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1,090 results on '"Dini, G"'

1. Reintroducing Fenfluramine as a Treatment for Seizures: Current Knowledge, Recommendations and Gaps in Understanding

Author

Dini G, Di Cara G, Ferrara P, Striano P, and Verrotti A

Subjects
fenfluramine, seizures, dravet syndrome, drug-resistant epilepsy, serotonin, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Gianluca Dini,1 Giuseppe Di Cara,1 Pietro Ferrara,2 Pasquale Striano,3 Alberto Verrotti1 1Department of Pediatrics, University of Perugia, Perugia, Italy; 2Department of Pediatrics, Campus Bio-Medico University, Rome, Italy; 3Pediatric Neurology and Muscular Diseases Unit, IRCCS Istituto “G. Gaslini”, Genoa, ItalyCorrespondence: Gianluca Dini, Department of Pediatrics, University of Perugia, Piazzale Giorgio Menghini 1, Perugia, 06129, Italy, Tel +39 3337797213, Email gianlucadini90@gmail.comAbstract: Despite the introduction of new anti-seizure medications in recent years, approximately one-third of the epileptic population continues to experience seizures. Recently, the anti-obesity medication fenfluramine (FFA) has been successfully repurposed, and it has received approval from various regulatory agencies for the treatment of seizures associated with Dravet syndrome and Lennox-Gastaut syndrome. The potential antiseizure effects of FFA were initially observed in patients with photosensitive epilepsy in the 1980s but it was not rigorously explored as a treatment option until 30 years later. This narrative review aims to provide an overview of the historical progression of FFA’s use, starting from initial clinical observations to preclinical studies and, ultimately, successful clinical trials in the field of epilepsy.Keywords: fenfluramine, seizures, Dravet syndrome, drug-resistant epilepsy, serotonin

Published
2023

3. Augmented Reality in Assembly Systems: State of the Art and Future Perspectives

Author

Dalle Mura, M., Dini, G., Rannenberg, Kai, Editor-in-Chief, Soares Barbosa, Luís, Editorial Board Member, Goedicke, Michael, Editorial Board Member, Tatnall, Arthur, Editorial Board Member, Neuhold, Erich J., Editorial Board Member, Stiller, Burkhard, Editorial Board Member, Tröltzsch, Fredi, Editorial Board Member, Pries-Heje, Jan, Editorial Board Member, Kreps, David, Editorial Board Member, Reis, Ricardo, Editorial Board Member, Furnell, Steven, Editorial Board Member, Mercier-Laurent, Eunika, Editorial Board Member, Winckler, Marco, Editorial Board Member, Malaka, Rainer, Editorial Board Member, and Ratchev, Svetan, editor

Published
2021
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15. Duration of SARS-CoV-2 shedding and infectivity in the working age population: a systematic review and meta-analysis

Author

Rahmani A., Dini G., Leso V., Montecucco A., Vitturi B. K., Iavicoli I., Durando P., Rahmani, A., Dini, G., Leso, V., Montecucco, A., Vitturi, B. K., Iavicoli, I., and Durando, P.

Subjects
shedding, Pandemic, infectivity, SARS-CoV-2, COVID-19, occupational, return to work, working age population, meta-analysi, Human
Abstract

