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306 results on '"Ding, Zhen-Bin"'

2. Macro CD5L+ deteriorates CD8+T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma

Author

Lu, Jia-Cheng, Wu, Lei-Lei, Sun, Yi-Ning, Huang, Xiao-Yong, Gao, Chao, Guo, Xiao-Jun, Zeng, Hai-Ying, Qu, Xu-Dong, Chen, Yi, Wu, Dong, Pei, Yan-Zi, Meng, Xian-Long, Zheng, Yi-Min, Liang, Chen, Zhang, Peng-Fei, Cai, Jia-Bin, Ding, Zhen-Bin, Yang, Guo-Huan, Ren, Ning, Huang, Cheng, Wang, Xiao-Ying, Gao, Qiang, Sun, Qi-Man, Shi, Ying-Hong, Qiu, Shuang-Jian, Ke, Ai-Wu, Shi, Guo-Ming, Zhou, Jian, Sun, Yi-Di, and Fan, Jia

Published
2024
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5. Single-cell and spatial architecture of primary liver cancer

Author

Zhou, Pei-Yun, Zhou, Cheng, Gan, Wei, Tang, Zheng, Sun, Bao-Ye, Huang, Jin-Long, Liu, Gao, Liu, Wei-Ren, Tian, Meng-Xin, Jiang, Xi-Fei, Wang, Han, Tao, Chen-Yang, Fang, Yuan, Qu, Wei-Feng, Huang, Run, Zhu, Gui-Qi, Huang, Cheng, Fu, Xiu-Tao, Ding, Zhen-Bin, Gao, Qiang, Zhou, Jian, Shi, Ying-Hong, Yi, Yong, Fan, Jia, and Qiu, Shuang-Jian

Published
2023
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13. Macro CD5L+ deteriorates CD8+T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma.

Author

Lu, Jia-Cheng, Wu, Lei-Lei, Sun, Yi-Ning, Huang, Xiao-Yong, Gao, Chao, Guo, Xiao-Jun, Zeng, Hai-Ying, Qu, Xu-Dong, Chen, Yi, Wu, Dong, Pei, Yan-Zi, Meng, Xian-Long, Zheng, Yi-Min, Liang, Chen, Zhang, Peng-Fei, Cai, Jia-Bin, Ding, Zhen-Bin, Yang, Guo-Huan, Ren, Ning, and Huang, Cheng

Subjects
CHOLANGIOCARCINOMA, T cells, IMMUNITY, CD8 antigen, TUMOR microenvironment, OXALIPLATIN
Abstract

Intratumoral immune status influences tumor therapeutic response, but it remains largely unclear how the status determines therapies for patients with intrahepatic cholangiocarcinoma. Here, we examine the single-cell transcriptional and TCR profiles of 18 tumor tissues pre- and post- therapy of gemcitabine plus oxaliplatin, in combination with lenvatinib and anti-PD1 antibody for intrahepatic cholangiocarcinoma. We find that high CD8 GZMB+ and CD8 proliferating proportions and a low Macro CD5L+ proportion predict good response to the therapy. In patients with a poor response, the CD8 GZMB+ and CD8 proliferating proportions are increased, but the CD8 GZMK+ proportion is decreased after the therapy. Transition of CD8 proliferating and CD8 GZMB+ to CD8 GZMK+ facilitates good response to the therapy, while Macro CD5L+–CD8 GZMB+ crosstalk impairs the response by increasing CTLA4 in CD8 GZMB+. Anti-CTLA4 antibody reverses resistance of the therapy in intrahepatic cholangiocarcinoma. Our data provide a resource for predicting response of the combination therapy and highlight the importance of CD8+T-cell status conversion and exhaustion induced by Macro CD5L+ in influencing the response, suggesting future avenues for cancer treatment optimization. The role of the tumor microenvironment in immunotherapy response in intrahepatic cholangiocarcinoma remains unclear. Here, single cell RNA and TCR sequencing of samples before and after immunotherapy highlights the role of CD8 T-cell status conversion and exhaustion induced by Macro CD5L+ in treatment response. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Inhibition of autophagy in macrophage promotes IL-1β-mediated hepatocellular carcinoma progression via inflammasome accumulation and self-recruitment

