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C88H64Cl4N8O12S4Cd2, monoclinic, P21/c (no. 14), a = 13.5247(6) Å, b = 15.3257(7) Å, c = 20.6985(8) Å, β = 101.8630(10)°, V = 4198.7(3) Å3, Z = 2, Rgt(F) = 0.0484, wRref(F2) = 0.0967, T = 173(2) K.

C18H16N2O5, triclinic, P1̄ (no. 2), a = 8.716(1) Å, b = 9.969(1) Å, c = 11.435(2) Å, α = 104.535(3)°, β = 104.039(4)°, γ = 111.181(2)°, V = 833.5 Å3, Z = 2, Rgt(F) = 0.0446, wRref(F2) = 0.1276, T = 296 K.

The plants in the genus Gardenia (Rubiaceae) have long been used as traditional medicines in China. In this study, two new 3,4-seco-cycloartane triterpenes, sootepin J (1) and sootepin K (2), and a novel nor-3,4-seco-cycloartane triterpenes, sootepin L (3), together with two known compounds (4-5), were isolated from the methanolic extract of the leaves and twigs of Gardenia sootepensis. The structures of the new compounds were elucidated by combinations of 1D, 2D NMR experiments and HR-MS data, while the known compounds were identified by comparison of the NMR data with previously published data. [ABSTRACT FROM AUTHOR]

Invasive mucinous adenocarcinoma (IMA) was formerly referred to as mucinous bronchioloalveolar carcinoma. The lack of effective chemotherapy and comprehensive treatment for this type of tumor poses a great challenge in clinical practice. We herein report the case of a male patient with IMA who was treated with a combination of pemetrexed (500 mg/m²), cisplatin (75 mg/m²) and bevacizumab (15 mg/kg) as first-line chemotherapy. The patient achieved significant radiological improvement with 6 courses of this regimen. After the tumor progressed, the patient again achieved marked improvement with an additional 4 courses of the same regimen. The patient survived for a total of 30 months after the first chemotherapy. Therefore, bevacizumab in combination with pemetrexed/cisplatin may be an effective strategy for the treatment of IMA. The available literature on this chemotherapy regimen was also reviewed and discussed in the present study. [ABSTRACT FROM AUTHOR]

C18H16N2O5, triclinic, P1̄ (no. 2), a = 8.716(1) Å, b = 9.969(1) Å, c = 11.435(2) Å, α = 104.535(3)°, β = 104.039(4)°, γ = 111.181(2)°, V = 833.5 Å3, Z = 2, Rgt(F) = 0.0446, wRref(F2) = 0.1276, T = 296 K. [ABSTRACT FROM AUTHOR]

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The article discusses the crystal structure of the title compound 1-(2-pyridyl)-3-(4-pyridyl)1H-pyrazol-5-ol (C13H10N4O). Topics discussed include the source of material, experimental data, and the importance of pyrazole compounds in medical chemistry. Also provided are tables which show atomic coordinates and displacement parameters.

Renin-angiotensin system (RAS) is involved in TGF- β -mediated epithelial-to-mesenchymal transition (EMT) and is responsible for airway remodeling in refractory asthma. Obstructive sleep apnea (OSA), which affects RAS activity, is a risk factor for refractory asthma. We aimed to investigate how chronic intermittent hypoxia (IH), the main pathophysiology of OSA, exacerbates asthma and whether Ang-(1-7) protects against chronic IH-induced airway remodeling in asthma. We exposed ovalbumin (OVA)-challenged asthma mice to chronic IH and observed that chronic IH aggravated airway inflammation and collagen deposit in OVA-challenged mice. Compared with the OVA group, the OVA + chronic IH group had a lower expression level of epithelial marker E-cadherin and higher expression levels of mesenchymal markers α -smooth muscle actin and collagen IV in airway epithelia, accompanied with activation of TGF- β /Smad pathway. These changes were reversed by the administration of Ang-(1-7). Consistently, Ang-(1-7) mitigated chronic IH-induced activation of TGF- β -mediated EMT in lipopolysaccharide-treated bronchial epithelial cells in a dose-dependent manner, which was blocked by Ang-(1-7)-specific Mas receptor antagonist A779. Taken together, Ang-(1-7) rescued chronic IH-aggravated TGF- β -mediated EMT to suppress airway remodeling, implying that RAS activity is involved in the mechanisms of OSA-related airway dysfunction in asthma. SIGNIFICANCE STATEMENT: OSA is a risk factor for refractory asthma. In this study, we aimed to explore the mechanisms of how OSA exacerbates refractory asthma. We found that chronic IH induces TGF- β -mediated EMT and aggravates airway collagen deposit. We also found that Ang-(1-7) erased the aggravation of TGF- β -mediated EMT and epithelial fibrosis upon chronic IH exposure. These findings provided new insights that the ACE2/Ang-(1-7)/Mas axis might be considered as a potential therapeutic target for patients with asthma and OSA., Competing Interests: All authors disclose no conflicts of interest., (Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics.)

In the crystal of the title compound, C(15)H(11)ClN(2)O, the molecules are linked by C-H⋯O and weak C-H⋯π inter-actions. The chloro-phenyl and phenyl rings are twisted with respect to the central pyrazolone ring, making dihedral angles of 18.23 (8) and 8.35 (8)°, respectively. The N-N and C=O bond lengths are comparable to those reported for pyrazolone compounds.

In the heteronuclear coordination polymer, {[CuNa(C(9)H(2)NO(8))(H(2)O)(7)]·4H(2)O}(n), the Cu(II) atom is coordinated by six O atoms from five water mol-ecules and one 5-nitro-benzene-1,2,3-tricarboxyl-ate ligand in a slightly distorted octa-hedral geometry. The Na(+) cation is surrounded by six water mol-ecules in an irregular trigonal-prismatic geometry. The Cu and Na atoms are connected by water bridges, forming an infinite chain. O-H⋯O hydrogen bonds involving the coordinated and uncoordinated water mol-ecules connect the chains into a three-dimensional network.