Background: During the COVID-19 pandemic, working age individuals have been implicated in sustaining the resurgence of SARS-CoV-2 infections, and multiple outbreaks have been observed in several occupational settings. In this regard, Occupational Physicians play a crucial role in the management of infected workers, particularly in the safe return-to-work of subjects after clinical resolution. To this end, knowledge of the duration of the infective phase in the working age population is essential, taking into account previous evidence suggesting that PCR positivity does not co-incide with virus viability. Methods: A systematic review and meta-analysis, searching major scientific databases, including PubMed/MEDLINE, Scopus and Web of Science, were performed in order to synthesize the available evidence regarding the mean and maximal duration of infectivity compared to the mean and maximal duration of viral RNA shedding. A subgroup analysis of the studies was performed according to the immunocompetent or immunocompromised immune status of the majority of the enrolled individuals. Results: Twenty studies were included in the final qualita-tive and quantitative analysis (866 individuals). Overall, a mean duration of RT-PCR positivity after symptom onset was found equal to 27.9 days (95%CI 23.3-32.5), while the mean duration of replicant competent virus isolation was 7.3 days (95%CI 5.7-8.8). The mean duration of SARS-CoV-2 shedding resulted equal to 26.5 days (95%CI 21.4-31.6) and 36.3 days (95%CI 21.9-50.6), and the mean duration of SARS-CoV-2 infectivity was 6.3 days (95%CI 4.9-7.8) and 29.5 days (95%CI 12.5-46.5), respectively considering immunocompetent and immunocompromised individuals. The maximum duration of infectivity among immunocompetent subjects was reported after 18 days from symptom onset, while in immunocompromised individuals it lasted up to 112 days. Conclusions: These findings sug-gest that the test-based strategy before return-to-work might not be warranted after 21 days among immunocompetent working age individuals, and could keep many workers out of occupation, reducing their livelihood and productivity.

Published
2022

30. Determinants of SARS-CoV-2 infection in Italian healthcare workers: a multicenter study

Author

Boffetta P., Violante F., Durando P., De Palma G., Pira E., Vimercati L., Cristaudo A., Icardi G., Sala E., Coggiola M., Tafuri S., Gattini V., Apostoli P., Spatari G., De Maria L., Caputi A., Sponselli S., Mastrippolito C., Zunarelli C., Di Felice G., Visci G., Albini E., Sansone E., Tomasi C., Bisioli A., Cipriani L., De Bellis A., Tiraboschi M. M., Paraggio E., Rubino S., Capuzzi M., Dini G., Bruzzone B., Debarbieri N., Montecucco A., Orsi A., Rahmani A., Ricucci V., Guglielmi G., Fiorentino L., Brilli C., Godono A., Declementi M., Mansour I., Milanesio N., Garzaro G., Scarmozzino A., Gullino A., Boffetta P., Violante F., Durando P., De Palma G., Pira E., Vimercati L., Cristaudo A., Icardi G., Sala E., Coggiola M., Tafuri S., Gattini V., Apostoli P., Spatari G., De Maria L., Caputi A., Sponselli S., Mastrippolito C., Zunarelli C., Di Felice G., Visci G., Albini E., Sansone E., Tomasi C., Bisioli A., Cipriani L., De Bellis A., Tiraboschi M.M., Paraggio E., Rubino S., Capuzzi M., Dini G., Bruzzone B., Debarbieri N., Montecucco A., Orsi A., Rahmani A., Ricucci V., Guglielmi G., Fiorentino L., Brilli C., Godono A., Declementi M., Mansour I., Milanesio N., Garzaro G., Scarmozzino A., and Gullino A.

Subjects
Adult, Male, medicine.medical_specialty, Science, Health Personnel, 030501 epidemiology, Logistic regression, Lower risk, Article, Malaise, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, COVID-19, Female, Humans, Italy, Mass Screening, Middle Aged, Occupational Diseases, SARS-CoV-2, Epidemiology, Medicine, 030212 general & internal medicine, Risk factor, Personal protective equipment, Mass screening, Multidisciplinary, business.industry, Risk of infection, Odds ratio, Confidence interval, Occupational Disease, Risk factors, Emergency medicine, medicine.symptom, 0305 other medical science, business, Health occupations, Human
Abstract