Author

Gao, Zheng, primary, Feng, Shan-Ru, additional, Chen, Jia‑Feng, additional, Li, Xiao‑Gang, additional, Shi, Ying‑Hong, additional, Tang, Zheng, additional, Liu, Wei‑Ren, additional, Zhang, Xin, additional, Huang, Ao, additional, Luo, Xuan‑Ming, additional, Zeng, Hai-Ying, additional, Gao, Qiang, additional, Shi, Guo‑Ming, additional, Ke, Ai‑Wu, additional, Zhou, Jian, additional, Fan, Jia, additional, Fu, Xiu‑Tao, additional, and Ding, Zhen‑Bin, additional

Published
2023
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20. Supplementary Tables 1-2 from Autophagy Activation in Hepatocellular Carcinoma Contributes to the Tolerance of Oxaliplatin via Reactive Oxygen Species Modulation

Author

Ding, Zhen-Bin, primary, Hui, Bo, primary, Shi, Ying-Hong, primary, Zhou, Jian, primary, Peng, Yuan-Fei, primary, Gu, Cheng-Yu, primary, Yang, Hua, primary, Shi, Guo-Ming, primary, Ke, Ai-Wu, primary, Wang, Xiao-Ying, primary, Song, Kang, primary, Dai, Zhi, primary, Shen, Ying-Hao, primary, and Fan, Jia, primary

Published
2023
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21. Supplementary Figure 1 from Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma

Author

Shi, Jie-Yi, primary, Gao, Qiang, primary, Wang, Zhi-Chao, primary, Zhou, Jian, primary, Wang, Xiao-Ying, primary, Min, Zhi-Hui, primary, Shi, Ying-Hong, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Ke, Ai-Wu, primary, Dai, Zhi, primary, Qiu, Shuang-Jian, primary, Song, Kang, primary, and Fan, Jia, primary

Published
2023
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22. Supplementary Figure 3 from Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma

Author

Shi, Jie-Yi, primary, Gao, Qiang, primary, Wang, Zhi-Chao, primary, Zhou, Jian, primary, Wang, Xiao-Ying, primary, Min, Zhi-Hui, primary, Shi, Ying-Hong, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Ke, Ai-Wu, primary, Dai, Zhi, primary, Qiu, Shuang-Jian, primary, Song, Kang, primary, and Fan, Jia, primary

Published
2023
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23. Supplementary Figure Legends 1-2, Tables 1-4 from Metadherin Promotes Hepatocellular Carcinoma Metastasis through Induction of Epithelial–Mesenchymal Transition

Author

Zhu, Kai, primary, Dai, Zhi, primary, Pan, Qi, primary, Wang, Zheng, primary, Yang, Guo-Huan, primary, Yu, Lei, primary, Ding, Zhen-Bin, primary, Shi, Guo-Ming, primary, Ke, Ai-Wu, primary, Yang, Xin-Rong, primary, Tao, Zhong-Hua, primary, Zhao, Yi-Ming, primary, Qin, Yi, primary, Zeng, Hai-Ying, primary, Tang, Zhao-You, primary, Fan, Jia, primary, and Zhou, Jian, primary

Published
2023
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24. Supplementary Figure 1 from Metadherin Promotes Hepatocellular Carcinoma Metastasis through Induction of Epithelial–Mesenchymal Transition

Author

Zhu, Kai, primary, Dai, Zhi, primary, Pan, Qi, primary, Wang, Zheng, primary, Yang, Guo-Huan, primary, Yu, Lei, primary, Ding, Zhen-Bin, primary, Shi, Guo-Ming, primary, Ke, Ai-Wu, primary, Yang, Xin-Rong, primary, Tao, Zhong-Hua, primary, Zhao, Yi-Ming, primary, Qin, Yi, primary, Zeng, Hai-Ying, primary, Tang, Zhao-You, primary, Fan, Jia, primary, and Zhou, Jian, primary

