Yin-Li, primary, Ma, Li-Li, primary, Li, Guang-Qiu, primary, Jiang, Qiang, primary, Hu, Chun-Ting, primary, Wang, Ya-Nan, primary, Liang, Yao-Ze, primary, Bian, Xiu-Wu, primary, Fang, Wei-Gang, primary, and Ding, Yan-Qing, primary

Published
2023
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36. Supplementary Figure 3 from CLIC4, ERp29, and Smac/DIABLO Derived from Metastatic Cancer Stem–like Cells Stratify Prognostic Risks of Colorectal Cancer

Author

Deng, Yong-Jian, primary, Tang, Na, primary, Liu, Chao, primary, Zhang, Jiang-Yu, primary, An, Sheng-Li, primary, Peng, Yin-Li, primary, Ma, Li-Li, primary, Li, Guang-Qiu, primary, Jiang, Qiang, primary, Hu, Chun-Ting, primary, Wang, Ya-Nan, primary, Liang, Yao-Ze, primary, Bian, Xiu-Wu, primary, Fang, Wei-Gang, primary, and Ding, Yan-Qing, primary

Published
2023
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37. Supplementary Figure 7 from CLIC4, ERp29, and Smac/DIABLO Derived from Metastatic Cancer Stem–like Cells Stratify Prognostic Risks of Colorectal Cancer

Author

Deng, Yong-Jian, primary, Tang, Na, primary, Liu, Chao, primary, Zhang, Jiang-Yu, primary, An, Sheng-Li, primary, Peng, Yin-Li, primary, Ma, Li-Li, primary, Li, Guang-Qiu, primary, Jiang, Qiang, primary, Hu, Chun-Ting, primary, Wang, Ya-Nan, primary, Liang, Yao-Ze, primary, Bian, Xiu-Wu, primary, Fang, Wei-Gang, primary, and Ding, Yan-Qing, primary

Published
2023
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39. Supplementary Figure 2 from microRNA-224 Promotes Cell Proliferation and Tumor Growth in Human Colorectal Cancer by Repressing PHLPP1 and PHLPP2

Author

Liao, Wen-Ting, primary, Li, Ting-Ting, primary, Wang, Zheng-Gen, primary, Wang, Shu-Yang, primary, He, Mei-Rong, primary, Ye, Ya-Ping, primary, Qi, Lu, primary, Cui, Yan-Mei, primary, Wu, Ping, primary, Jiao, Hong-Li, primary, Zhang, Chi, primary, Xie, Yi-Jun, primary, Wang, Jun-Xian, primary, and Ding, Yan-Qing, primary

Published
2023
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40. Supplementary Figure 2 from CLIC4, ERp29, and Smac/DIABLO Derived from Metastatic Cancer Stem–like Cells Stratify Prognostic Risks of Colorectal Cancer

Author

Deng, Yong-Jian, primary, Tang, Na, primary, Liu, Chao, primary, Zhang, Jiang-Yu, primary, An, Sheng-Li, primary, Peng, Yin-Li, primary, Ma, Li-Li, primary, Li, Guang-Qiu, primary, Jiang, Qiang, primary, Hu, Chun-Ting, primary, Wang, Ya-Nan, primary, Liang, Yao-Ze, primary, Bian, Xiu-Wu, primary, Fang, Wei-Gang, primary, and Ding, Yan-Qing, primary

Published
2023
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41. Supplementary Figure 4 from CLIC4, ERp29, and Smac/DIABLO Derived from Metastatic Cancer Stem–like Cells Stratify Prognostic Risks of Colorectal Cancer

Author

Deng, Yong-Jian, primary, Tang, Na, primary, Liu, Chao, primary, Zhang, Jiang-Yu, primary, An, Sheng-Li, primary, Peng, Yin-Li, primary, Ma, Li-Li, primary, Li, Guang-Qiu, primary, Jiang, Qiang, primary, Hu, Chun-Ting, primary, Wang, Ya-Nan, primary, Liang, Yao-Ze, primary, Bian, Xiu-Wu, primary, Fang, Wei-Gang, primary, and Ding, Yan-Qing, primary

Published
2023
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46. ASCL2induces an immune excluded microenvironment by activating cancer-associated fibroblasts in microsatellite stable colorectal cancer

Author

Zhang, Dan, Ni, Qi-Qi, Liang, Qiao-Yan, He, Li-Ling, Qiu, Bo-Wen, Zhang, Ling-Jie, Mou, Ting-Yu, Le, Chen-Chen, Huang, Yuan, Li, Ting-Ting, Wang, Shu-Yang, Ding, Yan-Qing, Jiao, Hong-Li, and Ye, Ya-Ping

Abstract

Proficient mismatch repair or microsatellite stable (pMMR/MSS) colorectal cancers (CRCs) are vastly outnumbered by deficient mismatch repair or microsatellite instability-high (dMMR/MSI-H) tumors and lack a response to immune checkpoint inhibitors (ICIs). In this study, we reported two distinct expression patterns of ASCL2in pMMR/MSS and dMMR/MSI-H CRCs. ASCL2is overexpressed in pMMR/MSS CRCs and maintains a stemness phenotype, accompanied by a lower density of tumor-infiltrating lymphocytes (TILs) than those in dMMR/MSI CRCs. In addition, coadministration of anti-PD-L1 antibodies facilitated T cell infiltration and provoked strong antitumor immunity and tumor regression in the MC38/shASCL2mouse CRC model. Furthermore, overexpression of ASCL2 was associated with increased TGFBlevels, which stimulate local Cancer-associated fibroblasts (CAFs) activation, inducing an immune-excluded microenvironment. Consistently, mice with deletion of Ascl2specifically in the intestine (Villin-Cre+, Ascl2flox/flox, named Ascl2CKO) revealed fewer activated CAFs and higher proportions of infiltrating CD8+T cells; We further intercrossed Ascl2CKO with ApcMin/+model suggesting that Ascl2-deficient expression in intestinal represented an immune infiltrating environment associated with a good prognosis. Together, our findings indicated ASCL2induces an immune excluded microenvironment by activating CAFs through transcriptionally activating TGFB, and targeting ASCL2combined with ICIs could present a therapeutic opportunity for MSS CRCs.

Published
2023
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