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In this article, we deal with orbital stability and Zhukovskiǐ quasi-stability of periodic or recurrent orbits in an impulsive dynamical system defined in the n-dimensional Euclidean space Rn{{\mathbb{R}}}^{n}. We show that for a periodic orbit of an impulsive system, its asymptotically orbital stability is equivalent to the asymptotically Zhukovskiǐ quasi-stability, and for a recurrent orbit, the orbital stability is equivalent to the Zhukovskiǐ quasi-stability.

BACKGROUND: Environmental contaminants (ECs) are increasingly recognized as crucial drivers of dyslipidemia and cardiovascular disease (CVD), but the comprehensive impact spectrum and interlinking mechanisms remain uncertain. OBJECTIVES: We aimed to systematically evaluate the association between exposure to 80 ECs across seven divergent categories and markers of dyslipidemia and investigate their underpinning biomolecular mechanisms via an unbiased integrative approach of internal chemical exposome and multi-omics. METHODS: A longitudinal study involving 76 healthy older adults was conducted in Jinan, China, and participants were followed five times from 10 September 2018 to 19 January 2019 in 1-month intervals. A broad spectrum of seven chemical categories covering the prototypes and metabolites of 102 ECs in serum or urine as well as six serum dyslipidemia markers [total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein (Apo)A1, ApoB, and ApoE4] were measured. Multi-omics, including the blood transcriptome, serum/urine metabolome, and serum lipidome, were profiled concurrently. Exposome-wide association study and the deletion/substitution/addition algorithms were applied to explore the associations between 80 EC exposures detection frequency >50% and dyslipidemia markers. Weighted quantile sum regression was used to assess the mixture effects and relative contributions. Multi-omics profiling, causal inference model, and pathway analysis were conducted to interpret the mediating biomolecules and underlying mechanisms. Examination of cytokines and electrocardiograms was further conducted to validate the observed associations and biomolecular pathways. RESULTS: Eight main ECs [1-naphthalene, 1-pyrene, 2-fluorene, dibutyl phosphate, tri-phenyl phosphate, mono-(2-ethyl-5-hydroxyhexyl) phthalate, chromium, and vanadium] were significantly associated with most dyslipidemia markers. Multi-omics indicated that the associations were mediated by endogenous biomolecules and pathways, primarily pertinent to CVD, inflammation, and metabolism. Clinical measures of cytokines and electrocardiograms further cross-validated the association of these exogenous ECs with systemic inflammation and cardiac function, demonstrating their potential mechanisms in driving dyslipidemia pathogenesis. DISCUSSION: It is imperative to prioritize mitigating exposure to these ECs in the primary prevention and control of the dyslipidemia epidemic. https://doi.org/10.1289/EHP13864, Introduction Cardiovascular disease (CVD) is the world's leading cause of disability and death, responsible for 18.6 million deaths globally in 2019. (1) Over the past four decades, the socioeconomic burdens [...]

Abstract In this article, a new nonlinear impulsive delay differential inequality is established, which can be applied in the dynamical analysis of nonlinear systems to improve many extant results. Using the inequality, we obtain some sufficient conditions to guarantee the exponential stability of nonlinear impulsive functional differential equations. Two examples are given to illustrate the effectiveness and advantages of our results.

The photocatalysis technique shows significant potential for wastewater degradation; however, the rapid recombination of photogenerated holes and electrons severely limits its photocatalytic efficiency. This situation necessitates the development of effective strategies to tackle these challenges. One well‐documented approach is built‐in electric field engineering in heterojunctions or composites, which has been shown to enhance electron transfer and thereby reduce the recombination of electrons and holes. This strategy has proven highly effective in significantly improving photocatalytic activity for the degradation of pollutants in wastewater. In this context, we summarize recent advancements in built‐in electric field engineering in photocatalysts, highlighting the fundamentals and modifications of this approach, as well as its positive impact on photocatalytic performance in the degradation of wastewater pollutants. [ABSTRACT FROM AUTHOR]

Background: Organophosphate esters (OPEs) are common endocrine-disrupting chemicals, and OPE exposure may be associated with type 2 diabetes (T2D). However, greater knowledge regarding the biomolecular intermediators underlying the impact of OPEs on T2D in humans are needed to understand biological etiology. Objectives: We explored the associations between OPE exposure and glycometabolic markers among older Chinese adults 60- 69 years of age to elucidate the underlying mechanisms using a multi-omics approach. Methods: This was a longitudinal panel study comprising 76 healthy participants 60-69 years of age who lived in Jinan city of northern China. The study was conducted once every month for 5 months, from September 2018 to January 2019. We measured a total of 17 OPEs in the blood, 11 OPE metabolites in urine, and 4 glycometabolic markers (fasting plasma glucose, glycated serum protein, fasting insulin, and homeostatic model assessment for insulin resistance). The blood transcriptome and serum/urine metabolome were also evaluated. The associations between individual OPEs and glycometabolic markers were explored. An adverse outcome pathway (AOP) was established to determine the biomolecules mediating the associations. Results: Exposure to five OPEs and OPE metabolites (trimethylolpropane phosphate, triphenyl phosphate, tri-iso- butyl phosphate, dibutyl phosphate, and diphenyl phosphate) was associated with increased levels of glycometabolic markers. The mixture effect analysis further indicated the adverse effect of OPE mixtures. Multi-omics analyses revealed that the endogenous changes in the transcriptional and metabolic levels were associated with OPE exposure. The putative AOPs model suggested that triggers of molecular initiation events (e.g., insulin receptor and glucose transporter type 4) with subsequent key events, including disruptions in signal transduction pathways (e.g., phosphatidylinositol 3- kinase/protein kinase B and insulin secretion signaling) and biological functions (glucose uptake and insulin secretion), may constitute the diabetogenic effects of OPEs. Discussion: OPEs are associated with the elevated risk of T2D among older Chinese adults 60-69 years of age. Implementing OPE exposure reduction strategies may help reduce the T2D burden among these individuals, if the relationship is causal. https://doi.org/10.1289/EHP11896, Introduction Diabetes mellitus, mainly type 2 diabetes (T2D), is one of the four most prevalent noncommunicable diseases. (1,2) In 2021, 536.6 (10.5%) million adults 20-79 years of age worldwide were [...]

A novel type of nanocomposite containing anti-spinel NiFe2O4 nanocrystals and reduced graphene oxide (RGO) is successfully reported for boosting the hydroxylation of phenol. According to a series of characterizations and experimental tests, it is uncovered that the optimal NiFe2O4-RGO20 is the best catalyst, the phenol conversion is 28.2%, the selectivity is 93.3%, and the molar ratio of catechol to hydroquinone is 2.6. The cyclic test shows that the catalyst still maintained good catalytic activity after 6 cycles of reaction. Deep mechanism study reveals that the outstanding catalytic performance is primarily attributed to the uniform dispersion of NiFe2O4 nanocrystals loaded on the surface of RGO, which not only prevents the stacking of RGO nanosheets, but also significantly enlarge the exposure of active sites. Moreover, it is also uncovered that the NiFe2O4-RGO20 composite can accelerate the decomposition of H2O2 into •OH, thus improving the reaction conversion efficiency towards the hydroxylation of phenol. [ABSTRACT FROM AUTHOR]