Published
2023
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25. Supplementary Figure 4 from Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma

Author

Shi, Jie-Yi, primary, Gao, Qiang, primary, Wang, Zhi-Chao, primary, Zhou, Jian, primary, Wang, Xiao-Ying, primary, Min, Zhi-Hui, primary, Shi, Ying-Hong, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Ke, Ai-Wu, primary, Dai, Zhi, primary, Qiu, Shuang-Jian, primary, Song, Kang, primary, and Fan, Jia, primary

Published
2023
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26. Supplementary Figure Legend, Tables 1 - 2 from Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma

Author

Shi, Jie-Yi, primary, Gao, Qiang, primary, Wang, Zhi-Chao, primary, Zhou, Jian, primary, Wang, Xiao-Ying, primary, Min, Zhi-Hui, primary, Shi, Ying-Hong, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Ke, Ai-Wu, primary, Dai, Zhi, primary, Qiu, Shuang-Jian, primary, Song, Kang, primary, and Fan, Jia, primary

Published
2023
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27. Supplementary Figure 2 from Metadherin Promotes Hepatocellular Carcinoma Metastasis through Induction of Epithelial–Mesenchymal Transition

Author

Zhu, Kai, primary, Dai, Zhi, primary, Pan, Qi, primary, Wang, Zheng, primary, Yang, Guo-Huan, primary, Yu, Lei, primary, Ding, Zhen-Bin, primary, Shi, Guo-Ming, primary, Ke, Ai-Wu, primary, Yang, Xin-Rong, primary, Tao, Zhong-Hua, primary, Zhao, Yi-Ming, primary, Qin, Yi, primary, Zeng, Hai-Ying, primary, Tang, Zhao-You, primary, Fan, Jia, primary, and Zhou, Jian, primary

Published
2023
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28. Supplementary Figure 1 from Autophagy Activation in Hepatocellular Carcinoma Contributes to the Tolerance of Oxaliplatin via Reactive Oxygen Species Modulation

Author

Ding, Zhen-Bin, primary, Hui, Bo, primary, Shi, Ying-Hong, primary, Zhou, Jian, primary, Peng, Yuan-Fei, primary, Gu, Cheng-Yu, primary, Yang, Hua, primary, Shi, Guo-Ming, primary, Ke, Ai-Wu, primary, Wang, Xiao-Ying, primary, Song, Kang, primary, Dai, Zhi, primary, Shen, Ying-Hao, primary, and Fan, Jia, primary

Published
2023
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29. Supplementary Figure 2 from Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma

Author

Shi, Jie-Yi, primary, Gao, Qiang, primary, Wang, Zhi-Chao, primary, Zhou, Jian, primary, Wang, Xiao-Ying, primary, Min, Zhi-Hui, primary, Shi, Ying-Hong, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Ke, Ai-Wu, primary, Dai, Zhi, primary, Qiu, Shuang-Jian, primary, Song, Kang, primary, and Fan, Jia, primary

Published
2023
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30. Supplementary Figure Legend from Autophagy Activation in Hepatocellular Carcinoma Contributes to the Tolerance of Oxaliplatin via Reactive Oxygen Species Modulation

Author

Ding, Zhen-Bin, primary, Hui, Bo, primary, Shi, Ying-Hong, primary, Zhou, Jian, primary, Peng, Yuan-Fei, primary, Gu, Cheng-Yu, primary, Yang, Hua, primary, Shi, Guo-Ming, primary, Ke, Ai-Wu, primary, Wang, Xiao-Ying, primary, Song, Kang, primary, Dai, Zhi, primary, Shen, Ying-Hao, primary, and Fan, Jia, primary

Published
2023
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32. Supplementary Figure 4 from CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma

Author

Gao, Qiang, primary, Zhao, Ying-Jun, primary, Wang, Xiao-Ying, primary, Qiu, Shuang-Jian, primary, Shi, Ying-Hong, primary, Sun, Jian, primary, Yi, Yong, primary, Shi, Jie-Yi, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Xiao, Yong-Sheng, primary, Zhao, Zhong-Hua, primary, Zhou, Jian, primary, He, Xiang-Huo, primary, and Fan, Jia, primary