BackgroundHealthcare workers (HCW) are at increased risk of being infected with SARS-CoV-2, yet limited information is available on risk factors of infection.MethodsWe pooled data on occupational surveillance of 10,654 HCW who were tested for SARS-CoV-2 infection in six Italian centers. Information was available on demographics, job title, department of employment, source of exposure, use of personal protective equipment (PPE), and COVID-19-related symptoms. We fitted multivariable logistic regression models to calculate odds ratios (OR) and 95% confidence intervals (CI).FindingsThe prevalence of infection varied across centers and ranged from 3.0% to 22.0%, being strongly correlated with that of the respective areas. Women were at lower risk of infection compared to men. Fever, cough, dyspnea and malaise were the symptoms most strongly associated with infection, together with anosmia and ageusia. No differences in the risk of infection were detected between job titles, or working in a COVID-19 designated department. Reported contact with a patient inside or outside the workplace was a risk factor. Use of a mask was strongly protective against risk of infection as was use of gloves. The use of a mask by the source of exposure (patient or colleague) had an independent effect in reducing infection risk.

Published
2021

32. No improvement of survival with reduced- versus high-intensity conditioning for allogeneic stem cell transplants in Ewing tumor patients

Author

Thiel, U., Wawer, A., Wolf, P., Badoglio, M., Santucci, A., Klingebiel, T., Basu, O., Borkhardt, A., Laws, H.-J., Kodera, Y., Yoshimi, A., Peters, C., Ladenstein, R., Pession, A., Prete, A., Urban, E.-C., Schwinger, W., Bordigoni, P., Salmon, A., Diaz, M.A., Afanasyev, B., Lisukov, I., Morozova, E., Toren, A., Bielorai, B., Korsakas, J., Fagioli, F., Caselli, D., Ehninger, G., Gruhn, B., Dirksen, U., Abdel-Rahman, F., Aglietta, M., Mastrodicasa, E., Torrent, M., Corradini, P., Demeocq, F., Dini, G., Dreger, P., Eyrich, M., Gozdzik, J., Guilhot, F., Holler, E., Koscielniak, E., Messina, C., Nachbaur, D., Sabbatini, R., Oldani, E., Ottinger, H., Ozsahin, H., Schots, R., Siena, S., Stein, J., Sufliarska, S., Unal, A., Ussowicz, M., Schneider, P., Woessmann, W., Jürgens, H., Bregni, M., and Burdach, S.

Published
2011
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39. Long-term persistency of hepatitis B immunity: an observational cross-sectional study on medical students and resident doctors

Author

Stefanati, A., Bolognesi, N., Sandri, F., Dini, G., Massa, E., Montecucco, A., Lupi, S., and Gabutti, G.

Subjects
Adult, Male, Secondary, Hepatitis B virus, Students, Medical, Immunization, Secondary, Immunological memory, NO, Occupational health, Vaccination, Cross-Sectional Studies, Female, Hepatitis B, Hepatitis B Antibodies, Hepatitis B Surface Antigens, Hepatitis B Vaccines, Humans, Immunologic Memory, Internship and Residency, Occupational Health, Young Adult, Medical Staff, Hospital, 03 medical and health sciences, Hospital, Medical, Medical Staff, Students, 0303 health sciences, Hepatitis B virus, Immunological memory, Occupational health, Vaccination, 030306 microbiology, Immunization, Original Article
Abstract

Hepatitis B virus (HBV) is a main cause of chronic and acute hepatitis. Healthcare workers (HCWs), including medical students and resident doctors, have an occupational risk of HBV infection. The study aimed to evaluate the long-term persistence of protective anti-HBs antibody levels in healthcare students and resident doctors at risk for occupational exposure to (HBV) at 15 years after primary vaccination course. Further objective was to evaluate the anamnestic response observed in non-seroprotected subjects receiving a booster dose. Data were collected from the clinical documentation filled in during the occupational medical check of medical students and resident doctors undergoing Occupational Health Surveillance by the University of Ferrara. Of the 621 included individuals, 27.7% had an anti-HBs concentration, Journal of Preventive Medicine and Hygiene, Vol 60 No 3 (2019): 2019603

Published
2019

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