Published
2023
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33. Supplementary Figure 3 from CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma

Author

Gao, Qiang, primary, Zhao, Ying-Jun, primary, Wang, Xiao-Ying, primary, Qiu, Shuang-Jian, primary, Shi, Ying-Hong, primary, Sun, Jian, primary, Yi, Yong, primary, Shi, Jie-Yi, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Xiao, Yong-Sheng, primary, Zhao, Zhong-Hua, primary, Zhou, Jian, primary, He, Xiang-Huo, primary, and Fan, Jia, primary

Published
2023
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34. Supplementary Methods, Tables 1-6, Figure Legends 1-4 from CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma

Author

Gao, Qiang, primary, Zhao, Ying-Jun, primary, Wang, Xiao-Ying, primary, Qiu, Shuang-Jian, primary, Shi, Ying-Hong, primary, Sun, Jian, primary, Yi, Yong, primary, Shi, Jie-Yi, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Xiao, Yong-Sheng, primary, Zhao, Zhong-Hua, primary, Zhou, Jian, primary, He, Xiang-Huo, primary, and Fan, Jia, primary

Published
2023
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36. Supplementary Figure 1 from CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma

Author

Gao, Qiang, primary, Zhao, Ying-Jun, primary, Wang, Xiao-Ying, primary, Qiu, Shuang-Jian, primary, Shi, Ying-Hong, primary, Sun, Jian, primary, Yi, Yong, primary, Shi, Jie-Yi, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Xiao, Yong-Sheng, primary, Zhao, Zhong-Hua, primary, Zhou, Jian, primary, He, Xiang-Huo, primary, and Fan, Jia, primary

Published
2023
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38. Supplementary Figure 2 from CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma

Author

Gao, Qiang, primary, Zhao, Ying-Jun, primary, Wang, Xiao-Ying, primary, Qiu, Shuang-Jian, primary, Shi, Ying-Hong, primary, Sun, Jian, primary, Yi, Yong, primary, Shi, Jie-Yi, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Xiao, Yong-Sheng, primary, Zhao, Zhong-Hua, primary, Zhou, Jian, primary, He, Xiang-Huo, primary, and Fan, Jia, primary

Published
2023
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39. Data from CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma

Author

Gao, Qiang, primary, Zhao, Ying-Jun, primary, Wang, Xiao-Ying, primary, Qiu, Shuang-Jian, primary, Shi, Ying-Hong, primary, Sun, Jian, primary, Yi, Yong, primary, Shi, Jie-Yi, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Xiao, Yong-Sheng, primary, Zhao, Zhong-Hua, primary, Zhou, Jian, primary, He, Xiang-Huo, primary, and Fan, Jia, primary

Published
2023
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44. Effectiveness and Safety of Avatrombopag in Liver Cancer Patients with Severe Thrombocytopenia: Real-World Data and Challenges

Author

Huang, Ao, primary, Chen, Jia-Feng, additional, Wu, Jian-Zhang, additional, Gao, Zheng, additional, Shi, Ying-Hong, additional, Fu, Xiu-Tao, additional, Zhang, Xin, additional, Liu, Wei-Ren, additional, Gao, Qiang, additional, Sun, Hui-Chuan, additional, Shi, Guo-Ming, additional, Fan, Jia, additional, Ding, Zhen-Bin, additional, and Zhou, Jian, additional

Published
2022
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45. Perioperative and oncologic outcomes of laparoscopic versus open liver resection for combined hepatocellular-cholangiocarcinoma: a propensity score matching analysis

Author

Song, Dan-Jun, primary, Zhu, Kai, additional, Tan, Jin-peng, additional, Cai, Jia-Bin, additional, Lv, Min-Zhi, additional, Hu, Jie, additional, Ding, Zhen-Bin, additional, Shi, Guo-Ming, additional, Ren, Ning, additional, Huang, Xiao-Wu, additional, Shi, Ying-Hong, additional, Qiu, Shuang-Jian, additional, Ye, Qing-Hai, additional, Sun, Hui-Chuan, additional, Gao, Qiang, additional, Zhou, Jian, additional, Fan, Jia, additional, and Wang, Xiao-Ying, additional

Published
2022
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46. Conversion therapy for initially unresectable hepatocellular carcinoma using a combination of toripalimab, lenvatinib plus TACE: real-world study

Author

Qu, Wei-Feng, primary, Ding, Zhen-Bin, additional, Qu, Xu-Dong, additional, Tang, Zheng, additional, Zhu, Gui-Qi, additional, Fu, Xiu-Tao, additional, Zhang, Zi-Han, additional, Zhang, Xin, additional, Huang, Ao, additional, Tang, Min, additional, Tian, Meng-Xin, additional, Jiang, Xi-Fei, additional, Huang, Run, additional, Tao, Chen-Yang, additional, Fang, Yuan, additional, Gao, Jun, additional, Wu, Xiao-Ling, additional, Zhou, Jian, additional, Fan, Jia, additional, Liu, Wei-Ren, additional, and Shi, Ying-Hong, additional

Published
2022
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48. CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor.

Author

Zhu, Gui-Qi, Tang, Zheng, Huang, Run, Qu, Wei-Feng, Fang, Yuan, Yang, Rui, Tao, Chen-Yang, Gao, Jun, Wu, Xiao-Ling, Sun, Hai-Xiang, Zhou, Yu-Fu, Song, Shu-Shu, Ding, Zhen-Bin, Dai, Zhi, Zhou, Jian, Ye, Dan, Wu, Duo-Jiao, Liu, Wei-Ren, Fan, Jia, and Shi, Ying-Hong

Subjects
MACROPHAGE migration inhibitory factor, HEPATOCELLULAR carcinoma, FIBROBLASTS, LIVER cells, SECRETION, PROGRAMMED cell death 1 receptors
Abstract

Hepatocellular carcinoma (HCC) is an immunotherapy-resistant malignancy characterized by high cellular heterogeneity. The diversity of cell types and the interplay between tumor and non-tumor cells remain to be clarified. Single cell RNA sequencing of human and mouse HCC tumors revealed heterogeneity of cancer-associated fibroblast (CAF). Cross-species analysis determined the prominent CD36+ CAFs exhibited high-level lipid metabolism and expression of macrophage migration inhibitory factor (MIF). Lineage-tracing assays showed CD36+CAFs were derived from hepatic stellate cells. Furthermore, CD36 mediated oxidized LDL uptake-dependent MIF expression via lipid peroxidation/p38/CEBPs axis in CD36+ CAFs, which recruited CD33+myeloid-derived suppressor cells (MDSCs) in MIF- and CD74-dependent manner. Co-implantation of CD36+ CAFs with HCC cells promotes HCC progression in vivo. Finally, CD36 inhibitor synergizes with anti-PD-1 immunotherapy by restoring antitumor T-cell responses in HCC. Our work underscores the importance of elucidating the function of specific CAF subset in understanding the interplay between the tumor microenvironment and immune system. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Serial circulating tumor DNA to predict early recurrence in patients with hepatocellular carcinoma: a prospective study

Author

Zhu, Gui‐Qi, primary, Liu, Wei‐Ren, additional, Tang, Zheng, additional, Qu, Wei‐Feng, additional, Fang, Yuan, additional, Jiang, Xi‐Fei, additional, Song, Shu‐Shu, additional, Wang, Han, additional, Tao, Chen‐Yang, additional, Zhou, Pei‐Yun, additional, Huang, Run, additional, Gao, Jun, additional, Sun, Hai‐Xiang, additional, Ding, Zhen‐Bin, additional, Peng, Yuan‐Fei, additional, Dai, Zhi, additional, Zhou, Jian, additional, Fan, Jia, additional, and Shi, Ying‐Hong, additional

Published
2021
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